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公开(公告)号：US20230348571A1
公开(公告)日：2023-11-02
申请号：US17917174
申请日：2021-04-06
Applicant: VANDERBILT UNIVERSITY , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Ivelin Stefanov Georgiev , Andrea R. Shiakolas , Kevin J. Kramer , James E. Crowe, Jr. , Robert Carnahan , Nianshuang Wang , Daniel Wrapp , Jason McLellan
CPC classification number: C07K16/1003 , A61P31/14 , A61K2039/505
Abstract: The present disclosure relates to antibodies and uses thereof for treating, preventing, and detecting coronavirus infection.
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公开(公告)号：US20230320649A1
公开(公告)日：2023-10-12
申请号：US18204091
申请日：2023-05-31
Applicant: The Trustees of Dartmouth College
Inventor： David W. ROBERTS , Keith D. PAULSEN , Alexander HARTOV , Songbai JI , Xiaoyao FAN
IPC: H04N13/239 , A61B5/00 , G06T7/33 , H04N13/257 , A61B5/377 , G06T3/00
CPC classification number: A61B5/377 , A61B5/0042 , A61B5/0077 , G06T3/0068 , G06T7/33 , H04N13/239 , H04N13/257 , A61B2034/104
Abstract: A surgical guidance system has two cameras to provide stereo image stream of a surgical field; and a stereo viewer. The system has a 3D surface extraction module that generates a first 3D model of the surgical field from the stereo image streams; a registration module for co-registering annotating data with the first 3D model; and a stereo image enhancer for graphically overlaying at least part of the annotating data onto the stereo image stream to form an enhanced stereo image stream for display, where the enhanced stereo stream enhances a surgeon’s perception of the surgical field. The registration module has an alignment refiner to adjust registration of the annotating data with the 3D model based upon matching of features within the 3D model and features within the annotating data; and in an embodiment, a deformation modeler to deform the annotating data based upon a determined tissue deformation.
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公开(公告)号：US20230293693A1
公开(公告)日：2023-09-21
申请号：US18175433
申请日：2023-02-27
Inventor： Samuel F. BAKHOUM , Bassem I. ZAKI , Duane A. COMPTON
CPC classification number: A61K41/0038 , A61N5/10 , A61N2005/1098
Abstract: Disclosed is a method for increasing susceptibility of cancer cells to ionizing radiation by delivering to the cells a radiosensitizing agent that has one of the following properties: (a) it perturbs the process of chromosome segregation thereby increasing chromosome missegregation; or (b) it is an inhibitor of an agent that promotes faithful chromosome segregation induces numeric chromosome instability in said cells and this instability is induced substantially simultaneously with or closely prior to or closely after irradiating the cells. Examples of such radiosensitizing agent include inhibitors of one or more of the following: Kif2b, MCAK, MPS1, Eg5/Kinesin-5 5, Polo-like kinase 4, MCAK, Bub1 and Hec1. Such agents specifically target proteins involved in maintaining or promoting faithful chromosome segregation.
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公开(公告)号：US11752189B2
公开(公告)日：2023-09-12
申请号：US16669552
申请日：2019-10-31
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE , KING'S COLLEGE LONDON
Inventor： Randolph J. Noelle , Sabrina Ceeraz , Isabelle LeMercier , Elizabeth Nowak , Janet Lines , Li Wang , Mark Spaller
CPC classification number: A61K38/10 , A61K9/0019 , A61K39/0005 , A61K45/06 , C07K7/08 , C07K16/2827 , G01N33/566 , A61K38/00 , C07K2317/74 , C07K2317/76 , C07K2319/30 , Y02A50/30
Abstract: The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.
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35.发明公开公开(公告)号：US20230280577A1
公开(公告)日：2023-09-07
申请号：US18144767
申请日：2023-05-08
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Pablo A. Valdes , David W. Roberts , Keith D. Paulsen , Frederic Leblond
Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.
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Patent Agency Ranking
公开(公告)号：US20230242594A1
公开(公告)日：2023-08-03
申请号：US18000112
申请日：2021-05-28
Inventor： Jason MCLELLAN , Jennifer MAYNARD , Andrea CHASSE , Ilya FINKELSTEIN , Mohammad JAVANMARDI , Jeffrey SCHAUB , Hung-Che KUO , Chia-Wei CHOU , Jory GOLDSMITH , Christy HJORTH , Ching-Lin HSIEH , Patrick BYRNE , Nicole JOHNSON , Nianshuang WANG , Daniel WRAPP
IPC: C07K14/005 , A61K39/215 , A61P31/14
CPC classification number: C07K14/005 , A61K39/215 , A61P31/14 , C12N2770/20022 , C12N2770/20034 , C07K2319/03
Abstract: Provided herein are engineered Coronavirus S proteins, such as engineered SARS-CoV-2 S proteins. In some aspects, the engineered S proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of engineered proteins as diagnostics, in screening platforms and/or in vaccine compositions.
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公开(公告)号：US20230233157A1
公开(公告)日：2023-07-27
申请号：US18159495
申请日：2023-01-25
Applicant: The Trustees of Dartmouth College
Inventor： Kenneth Tichauer , Robert W. Holt , Frederic Leblond , Pablo Valdes , Brian W. Pogue , Keith D. Paulsen , David W. Roberts
CPC classification number: A61B5/7278 , A61B5/0071 , A61K49/0058 , A61B5/0062 , A61B5/0035 , A61B2576/00
Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.
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公开(公告)号：US11695090B2
公开(公告)日：2023-07-04
申请号：US17958868
申请日：2022-10-03
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Zhiyuan Wang , Xiaoxin Wang , Jifeng Liu
IPC: H01L31/0232 , H01L31/119 , H01L27/146 , H01L27/148 , H01L27/144
CPC classification number: H01L31/119 , H01L27/146 , H01L27/1446 , H01L27/14875 , H01L31/02327
Abstract: Disclosed are infrared (IR) light detectors. The detectors operate by generating hot electrons in a metallic absorber layer on photon absorption, the electrons being transported through an energy barrier of an insulating layer to a metal or semiconductor conductive layer. The energy barrier is set to bar response to wavelengths longer than a maximum wavelength. Particular embodiments also have a pattern of metallic shapes above the metallic absorber layer that act to increase photon absorption while reflecting photons of short wavelengths; these particular embodiments have a band-pass response.
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公开(公告)号：US20230208373A1
公开(公告)日：2023-06-29
申请号：US18116755
申请日：2023-03-02
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Kofi ODAME , Yueh-Ching TENG
CPC classification number: H03G3/3036 , H03F3/24
Abstract: An amplitude detector has a phase shifter such as one using an analog differentiator and an adjustable gain stage, or one using a determinable delay, the phase shifter coupled to shift phase of an input signal to the amplitude detection apparatus. The detector also has a first analog multiplier coupled to square the input signal, a second analog multiplier coupled to square output of the phase shifter; and an analog adder coupled to sum outputs of the first and second analog multiplier. An automatic gain control circuit has the amplitude detector coupled to control gain of a controllable amplifier.
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40.发明授权公开(公告)号：US11662315B2
公开(公告)日：2023-05-30
申请号：US17516490
申请日：2021-11-01
Inventor： Keith D. Paulsen , David W. Roberts , Dennis Wirth , Brian C. Wilson , Mira Sibai
IPC: G01B11/22 , G01N21/64 , G01N21/47 , G01N33/483
CPC classification number: G01N21/6456 , G01B11/22 , G01N21/4795 , G01N33/4833 , G01N2201/062
Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.
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