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205 条记录 (耗时 0.063 秒)

    EG-VEGF NUCLEIC ACIDS AND POLYPEPTIDES AND METHODS OF USE
    41.
    发明申请
    EG-VEGF NUCLEIC ACIDS AND POLYPEPTIDES AND METHODS OF USE 有权
    EG-VEGF核酸和多肽及其使用方法

    公开(公告)号：US20100254999A1

    公开(公告)日：2010-10-07

    申请号：US12724964

    申请日：2010-03-16

    申请人： NAPOLEONE FERRARA ,  COLIN WATANABE ,  WILLIAM I. WOOD

    发明人： NAPOLEONE FERRARA ,  COLIN WATANABE ,  WILLIAM I. WOOD

    IPC分类号： A61K39/395 ,  A61K38/18 ,  A61P35/00 ,  A61P5/00

    CPC分类号： C07K14/52 ,  A61K38/1866 ,  C07K14/475 ,  G01N33/74 ,  G01N2333/515 ,  G01N2500/04

    摘要： The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.

    摘要翻译： 本发明涉及本文称为EG-VEGF的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了筛选EG-VEGF调节剂的方法。 此外，本文描述了涉及调节细胞增殖和趋化性的方法和相关的治疗方法。

    METHODS FOR USING CHIMERIC VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR PROTEINS
    49.
    发明申请
    METHODS FOR USING CHIMERIC VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR PROTEINS 有权
    使用重型血管内皮生长因子受体蛋白的方法

    公开(公告)号：US20090010933A1

    公开(公告)日：2009-01-08

    申请号：US12104825

    申请日：2008-04-17

    申请人： Terri Lynn Davis-Smyth ,  Helen Hsifei Chen ,  Leonard Presta ,  Napoleone Ferrara

    发明人： Terri Lynn Davis-Smyth ,  Helen Hsifei Chen ,  Leonard Presta ,  Napoleone Ferrara

    IPC分类号： A61K39/395 ,  C07K16/00 ,  C07H21/00 ,  C12P21/00 ,  A61P9/00 ,  C12N15/63 ,  C12N5/00

    CPC分类号： C07K14/71 ,  A61K38/00 ,  C07K16/2863 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/31

    摘要： The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and anglogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.

    摘要翻译： 本发明涉及包含衍生自血管内皮生长因子（VEGF）受体flt-1和KDR的氨基酸序列的新型嵌合VEGF受体蛋白，包括人KDR受体FLK-1的鼠同源物，其中所述嵌合VEGF受体 蛋白质与VEGF结合并拮抗其内皮细胞增殖和萌生活性。 本发明还涉及编码这些嵌合VEGF受体蛋白质的核酸和表达载体，含有这种表达载体的宿主细胞，包含这种蛋白质的药学上可接受的组合物，制备这种蛋白质的方法以及利用这些蛋白质治疗相关病症的方法 具有不希望的血管形成。