公开(公告)号：US06846453B1

公开(公告)日：2005-01-25

申请号：US09979878

申请日：2000-06-08

申请人： Yoshihiko Uesaka ,  Kumiko Shinohara ,  Yuichi Oku

发明人： Yoshihiko Uesaka ,  Kumiko Shinohara ,  Yuichi Oku

IPC分类号： G01N33/543 ,  B01L3/00 ,  G01N30/02 ,  G01N30/92 ,  G01N33/558 ,  G01N21/00 ,  G01N31/22

CPC分类号： G01N33/558 ,  B01L3/5023 ,  B01L2300/0654 ,  B01L2300/0825 ,  B01L2400/0406 ,  G01N30/02 ,  B01D15/3804 ,  G01N30/92 ,  G01N30/6047

摘要： A housing for an immunochromatography apparatus capable of detecting the concentration of an analyte contained in a sample even if it is relatively low in concentration is provided. In the housing 1 of immunochromatography apparatus having an observation window 5, the observation window 5 of the housing 1 is made of a colored transparent plastic material having a transmittance of at least 20%, preferably at least 40%, so that a detection line displayed on a developing strip 2 contained therewithin can be seen therethrough, the other portion of the housing than the observation window 5 is made of a colored transparent plastic material having a transmittance of at least 12%, and the observation window 5 and the housing 1 are simultaneously and integrally molded out of the same plastic material.

摘要翻译： 提供了能够检测样品中所含分析物的浓度的免疫色谱仪的壳体，即使其浓度相对较低。 在具有观察窗5的免疫层析装置的壳体1中，壳体1的观察窗5由具有至少20％，优选至少40％的透射率的有色透明塑料材料制成，使得检测线显示 在其中容纳的显影条2上可以看到，壳体的观察窗5的另一部分由具有至少12％的透光率的彩色透明塑料材料制成，观察窗5和壳体1是 由同一塑料材料同时整体模制出来。

公开(公告)号：US5824526A

公开(公告)日：1998-10-20

申请号：US667746

申请日：1996-06-21

申请人： David Avnir ,  Michael Ottolenghi ,  Sergei Braun ,  Rivka Zusman

发明人： David Avnir ,  Michael Ottolenghi ,  Sergei Braun ,  Rivka Zusman

IPC分类号： C07K16/00 ,  B01J20/281 ,  B01J20/283 ,  B01J20/291 ,  C03B8/02 ,  C03C4/00 ,  C07K1/14 ,  C12N11/04 ,  C12N11/14 ,  C12P1/00 ,  C12Q1/00 ,  G01N21/77 ,  G01N27/327 ,  G01N30/02 ,  G01N30/88 ,  G01N30/92 ,  G01N31/22 ,  G01N33/543 ,  G01N33/552 ,  G01N33/68 ,  G01N33/84 ,  G01N1/00 ,  A61K9/50 ,  B01J13/18

CPC分类号： G01N33/6869 ,  B01J20/283 ,  B01J20/291 ,  C03C4/0007 ,  C12N11/14 ,  C12P1/00 ,  G01N31/22 ,  G01N33/5436 ,  G01N33/552 ,  G01N33/84 ,  B01J2220/54 ,  G01N2030/484 ,  G01N30/02 ,  G01N30/92 ,  Y02P20/588 ,  Y10S514/944 ,  Y10S514/965 ,  Y10S530/811 ,  Y10T428/2989 ,  Y10T436/10

摘要： A sol-gel glass doped with one or more reagent that provides chemical interactions with diffusible solutes or components in an adjacent liquid or gas phase. The reagent(s), the solutes or the components can be any organic or inorganic compounds or materials of biological origin, including enzymes. The doped sol-gel glass in various forms is useful as an analytical test, chromatographic medium, sensor, catalyst or biocatalyst, electrode or enzyme electrode, and other detection devices.

摘要翻译： 掺有一种或多种试剂的溶胶 - 凝胶玻璃，其与相邻液相或气相中的可扩散溶质或组分提供化学相互作用。 试剂，溶质或组分可以是任何有机或无机化合物或生物来源的材料，包括酶。 各种形式的掺杂溶胶 - 凝胶玻璃可用作分析测试，色谱介质，传感器，催化剂或生物催化剂，电极或酶电极以及其他检测装置。

公开(公告)号：US5643447A

公开(公告)日：1997-07-01

申请号：US376646

申请日：1995-01-20

申请人： Ovadia Lev ,  Michael Tsionsky

发明人： Ovadia Lev ,  Michael Tsionsky

IPC分类号： G01N30/92 ,  B01D15/08

CPC分类号： G01N30/92

摘要： The invention provides a planar chromatographic plate comprising a supported homogeneous thin porous film of ceramic material produced by sol-gel technology the film being provided with a porous network enabling elution through the film whereby planar chromatographic separation of chemicals or biochemicals can be carried out therewith.

摘要翻译： 本发明提供了一种平面色谱板，其包括通过溶胶 - 凝胶技术生产的支撑的陶瓷材料的均匀薄多孔膜，该膜具有能够通过膜洗脱的多孔网络，由此可以进行化学品或生物化学品的平面色谱分离。

公开(公告)号：US5427663A

公开(公告)日：1995-06-27

申请号：US74432

申请日：1993-06-08

申请人： Robert H. Austin ,  Wayne D. Volkmuth ,  Lynn C. Rathburn

发明人： Robert H. Austin ,  Wayne D. Volkmuth ,  Lynn C. Rathburn

IPC分类号： B01J19/00 ,  B01L3/00 ,  C12M1/42 ,  C12M3/08 ,  G01N15/02 ,  G01N15/14 ,  G01N27/447 ,  G01N30/60 ,  G01N30/92 ,  G01N27/26 ,  B03B5/00

CPC分类号： G01N27/44791 ,  B01J19/0093 ,  B01L3/502753 ,  B01L3/502761 ,  C12M47/04 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2400/0421 ,  B01L2400/086 ,  G01N15/0255 ,  G01N2015/149 ,  G01N30/6095 ,  G01N30/92

摘要： A sorting apparatus and method for fractionating and simultaneously viewing individual microstructures, such as free cells, viruses, macromolecules, or minute particles in a fluid medium. The sorting apparatus is composed of a substrate having a receptacle located therein, the receptacle having sidewalls and a floor. An array of obstacles is positioned within the receptacle with the obstacles upstanding from the floor of the receptacle. A transparent cover overlies the array of obstacles to cover the receptacle and afford visual observation of migration of the microstructures exclusively through the array of obstacles. Electrodes may be positioned within the receptacle to generate an electric field in the fluid medium in the receptacle in order to induce the migration of the microstructures. Migration of the microstructures may also occur, for example, by a hydrodynamic field, an optical field, a magnetic field, or a gravity field applied to the receptacle. The obstacles of the array of obstacles may be of various shapes such as round posts, rectangular bunkers, or v-shaped or cup-shaped structures. The arrays of obstacles are formed of a predetermined and reproducible pattern, and can be reused. Methods for manufacturing and using the apparatus are also claimed.

摘要翻译： 一种用于分级并同时观察流体介质中的各种微结构（例如游离细胞，病毒，大分子或微小颗粒）的分选装置和方法。 分拣装置由具有位于其中的插座的基板构成，该插座具有侧壁和底板。 障碍物阵列位于容器内，其中障碍物从容器的地板竖立起来。 透明盖子覆盖障碍物阵列以覆盖容器，并提供目视观察微观结构仅通过障碍物阵列的迁移。 电极可以位于容器内以在容器中的流体介质中产生电场，以引起微结构的迁移。 微结构的移动也可以例如通过施加到容器的流体动力场，光场，磁场或重力场来发生。 障碍物阵列的障碍物可以是各种形状，例如圆柱，矩形掩体或v形或杯形结构。 障碍物阵列由预定和可再现的图案形成，并且可以重复使用。 还要求保护制造和使用该装置的方法。

公开(公告)号：US5310650A

公开(公告)日：1994-05-10

申请号：US925322

申请日：1992-08-04

申请人： Michael E. McMahon ,  Julian Gordon

发明人： Michael E. McMahon ,  Julian Gordon

IPC分类号： B01L3/00 ,  C12Q1/68 ,  C12Q1/70 ,  G01N30/38 ,  G01N30/60 ,  G01N30/92 ,  G01N33/558 ,  G01N37/00

CPC分类号： G01N33/558 ,  B01L3/5023 ,  C12Q1/6834 ,  C12Q1/6876 ,  C12Q1/689 ,  C12Q1/701 ,  B01L2300/0825 ,  B01L2300/087 ,  B01L2400/0406 ,  G01N30/38 ,  G01N30/6065 ,  G01N30/92 ,  Y10S435/81

摘要： The present invention relates to methods and test strips for performing nucleic acid hybridizations on a porous chromatographic material having the capacity for rapid chromatographic solvent transport of non-immobilized reagents and reactive solution components by means of a selected chromatographic solvent. The strip includes a first end or contact site, at which chromatographic solvent transport begins, a second end, at which chromatographic solvent transport ends, and at least one zone positioned between the first and second ends. The zone is impregnated with a capture nucleotide sequence which is immobilized against solvent transport and which is capable of hybridization with a complementary nucleotide sequence or probe so as to render it immobilized in the capture zone. The strip may further include a probe zone between the first end and the capture zone, wherein a labeled probe is impregnated such that it is mobilized by the solvent and transported to the capture zone where hybridization can occur. Interfering sample components and unhybridized nucleic acids are cleared from the capture zone by chromatographic solvent transport to form an inherent wash.

摘要翻译： 本发明涉及用于在多孔层析材料上进行核酸杂交的方法和测试条，该多孔层析材料具有通过选择的色谱溶剂快速色谱溶剂转运非固定化试剂和反应溶液组分的能力。 条带包括开始色谱溶剂转移的第一端或接触位置，色谱溶剂输送结束的第二端和位于第一端和第二端之间的至少一个区。 该区域被捕获核苷酸序列浸渍，该捕获核苷酸序列固定化以抵抗溶剂转运并且能够与互补核苷酸序列或探针杂交，以使其固定在捕获区中。 条带还可以包括在第一端和捕获区之间的探针区，其中标记的探针被浸渍，使得其被溶剂移动并被运送到可以发生杂交的捕获区。 干扰样品组分和未杂交的核酸通过色谱溶剂转移从捕获区域中清除，形成固有的洗涤液。

公开(公告)号：US4865729A

公开(公告)日：1989-09-12

申请号：US199469

申请日：1988-05-27

申请人： Vinit Saxena ,  Brian D. Andresen

发明人： Vinit Saxena ,  Brian D. Andresen

IPC分类号： B01D15/08 ,  B01D15/14 ,  G01N30/38 ,  G01N30/52 ,  G01N30/60 ,  G01N30/92 ,  G01N30/94

CPC分类号： G01N30/38 ,  B01D15/14 ,  B01D15/1807 ,  G01N2030/386 ,  G01N2030/522 ,  G01N30/6004 ,  G01N30/92 ,  G01N30/94

摘要： An improved liquid chromatography column having a horizontal flow of the liquid through the separating medium utilizing an improved fluid distribution system is disclosed. The improved fluid distribution system includes a screen or mesh arrangement, and a thin layer, plate or wafer-like separation medium. The screen or mesh type distribution system enables uniform distribution of the sample or eluting fluid radially over 360.degree. around the periphery of the separating medium bed, thus eliminating the high machining costs and other problems associated with systems employing grooves or passageways type distribution systems. The improved column as a whole may be fabricated so as to be disposable or may be constructed to have an even more simplified fluid distribution arrangement.

摘要翻译： 公开了一种改进的液相色谱柱，其具有利用改进的流体分配系统通过分离介质的液体的水平流动。 改进的流体分配系统包括筛网或网格布置，以及薄层，板或晶片状分离介质。 筛网或网状分布系统使得样品或洗脱液在分离介质床的周边周围径向360度均匀分布，从而消除了与使用槽或通道型分配系统的系统相关的高加工成本和其它问题。 改进的柱作为整体可以被制造成为一次性的，或者可以构造成具有甚至更简化的流体分布布置。

公开(公告)号：US4756828A

公开(公告)日：1988-07-12

申请号：US599386

申请日：1984-04-12

申请人： David Litman ,  Robert Zuk ,  Gerald Rowley

发明人： David Litman ,  Robert Zuk ,  Gerald Rowley

IPC分类号： B01D15/08 ,  G01N30/90 ,  G01N30/92 ,  G01N33/543 ,  G01N33/544 ,  G01N33/53

CPC分类号： G01N30/90 ,  G01N30/92 ,  Y10S435/803 ,  Y10S435/805 ,  Y10S436/81

摘要： A device is disclosed for use in a chromatographic system wherein a component of a mixture is partitioned between a liquid phase and an immobile phase. The device comprises at least one strip of a bibulous material. In the chromatographic system the component traverses at least a portion of the strip. The strip generally has a longitudinal edge substantially corresponding to the direction of traverse of the component. The longitudinal edge has the characteristic of substantially the same rate of traversal by the component along this edge when compared to the rate of traversal of the component along the body of the strip. The strips are prepared from a sheet of a bibulous material by non-deformative or non-compressive cutting of the sheet. The preferred cutting means is a laser beam.

摘要翻译： 公开了用于色谱系统的装置，其中混合物的组分在液相和固定相之间分配。 该装置包括至少一条吸水材料条。 在色谱系统中，组件穿过条带的至少一部分。 条带通常具有基本上对应于部件的横向方向的纵向边缘。 当与沿着带的主体的部件的穿过速率相比时，纵向边缘具有与沿着该边缘的部件完全相同的穿过速率的特征。 通过片材的非变形或非压缩切割从条形材料制备条带。 优选的切割装置是激光束。

公开(公告)号：US3878100A

公开(公告)日：1975-04-15

申请号：US32884373

申请日：1973-02-01

申请人： MARINE COLLOIDS INC

发明人： BIXLER HARRIS J

IPC分类号： G01N27/26 ,  B01D15/08 ,  G01N27/447 ,  G01N30/92 ,  G01N30/93

CPC分类号： G01N30/93 ,  Y10T428/24471

摘要： A thin layer medium for use in molecular diffusion or affinity separation processes having a layer of hydrated gel material, the surface of which is scored or cross-scored at intervals of 0.05 to 1 millimeter. The medium may be maintained wet until used or it may be dried for storage and rehydrated before use.

摘要翻译： 用于分子扩散或亲和分离方法的薄层介质，其具有一层水合凝胶材料，其表面以0.05至1毫米的间隔刻痕或交叉刻痕。 介质可以保持湿润直到使用，或者可以在使用前将其干燥以备存储和再水化。

公开(公告)号：US3591805A

公开(公告)日：1971-07-06

申请号：US3591805D

申请日：1969-02-20

申请人： SCHOEFFEL INSTRUMENT CORP

发明人： SCHOEFFEL DIETMAR M

IPC分类号： G01N30/92 ,  G01N21/20

CPC分类号： G01N30/92

摘要： A chromatographic plate wherein the spectral transmission is preadjusted and which is provided with preadjusted transparent and opaque intervals.

公开(公告)号：US3511775A

公开(公告)日：1970-05-12

申请号：US3511775D

申请日：1968-08-27

申请人： MAY & BAKER LTD

发明人： COLLINS RAYMOND FREDERICK

IPC分类号： G01N30/92 ,  B01D15/08

CPC分类号： G01N30/92