公开(公告)号：US20120328703A1

公开(公告)日：2012-12-27

申请号：US13601532

申请日：2012-08-31

Applicant: Hugh D. Smyth ,  Martin J. Donovan

Inventor： Hugh D. Smyth ,  Martin J. Donovan

IPC: A61K9/14 ,  B32B5/16 ,  A61P11/00 ,  A61K31/713 ,  A61K31/711

CPC classification number: A61K9/0073 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/1641 ,  A61K47/60 ,  A61K47/6949 ,  A61K48/00 ,  B82Y5/00 ,  Y10T428/2982

Abstract: Swellable particles for delivery of a drug or other working agent to the pulmonary system are provided. The swellable particles include a dehydrated (dry) aerodynamic particle diameter of 5 μm or less to enable delivery to the respiratory tract, such as for example to the tracheo-bronchial airways of the upper respiratory tract and/or to the alveolic regions of the deep lung, and a hydrated particle diameter that is greater than 6 μm volume mean diameter to retard or prevent their phagocytosis by the macrophages present in airways of the respiratory tract.

Abstract translation: 提供了用于将药物或其它工作剂递送至肺部系统的可溶胀颗粒。 可溶胀颗粒包括5μm或更小的脱水（干燥）空气动力学粒径，以使得能够输送到呼吸道，例如向上呼吸道的气管支气管气道和/或深层的通气区域 肺，以及大于6μm体积平均直径的水合颗粒直径，以阻止或阻止其由呼吸道气道中的巨噬细胞吞噬。

公开(公告)号：US08338818B1

公开(公告)日：2012-12-25

申请号：US12635151

申请日：2009-12-10

Applicant: Stephen D. Hersee

Inventor： Stephen D. Hersee

IPC: H01L29/06

CPC classification number: H01L29/0676 ,  H01L21/02439 ,  H01L21/02488 ,  H01L21/0254 ,  H01L21/02603 ,  H01L21/02609 ,  H01L21/02639 ,  H01L29/2003 ,  H01L29/7787

Abstract: Various embodiments provide non-planar nanowires, nanowire arrays, and nanowire networks as well as methods of their formation and applications. The non-planar nanowires and their arrays can be formed in a controlled manner on surfaces having a non-planar orientation. In embodiments, two or more adjacent nanowires from different surfaces can grow to merge together forming one or more nanowire branches and thus forming a nanowire network. In embodiments, the non-planar nanowires and nanowire networks can be used for cantilever oscillation, switching and transistor actions.

Abstract translation: 各种实施例提供非平面纳米线，纳米线阵列和纳米线网络以及它们的形成和应用的方法。 非平面纳米线及其阵列可以以受控的方式形成在具有非平面取向的表面上。 在实施例中，来自不同表面的两个或更多个相邻的纳米线可以生长以合并在一起形成一个或多个纳米线分支，从而形成纳米线网络。 在实施例中，非平面纳米线和纳米线网络可用于悬臂振荡，开关和晶体管动作。

公开(公告)号：US20120319724A1

公开(公告)日：2012-12-20

申请号：US13513941

申请日：2011-01-12

Applicant: James Plusquellic ,  Dhruva J. Acharyya ,  Ryan L. Helinski

Inventor： James Plusquellic ,  Dhruva J. Acharyya ,  Ryan L. Helinski

IPC: H03K19/00 ,  H05K3/00

CPC classification number: H04L9/0861 ,  G06F21/73 ,  G09C1/00 ,  H04L9/0866 ,  Y04S40/24 ,  Y10T29/49124

Abstract: A system and methods that generates a physical unclonable function (“PUF”) security key for an integrated circuit (“IC”) through use of equivalent resistance variations in the power distribution system (“PDS”) to mitigate the vulnerability of security keys to threats including cloning, misappropriation and unauthorized use.

Abstract translation: 通过使用配电系统（PDS）中的等效电阻变化来为集成电路（IC）生成物理不可克隆功能（PUF）安全密钥的系统和方法，以减轻安全密钥对包括克隆，盗用和 未经授权的使用。

公开(公告)号：US08268571B2

公开(公告)日：2012-09-18

申请号：US13136807

申请日：2011-08-11

Applicant: Larry A Sklar ,  Bruce Edwards ,  Frederick Kuckuck

Inventor： Larry A Sklar ,  Bruce Edwards ,  Frederick Kuckuck

IPC: G01N33/53 ,  G01N33/567 ,  G01N35/08

CPC classification number: G01N15/1436 ,  B01L3/5085 ,  G01N15/1404 ,  G01N15/1459 ,  G01N21/6428 ,  G01N21/6486 ,  G01N35/0099 ,  G01N35/085 ,  G01N35/1095 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1413 ,  G01N2015/1477 ,  G01N2015/149 ,  G01N2021/6439 ,  G01N2201/06113 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.

Abstract translation: 本发明提供了一种用于检测多个样品中的颗粒的流式细胞仪装置，包括：用于将包含多个相应源阱的颗粒的多个样品移动到流体流中的装置; 用于在所述流体流动流中的所述多个样品中的每一个之间引入分离气体的装置; 以及用于选择性地分析用于颗粒的多个样品中的每一个的装置。 本发明还提供了使用这种装置的流式细胞术方法。

公开(公告)号：US20120225526A1

公开(公告)日：2012-09-06

申请号：US13461331

申请日：2012-05-01

Applicant: Stephen D. Hersee ,  Xin Wang

Inventor： Stephen D. Hersee ,  Xin Wang

IPC: H01L21/335 ,  B82Y40/00

CPC classification number: H01L29/0665 ,  B82Y10/00 ,  H01L21/02389 ,  H01L21/02458 ,  H01L21/02513 ,  H01L21/0254 ,  H01L21/02603 ,  H01L21/0262 ,  H01L21/02639 ,  H01L21/8252 ,  H01L27/0605 ,  H01L29/2003 ,  H01L29/66462 ,  H01L29/7787 ,  H01L29/7788 ,  H01L29/7789

Abstract: Nanowire and larger, post-based HEMTs, arrays of such HEMTs, and methods for their manufacture are provided. In one embodiment, a HEMT can include a III-N based core-shell structure including a core member (e.g., GaN), a shell member (e.g., AlGaN) surrounding a length of the core member and a two-dimensional electron gas (2-DEG) at the interface therebetween. The core member including a nanowire and/or a post can be disposed over a doped buffer layer and a gate material can be disposed around a portion of the shell member. Exemplary methods for making the nanowire HEMTs and arrays of nanowire HEMTs can include epitaxially forming nanowire(s) and epitaxially forming a shell member from each formed nanowire. Exemplary methods for making the post HEMTs and arrays of post HEMTs can include etching a III-N layer to form III-N post(s) followed by formation of the shell member(s).

Abstract translation: 提供了纳米线和更大的后置HEMT，这样的HEMT的阵列及其制造方法。 在一个实施例中，HEMT可以包括基于III-N的核 - 壳结构，其包括芯构件（例如，GaN），围绕芯构件的长度的壳构件（例如，AlGaN）和二维电子气 2-DEG）。 包括纳米线和/或柱的芯构件可以设置在掺杂缓冲层上方，并且栅极材料可以围绕壳构件的一部分设置。 用于制造纳米线HEMT和纳米线HEMT阵列的示例性方法可以包括外延形成纳米线并从每个形成的纳米线外延地形成壳部件。 用于制造后HEMT和后HEMT阵列的示例性方法可以包括蚀刻III-N层以形成III-N柱，随后形成壳构件。

公开(公告)号：US20120175531A1

公开(公告)日：2012-07-12

申请号：US13322327

申请日：2010-09-30

Applicant: Luan Shuang ,  Ma Lijun ,  Chen Zhe

Inventor： Luan Shuang ,  Ma Lijun ,  Chen Zhe

IPC: B01J19/12

CPC classification number: A61N5/1084 ,  A61B6/4085 ,  A61N5/10 ,  A61N5/1031 ,  A61N5/1065 ,  A61N5/1067 ,  A61N5/1071 ,  A61N5/1081 ,  A61N2005/1074

Abstract: Photon-based radiosurgery is widely used for treating local and regional tumors. The key to improving the quality of radiosurgery is to increase the dose falloff rate from high dose regions inside the tumor to low dose regions of nearby healthy tissues and structures. Dynamic photon painting (DPP) further increases dose falloff rate by treating a target by moving a beam source along a dynamic trajectory, where the speed, direction and even dose rate of the beam source change constantly during irradiation. DPP creates dose gradient that rivals proton Bragg Peak and outperforms Gamma Knife® radiosurgery.

Abstract translation: 基于光子的放射外科手术广泛用于治疗局部和局部肿瘤。 提高放射外科手术质量的关键是提高肿瘤内部高剂量区域到附近健康组织和结构的低剂量区域的剂量衰减率。 动态光子绘画（DPP）通过沿着动态轨迹移动光束源来处理目标物体进一步增加剂量衰减速率，其中光束源的速度，方向和均匀剂量率在照射期间不断变化。 DPP产生与质子Bragg峰值相当的剂量梯度，并优于GammaKnife®放射外科手术。

公开(公告)号：US08187678B2

公开(公告)日：2012-05-29

申请号：US12271719

申请日：2008-11-14

Applicant: Ying-Bing Jiang ,  Joseph L. Cecchi ,  C. Jeffrey Brinker

Inventor： Ying-Bing Jiang ,  Joseph L. Cecchi ,  C. Jeffrey Brinker

IPC: H05H1/00 ,  H05H1/24 ,  C04B41/00 ,  C23C16/00

CPC classification number: B01D69/122 ,  B01D67/0002 ,  B01D67/0079 ,  B01D67/0083 ,  B01D67/009 ,  B01D69/148 ,  C23C16/401 ,  C23C16/45536 ,  C23C16/45555 ,  Y10T428/24521 ,  Y10T428/24545 ,  Y10T428/249953

Abstract: Ultra-thin hybrid and/or microporous materials and methods for their fabrication are provided. In one embodiment, the exemplary hybrid membranes can be formed including successive surface activation and reaction steps on a porous support that is patterned or non-patterned. The surface activation can be performed using remote plasma exposure to locally activate the exterior surfaces of porous support. Organic/inorganic hybrid precursors such as organometallic silane precursors can be condensed on the locally activated exterior surfaces, whereby ALD reactions can then take place between the condensed hybrid precursors and a reactant. Various embodiments can also include an intermittent replacement of ALD precursors during the membrane formation so as to enhance the hybrid molecular network of the membranes.

Abstract translation: 提供了超薄混合和/或微孔材料及其制造方法。 在一个实施方案中，可以形成示例性混合膜，包括在图案化或非图案化的多孔载体上的连续表面活化和反应步骤。 表面活化可以使用远程等离子体暴露来局部激活多孔载体的外表面。 有机/无机混合前体例如有机金属硅烷前体可以在局部活化的外表面上缩合，由此ALD反应可以在冷凝的杂化前体和反应物之间进行。 各种实施方案还可以包括在膜形成期间ALD前体的间歇替代，以增强膜的杂合分子网络。

公开(公告)号：US08184927B2

公开(公告)日：2012-05-22

申请号：US12406730

申请日：2009-03-18

Applicant: Ousseini Lankoande ,  Majeed M. Hayat ,  Balu Santhanam

Inventor： Ousseini Lankoande ,  Majeed M. Hayat ,  Balu Santhanam

IPC: G06K9/40

CPC classification number: G06K9/0063 ,  G01S13/9035 ,  G06K9/40 ,  G06K9/4638 ,  G06T5/002 ,  G06T7/11 ,  G06T7/143 ,  G06T2207/10032 ,  G06T2207/10132 ,  G06T2207/30004 ,  G06T2207/30181

Abstract: The present invention includes methods for the reduction of speckle noise in an image and methods for segmenting an image. Each of the methods disclosed herein includes steps for analyzing the uniformity of a pixel within a plurality of pixels forming a portion of the image and, based on the uniformity of the intensity of the plurality of pixels, adjusting and/or replacing the pixel in order to produce a speckle-noise reduced image, a segmented image, or a segmented and speckle-noise reduced image. The methods of the present invention can employ for example conditional probability density functions, nonlinear estimator functions, convex energy functions and simulated annealing algorithms in the performance of their respective steps.

公开(公告)号：US20120107237A1

公开(公告)日：2012-05-03

申请号：US13321942

申请日：2010-05-28

Applicant: Yubin Miao ,  Jianquan Yang

Inventor： Yubin Miao ,  Jianquan Yang

IPC: A61K51/08 ,  A61K38/21 ,  A61P35/00 ,  A61K38/20 ,  C07K7/64 ,  A61K38/12

CPC classification number: C07K14/68 ,  A61K38/00 ,  A61K51/082 ,  A61K51/086 ,  A61K51/088 ,  C12N9/88

Abstract: The present invention is directed to novel non-invasive diagnostic and therapeutic tools/compounds comprising a hybride cyclic peptide which utilizes a cyclic peptide chelating group wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compound according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

Abstract translation: 本发明涉及新颖的非侵入性诊断和治疗工具/化合物，其包含利用环肽螯合基团的杂环环肽，其中所述化合物结合MSH受体以成像和治疗癌症，特别是黑素瘤，包括转移性黑素瘤 体内。 本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。 新型成像探针能够检测癌细胞黑素瘤细胞，以及它们在组织中的转移扩散。 这代表了使用非侵入性分子成像技术在黑素瘤的诊断和治疗中包括转移性黑素瘤的量子进步。 本发明的新型探针也可用于启动黑素瘤的治疗以及监测患者对化疗治疗的反应和用于治疗黑素瘤/转移性黑色素瘤的其它干预或治疗。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

公开(公告)号：US20120065329A1

公开(公告)日：2012-03-15

申请号：US13320454

申请日：2010-05-11

Applicant: Gabriel Lopez ,  Nick Carroll ,  Kevin Cushing ,  Dimiter N. Petsev

Inventor： Gabriel Lopez ,  Nick Carroll ,  Kevin Cushing ,  Dimiter N. Petsev

IPC: C08L83/04

CPC classification number: C08L83/04 ,  A61K9/0009 ,  A61K9/1641 ,  A61K9/1682 ,  A61K47/34 ,  A61K49/225 ,  G01N33/538 ,  G01N33/54313

Abstract: We describe methods for synthesis and formulations of stable elastomeric negative acoustic contrast particles with controllable compressibility and density. These elastomeric negative acoustic contrast particles have a density/compressibility ratio that is less than that of water and therefore exhibit negative acoustic contrast under acoustic radiation exposure. This negative acoustic contrast allows our elastomeric negative acoustic contrast particles to be acoustically manipulated (e.g. separated) differently from other components (e.g. cells) within an aqueous solution. This disclosure also describes methods for biofunctionalization of the elastomeric negative acoustic contrast particles and as an example their use as platforms for bioassays. Potential applications of these elastomeric negative acoustic contrast particles include sensitive bioassays based on acoustic flow cytometry and other types of techniques that utilize acoustic fields, including ultrasound imaging and ultrasound triggered drug delivery.

Abstract translation: 我们描述了具有可压缩性和密度的稳定的弹性体负型声学造影颗粒的合成方法和配方。 这些弹性体负声学对比颗粒的密度/压缩比小于水的密度/压缩比，因此在声辐射暴露下呈现负的声学对比度。 这种负声学对比度允许我们的弹性体负声学对比粒子与水溶液中的其它组分（例如细胞）不同地被声学操纵（例如分离）。 本公开还描述了弹性体负声学对比粒子的生物功能化的方法，并且作为其用作生物测定平台的实例。 这些弹性体负声学对比粒子的潜在应用包括基于声流式细胞术的敏感生物测定和利用声场的其他类型的技术，包括超声成像和超声触发药物递送。