公开(公告)号：US07090874B2

公开(公告)日：2006-08-15

申请号：US10752643

申请日：2004-01-08

申请人： Tatsumasa Mae ,  Misuzu Tsukagawa ,  Hideyuki Kishida ,  Mitsuaki Kitano ,  Mikio Kitahara ,  Kaku Nakagawa ,  Minpei Kuroda ,  Yoshihiro Mimaki ,  Yutaka Sashida

发明人： Tatsumasa Mae ,  Misuzu Tsukagawa ,  Hideyuki Kishida ,  Mitsuaki Kitano ,  Mikio Kitahara ,  Kaku Nakagawa ,  Minpei Kuroda ,  Yoshihiro Mimaki ,  Yutaka Sashida

IPC分类号： A61K36/9066

CPC分类号： A61K31/12 ,  A21D2/14 ,  A23D7/0056 ,  A23D9/007 ,  A23K20/111 ,  A23K50/40 ,  A23L7/109 ,  A23L27/60 ,  A23L33/105 ,  A61K31/00

摘要： The object of the present invention is to provide PPARγ ligand derived from naturally occurring sources and a composition for preventing and/or improving Insulin Resistance Syndrome, diabetes mellitus, obesity or visceral fat obesity comprising the PPARγ ligand as an active agent.The present invention relates to a ligand for peroxisome proliferator-activated receptor which comprises curcumin or its derivatives. The composition according to the present invention, which comprises the PPARγ ligand as an active agent is useful for preventing and/or improving Insulin Resistance Syndrome, diabetes mellitus, obesity or visceral fat obesity.

公开(公告)号：US08071141B2

公开(公告)日：2011-12-06

申请号：US11206073

申请日：2005-08-18

申请人： Tatsumasa Mae ,  Misuzu Tsukagawa ,  Hideyuki Kishida ,  Mitsuaki Kitano ,  Mikio Kitahara ,  Kaku Nakagawa

发明人： Tatsumasa Mae ,  Misuzu Tsukagawa ,  Hideyuki Kishida ,  Mitsuaki Kitano ,  Mikio Kitahara ,  Kaku Nakagawa

IPC分类号： A61K36/236 ,  A61K36/00

CPC分类号： A61Q19/06 ,  A21D2/36 ,  A23K20/10 ,  A23K50/40 ,  A23L27/60 ,  A23L33/10 ,  A23L33/105 ,  A23L33/15 ,  A23L33/16 ,  A23L33/175 ,  A61K8/97 ,  A61K36/48 ,  A61K36/54 ,  A61K36/61 ,  A61K36/9066 ,  Y10S514/909 ,  A61K2300/00

摘要： A composition for preventing or ameliorating multiple risk factor syndrome involving visceral fat-type obesity, diabetes mellitus, hyperlipemia and hypertension, which comprises at least one member selected from the group consisting of a licorice hydrophobic extract, a turmeric extract, a clove extract, and a cinnamon extract.

摘要翻译： 一种预防或改善涉及内脏脂肪型肥胖，糖尿病，高脂血症和高血压的多发危险因素综合征的组合物，其包含选自甘草疏水提取物，姜黄提取物，丁香提取物和 肉桂提取物。

公开(公告)号：US20100213460A1

公开(公告)日：2010-08-26

申请号：US12699080

申请日：2010-02-03

申请人： Toshikazu Kondo ,  Hideyuki Kishida

发明人： Toshikazu Kondo ,  Hideyuki Kishida

IPC分类号： H01L29/786 ,  H01L21/34

CPC分类号： H01L27/1225 ,  H01L21/02554 ,  H01L21/02565 ,  H01L21/02614 ,  H01L21/0262 ,  H01L21/02631 ,  H01L21/477 ,  H01L27/1222 ,  H01L27/124 ,  H01L27/1248 ,  H01L27/1255 ,  H01L27/1259 ,  H01L27/3248 ,  H01L27/3262 ,  H01L29/24 ,  H01L29/45 ,  H01L29/458 ,  H01L29/4908 ,  H01L29/66765 ,  H01L29/66969 ,  H01L29/78603 ,  H01L29/78606 ,  H01L29/78618 ,  H01L29/78663 ,  H01L29/78678 ,  H01L29/7869 ,  H01L29/78693

摘要： In a thin film transistor, an increase in off current or negative shift of the threshold voltage is prevented. In the thin film transistor, a buffer layer is provided between an oxide semiconductor layer and each of a source electrode layer and a drain electrode layer. The buffer layer includes a metal oxide layer which is an insulator or a semiconductor over a middle portion of the oxide semiconductor layer. The metal oxide layer functions as a protective layer for suppressing incorporation of impurities into the oxide semiconductor layer. Therefore, in the thin film transistor, an increase in off current or negative shift of the threshold voltage can be prevented.

摘要翻译： 在薄膜晶体管中，防止阈值电压的关断电流的增加或负偏移。 在薄膜晶体管中，在氧化物半导体层与源极电极层和漏极电极层之间设置有缓冲层。 缓冲层包括在氧化物半导体层的中间部分上的绝缘体或半导体的金属氧化物层。 金属氧化物层用作抑制杂质掺入到氧化物半导体层中的保护层。 因此，在薄膜晶体管中，可以防止阈值电压的关断电流的增加或负偏移。

公开(公告)号：US20100092560A1

公开(公告)日：2010-04-15

申请号：US12579731

申请日：2009-10-15

申请人： Shinsuke Akao ,  Takashi Ueda ,  Takahiro Ueda ,  Yozo Nagira ,  Hideyuki Kishida

发明人： Shinsuke Akao ,  Takashi Ueda ,  Takahiro Ueda ,  Yozo Nagira ,  Hideyuki Kishida

IPC分类号： A61K38/43 ,  A61K31/122 ,  A23L1/30 ,  A23B4/03

CPC分类号： A61K9/0095 ,  A23F3/163 ,  A23L33/10 ,  A23L33/15 ,  A23P10/30 ,  A23V2002/00 ,  A61K9/0056 ,  A61K9/2054 ,  A61K9/4858 ,  A23V2200/224 ,  A23V2250/5028 ,  A23V2250/708 ,  A23V2250/314

摘要： The present invention aims to propose a particulate composition containing reduced coenzyme Q10, which simultaneously shows high oxidative stability and high absorbability in the body and a production method thereof, as well as a stabilizing method thereof, to be used in the fields of foods, foods with nutrient function claims, foods for specified health uses, nutritional supplements, nutritional products, animal drugs, beverages, feeds, cosmetics, pharmaceuticals, therapeutic drugs, prophylactic drugs and the like. The present inventors have conducted intensive studies in an attempt to solve the aforementioned problems and found that a particulate composition containing reduced coenzyme Q10, wherein an oil component containing the reduced coenzyme Q10 is polydispersed forming a domain in a matrix containing a water-soluble excipient as a main component and a water-soluble ascorbic acid is a composition simultaneously having high oxidative stability and high absorbability in the body, and completed the present invention.

摘要翻译： 本发明的目的是提出一种含有还原型辅酶Q10的颗粒组合物，其还具有在体内的高氧化稳定性和高吸收性及其制备方法及其稳定化方法，用于食品，食品领域 营养功能要求，特定健康用途的食品，营养补充剂，营养产品，动物药物，饮料，饲料，化妆品，药​​物，治疗药物，预防药物等。 为了解决上述问题，本发明人进行了深入研究，发现含有还原型辅酶Q10的微粒组合物，其中含有还原型辅酶Q10的油性成分多分散，在含有水溶性赋形剂的基质中形成结构域 主要成分和水溶性抗坏血酸是同时具有高氧化稳定性和高吸收性的组合物，完成了本发明。

公开(公告)号：US20100028319A1

公开(公告)日：2010-02-04

申请号：US12525446

申请日：2008-01-31

申请人： Hirokazu Sakamoto ,  Hideyuki Kishida ,  Kazunori Hosoe

发明人： Hirokazu Sakamoto ,  Hideyuki Kishida ,  Kazunori Hosoe

IPC分类号： A61K38/43 ,  C07H19/20 ,  A61P7/12

CPC分类号： A61K31/7076 ,  A23K20/10 ,  A23K20/105 ,  A23K20/116 ,  A23K20/121 ,  A23K20/137 ,  A23K20/174 ,  A23K50/40 ,  A23L33/10 ,  A23V2002/00 ,  A23V2200/328 ,  A23V2250/30

摘要： The present invention aims to provide a composition which has an extremely broad range of applications, has an excellent safety, and can be used for preventing, ameliorating, or therapeutically-treating diabetes.The present invention provides an agent for preventing, ameliorating, or therapeutically-treating diabetes or a diabetic complication, a glycemic control agent, and an insulin secretion-promoting agent, each of which contains reduced coenzyme A as an active ingredient. The present invention also provides a method for preventing, ameliorating, or therapeutically-treating diabetes or a diabetic complication, which includes administration of the aforementioned agent.

摘要翻译： 本发明旨在提供一种应用范围非常广泛，安全性优异的组合物，可用于预防，改善或治疗糖尿病。 本发明提供了用于预防，改善或治疗糖尿病或糖尿病并发症的药剂，血糖控制剂和胰岛素分泌促进剂，其各自含有还原型辅酶A作为活性成分。 本发明还提供了预防，改善或治疗性治疗糖尿病或糖尿病并发症的方法，其包括给药前述药剂。

公开(公告)号：US20090148426A1

公开(公告)日：2009-06-11

申请号：US12067783

申请日：2006-09-21

申请人： Hideyuki Kishida ,  Taizuo Kawabe ,  Kazunori Hosoe

发明人： Hideyuki Kishida ,  Taizuo Kawabe ,  Kazunori Hosoe

IPC分类号： A61K38/43 ,  C07C43/205 ,  A61K31/09 ,  A61K31/122

CPC分类号： A61K31/05 ,  A61K31/122

摘要： The present invention relates to a composition for life extension, comprising reduced coenzyme Q10 as an active ingredient, as well as relates to a method of extending a life span using the composition comprising reduced coenzyme Q10 as an active ingredient. In the present invention, it has been found that long-term ingestion of feed that contains reduced coenzyme Q10 enables the life span of senescence-accelerated model mice to be extended. No sign indicating toxicity is observed in the senescence-accelerated model mice that have been fed with reduced coenzyme Q10 over a long period. Based on these findings, it was found that the composition containing reduce coenzyme Q10 as an active ingredient has potential to be a composition for life extension with high safety, capable of being taken for a long period. The present invention provides a composition, which can extend the life span of humans or animals, enables them to spend active and healthy senectitudes and shows high safety during the ingestion over a long period.

摘要翻译： 本发明涉及一种延长寿命的组合物，其包含还原型辅酶Q10作为活性成分，以及涉及使用包含还原型辅酶Q10作为活性成分的组合物延长使用寿命的方法。 在本发明中，已经发现，含有还原型辅酶Q10的饲料的长期摄入使得能够延长衰老加速模型小鼠的寿命。 没有迹象表明，在衰老加速模型小鼠中观察到毒性，这些老鼠在长时间内补充还原型辅酶Q10。 基于这些发现，发现含有还原型辅酶Q10作为活性成分的组合物具有潜在的延长寿命的组合物，其安全性高，能够长时间服用。 本发明提供一种能够延长人类或动物寿命的组合物，使其能够在长时间摄取过程中花费积极和健康的感觉并显示高安全性。

公开(公告)号：US20080152636A1

公开(公告)日：2008-06-26

申请号：US11896976

申请日：2007-09-07

申请人： Takahiro Ueda ,  Shiro Kitamura ,  Yoshiyuki Shinagawa ,  Taizou Kawabe ,  Hideyuki Kishida ,  Kazunori Hosoe

发明人： Takahiro Ueda ,  Shiro Kitamura ,  Yoshiyuki Shinagawa ,  Taizou Kawabe ,  Hideyuki Kishida ,  Kazunori Hosoe

IPC分类号： A61K8/35

CPC分类号： A23K20/10 ,  A23K20/158 ,  A23L33/10 ,  A61K8/347 ,  A61K8/553 ,  A61K9/08 ,  A61K31/122 ,  A61Q19/00

摘要： The present invention provides a method of improving the absorbability of reduced coenzyme Q10, which includes affording a composition containing lysolecithin and reduced coenzyme Q10 in combination. The composition containing lysolecithin and reduced coenzyme Q10 of the present invention shows superior absorption of reduced coenzyme Q10 and can be utilized for food, food with nutrient function, food for specified health uses, nutritional supplement, nutritional product, animal drug, beverage, feed, pet food, cosmetics, pharmaceutical product, therapeutic drug, preventive drug and the like.

摘要翻译： 本发明提供了提高还原型辅酶Q 10的吸收性的方法，其包括组合物提供含有溶血卵磷脂和还原型辅酶Q 10的组合物。 含有本发明的溶血卵磷脂和还原型辅酶Q 10的组合物显示出优异的还原型辅酶Q 10的吸收，并且可以用于食品，具有营养功能的食物，具体的食品 保健用品，营养补充剂，营养制品，动物药，饮料，饲料，宠物食品，化妆品，药​​品，治疗药物，预防药物等。

公开(公告)号：US09496404B2

公开(公告)日：2016-11-15

申请号：US13034726

申请日：2011-02-25

申请人： Shunpei Yamazaki ,  Hideyuki Kishida

发明人： Shunpei Yamazaki ,  Hideyuki Kishida

IPC分类号： H01L29/12 ,  H01L29/786 ,  H01L21/02 ,  H01L21/322 ,  H01L27/115 ,  H01L27/12 ,  G02F1/1368

CPC分类号： H01L21/477 ,  G02F1/133345 ,  G02F1/134309 ,  G02F1/13439 ,  G02F1/1368 ,  G02F1/137 ,  G02F2201/121 ,  G02F2201/123 ,  G09G3/3648 ,  G09G2310/08 ,  G09G2330/021 ,  G11C16/10 ,  G11C16/14 ,  G11C16/26 ,  H01L21/02554 ,  H01L21/02565 ,  H01L21/02573 ,  H01L21/02614 ,  H01L21/02631 ,  H01L21/02667 ,  H01L21/3228 ,  H01L27/1052 ,  H01L27/11521 ,  H01L27/1156 ,  H01L27/1203 ,  H01L27/1225 ,  H01L29/247 ,  H01L29/66969 ,  H01L29/7869 ,  H01L29/78693 ,  H01L29/78696

摘要： An object of the present invention to provide a highly reliable semiconductor device. Another object is to provide a manufacturing method of a highly reliable semiconductor device. Still another object is to provide a semiconductor device having low power consumption. Yet another object is to provide a manufacturing method of a semiconductor device having low power consumption. Furthermore, another object is to provide a semiconductor device which can be manufactured with high mass productivity. Another object is to provide a manufacturing method of a semiconductor device which can be manufactured with high mass productivity. An impurity remaining in an oxide semiconductor layer is removed so that the oxide semiconductor layer is purified to have an extremely high purity. Specifically, after adding a halogen element into the oxide semiconductor layer, heat treatment is performed to remove an impurity from the oxide semiconductor layer. The halogen element is preferably fluorine.

摘要翻译： 本发明的目的是提供一种高度可靠的半导体器件。 另一个目的是提供一种高度可靠的半导体器件的制造方法。 另一个目的是提供一种具有低功耗的半导体器件。 另一个目的是提供一种具有低功耗的半导体器件的制造方法。 此外，另一个目的是提供一种可以高质量生产率制造的半导体器件。 本发明的另一个目的是提供一种能以高质量生产率制造的半导体器件的制造方法。 去除残留在氧化物半导体层中的杂质，使得氧化物半导体层被纯化成具有非常高的纯度。 具体地说，在向氧化物半导体层中添加卤素元素之后，进行热处理从氧化物半导体层去除杂质。 卤素元素优选为氟。

公开(公告)号：US08362478B2

公开(公告)日：2013-01-29

申请号：US12759220

申请日：2010-04-13

申请人： Shunpei Yamazaki ,  Hiromichi Godo ,  Hideyuki Kishida

发明人： Shunpei Yamazaki ,  Hiromichi Godo ,  Hideyuki Kishida

IPC分类号： H01L29/786

CPC分类号： H01L29/7869 ,  H01L21/02554 ,  H01L21/02565 ,  H01L27/12 ,  H01L27/1225 ,  H01L27/1255 ,  H01L29/66969 ,  H01L29/78609 ,  H01L29/78618 ,  H01L29/78696

摘要： An object is to provide a transistor including an oxide layer which includes Zn and does not include a rare metal such as In or Ga. Another object is to reduce an off current and stabilize electric characteristics in the transistor including an oxide layer which includes Zn. A transistor including an oxide layer including Zn is formed by stacking an oxide semiconductor layer including insulating oxide over an oxide layer so that the oxide layer is in contact with a source electrode layer or a drain electrode layer with the oxide semiconductor layer including insulating oxide interposed therebetween, whereby variation in the threshold voltage of the transistor can be reduced and electric characteristics can be stabilized.

公开(公告)号：US08247276B2

公开(公告)日：2012-08-21

申请号：US12699080

申请日：2010-02-03

申请人： Toshikazu Kondo ,  Hideyuki Kishida

发明人： Toshikazu Kondo ,  Hideyuki Kishida

IPC分类号： H01L21/00

CPC分类号： H01L27/1225 ,  H01L21/02554 ,  H01L21/02565 ,  H01L21/02614 ,  H01L21/0262 ,  H01L21/02631 ,  H01L21/477 ,  H01L27/1222 ,  H01L27/124 ,  H01L27/1248 ,  H01L27/1255 ,  H01L27/1259 ,  H01L27/3248 ,  H01L27/3262 ,  H01L29/24 ,  H01L29/45 ,  H01L29/458 ,  H01L29/4908 ,  H01L29/66765 ,  H01L29/66969 ,  H01L29/78603 ,  H01L29/78606 ,  H01L29/78618 ,  H01L29/78663 ,  H01L29/78678 ,  H01L29/7869 ,  H01L29/78693

摘要： In a thin film transistor, an increase in off current or negative shift of the threshold voltage is prevented. In the thin film transistor, a buffer layer is provided between an oxide semiconductor layer and each of a source electrode layer and a drain electrode layer. The buffer layer includes a metal oxide layer which is an insulator or a semiconductor over a middle portion of the oxide semiconductor layer. The metal oxide layer functions as a protective layer for suppressing incorporation of impurities into the oxide semiconductor layer. Therefore, in the thin film transistor, an increase in off current or negative shift of the threshold voltage can be prevented.

摘要翻译： 在薄膜晶体管中，防止了阈值电压的关断电流的增加或负偏移。 在薄膜晶体管中，在氧化物半导体层与源极电极层和漏极电极层之间设置有缓冲层。 缓冲层包括在氧化物半导体层的中间部分上的绝缘体或半导体的金属氧化物层。 金属氧化物层用作抑制杂质掺入到氧化物半导体层中的保护层。 因此，在薄膜晶体管中，可以防止阈值电压的关断电流的增加或负偏移。