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公开(公告)号：US20170173537A1
公开(公告)日：2017-06-22
申请号：US15124342
申请日：2015-03-09
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Peter Stanley GAGNON
Abstract: Methods and apparatus for purification of biological molecules using combinations of tangential flow filtration subunits and adsorption sub-units in a single apparatus where the subunits may be operated independently or in series and where the apparatus and methods are suitable for use in a wide range of formats distinct from conditions required for chromatographic processes such as conducting process steps using adsorption subunits for purification of a biological molecule in a contaminated sample without prior buffer equilibration.
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公开(公告)号：US20170159070A1
公开(公告)日：2017-06-08
申请号：US15316508
申请日：2014-06-06
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Chunxiao WU
CPC classification number: C12N15/85 , C12N9/1241 , C12N15/11 , C12N15/111 , C12N2303/00 , C12N2800/90 , C12N2830/48 , C12Y207/07
Abstract: Disclosed is a vector comprising a piggyBac like element (PLE) transposon and/or transposase. Also disclosed are vectors comprising a combination of the vectors of the present disclosure, a transformation system comprising the vectors of the present disclosure, an oligonucleotide primer, methods of amplifying nucleotide sequences, methods of transforming a cell with a gene and a transgenic organism.
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公开(公告)号：US20170151598A1
公开(公告)日：2017-06-01
申请号：US15313854
申请日：2015-05-29
Applicant: Agency for Science, Technology and Research
Inventor： Xue LI , Saifullah MSM , Yee Chong LOKE , Karen CHONG
CPC classification number: B21D22/022 , B81B2207/056 , B81C1/0046 , B81C99/0085 , C21D7/04 , C21D2261/00 , C22C12/00 , C22C13/02 , C22C30/04 , G03F7/0002
Abstract: The present invention relates to a method of forming an imprint on a metal substrate. The method comprises a step of providing a mold having a defined imprint surface pattern in the nano-sized or micro-sized range and a step of pressing the metal substrate against the mold at hot-working temperature to form a nano-sized or micro-sized imprint thereon.
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公开(公告)号：US09663874B2
公开(公告)日：2017-05-30
申请号：US14385562
申请日：2013-03-18
Applicant: Agency for Science, Technology and Research
Inventor： Andrew Chwee Aun Wan , Meng Fatt Leong , Tze Chiun Lim , Jackie Y. Ying , Jerry Kah Chin Toh
CPC classification number: D01D5/12 , A61L27/24 , A61L27/38 , A61L27/56 , C12N11/04 , C12N2500/34 , C12N2500/50 , D01D5/30 , D01D5/38
Abstract: There is provided a device, and related method and uses, for drawing a polymer fiber, the device comprising: a. at least two polymer compartments, wherein each polymer compartment is capable of retaining a polymer solution, and wherein adjacent compartments comprise different polymer solutions; and b. a slider comprising at least one prong, wherein the prong is capable of contacting the different polymer solutions, and wherein the slider is arranged in a retractable manner from the at least two polymer compartments. There is further provided a system and a related method for manufacturing a polymer fiber.
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公开(公告)号：US09644234B2
公开(公告)日：2017-05-09
申请号：US14368420
申请日：2012-12-28
Applicant: Agency for Science, Technology and Research
Inventor： Juergen Hans Pipper , Sankar Thulasinga
CPC classification number: C12Q1/686 , B01L7/52 , B01L2300/1805 , B01L2300/1861 , B01L2300/1872 , H05B3/0038 , H05B7/18 , C12Q2545/10 , C12Q2561/113 , C12Q2565/607
Abstract: A method and device for adjusting the temperature of a sample by heating a substrate with a laser diode light; said light projected on to the substrate to absorb the light and convert the light energy to a heat energy thereby raising the temperature of the substrate corresponding to the intensity of the light energy, the substrate configured to transfer the thermal energy substantially homogenously to the sample. The device or method suitable for amplification of a nucleic acid sample.
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Patent Agency Ranking
公开(公告)号：US09637592B2
公开(公告)日：2017-05-02
申请号：US15343537
申请日：2016-11-04
Applicant: International Business Machines Corporation , Agency For Science, Technology and Research
Inventor： James L. Hedrick , Ashlynn L. Z. Lee , Victor W. L. Ng , Yi Yan Yang
CPC classification number: C08G64/183 , A61K9/0024 , A61K9/06 , A61K31/355 , A61K31/592 , A61K31/593 , A61K47/34 , A61K47/551 , A61K47/60 , A61K2039/505 , A61K2039/54 , A61P35/00 , C07K16/32 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C08G65/3318 , C08G2210/00 , Y02A50/473
Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.
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公开(公告)号：US20170115170A1
公开(公告)日：2017-04-27
申请号：US15129277
申请日：2015-03-25
Applicant: Agency for Science, Technology and Research
Inventor： Zhihao CHEN , Ju Teng TEO , Soon Huat NG , Xiufeng YANG
IPC: G01L1/24
CPC classification number: G01L1/243
Abstract: According to embodiments of the present invention, a sensing device is provided. The sensing device includes a sensor arrangement including an optical fiber, and at least one spacer element arranged adjacent to the optical fiber, wherein the optical fiber and the at least one spacer element are adapted to cooperate to receive a force applied to the sensor arrangement to modulate an optical signal propagating in the optical fiber. According to further embodiments of the present invention, a method for sensing a force is also provided.
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公开(公告)号：US09631050B2
公开(公告)日：2017-04-25
申请号：US15154948
申请日：2016-05-14
Applicant: International Business Machines Corporation , Agency For Science, Technology and Research
Inventor： Daniel J. Coady , Richard A. Dipietro , Amanda C. Engler , James L. Hedrick , Victor W. L. Ng , Zhan-Yuin Ong , Jeremy P. K. Tan , Yi Yan Yang
CPC classification number: C08G63/64 , A01N33/12 , A01N43/50 , A01N57/34 , A61K9/0019 , A61K31/765 , A61K2800/54 , A61K2800/542 , A61K2800/5426 , C08G64/0233 , C08G64/0241 , C08G64/025 , C08G64/0258 , C08G64/0291 , C08G64/30 , A01N45/00
Abstract: Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.
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309.发明申请公开(公告)号：US20170109878A1
公开(公告)日：2017-04-20
申请号：US15121761
申请日：2015-02-27
Inventor： Xulei YANG , Yi SU , Si Yong YEO , Liang ZHONG , Ru San TAN
CPC classification number: G06T7/0012 , G06K9/342 , G06T7/11 , G06T7/12 , G06T2207/10088 , G06T2207/20116 , G06T2207/30048
Abstract: A method is proposed for identifying an anatomical structure within a spatial-temporal image (i.e. a series of frames captured as respective times). A current frame of spatial-temporal medical image is processed using information from one or more previous and/or subsequent temporal frames, to aid in the segmentation of an object or a region of interest (ROI) in a current frame. The invention is applicable to both two- and three-dimensional spatial-temporal images (i.e., 2D+time or 3D+time), and in particular to cardiac magnetic resonance (CMR images). An initialisation process for this method segments the left ventricle (LV) in a CMR image by a fuzzy c-means (FCM) clustering algorithm which employs a circular shape function as part of the definition of the dissimilarity measure.
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公开(公告)号：US09624191B2
公开(公告)日：2017-04-18
申请号：US14862365
申请日：2015-09-23
Applicant: International Business Machines Corporation , Agency For Science, Technology and Research
Inventor： Mareva B. Fevre , James L. Hedrick , Victor W. L. Ng , Robert J. Ono , Shrinivas Venkataraman , Zhi Xiang Voo , Yi Yan Yang
IPC: C07D323/00 , A01N47/06 , C08G64/02 , A01N43/72 , C07D273/01 , C08G64/30
CPC classification number: C07D323/00 , A01N47/06 , C07D273/01 , C08G64/0241 , C08G64/30
Abstract: Eight-membered ring cyclic carbonates having an oxygen or an acylated nitrogen at position 6 were prepared by reaction of precursor diols with ethyl chloroformate. The cyclic carbonates undergo organocatalyzed ring opening polymerization. In one instance, the initial polymer formed comprises a carbonate repeat unit having a Boc-protected nitrogen in the polymer backbone. Deprotecting the nitrogen with acid forms a cationic carbonate repeat unit having a positive charged secondary ammonium nitrogen in the polymer backbone.
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