公开(公告)号：US20150174579A1

公开(公告)日：2015-06-25

申请号：US14567179

申请日：2014-12-11

Applicant: TECAN TRADING AG

Inventor： Thomas ITEN ,  Hanna RETHWISCH

IPC: B01L9/00

CPC classification number: B01L9/543 ,  B65D25/108 ,  Y10T29/49826

Abstract: A frame-shaped, essentially rectangular spacer for pipette tip carriers stacked one on top of another includes a horizontal base surface, a peripheral side wall, which stands essentially perpendicular to the base surface and forms two longitudinal sides and two transverse sides, and an upper surface. Each longitudinal side and transverse side includes an inner side. The upper surface is arranged at an upper end of the side wall and essentially horizontally. The spacer is implemented to form a stabilizing support connection with an essentially rectangular pipette tip carrier positioned on the spacer. In addition, the spacer includes centering spring elements, which are arranged on the inner side of all longitudinal sides and transverse sides, having a springy part spaced apart in relation to the inner side of the respective side wall.

Abstract translation: 一个叠置在另一个顶部上的用于移液管末端载体的框形的基本上矩形的间隔件包括一个水平基面，一个周边侧壁，其基本上垂直于基座表面并且形成两个纵向侧面和两个横向侧面， 表面。 每个纵向侧和横向侧包括内侧。 上表面布置在侧壁的上端并且基本上是水平的。 间隔件被实现以形成与定位在间隔件上的基本上矩形的移液管末端载体的稳定支撑连接。 此外，间隔件包括定心弹簧元件，其布置在所有纵向侧面和横向侧面的内侧上，具有相对于相应侧壁的内侧间隔开的弹性部分。

公开(公告)号：US09060598B2

公开(公告)日：2015-06-23

申请号：US14055550

申请日：2013-10-16

Applicant: Tecan Trading AG

Inventor： Claudio Isgro

IPC: A47B13/00 ,  A47B13/08 ,  B01L9/02 ,  G01N35/00

CPC classification number: A47B13/088 ,  B01L9/02 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2300/0829 ,  G01N2035/00306

Abstract: Laboratory table has a frame with front and rear frame parts, at least one detent element, at least one detent extension and at least one replaceable tabletop element on the frame. Each tabletop element has at least one fixing mechanism for interacting with the frame parts and for holding a corresponding detent element and detent extension in fixing positions. A detent element or detent extension in each case is spaced apart from the fixing mechanism. The frame part opposite to the frame part the fixing mechanism is interacting with comprises a detent element or a detent extension that in each case is brought into a mutual fixing position with a corresponding detent extension or detent element of the corresponding tabletop element. The corresponding detent extension is thus guided in a detent element parallel to a tabletop axis of the corresponding tabletop element.

Abstract translation: 实验台具有框架，前框架和后框架部分，至少一个止动元件，至少一个制动器延伸件和框架上的至少一个可替换的桌面元件。 每个桌面元件具有至少一个固定机构，用于与框架部件相互作用并且用于在固定位置保持相应的制动元件和止动延伸部。 每种情况下的止动元件或止动器延伸部与固定机构间隔开。 与固定机构相互作用的框架部分相对的框架部分包括制动元件或制动器延伸部，每个壳体中的定位延伸件与相应的桌面元件的相应的制动器延伸部件或棘爪元件成为相互固定位置。 因此，相应的制动延伸部被引导到平行于相应桌面元件的台面轴的制动元件中。

公开(公告)号：US20150060700A1

公开(公告)日：2015-03-05

申请号：US14538422

申请日：2014-11-11

Applicant: TECAN TRADING AG

Inventor： Torleif Ove Bjornson ,  Thomas Geiges

IPC: G01N21/64 ,  G01N1/28

CPC classification number: G01N21/64 ,  B01L3/021 ,  B01L3/0241 ,  G01N1/28 ,  G01N21/01 ,  G01N21/17 ,  G01N21/33 ,  G01N21/645 ,  G01N21/6486 ,  G01N2021/0314 ,  G01N2021/035 ,  G01N2021/8564 ,  G01N2035/1046 ,  G01N2035/1062 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/08 ,  Y10T436/11 ,  Y10T436/119163 ,  Y10T436/143333 ,  Y10T436/2575

Abstract: An optical measuring apparatus and method for analysis of samples contained in liquid drops provided by a liquid handling system has a liquid handling tip. A light source irradiates the liquid drop; a detector measures sample light; and an optics system with first optical elements transmits irradiation light, and a processor processes the measurement signals. The liquid drop is suspended at the liquid handling orifice of the liquid handling tip in a position where the liquid drop is penetrated by a first optical axis defined by the light source and the first optical elements. The liquid drop is physically touched only by the liquid handling tip and the liquid sample inside the liquid handling tip. A mutual adaption of the size and position of the liquid drop with respect to the first optical elements is achieved.

Abstract translation: 用于分析由液体处理系统提供的液滴中包含的样品的光学测量装置和方法具有液体处理尖端。 光源照射液滴; 检测器测量样品光; 并且具有第一光学元件的光学系统透射照射光，并且处理器处理测量信号。 液滴在液体处理尖端的液体处理孔处悬挂在液滴被由光源和第一光学元件限定的第一光轴穿透的位置处。 只有液体处理尖端和液体处理尖端内的液体样品物理地接触液滴。 实现液滴相对于第一光学元件的尺寸和位置的相互适应。

公开(公告)号：US08936708B2

公开(公告)日：2015-01-20

申请号：US13784168

申请日：2013-03-04

Applicant: Tecan Trading AG

Inventor： Marc N. Feiglin ,  Michael Benjamin Franklin ,  Timothy Francis Lee ,  Joseph Mamone

IPC: G01N27/447 ,  G01N27/453 ,  B01L3/00 ,  B01L7/00 ,  B01F13/00 ,  C12Q1/68 ,  B01L3/02

CPC classification number: B01L3/502792 ,  B01F13/0071 ,  B01F13/0076 ,  B01F2215/0037 ,  B01L3/0268 ,  B01L3/502715 ,  B01L3/527 ,  B01L7/525 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/1822 ,  B01L2300/1883 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0475 ,  C12Q1/686 ,  G01N27/447 ,  G01N27/44756 ,  G01N27/453 ,  C12Q2563/143 ,  C12Q2563/149 ,  C12Q2563/159

Abstract: Liquid droplet manipulation instrument has electrode array for inducing movement of a droplet by electrowetting, substrate supporting the array and control with electrode selector connected to a voltage control. The selector selects each electrode and provides each with a controlled voltage. The control includes central processing unit for providing the selected electrode with an individual voltage pulse which is a drive voltage or a ground voltage or a stop voltage. The control defines a path for movement of a liquid portion of a larger volume that covers more than one electrode by the simultaneous selection of a group of two or more subsequent drive electrodes and to provide each selected drive electrode with a drive voltage pulse along the path. The control simultaneously provides a group of two or more electrodes adjacent to or identical with the pulsed drive electrodes, with a ground or stop voltage pulse.

Abstract translation: 液滴操作仪具有电极阵列，用于通过电润湿引起液滴的移动，支撑阵列的基板和用电压控制器连接的电极选择器进行控制。 选择器选择每个电极，并为每个电极提供受控电压。 该控制器包括用于向所选择的电极提供作为驱动电压或接地电压或停止电压的单独电压脉冲的中央处理单元。 控制器通过同时选择一组两个或更多个后续驱动电极来定义用于移动覆盖多于一个电极的较大体积的液体部分的路径，并且为每个选定的驱动电极提供沿路径的驱动电压脉冲 。 控制器同时提供与脉冲驱动电极相邻或相同的一组两个或更多个电极，具有接地或停止电压脉冲。

公开(公告)号：US20140353157A1

公开(公告)日：2014-12-04

申请号：US14361556

申请日：2014-01-06

Applicant: TECAN TRADING AG

Inventor： Daniel Hoffmeyer ,  Tiffany Lay ,  Travis Lee

IPC: G01N27/447

CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502792 ,  B01L3/505 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/044 ,  B01L2300/123 ,  B01L2400/0427 ,  B81B1/00 ,  G01N27/44756

Abstract: A digital microfluidics system for manipulating samples in liquid droplets within a gap between a first hydrophobic surface of a bottom layer and a second hydrophobic surface of at least one disposable cartridge. Disposable cartridges comprise a body and/or a rigid cover plate. The bottom layer of each disposable cartridge is a flexible film that is sealingly attached to the body or plate. The cartridge has no spacer between the first and second hydrophobic surfaces. When using these cartridges, the bottom layers configured as a working film for manipulating samples in liquid droplets thereon, is placed on an electrode array of a digital microfluidics system. The array has individual electrodes. The digital microfluidics system also comprises a central control unit for controlling the selection of the individual electrodes of the electrode array and for providing these electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting.

Abstract translation: 一种数字微流体系统，用于在底层的第一疏水表面和至少一个一次性盒的第二疏水表面之间的间隙内操作液滴中的样品。 一次性盒包括主体和/或刚性盖板。 每个一次性盒的底层是密封地附接到主体或板上的柔性膜。 墨盒在第一和第二疏水表面之间没有间隔物。 当使用这些盒时，将配置为工作膜的底层用于操作其上液滴的样品放置在数字微流体系统的电极阵列上。 该阵列具有单独的电极。 数字微流体系统还包括一个中央控制单元，用于控制电极阵列的各个电极的选择，并为这些电极提供单独的电压脉冲，用于通过电润湿来操纵液滴。

公开(公告)号：US08841925B2

公开(公告)日：2014-09-23

申请号：US12917015

申请日：2010-11-01

Applicant: Markus Schöni

Inventor： Markus Schöni

IPC: G01R27/26 ,  G01F23/26 ,  B01L3/02

CPC classification number: G01F23/266 ,  B01L3/021 ,  B01L2300/0627

Abstract: The invention relates to devices for liquid level detection (LLD). It relates to a laboratory device having an electronic circuit for detecting a liquid level in a liquid container, a feeler, which can be advanced, and which is connected to an input side of the electronic circuit, and having a movement device, which allows the feeler to be advanced in the direction of the liquid in the liquid container. Upon the immersion of the feeler in the liquid, a capacitance change is caused in the electronic circuit, which triggers a signal in the circuit. The laboratory device comprises a reference circuit, which is connected to the input side of the circuit, and which specifies an effective capacitance on the input side of the circuit. A sequence controller is used, which causes the triggering of a test by the application of a control signal to the reference circuit, the control signal causing an increase of the effective capacitance through a switching procedure. The processing of the corresponding capacitance change is monitored by the sequence controller, for example.

Abstract translation: 本发明涉及液位检测装置（LLD）。 本发明涉及一种具有用于检测液体容器中的液面的电子电路的实验室装置，可以前进的触针，并且连接到电子电路的输入侧，并且具有移动装置，其允许 触发器在液体容器中的液体方向前进。 当探测器浸没在液体中时，在电子电路中引起电容变化，这触发了电路中的信号。 实验室装置包括参考电路，其连接到电路的输入侧，并且指定电路输入侧的有效电容。 使用序列控制器，其通过向参考电路施加控制信号来引起测试触发，该控制信号通过切换过程引起有效电容的增加。 相应的电容变化的处理例如由序列控制器监视。

公开(公告)号：US20140046484A1

公开(公告)日：2014-02-13

申请号：US14049840

申请日：2013-10-09

Applicant: TECAN TRADING AG

Inventor： Beat GLAUSER ,  Michael LAAB ,  Eskil TROLLHAGEN

IPC: G01N35/10

CPC classification number: G01N35/1011 ,  B01L3/02 ,  B01L2200/087 ,  B01L2300/027 ,  G01N35/00722 ,  G01N2035/0091 ,  Y10T436/2575

Abstract: A control method for a computer-controlled liquid handling workstation which comprises a work surface, a motorized liquid handling robot with at least two pipettes each having a cone, and a control computer, to which the liquid handling robot is connected. A control program, activated in the control computer, enables the pipetting robot to position the pipette at specific positions on the work surface. The pipettes and at least one position are visualized as icons, using a visualization device. Upon selecting at least one pipette and designating a position, using an input mechanism, the selected pipette is moved down and up immediately after its selection, and moved to the designated position immediately after designating the position. These movements are carried out prior to selecting at least one action and its execution, enabling the operator to confirm the selection of the pipette and the designation of the position.

Abstract translation: 一种用于计算机控制的液体处理工作站的控制方法，其包括工作表面，具有至少两个具有锥体的移液管的电动液体处理机器人和控制计算机，液体处理机器人连接到该处理机器人。 在控制计算机中激活的控制程序使得移液机器人能够将移液管定位在工作表面上的特定位置。 移液器和至少一个位置可视化为图标，使用可视化设备。 在选择至少一个移液管并指定位置时，使用输入机构，所选移液管在其选择之后立即向下和向下移动，并在指定位置之后立即移动到指定位置。 这些移动在选择至少一个动作及其执行之前进行，使得操作者能够确认移液器的选择和位置的指定。

公开(公告)号：US08584602B2

公开(公告)日：2013-11-19

申请号：US13550900

申请日：2012-07-17

Applicant: Claudio Isgro

Inventor： Claudio Isgro

IPC: A47B13/00

CPC classification number: B01L9/02 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2300/0829 ,  G01N35/00

Abstract: A laboratory table has a frame with a front frame part and a rear frame part and replaceable tabletop elements positionable on the frame. A detent rail is arranged on the front or rear frame part, having detent openings. Each of these detent openings is for the insertion and sliding guiding of a detent bolt of a tabletop element. In addition, the tabletop elements has at least one detent bolt for insertion and sliding guiding in one of the detent openings of these detent rails. Each tabletop element has at least one fixing mechanism, which is spaced apart from the detent bolt, and which fixes the tabletop element in a locking position and holds the detent bolts, which are guided parallel to a plate axis of the tabletop element in the detent rail in a fixing position.

Abstract translation: 实验台具有框架，前框架部分和后框架部分以及可置换的桌面元件可定位在框架上。 制动导轨布置在前框架或后框架部分上，具有制动开口。 这些止动开口中的每一个用于桌面元件的止动螺栓的插入和滑动引导。 此外，桌面元件具有至少一个止动螺栓，用于在这些棘爪轨道的一个止动开口中插入和滑动导向。 每个台面元件具有至少一个固定机构，该固定机构与制动螺栓间隔开，并且将桌面元件固定在锁定位置并且保持定位螺栓，其平行于台面元件的板轴线被引导到制动器 轨道处于固定位置。

公开(公告)号：US20130092288A1

公开(公告)日：2013-04-18

申请号：US13696900

申请日：2011-05-06

Applicant: Armin Schriber

Inventor： Armin Schriber

IPC: B65B43/42

CPC classification number: B67D7/08 ,  B01L3/0265 ,  B01L2200/148 ,  B01L2300/021 ,  B01L2300/022 ,  B01L2400/0655 ,  B65B3/36 ,  B67D7/72 ,  G01N35/1016 ,  G01N35/1097 ,  G01N2035/1039 ,  G01N2035/1041

Abstract: A dispenser delivering flowable or pourable material has a line for transporting the material from a container to an outlet end of the line. The line, filled with material, has its inlet end in the container or connected to the container. A stop valve controls dispensing of the material from the outlet end and a control controls opening and closing of the valve. The line has an elastic section inserted in the valve and the valve is a pinch valve for the stationary compression of the elastic section and therefore for closure of the line. The control controls an opening time of the valve for delivery of a defined quantity of material into a sample vessel, wherein this opening time is exclusively determined by properties of the material and properties of the line filled with material.

Abstract translation: 提供可流动或可倾倒的材料的分配器具有用于将材料从容器输送到管线的出口端的管线。 填充有材料的管线的入口端在容器中或连接到容器。 一个截止阀控制从出口端分配材料，一个控制器控制阀的打开和关闭。 线路具有插入阀中的弹性部分，并且阀是用于弹性部分的固定压缩并因此用于闭合线的夹紧阀。 控制器控制阀的打开时间，用于将限定数量的材料输送到样品容器中，其中该打开时间仅由材料的特性和填充有材料的管线的特性决定。

公开(公告)号：US08231842B2

公开(公告)日：2012-07-31

申请号：US12692089

申请日：2010-01-22

Applicant: Jimmy Dzuong

Inventor： Jimmy Dzuong

IPC: B01L3/00

CPC classification number: B01L3/0217 ,  B01L3/0275 ,  B01L2200/025 ,  B01L2200/14 ,  B01L2300/0627 ,  B01L2300/0832 ,  B01L2300/0858 ,  B01L2300/14 ,  B01L2400/0478

Abstract: A positive displacement pump (1) is equipped with a pump cylinder (2), a pump piston (7), a cylinder space (9), a pressure sensor (10), and a pressure channel (12). A main portion (13) of the pressure channel (12) extends parallel to a longitudinal axis (3) of the pump cylinder (2), for providing fluidic connection between the cylinder space (9) and the pressure sensor (10). In the improved alternative positive displacement pump (1), the main portion (13) of the pressure channel (12) is located inside of the pump cylinder (2) or pump piston (7) and extends, at least in a foremost position of the pump piston (7), from a cylinder bottom (5) beyond or to an opening (11,11′) in the cylinder wall (4) or pump piston (7).

Abstract translation: 正排量泵（1）配备有泵缸（2），泵活塞（7），气缸空间（9），压力传感器（10）和压力通道（12）。 压力通道（12）的主要部分（13）平行于泵缸（2）的纵向轴线（3）延伸，用于在气缸空间（9）和压力传感器（10）之间提供流体连接。 在改进的替代正排量泵（1）中，压力通道（12）的主要部分（13）位于泵缸（2）或泵活塞（7）的内部，至少在 所述泵活塞（7）从气缸底部（5）超过所述气缸壁（4）中的开口（11,11'）或泵活塞（7）。