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公开(公告)号：US20070142629A1
公开(公告)日：2007-06-21
申请号：US10558649
申请日：2005-06-16
Applicant: Luc Guerrier , Egisto Boschetti , Frederic Fortis
Inventor： Luc Guerrier , Egisto Boschetti , Frederic Fortis
IPC: C07K1/12
CPC classification number: G01N33/6803 , B01D15/1871 , B01D15/327 , B01D15/361 , B01D15/3804 , B01D15/3809 , B01D15/3847 , B01J20/28052 , B01J20/3242 , B01J2220/54 , B01J2220/603 , C07K1/16 , C07K1/36 , G01N27/44773 , G01N33/6842 , G01N2030/027
Abstract: Methods, apparatuses, and kits for fractionating complex mixtures of biological molecules are provided. In one aspect the methods provided include providing a series of different sorbents, introducing the complex mixture to the series of sorbents, contacting serially the complex mixture with each of the sorbents, and capturing biomolecular components from the complex mixture on the sorbents so that each of the sorbents captures a substantially unique subset of said plurality of biomolecular components.
Abstract translation: 提供了用于分离生物分子的复杂混合物的方法，装置和试剂盒。 在一个方面，提供的方法包括提供一系列不同的吸附剂，将复杂混合物引入到一系列吸附剂中，将复合混合物与每种吸附剂连续地接触，并从吸附剂上的复合物混合物捕获生物分子组分， 吸附剂捕获所述多个生物分子组分的基本独特的子集。
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42.发明申请Methods for monitoring polypeptide production and purification using surface enhanced laser desorption/ionization mass spectrometry 审中-公开使用表面增强激光解吸/电离质谱监测多肽生产和纯化的方法公开(公告)号：US20070059776A1
公开(公告)日：2007-03-15
申请号：US11499898
申请日：2006-08-03
Applicant: Egisto Boschetti , Lisa Bradbury , Huw Davies , Lee Lomas , Thang Pham , Vanitha Thulasiraman , Tai-Tung Yip
Inventor： Egisto Boschetti , Lisa Bradbury , Huw Davies , Lee Lomas , Thang Pham , Vanitha Thulasiraman , Tai-Tung Yip
IPC: G01N33/567 , G01N33/53
CPC classification number: G01N33/6842 , C07K1/16 , C07K1/18 , C07K1/20 , C07K1/22 , G01N33/6803 , G01N2030/8411 , H01J49/00 , H01J49/0418 , G01N30/7233
Abstract: The invention provides methods of monitoring the production of a target polypeptide by generating surface enhanced laser desorption/ionization mass spectral profiles of samples taken from multiple cell culture batches or of samples taken at different times from a given batch. The invention additionally provides methods for monitoring the purification of a target polypeptide from a mixture by generating surface enhanced laser desorption/ionization mass spectral profiles of samples taken at various times during a purification process. In addition, the invention relates to methods of identifying conditions that can be used in increasing the scale of a given purification process.
Abstract translation: 本发明提供了通过产生从多个细胞培养物批次或从给定批次的不同时间采集的样品获取的样品的表面增强的激光解吸/电离质谱图来监测目标多肽的产生的方法。 本发明另外提供了通过产生在纯化过程中的不同时间采集的样品的表面增强的激光解吸/电离质谱图来监测来自混合物的目标多肽的纯化的方法。 此外，本发明涉及鉴定可用于增加给定纯化方法的规模的条件的方法。
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43.发明授权公开(公告)号：US07060298B2
公开(公告)日：2006-06-13
申请号：US10029294
申请日：2001-12-28
Applicant: Jean Marie Vogel , Richard Thomas , Egisto Boschetti
Inventor： Jean Marie Vogel , Richard Thomas , Egisto Boschetti
CPC classification number: A61K9/0034 , A61K9/1635 , A61K9/1641 , A61K47/62 , A61K47/6927 , A61K49/0442 , A61K49/048
Abstract: The invention encompasses the treatment of urinary incontinence, gastroesophageal reflux disease and the amelioration of skin wrinkles using biocompatible hydrophilic cationic microparticles and a cell adhesion promoter.
Abstract translation: 本发明包括使用生物相容的亲水性阳离子微粒和细胞粘附促进剂治疗尿失禁，胃食管反流疾病和改善皮肤皱纹。
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公开(公告)号：US20050214815A1
公开(公告)日：2005-09-29
申请号：US11014225
申请日：2004-12-17
Applicant: Egisto Boschetti , Luc Bourgeois
Inventor： Egisto Boschetti , Luc Bourgeois
CPC classification number: B01J39/26 , B01D15/361 , B01J20/3204 , B01J20/3208 , B01J20/3217 , B01J20/3219 , B01J20/3221 , B01J20/3257 , B01J20/3272 , B01J20/3274 , B01J20/3289 , B01J41/20 , B01J47/016 , B01J2220/54 , G01N33/54393 , G01N33/6851
Abstract: In relation to a chromatographic chip, for protein separation, a polymer surface is provided that has a first polymer layer, attached to a support surface, which can be anionic or cationic. To the first layer is attached a second polymer layer, characterized by an opposite charge.
Abstract translation: 关于色谱芯片，对于蛋白质分离，提供聚合物表面，其具有连接到支撑表面的第一聚合物层，其可以是阴离子或阳离子的。 第一层附着有第二聚合物层，其特征在于相反的电荷。
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45.发明授权Passivated porous polymer supports and methods for the preparation and use of same 失效钝化多孔聚合物载体及其制备和使用方法
公开(公告)号：US6045697A
公开(公告)日：2000-04-04
申请号：US200884
申请日：1998-11-30
Applicant: Pierre Girot , Egisto Boschetti
Inventor： Pierre Girot , Egisto Boschetti
CPC classification number: B01D15/08 , B01D15/20 , B01J20/28004 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/288 , B01J20/3204 , B01J20/321 , B01J20/327 , B01J20/3282 , B01J20/3289 , B01J39/26 , B01J41/20 , B01J2220/54 , B01J2220/58
Abstract: This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous supports are disclosed which are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by use of a passivation mixture comprising a main monomer, a passivating agent comprising polyethyleneimine, and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction with biomolecules.
Abstract translation: 本发明一般涉及改性多孔固体载体及其制备和使用方法。 特别地，公开了钝化多孔载体，其特征在于基本上不伴随生物分子的非特异性吸附或相互作用的可逆高吸附能力。 通过使用包含主单体，包含聚乙烯亚胺的钝化剂和交联剂的钝化混合物来实现钝化，该聚合物上的该混合物导致基本上消除了与生物分子的不期望的非特异性相互作用。
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Patent Agency Ranking46.发明授权Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same 失效用于治疗性血管闭塞的微球和含有其的可注射溶液
公开(公告)号：US5648100A
公开(公告)日：1997-07-15
申请号：US471303
申请日：1995-06-06
Applicant: Egisto Boschetti , Michel Brouard , Ludovic Drouet , Pierre Girot , Alexandre Laurent , Michel Wassef
Inventor： Egisto Boschetti , Michel Brouard , Ludovic Drouet , Pierre Girot , Alexandre Laurent , Michel Wassef
IPC: A61K9/50 , A61K9/16 , A61K31/715 , A61K31/726 , A61K31/78 , A61K38/00 , A61K38/16 , A61K38/17 , A61K49/00 , A61L24/06 , A61P9/00 , A61K9/14
CPC classification number: A61L24/06 , A61K9/1676 , A61L2400/06 , A61L2430/36
Abstract: The present invention concerns the use of microspheres for therapeutic embolization consisting of a hydrophilic acrylic copolymer coated with a cell adhesion promoter.
Abstract translation: 本发明涉及微球用于治疗栓塞的用途，其由涂覆有细胞粘附促进剂的亲水丙烯酸共聚物组成。
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47.发明授权Passivated porous polymer supports and methods for the preparation and use of same 失效钝化多孔聚合物载体及其制备和使用方法
公开(公告)号：US5445732A
公开(公告)日：1995-08-29
申请号：US254625
申请日：1994-06-06
Applicant: Pierre Girot , Egisto Boschetti
Inventor： Pierre Girot , Egisto Boschetti
CPC classification number: B01D15/20 , B01J20/28004 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/288 , B01J20/3204 , B01J20/321 , B01J20/327 , B01J20/3282 , B01J20/3289 , B01J39/165 , B01D15/3804 , B01J2220/54 , B01J2220/58
Abstract: This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous polymeric supports are disclosed which are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by use of a passivation mixture comprising a main monomer, a passivating monomer that is different from the main monomer, and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction with biomolecules.
Abstract translation: 本发明一般涉及改性多孔固体载体及其制备和使用方法。 特别地，公开了钝化的多孔聚合物载体，其特征在于基本上不伴随生物分子的非特异性吸附或相互作用的可逆的高吸附能力。 通过使用包含主单体，不同于主单体的钝化单体和交联剂的钝化混合物实现钝化，该聚合物上的该混合物导致基本上消除了与生物分子的不期望的非特异性相互作用。
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48.发明授权Composite polymers and their preparation which are useful in liquid chromatography 失效复合聚合物及其在液相色谱中有用的制备
公开(公告)号：US5075371A
公开(公告)日：1991-12-24
申请号：US619822
申请日：1990-11-29
Applicant: Egisto Boschetti , Pierre Girot
Inventor： Egisto Boschetti , Pierre Girot
IPC: B01J20/281 , B01D15/08 , B01J20/26 , B01J20/285 , B01J41/08 , C08F2/44 , C08K3/36 , C08L33/00 , C08L33/04 , G01N30/88
CPC classification number: C08K3/36 , B01D15/08 , B01J20/26 , C08F2/44 , Y10S524/903
Abstract: A homogeneous composite polymer containing, in an interpenetrated form, 20% to 80% by weight of silica and 80% to 20% by weight of a three-dimensional crosslinked acrylic, vinyl and/or allyl copolymer comprising, in a copolymerized form, 98% to 70% by weight of at least one monofunctional acrylic, vinyl or allyl monomer and 2% to 30% by weight of a difunctional acrylic or allyl crosslinking monomer is useful in liquid chromatography.
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49.发明授权Composite polymers, their preparation and their use in liquid chromatography 失效复合聚合物，其制备及其在液相色谱中的应用
公开(公告)号：US5053135A
公开(公告)日：1991-10-01
申请号：US521988
申请日：1990-05-11
Applicant: Egisto Boschetti , Pierre Girot
Inventor： Egisto Boschetti , Pierre Girot
IPC: B01J20/281 , B01D15/08 , B01J20/26 , B01J20/285 , B01J41/08 , C08F2/44 , C08K3/36 , C08L33/00 , C08L33/04 , G01N30/88
CPC classification number: C08K3/36 , B01D15/08 , B01J20/26 , C08F2/44 , Y10S524/903
Abstract: A homogeneous composite polymer containing, in an interpenetrated form, 20% to 80% by weight of silica and 80% to 20% by weight of a three-dimensional crosslinked acrylic, vinyl and/or allyl copolymer comprising, in a copolymerized form, 98% to 70% by weight of at least one monofunctional acrylic, vinyl or allyl monomer and 2 % to 30% by weight of a difunctional acrylic or allyl crosslinking monomer is useful in liquid chromatography.
Abstract translation: 一种均匀的复合聚合物，其以相互渗透的形式包含20重量％至80重量％的二氧化硅和80重量％至20重量％的三维交联的丙烯酸，乙烯基和/或烯丙基共聚物，其以共聚形式包含98 至少一种单官能丙烯酸，乙烯基或烯丙基单体的重量百分比至70％，双官能丙烯酸或烯丙基交联单体的重量百分比为2％至30％可用于液相色谱。
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50.发明授权公开(公告)号：US08906608B2
公开(公告)日：2014-12-09
申请号：US11495842
申请日：2006-07-28
Applicant: Egisto Boschetti , David Hammond
Inventor： Egisto Boschetti , David Hammond
CPC classification number: G01N33/6803 , C40B30/04 , G01N33/543 , G01N33/54306 , G01N33/6845
Abstract: The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes methods and kits for dynamically reducing the variance between analyte taken from complex mixtures.
Abstract translation: 本发明涉及分子生物学，组合化学和生物化学领域。 特别地，本发明描述了用于动态地减少从复杂混合物中取出的分析物之间的方差的方法和试剂盒。
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