公开(公告)号：US20220082531A1

公开(公告)日：2022-03-17

申请号：US17471393

申请日：2021-09-10

Applicant: Waters Technologies Corporation

Inventor： Amit Patel ,  Moon Chul Jung ,  Susan Rzewuski ,  Thomas H. Walter ,  Matthew A. Lauber ,  Kevin Wyndham ,  Mathew DeLano ,  Jennifer Simeone

IPC: G01N30/04

Abstract: The present disclosure is directed to methods of characterizing a system containing a chromatographic column. The methods can include introducing a sample comprising a positive control and a negative control to the system containing a chromatographic column, wherein the positive control is a sensitive probe that interacts with the system and the negative control is substantially non-interacting with the system; after passing the sample through the chromatographic column, detecting the positive control and the negative control; and determining system suitability by comparing the amount of detected positive control to negative control. In some embodiments, determining system suitability (e.g., inertness of sample to the system) is accomplished by determining a ratio of detected positive control to negative control.

公开(公告)号：US10953346B2

公开(公告)日：2021-03-23

申请号：US15873280

申请日：2018-01-17

Applicant: Waters Technologies Corporation

Inventor： Xiangjin Song ,  James P. Murphy ,  Keith Fadgen ,  Wade P. Leveille ,  Joseph D. Michienzi ,  Jonathan L. Belanger ,  Moon Chul Jung ,  Abhijit Tarafder

IPC: B01D15/14 ,  B01L3/00 ,  B65D1/02 ,  B65D23/14 ,  G01N35/00 ,  G01N30/80 ,  B01L9/00 ,  G01N30/26

Abstract: Solvent containers and solvent container trays for chromatography systems are described for providing control over solvent supply and waste collection. Designated solvent containers and exclusively designated solvent containers provide solvents for use by chromatography systems. Control over solvent supply is achieved by requiring matched container shape and container receiving position shape within the tray, and additionally or alternatively, through solvent container coding readable by the solvent tray and chromatography system which provide information about the solvent container to the chromatography system.

公开(公告)号：US10823713B2

公开(公告)日：2020-11-03

申请号：US15847586

申请日：2017-12-19

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Wade P. Leveille ,  Jonathan L. Belanger ,  Moon Chul Jung ,  Abhijit Tarafder ,  Joseph Michienzi ,  Keith Fadgen ,  Kevin Wyndham ,  Xiangjin Song

IPC: G01N30/32 ,  B01D15/16 ,  B65D83/14 ,  G01N30/38

Abstract: The present disclosure generally relates to systems, methods and devices for providing pressurized solvent flow in chromatography systems.

公开(公告)号：US10753916B2

公开(公告)日：2020-08-25

申请号：US15872842

申请日：2018-01-16

Applicant: Waters Technologies Corporation

Inventor： Moon Chul Jung ,  Jonathan L. Belanger ,  Xiangjin Song ,  Abhijit Tarafder ,  Joseph A. Jarrell ,  Wade P. Leveille

IPC: G01N30/88 ,  G01M3/20 ,  G01N30/60 ,  G01N30/86 ,  G01M3/26 ,  G01N30/02 ,  G01N30/26 ,  G01N30/04

Abstract: Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. The leak detection system includes a sealable compartment disposed to surround at least one component of a chromatography system. The detector is in communication, e.g., fluid communication, with an interior of the sealable compartment and configured to detect the leak by various mean including the presence of liquid or the presence of vapor, or both within the sealable compartment.

公开(公告)号：US10690563B2

公开(公告)日：2020-06-23

申请号：US15872755

申请日：2018-01-16

Applicant: Waters Technologies Corporation

Inventor： Abhijit Tarafder ,  Moon Chul Jung ,  Jonathan L. Belanger ,  Xiangjin Song ,  Wade P. Leveille ,  Darryl W. Brousmiche

IPC: G01N30/34 ,  G01N30/02 ,  G01M3/20

Abstract: Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. A coating is disposed to conform to at least one component of a chromatography system, such as a fitting or a section of tubing. The coating is made of or contains a responsive material that can undergo a detectable change when exposed to a chromatographic fluid or mobile phase. The change of the responsive material can indicate the presence of the fluid or mobile phase, a change in at least one physical property of the coating to prevent passage of the fluid or mobile phase, or a combination thereof.

公开(公告)号：US20190321759A1

公开(公告)日：2019-10-24

申请号：US16375908

申请日：2019-04-05

Applicant: Waters Technologies Corporation

Inventor： Kevin D. Wyndham ,  Moon Chul Jung ,  Abhijit Tarafder ,  Wade P. Leveille, SR.

IPC: B01D29/96 ,  B01D29/05 ,  B01D29/50 ,  B01D29/66 ,  B01D15/12 ,  B01D35/143

Abstract: A liquid chromatography system, includes a fluidic flow path, a chromatography column located in the fluidic flow path, a filtration device located in the fluidic flow path before the chromatography column, the filtration device including a housing having a fluidic inlet, a fluidic outlet, wherein at least a portion of the fluidic flow path is located between the fluidic inlet and the fluidic outlet and at least one filter disposed in the portion of the fluidic flow path, wherein the at least one filter is made of a micromachined material. Liquid chromatography filtration methods are further disclosed.

公开(公告)号：US10384206B2

公开(公告)日：2019-08-20

申请号：US14434316

申请日：2013-09-25

Applicant: Waters Technologies Corporation

Inventor： Pamela J. Longenbach ,  Moon Chul Jung ,  Frank John Marszalkowski, Jr.

IPC: B01D35/00 ,  B01L3/00 ,  G01N30/06 ,  G01N1/40

Abstract: Described is a matrix spot processing device comprising a tubular apparatus. An absorbent media is located either separate from, or attached to, the tubular apparatus. A sample is spotted on the absorbent media. A reservoir is in the tubular apparatus. A first region of the reservoir is constructed and arranged to have an extraction solvent. A second region of the reservoir, which may or may not be the same as the first region, is constructed and arranged to receive an extract generated from an interaction between the extraction solvent and the spotted sample at the absorbent media.

公开(公告)号：US20180202983A1

公开(公告)日：2018-07-19

申请号：US15872842

申请日：2018-01-16

Applicant: Waters Technologies Corporation

Inventor： Moon Chul Jung ,  Jonathan L. Belanger ,  Xiangjin Song ,  Abhijit Tarafder ,  Joseph A. Jarrell ,  Wade P. Leveille, SR.

IPC: G01N30/88 ,  G01N30/86 ,  G01M3/20 ,  G01N30/60

CPC classification number: G01N30/88 ,  G01M3/202 ,  G01M3/26 ,  G01N30/02 ,  G01N30/04 ,  G01N30/26 ,  G01N30/6052 ,  G01N30/8675 ,  G01N2030/889

Abstract: Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. The leak detection system includes a sealable compartment disposed to surround at least one component of a chromatography system. The detector is in communication, e.g., fluid communication, with an interior of the sealable compartment and configured to detect the leak by various mean including the presence of liquid or the presence of vapor, or both within the sealable compartment.

公开(公告)号：US20180202980A1

公开(公告)日：2018-07-19

申请号：US15847586

申请日：2017-12-19

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Wade P. Leveille ,  Jonathan L. Belanger ,  Moon Chul Jung ,  Abhijit Tarafder ,  Joseph Michienzi ,  Keith Fadgen ,  Kevin Wyndham ,  Xiangjin Song

IPC: G01N30/32 ,  B01D15/16 ,  G01N30/38 ,  B65D83/14

Abstract: The present disclosure generally relates to systems, methods and devices for providing pressurized solvent flow in chromatography systems.

公开(公告)号：US20180140971A1

公开(公告)日：2018-05-24

申请号：US15874469

申请日：2018-01-18

Applicant: Waters Technologies Corporation

Inventor： Moon Chul Jung ,  Hua Yang ,  Edouard S.P. Bouvier

IPC: B01D15/22 ,  B01J20/28 ,  B01D15/10 ,  B01D15/08 ,  B01D15/18 ,  B32B5/02 ,  B32B3/26 ,  B32B1/02 ,  B01J35/10 ,  B01D15/38 ,  B01J20/32 ,  B01J20/285 ,  B01J20/26 ,  B01D15/34

CPC classification number: B01D15/22 ,  B01D15/08 ,  B01D15/10 ,  B01D15/18 ,  B01D15/34 ,  B01D15/3804 ,  B01J20/262 ,  B01J20/264 ,  B01J20/28 ,  B01J20/28007 ,  B01J20/28014 ,  B01J20/28042 ,  B01J20/28088 ,  B01J20/285 ,  B01J20/3212 ,  B01J20/3268 ,  B01J35/108 ,  B01J2220/82 ,  B01J2220/86 ,  B32B1/02 ,  B32B3/26 ,  B32B5/02 ,  Y10T428/1321 ,  Y10T428/1352 ,  Y10T428/1376 ,  Y10T428/249978

Abstract: Embodiments of the present invention are directed to a porous monolith polymeric composition having utility in catalysis, chromatography, filtration, and electro-kinetic pumps, devices incorporating such composition and methods or making and using such monoliths. The monoliths are characterized by a substantially homogeneous skeletal core with little shrinkage, few voids and few channels.