公开(公告)号：US11122982B2

公开(公告)日：2021-09-21

申请号：US16090083

申请日：2017-04-03

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Patrick Mercier

IPC: A61B5/02 ,  A61B5/0205 ,  A61B5/053 ,  A61B5/00 ,  A61B5/1468 ,  A61B5/259 ,  A61B5/282 ,  A61B5/318 ,  A61B5/08 ,  A61B5/145 ,  A61B5/1486

Abstract: Methods, systems, and devices are disclosed for wearable, real-time multimodal sensing of electrochemical and electrophysiological and/or physical parameters of a user. In some aspects, a multimodal sensor device includes a flexible substrate; an electrochemical sensor disposed on the substrate and including electrochemical sensing electrodes operable to measure an electrical signal corresponding to a reaction including a chemical substance via an electrochemical sensing electrode and an analyte at the electrochemical sensor; and an electrophysiological sensor including two or more electrodes disposed on the substrate to acquire an electrophysiological signal of the user, such that when the multimodal sensor device is electrically coupled to an electronics unit and adhered to the user, the device is operable to simultaneously monitor an electrochemical parameter and an electrophysiological parameter of the user.

公开(公告)号：US11007281B2

公开(公告)日：2021-05-18

申请号：US15939104

申请日：2018-03-28

Applicant: The regents of the University of California

Inventor： Joseph Wang ,  Berta Esteban-Fernández de Ávila ,  Yi Chen ,  Chava Angell ,  Fernando Soto ,  Liangfang Zhang ,  Malthe Hansen-Bruhn

IPC: A61K48/00 ,  A61K38/48 ,  A61K41/00 ,  A61M31/00 ,  A61M37/00 ,  C12N15/11 ,  C12N15/113 ,  C12N9/22 ,  C12N9/64 ,  C12N15/87 ,  B82Y15/00

Abstract: Methods, systems, and devices are disclosed for intracellular payload delivery by nanomotor structures. In some aspects, a nanomotor for intracellular payload delivery includes an asymmetric body having a concave cavity at one end of the nanowire body; a functionalization layer on an outer surface of the nanowire body; and a payload substance coupled to the nanomotor by the functionalization layer in a biologically active conformation, wherein the payload substance is attached to a portion of the functionalization layer or at least partially encapsulated within the functionalization layer, in which the nanomotor is operable to propel in a biological medium and into an intracellular region of a living cell to initiate an interaction of the biologically active payload substance with an intracellular constituent of the living cell.

公开(公告)号：US20200337641A1

公开(公告)日：2020-10-29

申请号：US16760431

申请日：2018-11-02

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Juliane Sempionatto Moreto ,  Jonas Felipe Kurniawan ,  Aida Martin Galan ,  Jayoung Kim ,  Alan Campbell ,  Jose Roberto Moreto

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/05

Abstract: Disclosed are devices, systems and methods for epidermal monitoring of a fluid on skin. In some aspects, a device includes an electrochemical sensor comprising two or more electrodes disposed on a first flexible substrate; a microfluidic device comprising a second flexible substrate coupled to the first substrate and structured to include (i) a channel in a first cavity of the second substrate, (ii) one or more holes that connect to the channel and provide one or more inlets, and (iii) a reservoir connected to the channel, in which the electrochemical sensor is aligned with the reservoir; and an adhesion layer coupled to the microfluidic device and attachable to skin, and the device being operable to detect a biomarker in a fluid in secreted by the skin into the microfluidic device.

公开(公告)号：US20200253520A1

公开(公告)日：2020-08-13

申请号：US16785507

申请日：2020-02-07

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Patrick Mercier ,  Ali Fazli Yeknami ,  Somayeh Imani

IPC: A61B5/1486 ,  A61B5/00 ,  A61B5/145 ,  H01M8/16 ,  H01M8/04858 ,  G01N27/327

Abstract: Disclosed are self-powering biofuel cell and sensor devices, systems and techniques. In some aspects, a self-powered biosensing system includes an electronic circuit; an anode including an enzymatic layer electrically coupled to a power supply voltage terminal of the electronic circuit and configured to interact with an analyte in a fluid, such as glucose or lactate; and a cathode electrically coupled to a ground voltage terminal of the electronic circuit, where the electronic circuit is operable to control and use the electrical energy generated at the anode and cathode for powering the biosensing system and detecting a concentration of the analyte in the fluid.

公开(公告)号：US10653803B2

公开(公告)日：2020-05-19

申请号：US15356977

申请日：2016-11-21

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Liangfang Zhang

IPC: A61K41/00 ,  A61K49/00 ,  A61K35/18 ,  A61K9/50 ,  A61K47/69 ,  A61K9/51 ,  A61K9/00 ,  A61K35/12

Abstract: Living cells, such as red blood cells (RBCs) modified with functional micromotors with the aid of ultrasound propulsion and magnetic guidance. Iron oxide nanoparticles are loaded into the RBCs, where their asymmetric distribution within the cells results in a net magnetization, thus enabling magnetic alignment and guidance under acoustic propulsion. The RBC motors display efficient guided and prolonged propulsion in various biological fluids, including undiluted whole blood.

公开(公告)号：US20180146545A1

公开(公告)日：2018-05-24

申请号：US15820284

申请日：2017-11-21

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Rajan Kumar ,  Ying Meng ,  Jae Wook Shin ,  Lu Yin

IPC: H05K1/02 ,  C08F297/04 ,  H05K1/11 ,  H05K1/03 ,  H05K1/16 ,  H05K3/32

CPC classification number: H05K1/0283 ,  A61B5/1477 ,  A61B5/14865 ,  A61B2562/164 ,  A61B2562/166 ,  A61F13/4902 ,  C01B32/158 ,  C08F297/046 ,  C08L53/02 ,  H01M4/38 ,  H01M4/48 ,  H01M4/622 ,  H01M4/663 ,  H01M4/666 ,  H01M4/668 ,  H01M10/0565 ,  H01M10/24 ,  H05K1/028 ,  H05K1/0393 ,  H05K1/118 ,  H05K1/16 ,  H05K3/326 ,  H05K2201/0133

Abstract: Disclosed are compositions, devices, systems and fabrication methods for stretchable composite materials and stretchable electronics devices. In some aspects, an elastic composite material for a stretchable electronics device includes a first material having a particular electrical, mechanical or optical property; and a multi-block copolymer configured to form a hyperelastic binder that creates contact between the first material and the multi-block copolymer, in which the elastic composite material is structured to stretch at least 500% in at least one direction of the material and to exhibit the particular electrical, mechanical or optical property imparted from the first material. In some aspects, the stretchable electronics device includes a stretchable battery, biofuel cell, sensor, supercapacitor or other device able to be mounted to skin, clothing or other surface of a user or object.

公开(公告)号：US09713459B2

公开(公告)日：2017-07-25

申请号：US14407450

申请日：2013-06-11

Applicant: The Regents of the University of California

Inventor： Robert Mattrey ,  Zhe Wu ,  Emilia Olson ,  Joseph Wang ,  Wei Gao ,  Christopher D. Malone

IPC: A61B5/05 ,  A61B8/08 ,  A61K49/22 ,  A61B8/00 ,  A61F2/00 ,  A61F2/02 ,  A61M25/01 ,  A61B90/00

CPC classification number: A61B8/481 ,  A61B8/0841 ,  A61B8/4483 ,  A61B90/39 ,  A61B2090/3925 ,  A61F2/0063 ,  A61F2/02 ,  A61F2250/0096 ,  A61K49/223 ,  A61K49/225 ,  A61M25/0108

Abstract: A method and system are provided for detection of localized hydrogen peroxide within tissue by introducing a catalase-containing material into at location of interest, positioning an ultrasound transducer over the location, and generating an ultrasound image to detect microbubbles, where the presence of microbubbles indicate the presence of localized hydrogen peroxide. The catalase-coated surface may be the inner surface of a microtube, on the surface of or incorporated within a nanosphere or microsphere, or an implantable device.

公开(公告)号：US20150126834A1

公开(公告)日：2015-05-07

申请号：US14400242

申请日：2013-05-10

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Joshua Ray Windmiller ,  Amay Jairaj Bandodkar

IPC: A61B5/00 ,  B32B38/00 ,  B32B38/10 ,  A61B5/1477 ,  B32B37/12

CPC classification number: A61B5/6833 ,  A61B5/14517 ,  A61B5/14539 ,  A61B5/1477 ,  A61B5/1486 ,  B32B37/1284 ,  B32B38/10 ,  B32B38/145 ,  B32B2255/12 ,  B32B2307/202 ,  B32B2307/206 ,  B32B2311/02 ,  B32B2323/04 ,  B32B2367/00 ,  B32B2383/00 ,  B32B2405/00 ,  B32B2556/00 ,  Y10T156/10

Abstract: Methods, structures, devices and systems are disclosed for fabricating and implementing electrochemical biosensors and chemical sensors. In one aspect, a method of producing an epidermal biosensor includes forming an electrode pattern onto a coated surface of a paper-based substrate to form an electrochemical sensor, the electrode pattern including an electrically conductive material and an electrically insulative material configured in a particular design layout, and attaching an adhesive sheet on a surface of the electrochemical sensor having the electrode pattern, the adhesive sheet capable of adhering to skin or a wearable item, in which the electrochemical sensor, when attached to the skin or the wearable item, is operable to detect chemical analytes within an external environment.

Abstract translation: 公开了用于制造和实施电化学生物传感器和化学传感器的方法，结构，装置和系统。 一方面，一种生产表皮生物传感器的方法包括：将电极图案形成在纸基基板的涂布表面上以形成电化学传感器，该电极图案包括导电材料和以特定设计配置的电绝缘材料 布置，并且将粘合片附着在具有电极图案的电化学传感器的表面上，粘附到皮肤上的粘合片或可穿戴物品，其中电化学传感器在附着于皮肤或可穿戴物品时是可操作的 检测外部环境中的化学分析物。

公开(公告)号：US20250114020A1

公开(公告)日：2025-04-10

申请号：US18984998

申请日：2024-12-17

Applicant: The Regents of the University of California

Inventor： Farshad Tehrani ,  Joseph Wang ,  Hazhir Teymourian

IPC: A61B5/1473 ,  A61B5/00

Abstract: Disclosed here are devices, systems, and methods for continuous monitoring of biomarkers using a wearable, non-intrusive microneedle sensor patch platform. In some aspects, a wearable, non-intrusive microneedle sensor device includes a microneedle sensor unit couplable to an electronics unit, where the microneedle sensor unit comprises a substrate, an array of spiked microneedle structures configured as electrochemical sensor electrodes, an array of base structures that encase a lower portion of spiked microneedle structures, and electrical interconnections that electrically couple the electrodes to the electronics unit for processing of detectable signals associated with one or multiple biomarkers in a biofluid.

公开(公告)号：US20250064360A1

公开(公告)日：2025-02-27

申请号：US18727062

申请日：2023-01-06

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Joseph Wang ,  Jong-Min Moon ,  Lu Yin

IPC: A61B5/1486 ,  A61B5/0205 ,  A61B5/145

Abstract: Methods, materials and devices that pertain to solid-state gel-free sensor for touch-based rapid physiological and chemical sensing are disclosed. In some embodiments of the disclosed technology, a sensor device includes a substrate, a plurality of first electrodes and a plurality of second electrodes formed over the substrate, a first current collector formed over the substrate and coupled to the plurality of first electrodes at one end of each first electrode, and a second current collector formed over the substrate and coupled to the plurality of second electrodes at one end of each second electrode, wherein the first electrodes and the second electrodes are alternately arranged, and adjacent first and second electrodes are spaced apart from each other by a predetermined distance.