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    Capillary electrophoresis
    32.
    发明授权
    Capillary electrophoresis 失效
    毛细管电泳

    公开(公告)号：US5384024A

    公开(公告)日：1995-01-24

    申请号：US850764

    申请日：1992-03-13

    申请人： Stephen E. Moring ,  Michael S. Albin ,  Reid B. Kowallis ,  Thomas E. Lee ,  Dennis E. Mead ,  John H. Nickel ,  Mark F. Oldham ,  Richard T. Reel ,  Timothy S. Orpin ,  Janice C. Woods

    发明人： Stephen E. Moring ,  Michael S. Albin ,  Reid B. Kowallis ,  Thomas E. Lee ,  Dennis E. Mead ,  John H. Nickel ,  Mark F. Oldham ,  Richard T. Reel ,  Timothy S. Orpin ,  Janice C. Woods

    IPC分类号： G01N27/447 ,  B01D61/46 ,  B01D57/02 ,  G01N27/26

    CPC分类号： G01N27/44782

    摘要： An instrument for capillary electrophoresis has a vertically translatable carrier holding one end of the capillary and an electrode connected to a power supply, and a rotary carousel for presenting containers of sample and buffer solutions to a load position where the end of the capillary and the electrode may be inserted by operating the carrier. The other end of the capillary and a second electrode connected to the power supply are immersed in an outlet buffer reservoir. The instrument has a vacuum supply for providing a relative vacuum over the solution in the outlet buffer reservoir, so simple material may be injected into the capillary either by electromigration or by differential pressure. After injection, the first end of the capillary and the electrode may be immersed in buffer to accomplish electrophoresis. By manipulating the carousel and carrier, multiple samples may be electrophoresed in series. In a preferred embodiment the instrument includes a flexible duck-billed septum for closing containers while permitting easy access for the electrode and the capillary tube. Also in a preferred embodiment the instrument is controlled by a microprocessor-based controller.

    摘要翻译： 用于毛细管电泳的仪器具有保持毛细管的一端和连接到电源的电极的可垂直平移的载体，以及用于将样品和缓冲溶液的容器呈现到毛细管和电极的端部的负载位置的旋转转盘 可以通过操作载体来插入。 毛细管的另一端和连接到电源的第二电极浸入出口缓冲储存器中。 该仪器具有用于在出口缓冲储存器中的溶液上提供相对真空的真空源，因此可以通过电迁移或通过差压将简单的材料注入毛细管。 注射后，将毛细管和电极的第一端浸入缓冲液中以完成电泳。 通过操纵转盘和载体，可以将多个样品串联进行电泳。 在优选实施例中，该仪器包括用于封闭容器的柔性鸭嘴孔隔膜，同时允许容易地接近电极和毛细管。 同样在优选实施例中，仪器由基于微处理器的控制器控制。

    Optical System and Method for Optically Analyzing Light From a Sample
    34.
    发明申请
    Optical System and Method for Optically Analyzing Light From a Sample 审中-公开
    用于从样品光学分析光的光学系统和方法

    公开(公告)号：US20090116028A1

    公开(公告)日：2009-05-07

    申请号：US12352742

    申请日：2009-01-13

    申请人： Richard T. Reel

    发明人： Richard T. Reel

    IPC分类号： G01J3/45 ,  G01J3/28 ,  G01N21/00

    CPC分类号： G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0262 ,  G01J3/0294 ,  G01J3/04 ,  G01J3/2803 ,  G01N21/05 ,  G01N21/31 ,  G01N27/44721 ,  G01N2021/0346

    摘要： An optical system for analyzing light from a plurality of samples is provided. The optical system includes a plurality of holders adapted to have samples located therein, a collection lens, a transmission grating, and a reimaging lens. The collection lens is configured to receive and substantially collimate light from the samples. The transmission grating is configured to spectrally disperse the substantially collimated light from the collection lens. The reimaging lens is configured to receive the light from the light dispersing element and direct the light onto a light detection device. A method of optically analyzing at least one sample is also provided.

    摘要翻译： 提供了一种用于分析来自多个样品的光的光学系统。 光学系统包括多个保持器，其适于使样本位于其中，收集透镜，透射光栅和再成像透镜。 收集透镜被配置为接收并基本上准直来自样品的光。 透射光栅被配置为光谱地分散来自收集透镜的基本上准直的光。 该成像透镜被配置为接收来自光分散元件的光并将光引导到光检测装置上。 还提供了一种光学分析至少一个样品的方法。

    Optical system and method for optically analyzing light from a sample
    35.
    发明授权
    Optical system and method for optically analyzing light from a sample 失效
    用于光学分析来自样品的光的光学系统和方法

    公开(公告)号：US06927852B2

    公开(公告)日：2005-08-09

    申请号：US10773712

    申请日：2004-02-05

    申请人： Richard T. Reel

    发明人： Richard T. Reel

    IPC分类号： G01N21/64 ,  G01J3/04 ,  G01J3/28 ,  G01N21/03 ,  G01N21/05 ,  G01N21/27 ,  G01N21/31 ,  G01N27/447 ,  G01J3/30

    CPC分类号： G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0262 ,  G01J3/0294 ,  G01J3/04 ,  G01J3/2803 ,  G01N21/05 ,  G01N21/31 ,  G01N27/44721 ,  G01N2021/0346

    摘要： An optical system for analyzing light from a plurality of samples is provided. The optical system includes a plurality of holders adapted to have samples located therein, a collection lens, a transmission grating, and a reimaging lens. The collection lens is configured to receive and substantially collimate light from the samples. The transmission grating is configured to spectrally disperse the substantially collimated light from the collection lens. The reimaging lens is configured to receive the light from the light dispersing element and direct the light onto a light detection device. A method of optically analyzing at least one sample is also provided.

    摘要翻译： 提供了一种用于分析来自多个样品的光的光学系统。 光学系统包括多个保持器，其适于使样本位于其中，收集透镜，透射光栅和再成像透镜。 收集透镜被配置为接收并基本上准直来自样品的光。 透射光栅被配置为光谱地分散来自收集透镜的基本上准直的光。 该成像透镜被配置为接收来自光分散元件的光并将光引导到光检测装置上。 还提供了一种光学分析至少一个样品的方法。

    Methods for fluorescence detection that minimizes undesirable background fluorescence
    36.
    发明授权
    Methods for fluorescence detection that minimizes undesirable background fluorescence 有权
    荧光检测方法，使不需要的背景荧光最小化

    公开(公告)号：US06921908B2

    公开(公告)日：2005-07-26

    申请号：US10833425

    申请日：2004-04-28

    申请人： Richard T. Reel

    发明人： Richard T. Reel

    IPC分类号： G01N21/64 ,  F21V9/16

    CPC分类号： G01N21/645 ,  G01N2021/6482 ,  G01N2021/6495

    摘要： The present invention provides a method for the excitation of a fluorescent sample and the measurement of the fluorescent emission. The method of the present invention has the advantage of significantly reducing the amount of background fluorescence. The method includes the steps of exciting a sample in a substrate with a beam of light that enters the substrate at an angle less than or equal to 45° C., and preferably, less than or equal to 20°, and then collecting the fluorescent emission form the sample with a lens system which focuses the emitted light onto a CCD for detection. Although the following description of the present invention uses a scanning system using channel plates by way of illustration, the method described herein may also be used with non-scanning systems as well as capillary systems.

    摘要翻译： 本发明提供一种激发荧光样品和荧光发射测量的方法。 本发明的方法具有显着减少背景荧光量的优点。 该方法包括以小于或等于45℃，优选小于或等于20°的角度进入衬底的光束激发衬底中的样品的步骤，然后收集荧光 发射形成具有将发射的光聚焦到CCD上以进行检测的透镜系统的样品。 虽然本发明的以下描述使用了使用通道板的扫描系统作为说明，但是本文所述的方法也可以与非扫描系统以及毛细管系统一起使用。

    Detection cell for guiding excitation light therein and method for using same
    37.
    发明授权
    Detection cell for guiding excitation light therein and method for using same 有权
    用于引导激发光的检测单元及其使用方法

    公开(公告)号：US06797139B2

    公开(公告)日：2004-09-28

    申请号：US09812750

    申请日：2001-03-19

    申请人： Dar Bahatt ,  Richard T. Reel

    发明人： Dar Bahatt ,  Richard T. Reel

    IPC分类号： B01D5702

    CPC分类号： G01N21/05 ,  G01N21/645 ,  G01N27/44721 ,  G01N2021/0346 ,  G01N2021/6482

    摘要： The present invention provides a detection cell that comprises a body having a first end that defines a first opening, a second end that defines a second opening, and an internal surface that defines an interior cavity that fluidly connects the first opening and the second opening; wherein the interior cavity is capable of holding a support matrix for receiving a chemical species through the first opening, passing the chemical species through the interior cavity, and discharging the chemical species through the second opening; and wherein at least two portions of the body are capable of providing a first and a second guiding region each having an index of refraction less than that of the support matrix. A system utilizing the detection cell of the present invention is also provided. In another embodiment, the present invention provides a method for guiding light through a support matrix through which a chemical species is passing.

    摘要翻译： 本发明提供了一种检测单元，其包括具有限定第一开口的第一端，限定第二开口的第二端和限定使第一开口和第二开口流体连接的内部空腔的内表面的主体; 其中所述内部空腔能够保持用于通过所述第一开口接收化学物质的支撑矩阵，使所述化学物质通过所述内部空腔，并且通过所述第二开口排出所述化学物质; 并且其中所述主体的至少两个部分能够提供每个具有小于所述支撑矩阵的折射率的折射率的第一和第二引导区域。 还提供了利用本发明的检测单元的系统。 在另一个实施方案中，本发明提供一种用于引导光通过化学物质通过的载体基质的方法。

    Optical system and method for optically analyzing light from a sample
    38.
    发明授权
    Optical system and method for optically analyzing light from a sample 失效
    用于光学分析来自样品的光的光学系统和方法

    公开(公告)号：US07477381B2

    公开(公告)日：2009-01-13

    申请号：US11548210

    申请日：2006-10-10

    申请人： Richard T. Reel

    发明人： Richard T. Reel

    IPC分类号： G01J3/28

    CPC分类号： G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0262 ,  G01J3/0294 ,  G01J3/04 ,  G01J3/2803 ,  G01N21/05 ,  G01N21/31 ,  G01N27/44721 ,  G01N2021/0346

    摘要： An optical system for analyzing light from a plurality of samples is provided. The optical system includes a plurality of holders adapted to have samples located therein, a collection lens, a transmission grating, and a reimaging lens. The collection lens is configured to receive and substantially collimate light from the samples. The transmission grating is configured to spectrally disperse the substantially collimated light from the collection lens. The reimaging lens is configured to receive the light from the light dispersing element and direct the light onto a light detection device. A method of optically analyzing at least one sample is also provided.

    摘要翻译： 提供了一种用于分析来自多个样品的光的光学系统。 光学系统包括多个保持器，其适于使样本位于其中，收集透镜，透射光栅和再成像透镜。 收集透镜被配置为接收并基本上准直来自样品的光。 透射光栅被配置为光谱地分散来自收集透镜的基本上准直的光。 该成像透镜被配置为接收来自光分散元件的光并将光引导到光检测装置上。 还提供了一种光学分析至少一个样品的方法。

    Optical system and method for optically analyzing light from a sample
    40.
    发明授权
    Optical system and method for optically analyzing light from a sample 失效
    用于光学分析来自样品的光的光学系统和方法

    公开(公告)号：US06690467B1

    公开(公告)日：2004-02-10

    申请号：US09564790

    申请日：2000-05-05

    申请人： Richard T. Reel

    发明人： Richard T. Reel

    IPC分类号： G01J328

    CPC分类号： G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0262 ,  G01J3/0294 ,  G01J3/04 ,  G01J3/2803 ,  G01N21/05 ,  G01N21/31 ,  G01N27/44721 ,  G01N2021/0346

    摘要： An optical system for analyzing light from a plurality of samples is provided. The optical system includes a plurality of holders adapted to have samples located therein, a collection lens, a transmission grating, and a reimaging lens. The collection lens is configured to receive and substantially collimate light from the samples. The transmission grating is configured to spectrally disperse the substantially collimated light from the collection lens. The reimaging lens is configured to receive the light from the light dispersing element and direct the light onto a light detection device. A method of optically analyzing at least one sample is also provided.

    摘要翻译： 提供了一种用于分析来自多个样品的光的光学系统。 光学系统包括多个保持器，其适于使样本位于其中，收集透镜，透射光栅和再成像透镜。 收集透镜被配置为接收并基本上准直来自样品的光。 透射光栅被配置为光谱地分散来自收集透镜的基本上准直的光。 该成像透镜被配置为接收来自光分散元件的光并将光引导到光检测装置上。 还提供了一种光学分析至少一个样品的方法。