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    Residence structures and related methods
    34.
    发明授权
    Residence structures and related methods 有权

    公开(公告)号：US10596110B2

    公开(公告)日：2020-03-24

    申请号：US16014549

    申请日：2018-06-21

    Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    Inventor： Andrew Bellinger ,  Shiyi Zhang ,  Carlo Giovanni Traverso ,  Robert S. Langer ,  Stacy Mo ,  Tyler Grant ,  Mousa Jafari ,  Dean Liang Glettig ,  Angela DiCiccio ,  Omar Abouzid ,  Ameya R. Kirtane

    IPC: A61K9/00 ,  A61K9/48 ,  A61K47/34 ,  A61K47/10 ,  A61K31/65 ,  A61K31/7048 ,  A61K47/32

    Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

    RESIDENCE STRUCTURES AND RELATED METHODS
    39.
    发明申请
    RESIDENCE STRUCTURES AND RELATED METHODS 审中-公开

    公开(公告)号：US20190175500A1

    公开(公告)日：2019-06-13

    申请号：US16277516

    申请日：2019-02-15

    Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    Inventor： Andrew Bellinger ,  Shiyi Zhang ,  Carlo Giovanni Traverso ,  Robert S. Langer ,  Stacy Mo ,  Tyler Grant ,  Mousa Jafari ,  Dean Liang Glettig ,  Angela DiCiccio ,  Lowell L. Wood, JR. ,  Philip A. Eckhoff

    IPC: A61K9/00 ,  A61K47/58 ,  A61K47/69 ,  A61K31/357 ,  A61K31/65 ,  A61K31/7048 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/40 ,  A61K47/42 ,  A61M31/00 ,  C08G18/42 ,  C08G18/73 ,  C08G63/08 ,  C08G83/00 ,  C08L33/02 ,  C08L33/08 ,  C08L33/14 ,  A61K9/48

    Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

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