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公开(公告)号:US20040194704A1
公开(公告)日:2004-10-07
申请号:US10409434
申请日:2003-04-07
Applicant: Surmodics, Inc.
Inventor: Ralph A. Chappa , Steven J. Porter
IPC: C23C016/00
CPC classification number: B05D1/002 , A61L31/10 , B05B13/0242 , B05B13/0442 , B05B16/40
Abstract: The invention provides an apparatus for coating a device comprising a coating chamber and a device rotator having at least one device mount wherein the apparatus allows insertion and retraction of the device on the device mount into and out of the coating chamber. In another aspect, the invention provides a method of applying a substantially uniform coating on a device comprising the steps of providing an apparatus for coating a device, mounting the device onto the device mount, purging the coating chamber to reduce humidity in the coating chamber, maintaining a reduced humidity content in the coating chamber, inserting the device into the coating chamber, disposing a coating material on the device and rotating the device mounts about the device axis.
Abstract translation: 本发明提供了一种用于涂覆装置的装置,该装置包括涂覆室和具有至少一个装置安装件的装置旋转器,其中装置允许装置在装置安装件上进出涂层室的插入和缩回。 另一方面,本发明提供了一种在装置上施加基本上均匀的涂层的方法,包括以下步骤:提供用于涂覆装置的装置,将装置安装到装置安装件上,清洗涂布室以减少涂覆室中的湿度, 保持涂布室中的湿度降低,将装置插入涂覆室中,将涂层材料设置在装置上并使装置围绕装置轴线旋转。
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公开(公告)号:US20040161547A1
公开(公告)日:2004-08-19
申请号:US10371043
申请日:2003-02-19
Applicant: SurModics, Inc.
Inventor: Mark F. Carlson , Steven J. Porter , Sean M. Stucke , Ralph A. Chappa
IPC: B05D003/06
CPC classification number: B05C3/109 , B05C9/14 , B05D1/18 , B05D3/061 , B05D2258/02
Abstract: This invention provides a coating apparatus and methods for coating a device, such as an industrially or medically applicable device. The apparatus is suitable for providing a coating using a photoactivatable compound and a polymerizable compound. In another aspect, the apparatus and methods are useful for coating a device wherein the surface of the device has small pores or apertures. The apparatus includes of containers suitable for holding the object to be coated and the coating solution, a gas supply source for supplying gas to solution, an irradiation station for providing light used in the coating process, and a conveyor mechanism to direct the containers to and from the irradiation station.
Abstract translation: 本发明提供一种涂覆装置和涂覆装置的方法,例如工业上或医学上适用的装置。 该装置适用于使用可光活化化合物和可聚合化合物提供涂层。 在另一方面,该装置和方法可用于涂覆装置,其中该装置的表面具有小的孔或孔。 该装置包括适于保持待涂覆物体和涂布溶液的容器,用于向溶液供应气体的气体供应源,用于提供在涂布过程中使用的光的照射台,以及输送机构, 从照射站。
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公开(公告)号:US20030170914A1
公开(公告)日:2003-09-11
申请号:US10357679
申请日:2003-02-03
Applicant: SurModics, Inc
Inventor: Patrick E. Guire , Melvin J. Swanson
IPC: C12Q001/68 , G01N033/543
CPC classification number: C12Q1/6837 , B01J19/0046 , B01J2219/005 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , C40B40/06 , Y10S436/807 , Y10S436/809 , Y10S977/849
Abstract: A system for producing substantially identical specific binding ligand (e.g., nucleic acid) probe arrays, for instance, by preparing and replicating an original master array and/or by providing a reusable assay array that is capable of being regenerated. In one embodiment the system includes the preparation and use of a) a master array surface having address sequences immobilized in the form of a patterned, and optionally random, array, b) a multi-ligand conjugate having a binding domain complementary to an address sequence, a binding domain complementary to a target sequence, and a third ligand for use in forming (e.g., by binding or polymerization) the conjugates into or onto the surface of assay array, which can be used with or upon disassociation of the address and its complementary sequences.
Abstract translation: 用于制备基本相同的特异性结合配体(例如,核酸)探针阵列的系统,例如通过制备和复制原始主阵列和/或通过提供能够再生的可重复使用的分析阵列。 在一个实施方案中,该系统包括a)主阵列表面的制备和使用,该主阵列表面具有以图案化和任选的阵列的形式固定的地址序列,b)具有与地址序列互补的结合结构域的多配体缀合物 ,与靶序列互补的结合结构域,以及用于将缀合物形成(例如通过结合或聚合)到测定阵列表面中或表面上的第三配体,其可以在解除地址及其使用时使用 互补序列。
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公开(公告)号:US20230338623A1
公开(公告)日:2023-10-26
申请号:US18139125
申请日:2023-04-25
Applicant: Surmodics, Inc.
Inventor: Joram Slager , Michael Schneider , Sedef Piril Ertem , Travis Lemke , Ralph A. Chappa
CPC classification number: A61L29/16 , A61L29/085 , A61L2300/216 , A61L2300/802 , A61L2300/416
Abstract: Embodiments herein relate to medical devices and coatings for the same. In an embodiment, a drug delivery coating can be included having a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The drug delivery coating can also include an active agent layer disposed over the polymeric layer. The active agent layer can include a microcrystalline active agent and a cationic agent. Other embodiments are also included herein.
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公开(公告)号:US11712545B2
公开(公告)日:2023-08-01
申请号:US15704765
申请日:2017-09-14
Applicant: SURMODICS, Inc.
Inventor: Amy Trocke , Gregg Sutton , Joram Slager
CPC classification number: A61M25/1002 , A61M25/0668 , A61M25/0097 , A61M39/06 , A61M2025/1004 , A61M2025/105 , A61M2025/1079 , A61M2025/1081 , A61M2205/6081
Abstract: The disclosure provides insertion tools and articles that facilitate entry of a medical device, such as a balloon catheter, into the body, and that can provide advantages in terms of balloon insertion, safety, and drug delivery. The insertion tool includes a tubular portion that accommodates a balloon portion of a balloon catheter, and one or more separation margin(s) in the wall of the tubular portion or one or more split(s) in the tubular wall. The insertion tool also includes a proximal tab that extends from a second lengthwise half having a portion at an angle skew to the lengthwise axis, or that is in the form of a solid article comprising a concave surface that is fastened to an outer surface of the second lengthwise half of the tubular portion; or first and second tabs that extend from first and second lengthwise halves of the tubular portion, respectively.
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公开(公告)号:US11504141B2
公开(公告)日:2022-11-22
申请号:US16687256
申请日:2019-11-18
Applicant: Surmodics, Inc.
Inventor: Charlie Olson
IPC: A61B17/22 , A61B17/3207 , A61M25/10 , A61B17/32 , A61B17/00
Abstract: The disclosure provides plaque treatment catheter assemblies for the treatment of arterial plaques and removal of clots. One assembly includes a second catheter tube movable within a first catheter tube, and an expansion member movable within the second tube. The second catheter tube has one or more distally-disposed and outwardly-expandable plaque treatment portion(s). Another assembly includes a catheter tube and at least one channel(s) within the catheter. The channel includes an elongate member with a distally-disposed plaque scoring or clot retrieval member. Optionally, the assembly includes an expandable member that can cause movement of the scoring member.
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公开(公告)号:US11318204B2
公开(公告)日:2022-05-03
申请号:US15373174
申请日:2016-12-08
Applicant: Surmodics, Inc.
Inventor: Ralph A. Chappa
IPC: A61K47/22 , A61K9/00 , A61K31/337 , A61M25/00 , A61K31/436 , A61M25/10 , A61L29/16
Abstract: The present invention relates to a pharmaceutical composition for intravascular delivery of a therapeutic agent, such as paclitaxel, rapamycin, or an analog thereof. The composition includes the therapeutic agent and a biocompatible solvent, such as glycofurol. The composition can aid tissue penetration by the therapeutic agent. A catheter assembly that protects the pharmaceutical composition from the surroundings can be used for its intravascular delivery.
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公开(公告)号:USD940080S1
公开(公告)日:2022-01-04
申请号:US29726126
申请日:2020-02-28
Applicant: Surmodics, Inc.
Designer: Karl Ganske
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公开(公告)号:US11174447B2
公开(公告)日:2021-11-16
申请号:US16505145
申请日:2019-07-08
Applicant: Surmodics, Inc.
Inventor: David E. Babcock , Joram Slager , Robert W. Hergenrother
IPC: B32B27/30 , A61L27/34 , A61L27/28 , A61L31/10 , A61L31/08 , A61L29/08 , C10M107/26 , C10M107/46 , C10M107/42 , A61M25/10 , B32B27/00 , C10N40/00 , C10N50/08
Abstract: Embodiments herein include coated medical devices and coatings with salt groups. In an embodiment, a coated medical device is included, the coated medical device including a substrate and a polymeric layer disposed over the substrate. The polymeric layer includes a polymer and has an exterior surface. The coated medical device further includes a plurality of salt groups bonded to the polymer of the polymeric layer and disposed on the exterior surface of the polymeric layer. The salt groups can be the reaction product of a reactive group with an acid or base. In an embodiment, a method of making a medical device is included. Other embodiments are also included herein.
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公开(公告)号:US20210220866A1
公开(公告)日:2021-07-22
申请号:US17149390
申请日:2021-01-14
Applicant: Surmodics, Inc.
Inventor: Ralph A. Chappa , Michael Militello
Abstract: Aspects herein relate to coating apparatus and methods for coating medical devices. In an embodiment, a coating system is included having a valve, a fluid supply reservoir in fluid communication with the valve, a reciprocating positive displacement pump in fluid communication with the valve, and a fluid applicator in fluid communication with the three-way valve. The valve can be configured to assume a first fluid transport state and a second fluid transport state, wherein the valve provides fluid communication between the fluid supply reservoir and the reciprocating positive displacement pump when in the first fluid transport state for filling of the reciprocating positive displacement pump, and wherein the valve provides fluid communication between the reciprocating positive displacement pump and the fluid applicator when in the second fluid transport state for applying a coating suspension to a medical device surface. Other embodiments are also included herein.
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