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130 条记录 (耗时 0.047 秒)

    Wearable Inductive Damping Sensor
    31.
    发明申请
    Wearable Inductive Damping Sensor 审中-公开

    公开(公告)号：US20200082926A1

    公开(公告)日：2020-03-12

    申请号：US16568059

    申请日：2019-09-11

    申请人： California Institute of Technology

    发明人： Yu-Chong Tai ,  Tzu-Chieh Chou ,  Shane S. Shahrestani

    IPC分类号： G16H20/30 ,  G16H50/20 ,  A61B5/04 ,  A61B5/00 ,  G01N27/04 ,  G01R27/26

    摘要： Techniques are described for a non-invasive detection of a health condition of an organ. In an example, the electrical conductivity of the organ reflects the organ's health of. An inductive damping sensor can be used to detect the organ's electrical conductivity and, thus, its health. The inductive damping sensor can be placed in proximity of the organ such as the organ is within the magnetic field generated based on a coil of the inductive damping sensor. The conductivity of the organ impacts the inductance and the resistance of the coil. Hence, the inductance and/or resistance of the coil can be measured, where the measurements can be associated with the health of the organ.

    In-situ heated disposition of parylene to enhance pore penetration into silicone
    33.
    发明授权
    In-situ heated disposition of parylene to enhance pore penetration into silicone 有权

    公开(公告)号：US10287451B2

    公开(公告)日：2019-05-14

    申请号：US15276328

    申请日：2016-09-26

    申请人： California Institute of Technology

    发明人： Yu-Chong Tai ,  Dongyang Kang

    IPC分类号： B32B19/00 ,  C09D165/04 ,  B05D1/00 ,  C03C17/32

    摘要： A composition of matter is described in which a porous material, such as polydimethylsiloxane (PDMS), is coated with parylene N, C, D, or AF-4 by vapor deposition polymerization while a temperature of the porous material's surface being coated is heated to between 60° C. and 120° C., or 80° C. and 85° C., during deposition. The parylene forms nano roots within the porous material that connect with a conformal surface coating of parylene. In some embodiments, a watertight separation chamber in an integrated microfluidic liquid chromatography device is fabricated by heating tunnels in micro-fabricated PDMS and depositing parylene within the heated tunnels.

    SUBSTRATES FOR HIGH-DENSITY CELL GROWTH AND METABOLITE EXCHANGE
    34.
    发明申请
    SUBSTRATES FOR HIGH-DENSITY CELL GROWTH AND METABOLITE EXCHANGE 审中-公开

    公开(公告)号：US20190002813A1

    公开(公告)日：2019-01-03

    申请号：US16100468

    申请日：2018-08-10

    申请人： California Institute of Technology ,  City of Hope

    发明人： Yu-Chong Tai ,  Yang Liu ,  Colin A. Cook ,  Yuman Fong

    IPC分类号： C12M1/04 ,  C12M1/00 ,  C12M1/12

    摘要： A polymer or other substrate optimized for growing cells is described, which takes the form of a micro-thin bag with gas permeable sides. Sides of the bag can be held at a fixed distance from one another with a multitude of tiny micropillars or other spacers extending between them, keeping the bag at a predetermined thickness and preventing the bag from collapsing and the sides from sticking together. In other embodiments, the sides may be held apart by gas pressure alone. A 0.01 μm to 1000 μm parylene or other biocompatible coating over the bag outsides controls the permeability of the bag material and provides a bio-safe area for cell growth. An alternate configuration uses open-cell foam with skins coated with a biocompatible coating. Tubes going into multiple bags can be connected to a manifold that delivers gaseous oxygen or removes carbon dioxide and other waste gases. Multiple bags can be stacked together tightly, with o-ring spacers in between, and housed within a vessel to form a high-surface area, ultra-compact cell growing system. For cells growing on the bags, liquid nutrients can be fed by way of the tube spacers, and oxygen and waste gases permeated through the bag sides and transported within the bags.

    RELIABLE DEPOSITION OF THIN PARYLENE
    38.
    发明申请
    RELIABLE DEPOSITION OF THIN PARYLENE 审中-公开

    公开(公告)号：US20170113246A1

    公开(公告)日：2017-04-27

    申请号：US15331544

    申请日：2016-10-21

    申请人： California Institute of Technology

    发明人： Yu-Chong Tai ,  Wei Wang ,  Dongyang Kang

    IPC分类号： B05D1/00 ,  B05D3/04 ,  B81C1/00

    CPC分类号： B05D1/60 ,  B05D3/0486 ,  B05D3/0493 ,  B81C1/00674 ,  C23C16/45559

    摘要： Apparatus, system, and method of depositing thin and ultra-thin parylene are described. In an example, a core deposition chamber is used. The core deposition chamber includes a base and a rigid, removable cover configured to mate and seal with the base to create the core deposition chamber and to define an inside and an outside of the core deposition chamber. The core deposition chamber also includes a conduit through a top of the cover. The conduit has a lumen connecting the inside to the outside of the core deposition chamber. The lumen has a length and a cross-section. The cross-section has a width between 50 μm and 6000 μm. The length is less than 140 times the cross-section width. The core deposition chamber can be placed in an outer deposition chamber and can achieve parylene deposition less than 1 μm thick inside the core deposition chamber.

    IMPLANTABLE OXYGEN GENERATOR AND TRANSPORTER
    39.
    发明申请
    IMPLANTABLE OXYGEN GENERATOR AND TRANSPORTER 有权
    可植入氧气发生器和运输机

    公开(公告)号：US20170071785A1

    公开(公告)日：2017-03-16

    申请号：US15261435

    申请日：2016-09-09

    申请人： California Institute of Technology ,  University of Southern California ,  Doheny Eye Institute

    发明人： Yu-Chong Tai ,  Nicholas E. Scianmarello ,  Karthik Murali ,  Mark S. Humayun ,  Ramiro Magalhaes Ribeiro

    IPC分类号： A61F9/00 ,  A61N1/05 ,  A61M5/142 ,  A61M37/00

    CPC分类号： A61F9/0017 ,  A61M5/14276 ,  A61M37/00 ,  A61M2005/14204 ,  A61M2205/04 ,  A61M2210/0612 ,  A61N1/0543 ,  A61N1/20 ,  A61N1/3787

    摘要： An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.

    摘要翻译： 描述了可植入医疗装置。 可植入医疗装置包括小分子发生器，小分子扩散器和连接两者的插管。 小分子发生器包括电解质储存器和一组电极。 电解质储存器的第一部分对于预定类别的小分子是不可渗透的。 电解液储存器的第二部分对小分子是可渗透的。 该组电极设置在电解质储存器的内部，并且构造成基于对该组电极的电力施加和电解质储存器内的电解质的存在来促进小分子的电解。 至少一部分小分子扩散剂对小分子是可渗透的。