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92 条记录 (耗时 0.033 秒)

    POST-EXPOSURE PROPHYLAXIS AND TREATMENT OF INFECTIONS
    32.
    发明申请
    POST-EXPOSURE PROPHYLAXIS AND TREATMENT OF INFECTIONS 审中-公开
    暴露后预防和治疗感染

    公开(公告)号：US20110046039A1

    公开(公告)日：2011-02-24

    申请号：US12530538

    申请日：2008-03-06

    申请人： Serguei G. Popov ,  Taissia Popov ,  Virginia Espina ,  Charles Bailey ,  Lance A. Liotta ,  Emanuel Petricoin

    发明人： Serguei G. Popov ,  Taissia Popov ,  Virginia Espina ,  Charles Bailey ,  Lance A. Liotta ,  Emanuel Petricoin

    IPC分类号： A61K38/07 ,  A61P31/04

    CPC分类号： A61K45/06 ,  A61K31/496 ,  A61K2300/00

    摘要： The invention provides methods and materials for identifying agents for preventing and/or treating anthrax and similar diseases. Embodiments provide strains and model systems for studying non-lethal and lethal exposure to anthrax and similar disease vectors. Embodiments provide materials and methods for using the strains and model systems for differential profiling, such as proteomic profiling, such as differentiation phosphorylation profiling, to target identification and therapeutics discovery and development. Embodiments provide pharmaceutically acceptable compositions, and methods for using them to prevent and/or treat anthrax and similar diseases comprising an agent that decreases the activity of caspase ¼, such as YVAD, and/or an agent that increases the phosphorylation of AKT, such as IB-MECA or Cl-IB-MECA, together with, in particular embodiments, an antibiotic, such as ciprofloxacin. Kits comprising the same are provided as well, among other things.

    摘要翻译： 本发明提供用于鉴定用于预防和/或治疗炭疽和类似疾病的药剂的方法和材料。 实施例提供用于研究非致死和致死性暴露于炭疽和类似疾病载体的菌株和模型系统。 实施例提供了用于使用菌株和模型系统进行差异分析的材料和方法，例如蛋白质组学分析，例如分化磷酸化分析，以靶向鉴定和治疗发现和发展。 实施方案提供了药学上可接受的组合物，以及使用它们来预防和/或治疗炭疽和类似疾病的方法，其包括降低半胱天冬酶（例如YVAD）的活性的试剂和/或增加AKT磷酸化的试剂，例如 在特定实施方案中，IB-MECA或Cl-IB-MECA，以及抗生素，如环丙沙星。 还提供了包括其的套件，以及其他。

    Isolation of cellular material under microscopic visualization
    36.
    发明授权
    Isolation of cellular material under microscopic visualization 失效
    在微观可视化下分离细胞材料

    公开(公告)号：US06204030B1

    公开(公告)日：2001-03-20

    申请号：US09388805

    申请日：1999-09-02

    申请人： Lance A. Liotta ,  Michael E. Buck ,  Rhonda Ann Weiss ,  Zhengping Zhuang ,  Robert F. Bonner

    发明人： Lance A. Liotta ,  Michael E. Buck ,  Rhonda Ann Weiss ,  Zhengping Zhuang ,  Robert F. Bonner

    IPC分类号： C12P1912

    CPC分类号： G02B21/32 ,  C12M33/02 ,  G01N1/04 ,  G01N1/08 ,  G01N1/2806 ,  G01N1/2813 ,  G01N1/286 ,  G01N1/31 ,  G01N15/1468 ,  G01N33/50 ,  G01N2001/028 ,  G01N2001/2833 ,  G01N2001/284 ,  G01N2035/00237 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375

    摘要： A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.

    摘要翻译： 一种显微切割的方法，其包括：使用显微镜形成组织样品的细胞的图像场，从细胞的图像区域鉴定感兴趣的细胞的至少一个区域，所述细胞的至少一个区域包括不同类型的细胞 而不是相邻的细胞区域，并且从组织样品中提取感兴趣的细胞的至少一个区域。 通过使组织样品与可以选择性活化的转移表面接触使得其区域粘附到待提取的感兴趣的细胞区域来实现提取。 转移表面包括可激发的粘合剂层，其向组织样品的选定区域提供化学或静电粘附。 转移表面被激活后，分离转移表面和组织样品。 在分离期间，感兴趣的细胞区域保持粘附到转移表面，并因此与组织样品分离。