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    Cell growth inhibitor and method
    26.
    发明授权
    Cell growth inhibitor and method 失效
    细胞生长抑制剂和方法

    公开(公告)号：US4672107A

    公开(公告)日：1987-06-09

    申请号：US723614

    申请日：1985-04-15

    Applicant: Jack Kilmon

    Inventor： Jack Kilmon

    IPC: A61K35/58 ,  C07K15/00

    CPC classification number: A61K35/58

    Abstract: A cell growth inhibitor consisting essentially of a peptide substantially free of cytotoxins and containing an amino acid sequence of Phe-Cys-Arg-Phe-Leu-Leu-Cys-Pro-Ser-Arg-Thr-Ser-Asp. The peptide may be obtained by fractionation of venom from proteroglyphodont snakes. One cytostatically active fraction contains a peptide with a molecular weight of 3200-3500 daltons, 27-29 amino acid groups, and a blocked amino terminus. Another fraction contains an oligomer or precursor of the lower molecular weight peptide. Also disclosed is a method of inhibiting the growth of cells by introducing the cell growth inhibitor to the cells to be inhibited in an effective amount.

    Abstract translation: 基本上由基本上不含细胞毒素的肽组成并含有Phe-Cys-Arg-Phe-Leu-Leu-Cys-Pro-Ser-Arg-Thr-Ser-Asp的氨基酸序列的细胞生长抑制剂。 肽可以通过从前列腺蛇分离毒液来获得。 一种细胞活性级分含有分子量为3200-3500道尔顿，27-29个氨基酸和封闭的氨基末端的肽。 另一部分含有低分子量肽的低聚物或前体。 还公开了通过将细胞生长抑制剂以有效量引入待抑制细胞来抑制细胞生长的方法。

    Propiophenone derivative and a process for preparing the same
    28.
    发明授权
    Propiophenone derivative and a process for preparing the same 失效
    苯丙酮衍生物及其制备方法

    公开(公告)号：US5830873A

    公开(公告)日：1998-11-03

    申请号：US429567

    申请日：1995-04-27

    Applicant: Kenji Tsujihara ,  Mitsuya Hongu ,  Nobuyuki Funami ,  Masanori Inamasu ,  Kenji Arakawa

    Inventor： Kenji Tsujihara ,  Mitsuya Hongu ,  Nobuyuki Funami ,  Masanori Inamasu ,  Kenji Arakawa

    IPC: C07H15/203 ,  C07H15/26 ,  A61K31/70 ,  C07K15/00

    CPC classification number: C07H15/203 ,  C07H15/26

    Abstract: A propiophenone derivative of the formula �I!: ##STR1## wherein X is O, S or methylene, OY is a protected or unprotected OH, Z is .beta.-D-glucopyranosyl or 4-O-(.alpha.-D-glucopyranosyl)-.beta.-D-glucopyranosyl or wherein one or more hydroxy groups of these groups may optionally be acylated, and the dotted line means the presence or absence of a double bond, or a pharmaceutically acceptable salt thereof. Said compounds have excellent hypoglycemic activity so that they are useful in the prophylaxis or treatment of diabetes.

    Abstract translation: 式[I]的苯丙酮衍生物：其中X为O，S或亚甲基，OY为被保护或未被保护的OH，Z为β-D-吡喃葡萄糖基或4-O-（α-D- 吡喃葡萄糖基）-β-D-吡喃葡萄糖基或其中这些基团的一个或多个羟基可以任选地被酰化，并且虚线表示双键的存在或不存在或其药学上可接受的盐。 所述化合物具有优异的降血糖活性，因此它们可用于预防或治疗糖尿病。

    Compounds having the antigenicity of hCG
    30.
    发明授权
    Compounds having the antigenicity of hCG 失效
    具有hCG抗原性的化合物

    公开(公告)号：US5380668A

    公开(公告)日：1995-01-10

    申请号：US89994

    申请日：1993-07-06

    Applicant: James N. Herron

    Inventor： James N. Herron

    IPC: G01N33/53 ,  C07K7/06 ,  C07K14/59 ,  C07K7/00 ,  A61K37/02 ,  C07K15/00

    CPC classification number: C07K14/59 ,  Y10S436/814 ,  Y10S436/818

    Abstract: Disclosed are compounds having antigenic binding affinity with antibodies directed against human chorionic gonadotropin. The compounds typically include or consist of an oligopeptide with the sequence:AA1' AA2' AA3' AA4' AA5' AA6'wherein AA1' is Gly, Asn, Ser, Phe, Arg Leu, or Lys; AA2' is Pro, Trp, Ala, Val, or Glu; AA3' is Arg, Gln, Ile, Met, Val, Thr, Ser, Gly, or Phe; AA4' is Tyr, Glu, Leu, Phe, Pro, or Thr; AA5' is Asp, Asn, Leu, Met, Val, Tyr, Ser, Ile, Ala, Gly, or Phe; and AA6' is Phe, Trp, Ala, Thr, Arg, Asp, or Val.

    Abstract translation: 公开了与针对人绒毛膜促性腺激素的抗体具有抗原结合亲和力的化合物。 化合物通常包含或由具有以下序列的氨基酸组成：AA1'AA2'AA3'AA4'AA5'AA6'，其中AA1'是Gly，Asn，Ser，Phe，Arg Leu或Lys; AA2'是Pro，Trp，Ala，Val或Glu; AA3'是Arg，Gln，Ile，Met，Val，Thr，Ser，Gly或Phe; AA4'是Tyr，Glu，Leu，Phe，Pro或Thr; AA5'是Asp，Asn，Leu，Met，Val，Tyr，Ser，Ile，Ala，Gly或Phe; 和AA6'是Phe，Trp，Ala，Thr，Arg，Asp或Val。

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