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    Penicillins
    31.
    发明授权
    Penicillins 失效
    青霉素

    公开(公告)号：US4008220A

    公开(公告)日：1977-02-15

    申请号：US495914

    申请日：1974-08-08

    申请人： Hisao Tobiki ,  Hirotada Yamada ,  Iwao Nakatsuka ,  Kozo Shimago ,  Shigeru Okano ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Hiroshi Noguchi ,  Yasuko Eda

    发明人： Hisao Tobiki ,  Hirotada Yamada ,  Iwao Nakatsuka ,  Kozo Shimago ,  Shigeru Okano ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Hiroshi Noguchi ,  Yasuko Eda

    IPC分类号： C07D499/00 ,  C07D499/68 ,  C07D499/48

    CPC分类号： C07D499/00 ,  Y02P20/55

    摘要： A penicillin of the formula: ##STR1## wherein ##STR2## is a six-membered heteroaromatic ring containing 1 or 2 nitrogen atoms as the hetero atom, Y is hydrogen, lower alkanoyl or lower alkoxycarbonyl, R.sub.1 and R.sub.2 are each hydrogen, lower alkyl, lower alkanoyl, benzoyl, lower alkylmercapto, hydroxyl, mercapto, hydroxy(lower)alkyl, halogen or cyano or R.sub.1 and R.sub.2 may link together to form a lower alkylene chain which may be substituted with an oxo group, and Z is phenyl, hydroxyphenyl, lower alkyl, cyclohexadienyl, thienyl or isothiazolyl, which is prepared by reacting a compound of the formula: ##STR3## wherein Z is as defined above or its derivative with a carboxylic acid of the formula: ##STR4## wherein ##STR5## and R.sub.2 are each as defined above or its reactive derivative, if necessary, followed by hydrolysis or acylation of the resulting product and/or elimination of any protective group and which is useful as an antimicrobial agent against various gram-positive and gram-negative bacteria including Pseudomonas.

    摘要翻译： 一种下式的青霉素：其中是含有1或2个氮原子作为杂原子的六元杂芳环，Y是氢，低级烷酰基或低级烷氧基羰基，R 1和R 2各自是氢，低级烷基 ，低级烷酰基，苯甲酰基，低级烷基巯基，羟基，巯基，羟基（低级）烷基，卤素或氰基，或者R 1和R 2可以连接在一起形成可被氧代基取代的低级亚烷基链，Z是苯基， 低级烷基，环己二烯基，噻吩基或异噻唑基，其通过使下式化合物：其中Z如上所定义或其衍生物与下式的羧酸反应制备：其中和R2 各自如上所定义，或其反应性衍生物，如果需要，随后水解或酰化所得产物和/或消除任何保护基团，并且其可用作针对各种革兰氏阳性和革兰氏阴性菌的抗微生物剂，包括 uding假单胞菌

    Penicillins substituted with heterocyclic and substituted phenyl groups
    32.
    发明授权
    Penicillins substituted with heterocyclic and substituted phenyl groups 失效
    用杂环和取代的苯基取代的青霉素

    公开(公告)号：US3992371A

    公开(公告)日：1976-11-16

    申请号：US536181

    申请日：1974-12-24

    申请人： Hisao Tobiki ,  Hirotada Yamada ,  Iwao Nakatsuka ,  Kozo Shimago ,  Shigeru Okano ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Hiroshi Noguchi ,  Yasuko Eda

    发明人： Hisao Tobiki ,  Hirotada Yamada ,  Iwao Nakatsuka ,  Kozo Shimago ,  Shigeru Okano ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Hiroshi Noguchi ,  Yasuko Eda

    IPC分类号： C07D499/10 ,  C07D471/04 ,  C07D499/00 ,  C07D499/04 ,  C07D499/64 ,  C07D499/68 ,  C07D519/06 ,  C07D499/70

    CPC分类号： C07D471/04 ,  C07D499/00

    摘要： Novel penicillins of the formula ##SPC1##Wherein ##EQU1## represents a substituted or unsubstituted benzene or nitrogen atom-containing heteroaromatic ring which may be substituted, ##EQU2## represents a pyridine, pyrazine or pyridazine ring, X represents an oxygen or sulfur atom, Y represents a hydrogen atom or a loer alkoxycarbonyl or lower alkanoyl group, and R.sub.1, R.sub.2 and R.sub.3 are each a hydrogen or halogen atom or a nitro, lower alkylamino, di(lower)alkylamino, aine, lower alkoxycarbonylamino, lower alkanoylamino, amino(lower)alkyl, lower alkyl, lower alkoxy, hydroxyl, sulfamoyl, trifluoromethyl, lower alkylthio or lower alkylsulfonyl group, excluding the cases where all of R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms and where R.sub.1 is a hydroxyl group and R.sub.2 and R.sub.3 are each a hydrogen or halogen atom, and their nontoxic, pharmaceutically acceptable salts, which can be prepared by reacting a carboxylic acid of the formula: ##EQU3## wherein ##EQU4## X and Y are each as defined above or its reactive derivative with a compound of the formula: ##SPC2##Wherein R.sub.1, R.sub.2 and R.sub.3 are each as defined above or its reactive derivative, and are ueful as antimicrobial agents against gram-positive and gram-negative bacteria including Pseudomonas.

    摘要翻译： 式+ q，10的新型青霉素其中C | A C表示可被取代的取代或未取代的含有苯或含氮原子的杂芳环，C | C | CB表示吡啶，吡嗪或哒嗪环，X表示 氧或硫原子，Y表示氢原子或低级烷氧基羰基或低级烷酰基，R 1，R 2和R 3各自为氢或卤素原子或硝基，低级烷基氨基，二（低级）烷基氨基，亚氨基，低级烷氧基羰基氨基， 低级烷酰基氨基，氨基（低级）烷基，低级烷基，低级烷氧基，羟基，氨磺酰基，三氟甲基，低级烷硫基或低级烷基磺酰基，不包括R1，R2和R3全部为氢原子，其中R1为羟基， R2和R3各自为氢或卤素原子，以及它们的无毒的药学上可接受的盐，其可以通过使下式的羧酸：XY | C | C-COOH A | CB反应而制备，其中CC | | CA | | C，CB，X和Y为ea ch或其反应性衍生物与下式的化合物：+ q，21，其中R1，R2和R3各自如上所定义，或其反应性衍生物，并且作为抗革兰氏阳性和革兰氏阴性细菌的抗微生物剂 包括假单胞菌。

    Membrane unit and membrane separation device
    33.
    发明授权
    Membrane unit and membrane separation device 有权
    膜单元和膜分离装置

    公开(公告)号：US08591738B2

    公开(公告)日：2013-11-26

    申请号：US13641944

    申请日：2011-03-25

    申请人： Kazuhiro Toyooka ,  Hiroshi Noguchi ,  Shigeo Sato

    发明人： Kazuhiro Toyooka ,  Hiroshi Noguchi ,  Shigeo Sato

    IPC分类号： B01D65/02

    CPC分类号： B01D65/08 ,  B01D61/20 ,  B01D63/082 ,  B01D2313/26 ,  B01D2315/06 ,  B01D2321/185 ,  C02F3/1273 ,  C02F2303/16 ,  Y02W10/15

    摘要： In a membrane separation apparatus, a cleaning effect for membrane elements by scrubbing is improved. In the membrane separation apparatus 14 including a separation membrane 5 (membrane element) dipped in treated liquid in a treatment bath 15, and air diffusing means 2 for diffusing air bubbles 6 for cleaning the separation membrane 5, an air bubbles staying plate 3 is provided between the air diffusing means 2 and the separation membrane 5. The air bubbles staying plate 3 is configured to allow air bubbles 6 diffused from the air diffusing device 2 to stay, by which air bubbles 6 gather each other to form air bubbles 6 having large diameters. By causing air bubbles having large diameters to act on the separation membrane 5, air bubbles 6 can be allowed to act whole the separation membrane 5.

    摘要翻译： 在膜分离装置中，通过洗涤来提高膜元件的清洁效果。 在处理浴15中浸渍处理液的分离膜5（膜元件）的膜分离装置14以及用于扩散用于清洗分离膜5的气泡6的空气扩散装置2设置有气泡滞留板3 空气扩散装置2和分离膜5之间。气泡滞留板3被构造成允许从空气扩散装置2扩散的气泡6停留，由此气泡6彼此聚集以形成具有大的气泡6 直径。 通过使大直径的气泡作用在分离膜5上，可以使气泡6作用于整个分离膜5。

    Frame rate conversion apparatus and method
    34.
    发明授权
    Frame rate conversion apparatus and method 有权
    帧速率转换装置和方法

    公开(公告)号：US08319889B2

    公开(公告)日：2012-11-27

    申请号：US13142735

    申请日：2010-10-07

    申请人： Hiroshi Noguchi

    发明人： Hiroshi Noguchi

    IPC分类号： H04N7/01

    CPC分类号： H04N7/0132 ,  G06T3/4007 ,  H04N7/014 ,  H04N19/132 ,  H04N19/139 ,  H04N19/172 ,  H04N19/176 ,  H04N19/587

    摘要： Correlation detectors 21 and 22 employ two different correlation detecting methods to determine correlations. Correlation comparators 23 and 24 output correlation values DF1 and DF2, and motion vectors MV1 and MV2 in directions representing largest correlation values. A correlation comparator 25 selects one of the motion vectors larger in correlation, as a motion vector MV3, to output an interpolation control signal FS1 to determine an interpolation method at an interpolator 3. The interpolator 3 is operative in accordance with the interpolation control signal FS1, to select any one out of two different one-side interpolations and a both-side interpolation, to generate interpolation pixel data fp0.

    摘要翻译： 相关检测器21和22采用两种不同的相关检测方法来确定相关性。 相关比较器23和24在表示最大相关值的方向上输出相关值DF1和DF2以及运动矢量MV1和MV2。 相关比较器25选择相关性较大的运动矢量作为运动矢量MV3输出插值控制信号FS1，以在插值器3中确定插值方法。内插器3根据插值控制信号FS1 选择两个不同的单面内插中的任何一个和双面内插，以生成内插像素数据fp0。

    Rear independent suspension for automotive vehicle
    39.
    发明授权
    Rear independent suspension for automotive vehicle 失效
    后置独立悬架的汽车

    公开(公告)号：US4706989A

    公开(公告)日：1987-11-17

    申请号：US871482

    申请日：1986-06-06

    申请人： Yoshitaka Iijima ,  Hiroshi Noguchi

    发明人： Yoshitaka Iijima ,  Hiroshi Noguchi

    IPC分类号： B60G7/00 ,  B60G3/00

    CPC分类号： B60G7/006 ,  B60G2200/132 ,  B60G2200/1322 ,  B60G2200/142 ,  B60G2200/462 ,  B60G2202/413 ,  B60G2204/14 ,  B60G2204/143 ,  B60G2204/422 ,  B60G2204/62 ,  B60G2500/2043

    摘要： In order to enable the appropriate amount of understeer to be produced in a suspension wherein the rear wheel is steered to produce a toe-in effect by a lateral rod/knuckle arm arrangement, a device which in some embodiments is hydraulically controlled and in others is mechanical, permits distortion of the elastomeric bushes which form part of the suspension unit to produce a relatively large amount of understeer at high speeds and restricts the distortion at lower speeds to reduce the amount of understeer to a level suitable for that speed.

    摘要翻译： 为了能够在悬架中产生适当数量的转向不足，其中后轮被转向以通过横向杆/转向节臂装置产生脚趾，在一些实施例中，液压控制并且在其它实施例中的装置是 机械地允许形成悬挂单元的一部分的弹性衬套的变形，以在高速下产生相对大量的转向不足，并且以较低速度限制变形，以将转向量减少到适合于该速度的水平。