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    Optimization of Gene Expression Analysis using Immobilized Capture Probes
    31.
    发明申请
    Optimization of Gene Expression Analysis using Immobilized Capture Probes 有权
    使用固定化捕获探针优化基因表达分析

    公开(公告)号：US20090263820A1

    公开(公告)日：2009-10-22

    申请号：US12480215

    申请日：2009-06-08

    Applicant: Michael Seul ,  Sukanta Banerjee ,  Jiacheng Yang ,  Tatiana Vener

    Inventor： Michael Seul ,  Sukanta Banerjee ,  Jiacheng Yang ,  Tatiana Vener

    IPC: C12Q1/68

    CPC classification number: C12Q1/6832 ,  B01J2219/00459 ,  B01J2219/00576 ,  B01J2219/00608 ,  B01J2219/00648 ,  B01J2219/00722 ,  C12Q1/6809 ,  C12Q1/6834 ,  C12Q1/6837 ,  C12Q2537/143 ,  C12Q2565/501 ,  C12Q2565/507 ,  C12Q2533/101 ,  C12Q2565/514 ,  C12Q2565/519

    Abstract: Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including: methods of probe and target “engineering”, as well as methods of assay signal analysis relating to the modulation of the probe-target affinity constant, K by a variety of factors including the elastic properties of target strands and layers of immobilized (“grafted”) probes; and assay methodologies relating to: the tuning of assay signal intensities including dynamic range compression and on-chip signal amplification; the combination of hybridization-mediated and elongation-mediated detection for the quantitative determination of abundance of messages displaying a high degree of sequence similarity, including, for example, the simultaneous determination of the relative expression levels, and identification of the specific class of, untranslated AU-rich subsequences located near the 3′ terminus of mRNA; and a new method of subtractive differential gene expression analysis which requires only a single color label.

    Abstract translation: 公开了样品中寡核苷酸多重分析的方法，包括：探针和靶标“工程”的方法，以及通过多种因素与探针 - 靶亲和常数K的调节相关的信号分析方法，包括 目标链和固定（“接枝”）探针层的弹性性质; 以及与以下方法相关的测定方法：调整测定信号强度，包括动态范围压缩和片上信号放大; 杂交介导和延长介导检测的组合用于定量测定显示高度序列相似性的消息丰度，包括例如同时确定相对表达水平，以及鉴定特异性类别，未翻译 位于mRNA的3'末端附近的富含子序列; 以及仅需要单一颜色标签的减法差分基因表达分析的新方法。

    Dynamically configurable electrode formed of pixels
    32.
    发明授权
    Dynamically configurable electrode formed of pixels 有权
    由像素组成的动态配置电极

    公开(公告)号：US07604718B2

    公开(公告)日：2009-10-20

    申请号：US10778520

    申请日：2004-02-14

    Applicant: Yi Zhang ,  Michael Seul

    Inventor： Yi Zhang ,  Michael Seul

    IPC: B03C5/00

    CPC classification number: B01L3/502715 ,  B01J2219/00653 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/089 ,  B01L2400/0415 ,  B03C5/005 ,  B03C5/026

    Abstract: A dynamically configurable electrode includes a first planar electrode and a planar array of pixels in a different plane, wherein a polarizable liquid medium (including electrolyte solutions) is to reside in the gap between electrodes. The pixels are individually addressable by a time-varying voltage, and adjacent pixels receive, at any instant in time, either the same voltage waveform or a different voltage waveform. Adjacent pixels receiving different voltage waveforms generate corresponding movement of dipolar entities, including dipolar particles, ions, or dipolar molecules in the polarizable liquid medium between the electrodes, which can in turn generate fluid flow and movement of particles suspended in the fluid along the planar array surface.

    Abstract translation: 动态配置的电极包括第一平面电极和不同平面中的平面像素阵列，其中可极化液体介质（包括电解质溶液）驻留在电极之间的间隙中。 这些像素可以通过时变电压单独寻址，并且相邻像素在任何时刻接收相同的电压波形或不同的电压波形。 接收不同电压波形的相邻像素产生偶极实体的相应运动，包括在电极之间的可极化液体介质中的偶极子，离子或偶极子分子，这反过来又会沿平面阵列产生悬浮在流体中的流体流动和运动 表面。

    Optimization of gene expression analysis using immobilized capture probes
    33.
    发明授权
    Optimization of gene expression analysis using immobilized capture probes 有权
    使用固定化捕获探针优化基因表达分析

    公开(公告)号：US07563569B2

    公开(公告)日：2009-07-21

    申请号：US10974036

    申请日：2004-10-26

    Applicant: Michael Seul ,  Sukanta Banerjee ,  Jiacheng Yang ,  Tatiana Vener

    Inventor： Michael Seul ,  Sukanta Banerjee ,  Jiacheng Yang ,  Tatiana Vener

    IPC: C12Q1/68 ,  C12P19/34 ,  C12M1/00 ,  C12M1/34 ,  C12M3/00 ,  C07H21/02 ,  C07H21/04

    CPC classification number: C12Q1/6832 ,  B01J2219/00459 ,  B01J2219/00576 ,  B01J2219/00608 ,  B01J2219/00648 ,  B01J2219/00722 ,  C12Q1/6809 ,  C12Q1/6834 ,  C12Q1/6837 ,  C12Q2537/143 ,  C12Q2565/501 ,  C12Q2565/507 ,  C12Q2533/101 ,  C12Q2565/514 ,  C12Q2565/519

    Abstract: Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including: methods of probe and target “engineering”, as well as methods of assay signal analysis relating to the modulation of the probe-target affinity constant, K by a variety of factors including the elastic properties of target strands and layers of immobilized (“grafted”) probes; and assay methodologies relating to: the tuning of assay signal intensities including dynamic range compression and on-chip signal amplification; the combination of hybridization-mediated and elongation-mediated detection for the quantitative determination of abundance of messages displaying a high degree of sequence similarity, including, for example, the simultaneous determination of the relative expression levels, and identification of the specific class of, untranslated AU-rich subsequences located near the 3′ terminus of mRNA; and a new method of subtractive differential gene expression analysis which requires only a single color label.

    Abstract translation: 公开了样品中寡核苷酸多重分析的方法，包括：探针和靶标“工程”的方法，以及通过多种因素与探针 - 靶亲和常数K的调节相关的信号分析方法，包括 目标链和固定（“接枝”）探针层的弹性性质; 以及与以下方法相关的测定方法：调整测定信号强度，包括动态范围压缩和片上信号放大; 杂交介导和延长介导检测的组合用于定量测定显示高度序列相似性的消息丰度，包括例如同时确定相对表达水平，以及鉴定特异性类别，未翻译 位于mRNA的3'末端附近的富含子序列; 以及仅需要单一颜色标签的减法差分基因表达分析的新方法。

    Programmable Illumination Pattern for Transporting Microparticles
    35.
    发明申请
    Programmable Illumination Pattern for Transporting Microparticles 有权
    用于运输微粒的可编程照明模式

    公开(公告)号：US20080173544A1

    公开(公告)日：2008-07-24

    申请号：US12029189

    申请日：2008-02-11

    Applicant: Michael Seul ,  Chiu Wo Chau

    Inventor： Michael Seul ,  Chiu Wo Chau

    IPC: C25D13/00

    CPC classification number: B01L3/502792 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0819 ,  B01L2300/089 ,  B01L2400/0454 ,  C12Q1/6837 ,  G01N15/0266 ,  G01N30/0005 ,  G01N33/54313 ,  G01N2015/0288 ,  G01N2015/149 ,  C12Q2565/607 ,  C12Q2563/155

    Abstract: An apparatus providing programmable illumination pattern generation for the manipulation of colloidal particulates and biomolecules in suspension between electrodes, is disclosed. The apparatus implements LEAPS (Light-controlled electrokinetic assembly of particles near surfaces), which relies on: AC electric field-induced assembly of particles: the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The apparatus generates patterns of illumination and projects them onto planar surfaces. i.e., a LEAPS electrode. This enables the creation of patterns using graphical design or drawing software on a personal computer and the projection of said patterns, or sequences of patterns (“time-varying patterns”), onto the interface using a liquid crystal display (LCD) panel and an optical design which images the LCD panel onto the surface of interest, to provide for arrangements and assembly of particles in such patterns.

    Abstract translation: 公开了一种提供用于在电极之间悬浮的胶体颗粒和生物分子的操作的可编程照明图案生成的装置。 该装置实现LEAPS（表面附近的颗粒的光控电动组装），其依赖于：AC电场引起的颗粒组装：电解质/氧化硅/硅界面的图案化以对组装过程施加空间控制; 并通过外部照明实现对装配过程的实时控制。 该设备产生照明模式并将其投影到平面上。 即LEAPS电极。 这使得能够使用个人计算机上的图形设计或绘图软件来创建图案，并且使用液晶显示器（LCD）面板将所述图案或图案序列（“时变图案”）投影到界面上 将LCD面板成像到感兴趣的表面上的光学设计，以提供这种图案中的颗粒的布置和装配。

    Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
    37.
    发明授权
    Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products 有权
    输血注册网络提供用户和遗传特征的血液制品提供者之间的实时交互

    公开(公告)号：US07363170B2

    公开(公告)日：2008-04-22

    申请号：US11092420

    申请日：2005-03-29

    Applicant: Michael Seul ,  Robert James Danegy

    Inventor： Michael Seul ,  Robert James Danegy

    IPC: G06F17/00 ,  C12Q1/68

    CPC classification number: G06F19/322 ,  G06F19/00 ,  G06F19/18 ,  G06F19/24 ,  G06F19/28 ,  G06F19/3481 ,  G06Q10/10 ,  G06Q50/22 ,  G06Q50/24 ,  G16H10/60 ,  G16H40/20 ,  Y02A90/22 ,  Y02A90/26

    Abstract: Disclosed is a registry system, including member institutions, in which transfusion donors and recipients are registered following genotyping, which would typically take place in a member institution, or a member institution would have access to the genotyping information, if performed outside. The registry database can be accessed and searched by members seeking samples of particular type(s). Systems are disclosed for maintaining economic viability of genotyping in connection with transfusions, by maximizing the number of units placed with the minimal number of candidate donors typed. Genotyping of potential donors, and product supply, is matched to forecasted demand. Genotyping can also be limited to the more clinically relevant markers. The registry system can also be integrated with one format of assay which generates an image for analysis, whereby the imaged results can be analyzed and redacted by experts in a central location, and then transmitted back to the patient or their representative.

    Abstract translation: 披露了一个注册系统，包括成员机构，其中输血捐赠者和接受者在基因分型之后注册，通常在成员机构中进行注册，或者成员机构如果在外部执行，则可以访问基因分型信息。 可以通过搜索特定类型的样本的成员访问和搜索注册表数据库。 公开了系统，用于通过最大限度地利用输入的候选捐赠者的数量最大化来维持与输血相关的基因分型的经济可行性。 潜在捐赠者的基因分型和产品供应与预测需求相匹配。 基因分型也可以限于更临床相关的标记物。 注册系统也可以与生成用于分析的图像的一种形式的测定结合，由此可以在中心位置的专家分析和编辑成像结果，然后传送回患者或其代表。

    Real-time monitoring of nucleic acid target-identifying signals
    39.
    发明授权
    Real-time monitoring of nucleic acid target-identifying signals 有权
    实时监测核酸靶标识别信号

    公开(公告)号：US07344841B2

    公开(公告)日：2008-03-18

    申请号：US11438161

    申请日：2006-05-22

    Applicant: Ghazala Hashmi ,  Michael Seul ,  Joachim Messing

    Inventor： Ghazala Hashmi ,  Michael Seul ,  Joachim Messing

    IPC: C12Q1/68 ,  C07H21/02 ,  C07H21/04

    CPC classification number: C12Q1/6827 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y20/00 ,  C12Q1/6837 ,  C12Q2565/102 ,  C12Q2563/149 ,  C12Q2537/143

    Abstract: This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.

    Abstract translation: 本发明提供了用于生物体的遗传测试的组合物和方法，并且用于将遗传测试的结果与明确识别生物体的唯一标记相关联。 标记可以是内部标记，例如单核苷酸多态性（SNP），短串联重复序列（STR）或基因组基因座内的其他位点。 或者，标记可以是外部的，使得它们在测试之前分开地添加到遗传样品中。

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