公开(公告)号：US20140239174A1

公开(公告)日：2014-08-28

申请号：US14190785

申请日：2014-02-26

Applicant: Implant Sciences Corporation

Inventor： Andrew G. Anderson ,  Troy A. Velazquez ,  Dmitriy V. Ivashin ,  Said Boumsellek

IPC: H01J49/02 ,  H01J49/00 ,  G01N27/62

CPC classification number: H01J49/025 ,  G01N27/622 ,  H01J49/00 ,  H01J49/0013 ,  H05K3/0014 ,  H05K3/0044 ,  H05K3/4038

Abstract: For ion mobility spectrometry applications, a desired shape of a sensor structure may be created by forming a desired shape from a ceramic material, such as aluminum nitride. In various embodiments, the sensor structure may be formed using discrete individual ceramic sheets and/or from a preformed ceramic tube. Via holes are formed into the sensor structure to provide for efficient circuitry configurations of the IMS drift tube and/or providing electrical connections between the interior and exterior of the drift tube.

Abstract translation: 对于离子迁移谱分析应用，传感器结构的期望形状可以通过从诸如氮化铝的陶瓷材料形成期望的形状来产生。 在各种实施例中，传感器结构可以使用离散的单独的陶瓷片和/或来自预先形成的陶瓷管来形成。 通孔形成在传感器结构中，以提供IMS漂移管的有效电路配置和/或在漂移管的内部和外部之间提供电连接。

公开(公告)号：US20140231643A1

公开(公告)日：2014-08-21

申请号：US14227563

申请日：2014-03-27

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Zheng Ouyang ,  Liang Gao ,  Robert Graham Cooks

IPC: H01J49/04 ,  H01J49/10 ,  H01J49/00

CPC classification number: H01J49/24 ,  H01J49/00 ,  H01J49/0013 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/04 ,  H01J49/0404 ,  H01J49/0422 ,  H01J49/0495 ,  H01J49/10 ,  H01J49/165 ,  H01J49/26

Abstract: A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample. The reduced duty cycle of sample introduction is offset by operation of the mass spectrometer under higher performance conditions and by ion accumulation at atmospheric pressure.

Abstract translation: 将大气压力离子源（包括电喷雾和解吸电喷雾离子源）与将其离子化样品不连续地引入质谱仪的质谱仪（例如微型质谱仪）进行接口的方法。 不连续的介绍改善了仪器的抽吸能力与含有电离样品的大气压气体的体积之间的匹配。 样品引入的减少的占空比通过质谱仪在较高性能条件下的操作和大气压下的离子积聚来抵消。

公开(公告)号：US08742336B2

公开(公告)日：2014-06-03

申请号：US13727018

申请日：2012-12-26

Applicant: Korea Research Institute of Standards and Science

Inventor： Young-Pil Kim ,  Tae Geol Lee

IPC: H01J49/04

CPC classification number: H01J49/0409 ,  B82Y15/00 ,  G01N1/00 ,  H01J49/00 ,  H01J49/26 ,  Y10S977/902

Abstract: There are provided a bio-chip for secondary ion mass spectrometry and a method of fabricating the same, the bio-chip, which is a bio-chip for analyzing a biochemical material using the secondary ion mass spectrometry, including: a substrate; and core-shell particles positioned above substrate, wherein the core-shell particles each include a metal nanoparticle as a core and a metal shell surrounding the metal nanoparticle.

Abstract translation: 提供了二次离子质谱法的生物芯片及其制造方法，该生物芯片是使用二次离子质谱法分析生化材料的生物芯片，其包括：底物; 以及位于基材上方的核 - 壳颗粒，其中核 - 壳颗粒各自包括作为芯的金属纳米颗粒和围绕金属纳米颗粒的金属壳。

公开(公告)号：US20140117223A1

公开(公告)日：2014-05-01

申请号：US14122534

申请日：2012-05-25

Applicant: MSDETECTION CORP.

Inventor： William R. Stott ,  Gholamreza Javahery

IPC: H01J49/04

CPC classification number: H01J49/0459 ,  G01N1/22 ,  G01N1/24 ,  G01N2001/022 ,  G01N2001/024 ,  H01J49/00 ,  H01J49/02 ,  H01J49/04

Abstract: Methods and devices for detecting a target substance on a subject without contacting the subject are disclosed. At least one air jet blows analyte from a surface of the subject into an airflow, the airflow entraining the analyte. A desorption channel desorbs molecules from analyte in a portion of the airflow travelling through the desorption channel. An ionizer forms ions from vapour molecules in the portion of the airflow. At least one mass spectrometer analyzes the ions to detect the target substance. The flow travels without interruption from the subject to the at least one mass spectrometer. The desorption channel causes a sufficient quantity of molecules to desorb from the analyte to enable the at least one mass spectrometer to detect the target substance.

Abstract translation: 公开了用于在不接触受试者的情况下检测被检物体上的目标物质的方法和装置。 至少一个空气喷射器将被分析物从受试者的表面吹入气流，夹带分析物的气流。 解吸通道在通过解吸通道行进的气流的一部分中从分析物解吸分子。 电离器在气流的一部分形成来自蒸气分子的离子。 至少一个质谱仪分析离子以检测目标物质。 该流动不间断地从受试者移动到至少一个质谱仪。 解吸通道导致足够数量的分子从分析物解吸，使得至少一个质谱仪能够检测目标物质。

公开(公告)号：US08692186B2

公开(公告)日：2014-04-08

申请号：US12914353

申请日：2010-10-28

Applicant: Martin Lehmann

Inventor： Martin Lehmann

IPC: G01M3/04 ,  H01J47/00

CPC classification number: G01M3/02 ,  B65B3/04 ,  B65B57/00 ,  G01M3/202 ,  G01M3/227 ,  G01M3/329 ,  H01J49/00 ,  H01J49/04

Abstract: Closed containers which are filled with a consumer product are tested on leakiness by means of mass spectrometry (10) in that an impact (AN(P)) by the consumer product (P) upon the surrounding atmosphere (A(P)) of the container to be leak tested is monitored by the mass spectrometry (10).

Abstract translation: 填充有消费品的封闭容器通过质谱法（10）进行泄漏测试，其中消费品（P）对周围环境（A（P））的影响（AN（P））为 通过质谱法（10）监测要进行泄漏测试的容器。

公开(公告)号：US08673653B2

公开(公告)日：2014-03-18

申请号：US12937139

申请日：2009-04-10

Applicant: Hyung-Soon Park ,  Sang-Wan So ,  Woon-Seok Yeo ,  Soo-Jae Lee ,  Jung-Rok Lee ,  Ju-Hee o Lee ,  Kwang-Pyo Kim

Inventor： Hyung-Soon Park ,  Sang-Wan So ,  Woon-Seok Yeo ,  Soo-Jae Lee ,  Jung-Rok Lee ,  Ju-Hee o Lee ,  Kwang-Pyo Kim

IPC: G01N33/553

CPC classification number: G01N33/553 ,  G01N33/585 ,  G01N33/6848 ,  G01N2458/15 ,  H01J49/00 ,  Y10T436/24

Abstract: Provided is a novel method for amplifying mass spectrometric signals. A novel method for detecting signals of a target molecule includes: allowing a sample, which comprises a target molecule, to contact a gold particle having a surface modified to selectively bind the target molecule, allowing a low molecular weight molecule engrafted to the gold particle generate mass spectrometric signals after the interaction, e.g., binding, between the gold particle and the target molecule, and amplifying the mass spectrometric signals to generate much mass spectrometric signals of the low molecular weight molecule even when trace amounts of the target molecule are present. An assay system using the method and the gold particle prepared in the method are provided. The method amplifies signals of the target molecule without pretreatment of a sample, making it possible to measure the target molecule simply and precisely.

Abstract translation: 提供了一种扩增质谱信号的新方法。 用于检测靶分子信号的新方法包括：允许包含目标分子的样品接触具有修饰以选择性结合靶分子的表面的金颗粒，允许移植到金颗粒的低分子量分子产生 即使存在痕量的目标分子，即使在金颗粒与靶分子之间的相互作用之后的质谱信号，也可以扩增质谱信号以产生低分子量分子的大量质谱信号。 提供了使用该方法的测定系统和该方法中制备的金颗粒。 该方法在不预处理样品的情况下放大靶分子的信号，使得可以简单且准确地测量目标分子。

公开(公告)号：US08653448B1

公开(公告)日：2014-02-18

申请号：US13943130

申请日：2013-07-16

Applicant: Riken ,  Shimadzu Corporation

Inventor： Koji Ueda ,  Atsuhiko Toyama

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/0027 ,  B01D59/44 ,  G01N33/6848 ,  G01N33/6854 ,  G01N2400/00 ,  G01N2440/38 ,  H01J49/00 ,  Y10T436/173076 ,  Y10T436/24

Abstract: In order to provide an analysis method that is capable of determining a glycan structure with high detection sensitivity, a method of the present invention includes the steps of: carrying out triple quadrupole mass spectrometry at various values of CID energy; creating an energy-resolved profile including yield curves representing relationships between (i) a value of the CID energy and (ii) measured amounts of specific types of product ions; preparing a reference profile, and identifying a glycan structure of a test material by comparing the energy-resolved profile with the reference profile.

Abstract translation: 为了提供能够确定具有高检测灵敏度的聚糖结构的分析方法，本发明的方法包括以下步骤：以各种CID能量进行三重四极杆质谱; 产生能量分辨曲线，其包括表示（i）CID能量的值和（ii）特定类型的产物离子的测量量之间的关系的收益率曲线; 准备参考分布图，以及通过将能量分辨分布与参考分布进行比较来识别测试材料的聚糖结构。

公开(公告)号：US08637808B2

公开(公告)日：2014-01-28

申请号：US13632615

申请日：2012-10-01

Applicant: Canon Kabushiki Kaisha

Inventor： Masafumi Kyogaku ,  Koichi Tanji

IPC: H01J49/00

CPC classification number: H01J49/00 ,  H01J49/0004 ,  H01J49/142

Abstract: To provide a method that reduces an influence of dependence of an ionizing beam in an incident direction or uneven irradiation to a sample on a result of mass spectrometry, and can measure mass distribution with high reliability. A mass distribution measuring method according to the present invention includes: changing a direction of irradiating the ionizing beam to a sample surface; acquiring a plurality of mass distribution images in a plurality of incident directions; performing image transform of the mass distribution images according to an angle formed by an incident direction of the ionizing beam and a substrate surface; synthesizing the plurality of transformed images; and outputting the synthesized mass distribution images.

Abstract translation: 为了提供一种降低离子束在入射方向上的依赖性的影响的方法或者对质谱的结果的不均匀照射的方法，可以高可靠性地测定质量分布。 根据本发明的质量分布测量方法包括：改变将电离束照射到样品表面的方向; 在多个入射方向获取多个质量分布图像; 根据由电离束的入射方向和基板表面形成的角度进行质量分布图像的图像变换; 合成多个变换图像; 并输出合成质量分布图像。

公开(公告)号：US20140004616A1

公开(公告)日：2014-01-02

申请号：US13897628

申请日：2013-05-20

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Subhakar Dey ,  Sasi Pillal ,  Brian L. Williamson ,  Subhasish Purkayastha ,  Michal Weinstock

IPC: G01N27/62

CPC classification number: G01N30/72 ,  G01N27/62 ,  G01N33/64 ,  G01N33/743 ,  G01N2030/045 ,  G01N2030/884 ,  H01J49/00 ,  H01J49/0045 ,  H01J49/164 ,  Y10T436/147777 ,  Y10T436/200833

Abstract: Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids. The analytes can be medical or pharmaceutical compounds in biological samples. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry.

Abstract translation: 提供了标记试剂，一组标记试剂和标记技术用于酮或醛化合物的相对定量，绝对定量或两者，包括但不限于包含类固醇或酮类固醇的分析物。 分析物可以是生物样品中的医药或药物化合物。 还公开了用于标记，分析和定量酮或醛化合物的方法，也是也使用质谱法的方法。

公开(公告)号：US08614418B2

公开(公告)日：2013-12-24

申请号：US13937434

申请日：2013-07-09

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Michael P. Caulfield ,  Gloria Kwangja Lee

IPC: H01J49/00

CPC classification number: H01J49/0009 ,  G01N1/34 ,  G01N33/9406 ,  H01J49/00 ,  Y10T436/17

Abstract: Provided are methods for determining the amount of one or more of one or more of epinephrine (E), norepinephrine (NE), and dopamine (D) in a sample using mass spectrometry. The methods generally involve ionizing one or more of E, NE, and D in a sample and detecting and quantifying the amount of the ion to determine the amount of one or more of E, NE, and D in the sample.

Abstract translation: 提供了使用质谱法测定样品中的一种或多种肾上腺素（E），去甲肾上腺素（NE）和多巴胺（D）的量的方法。 这些方法通常涉及电离样品中的一种或多种E，NE和D，并且检测和定量离子的量以确定样品中E，NE和D中的一种或多种的量。