公开(公告)号：US09101598B2

公开(公告)日：2015-08-11

申请号：US13689572

申请日：2012-11-29

Applicant: Michel Bublot ,  Teshome Mebatsion ,  Joyce Pritchard ,  Perry Linz

Inventor： Michel Bublot ,  Teshome Mebatsion ,  Joyce Pritchard ,  Perry Linz

IPC: A61K39/245 ,  A61K39/17 ,  A61K39/295 ,  A61K39/12 ,  C12N15/869 ,  C12N15/38 ,  C12N15/45 ,  A61K39/00

CPC classification number: A61K39/17 ,  A61K39/12 ,  A61K39/295 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/16043 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2710/20034 ,  C12N2720/10034 ,  C12N2720/10071 ,  C12N2760/18134 ,  C12N2760/18171

Abstract: The present invention provides recombinant Gallid herpesvirus 3 (MDV-2) vectors that contain and express antigens of avian pathogens, recombinant Gallid herpesvirus 3 (MDV-2) vectors that contain a mutated gC gene, compositions comprising the recombinant Gallid herpesvirus 3 (MDV-2) vectors, polyvalent vaccines comprising the recombinant Gallid herpesvirus 3 (MDV-2) vectors and one or more wild type viruses or recombinant vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant Gallid herpesvirus 3 (MDV-2) vectors.

Abstract translation: 本发明提供含有禽类病原体抗原的重组Gallid疱疹病毒3（MDV-2）载体，含有突变gC基因的重组Galid疱疹病毒3（MDV-2）载体，包含重组Gallid疱疹病毒3（MDV- 2）载体，包含重组Gallid疱疹病毒3（MDV-2）载体和一种或多种野生型病毒或重组载体的多价疫苗。 本发明进一步提供针对各种禽类病原体的疫苗接种方法和生产重组Gallid疱疹病毒3（MDV-2）载体的方法。

公开(公告)号：US09040053B2

公开(公告)日：2015-05-26

申请号：US13272651

申请日：2011-10-13

Applicant: Laurent Bernard Fischer

Inventor： Laurent Bernard Fischer

IPC: A61K39/00 ,  A61P35/00 ,  C12N15/85 ,  A61M37/00

CPC classification number: A61K39/0011 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/545

Abstract: The application discloses therapeutic vaccines based upon the “pING” DNA plasmid vector expressing the gene encoding the rat Her2 protein. Vaccines according to the instant disclosure are used as an adjunct treatment for surgery, radiation and/or chemotherapy for dogs and cats with cancers that over express the Her2 antigen, and prolong the post-surgical disease free interval and/or survival time. Also included are therapeutically effective methods of immunization using said vaccines.

Abstract translation: 该申请公开了基于表达编码大鼠Her2蛋白的基因的“pING”DNA质粒载体的治疗性疫苗。 根据本公开的疫苗被用作用于具有过表达Her2抗原的癌症的狗和猫的手术，放射和/或化学疗法的辅助治疗，并且延长了手术后无疾病间隔和/或存活时间。 还包括使用所述疫苗的治疗有效的免疫方法。

公开(公告)号：US09023874B2

公开(公告)日：2015-05-05

申请号：US13510197

申请日：2010-11-11

Applicant: Sebastian Soergel ,  Ralph Paulini ,  Steffen Gross ,  Carsten Beyer ,  Matthias Pohlman ,  Henricus Maria Martinus Bastiaans ,  Michael Rack ,  Deborah L. Culbertson ,  Douglas D. Anspaugh ,  Sarah Thompson ,  Vincent Salgado

Inventor： Sebastian Soergel ,  Ralph Paulini ,  Steffen Gross ,  Carsten Beyer ,  Matthias Pohlman ,  Henricus Maria Martinus Bastiaans ,  Michael Rack ,  Deborah L. Culbertson ,  Douglas D. Anspaugh ,  Sarah Thompson ,  Vincent Salgado

IPC: A01N43/824 ,  A01N43/08 ,  A01N43/22 ,  A01N43/40 ,  A01N43/46 ,  A01N43/50 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58 ,  A01N43/60 ,  A01N43/62 ,  A01N43/647 ,  A01N43/66 ,  A01N43/713 ,  A01N43/72 ,  A01N43/78 ,  A01N43/80 ,  A01N43/82 ,  C07D207/325 ,  C07D209/12 ,  C07D209/10 ,  C07D213/32 ,  C07D231/12 ,  C07D233/66 ,  C07D235/12 ,  C07D237/08 ,  C07D239/20 ,  C07D249/08 ,  C07D251/16 ,  C07D257/04 ,  C07D261/08 ,  C07D263/32 ,  C07D271/06 ,  C07D277/26 ,  C07D285/12 ,  C07D307/40 ,  C07D307/38 ,  C07D307/79 ,  C07D307/80 ,  C07D333/18 ,  C07D333/54 ,  C07D333/56 ,  C07D213/34 ,  A01N43/10

CPC classification number: C07D285/12 ,  A01N43/08 ,  A01N43/10 ,  A01N43/22 ,  A01N43/40 ,  A01N43/46 ,  A01N43/50 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58 ,  A01N43/60 ,  A01N43/62 ,  A01N43/647 ,  A01N43/66 ,  A01N43/713 ,  A01N43/72 ,  A01N43/78 ,  A01N43/80 ,  A01N43/82 ,  C07D207/325 ,  C07D209/10 ,  C07D209/12 ,  C07D213/32 ,  C07D213/34 ,  C07D233/66 ,  C07D235/12 ,  C07D237/08 ,  C07D239/20 ,  C07D249/08 ,  C07D251/16 ,  C07D257/04 ,  C07D261/08 ,  C07D263/32 ,  C07D271/06 ,  C07D277/26 ,  C07D307/38 ,  C07D307/40 ,  C07D307/79 ,  C07D307/80 ,  C07D333/18 ,  C07D333/54 ,  C07D333/56

Abstract: The invention relates to alkylsulfide derivatives compounds of formula I as hereunder depicted or the enantiomers or veterinarily acceptable salts thereof which are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to methods for controlling invertebrate pests by using these compounds and to plant propagation material and to agricultural and veterinary compositions comprising said compounds. wherein U, R1, R2, R3U, X, n and p are defined as in the description.

Abstract translation: 本发明涉及用于对抗或控制无脊椎动物害虫，特别是节肢动物害虫和线虫的对映异构体或其兽医学上可接受的盐的烷基硫醚衍生物化合物。 本发明还涉及通过使用这些化合物和植物繁殖材料以及包含所述化合物的农业和兽用组合物来控制无脊椎害虫的方法。 其中U，R1，R2，R3U，X，n和p如说明书中所定义。

公开(公告)号：US08986706B2

公开(公告)日：2015-03-24

申请号：US13220196

申请日：2011-08-29

Applicant: Michel Bublot ,  Frederic Reynard ,  Herve Poulet ,  Frederic Raymond David

Inventor： Michel Bublot ,  Frederic Reynard ,  Herve Poulet ,  Frederic Raymond David

IPC: A61K39/245 ,  C07K14/005 ,  C12N7/00 ,  A61K39/12 ,  A61P37/04 ,  A61P31/22 ,  C12N15/63 ,  C12N15/86 ,  A61K39/00

CPC classification number: A61K39/17 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/5256 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16722 ,  C12N2710/16734 ,  C12N2760/18134 ,  C12N2760/18143 ,  C12N2760/18152

Abstract: The present invention encompasses recombinant Newcastle Disease Virus-Herpesvirus vaccines or compositions. The invention encompasses recombinant NDV vectors encoding and expressing herpesvirus pathogen, antigens, proteins, epitopes or immunogens. Such vaccines or compositions can be used to protect animals against disease.

Abstract translation: 本发明包括重组新城疫病毒 - 疱疹病毒疫苗或组合物。 本发明包括编码和表达疱疹病毒病原体，抗原，蛋白质，表位或免疫原的重组NDV载体。 这样的疫苗或组合物可用于保护动物免受疾病。

公开(公告)号：US10433552B2

公开(公告)日：2019-10-08

申请号：US15480316

申请日：2017-04-05

Applicant: MERIAL INC.

Inventor： Chunhua Yang ,  Loic Patrick Le Hir de Fallois ,  Charles Q. Meng ,  Alan Long ,  Roelof Johannes Gorter de Vries ,  Bruno Baillon ,  Sylvaine Lafont ,  Myriam Gay de Saint Michel ,  Stephane Kozlovic

IPC: C07D453/04 ,  A01N43/80 ,  C07D261/04 ,  A01N43/42 ,  A61K31/42

Abstract: This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.

公开(公告)号：US20190091133A1

公开(公告)日：2019-03-28

申请号：US15774534

申请日：2016-11-09

Applicant: MERIAL INC.

Inventor： Eric Anthony Hansen

IPC: A61K8/892 ,  A61Q5/02 ,  A61K8/34 ,  A61K8/33 ,  A61K8/49 ,  A61K8/9794 ,  A61K8/9789 ,  A61K8/67

Abstract: A method of treating the skin or hair on a dog containing an effective amount of an ectoparasiticide previously applied to the skin or hair, comprising applying a quantity of a cleansing composition directly to the skin or hair, wherein the treatment does not result in reducing the efficacy of the ectoparasiticide against adult fleas (C. felis) or adult ticks (R. sanguineus) below 90% efficacy for at least a month after application of the ectoparasiticide; wherein the cleansing composition comprises about 1-3% glycerin; about 2-4% silicone copolyol esters, water and is essentially free of surfactant.

公开(公告)号：US10188721B2

公开(公告)日：2019-01-29

申请号：US15419418

申请日：2017-01-30

Applicant: MERIAL INC. ,  GENVEC INC. ,  THE UNITED STATES OF AMERICA, as represented by the Secretary of Homeland Security

Inventor： Justin Widener ,  Leszlie Woodyard ,  Leonardo Siger ,  Douglas Brough ,  Damodar Ettyreddy ,  Jason Gall ,  Duncan McVey ,  Tom Burrage ,  Lauri Motes-Kreimeyer ,  Marc Fiorucci

IPC: A61K39/135 ,  C07K14/005 ,  C12N7/00 ,  A61K39/12 ,  C12N15/86 ,  A61K39/00

Abstract: The present invention encompasses FMDV vaccines or compositions. The invention encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV.

公开(公告)号：US20190021831A1

公开(公告)日：2019-01-24

申请号：US15895876

申请日：2018-02-13

Applicant: MERIAL INC.

Inventor： Aurelie de Malibran-Santibanez ,  Alonso Prado-Masias ,  Frederic David

IPC: A61D1/02 ,  A61K39/02 ,  A61J1/20 ,  A61M3/00

Abstract: The invention relates to a liquid applicator, for administering liquids, including vaccines, to animals. In particular, the applicator is useful for delivering liquids to mouths of animals.

公开(公告)号：US10155725B2

公开(公告)日：2018-12-18

申请号：US14981847

申请日：2015-12-28

Applicant: MERIAL, INC.

Inventor： Charles Q. Meng ,  Alan Long ,  Scot Huber ,  Srinivas Reddy Gurrala ,  Douglas Edward Wilkinson ,  Gregory Pacofsky

IPC: A61K31/497 ,  C07D215/38 ,  A61K31/167 ,  A61K31/4704 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4995 ,  A61K45/06 ,  C07D241/04 ,  C07D277/64 ,  C07D307/81 ,  C07D401/06 ,  C07D401/12 ,  C07D417/06 ,  C07D471/08 ,  C07D403/12 ,  C07D213/74 ,  C07D215/42 ,  C07D217/06 ,  C07D333/66 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D263/58 ,  C07D277/82 ,  C07D295/15 ,  C07D295/185 ,  C07D295/215 ,  C07D307/14 ,  C07D307/82 ,  C07C233/56 ,  C07C235/16 ,  A61K31/47 ,  A61K31/472 ,  C07D211/58 ,  C07D295/16 ,  C07D333/60

Abstract: The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.

公开(公告)号：US10131744B2

公开(公告)日：2018-11-20

申请号：US14204339

申请日：2014-03-11

Applicant: Merial Limited ,  Genzyme Corporation

Inventor： Susan Mancini Cady ,  Izabela Galeska ,  Pradeep K. Dhal

IPC: A61K31/787 ,  C08G69/26 ,  C08G63/672 ,  C08G73/02 ,  C08G73/06 ,  C07D211/14 ,  C07D211/16 ,  A61K47/60 ,  A61K47/54

Abstract: The present invention relates to veterinary compositions and methods of treating and/or preventing mastitis in non-human mammals. More particularly, the present invention relates to the treatment of mastitis in cows. The veterinary composition comprises a water soluble, locally-acting, antimicrobial amine functional polyamide polymer.