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    Tissue plasminogen activator-like protease
    37.
    发明申请
    Tissue plasminogen activator-like protease 审中-公开
    组织纤溶酶原激活物样蛋白酶

    公开(公告)号：US20050164366A1

    公开(公告)日：2005-07-28

    申请号：US11035988

    申请日：2005-01-18

    申请人： Paul Moore ,  Steven Ruben ,  Reinhard Ebner

    发明人： Paul Moore ,  Steven Ruben ,  Reinhard Ebner

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P7/02 ,  A61P9/00 ,  C12N1/21 ,  C12N5/10 ,  C12N9/64 ,  C12N15/55 ,  C07H21/04 ,  C07K16/40

    CPC分类号： C12N9/6421 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/026

    摘要： The present invention relates to a novel t-PALP protein which is a member of the serine protease family. In particular, isolated nucleic acid molecules are provided encoding the human t-PALP protein. t-PALP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of t-PALP activity. Also provided are diagnostic methods for detecting circulatory system-related disorders and therapeutic methods for treating circulatory system-related disorders.

    摘要翻译： 本发明涉及一种作为丝氨酸蛋白酶家族成员的新型t-PALP蛋白。 特别地，提供编码人t-PALP蛋白的分离的核酸分子。 还提供t-PALP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定t-PALP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测循环系统相关疾病的诊断方法和用于治疗循环系统相关疾病的治疗方法。

    Dental Device
    39.
    发明申请
    Dental Device 有权

    公开(公告)号：US20220142738A1

    公开(公告)日：2022-05-12

    申请号：US17433510

    申请日：2020-02-25

    申请人： Paul Moore ,  Hazel Hendy

    发明人： Paul Moore ,  Hazel Hendy

    IPC分类号： A61C5/90 ,  A61C5/82

    摘要： Aspects of the present invention relate to a dental retractor for controlling the position of soft tissue within a mouth, the dental retractor comprising: a lip retractor for controlling the position of a lip; and a cheek retractor comprising a pair of arms for controlling the position of a cheek; and wherein the dental retractor comprises a tongue retractor removably coupled to the dental retractor for controlling the position of a tongue.

    TYRE APPARATUS
    40.
    发明申请
    TYRE APPARATUS 审中-公开
    轮胎装置

    公开(公告)号：US20160332486A1

    公开(公告)日：2016-11-17

    申请号：US15110441

    申请日：2014-11-17

    申请人： Igor STRASHNY ,  Paul MOORE ,  CATERPILLAR INC.

    发明人： Igor Strashny ,  Paul Moore

    IPC分类号： B60C5/22 ,  B60C23/00 ,  B60C17/01

    CPC分类号： B60C5/22 ,  B60C17/01 ,  B60C23/004 ,  B60C2200/06

    摘要： A tyre apparatus is provided, the apparatus including a tyre body for attachment to a wheel rim to define a first inflatable volume. An inner chamber defines a second inflatable volume which is located within the first inflatable volume of the tyre body. A first fluid communication path is provided between the first and second inflatable volumes and a second fluid communication path is provided between the first inflatable volume and the atmosphere. A first valve opens and closes the first fluid communication path, and a second valve opens and closes the second fluid communication path. The tensile strength and pressure-containing capacity of the material structure of the second inflatable volume is greater than that of the tyre first inflatable volume. A first fluid pressure within the first inflatable volume of the tyre body is optimisable by opening the first valve to allow pressure transfer from the second inflatable volume into the tyre body, and/or opening the second valve to allow pressure to vent from the tyre body to atmosphere. A vehicle wheel and active tyre pressure control system incorporating the tyre apparatus are also provided.

    摘要翻译： 提供了一种轮胎装置，该装置包括用于附接到轮缘的轮胎主体，以限定第一可充气体积。 内室限定位于轮胎主体的第一可充气体积内的第二可充气体积。 在第一和第二可膨胀体积之间提供第一流体连通路径，并且在第一可充气体积和大气之间设置第二流体连通路径。 第一阀打开和关闭第一流体连通路径，第二阀打开和关闭第二流体连通路径。 第二可膨胀体积的材料结构的拉伸强度和耐压容量大于轮胎第一可充气体积的拉伸强度和压力容纳能力。 轮胎主体的第一可膨胀体积内的第一流体压力通过打开第一阀来允许压力从第二可膨胀容积传递到轮胎主体中并且/或打开第二阀以允许压力从轮胎本体排出而是最佳的 到大气。 还提供了一种结合轮胎装置的车轮和主动轮胎压力控制系统。