公开(公告)号：US09225943B2

公开(公告)日：2015-12-29

申请号：US13981163

申请日：2011-08-11

申请人： Bo Li ,  Jian Yu ,  Xiao Zhang ,  Rong Dong ,  Dengbiao Jiang ,  Zhaozheng Chen ,  Qimei Chen

发明人： Bo Li ,  Jian Yu ,  Xiao Zhang ,  Rong Dong ,  Dengbiao Jiang ,  Zhaozheng Chen ,  Qimei Chen

IPC分类号： H04N7/00 ,  H04N7/18 ,  G01N21/53 ,  G06T7/00

CPC分类号： H04N7/18 ,  G01N21/538 ,  G06T7/00 ,  G06T2207/10016 ,  G06T2207/30252

摘要： Disclosed is a PTZ video visibility detection method based on luminance characteristic, which includes acquiring a road condition video image by utilizing a PTZ video camera, extracting the region of interest ROI of the road surface to obtain high constancy of selected pixels; acquiring precise road surface region by utilizing region-growing algorism based on Nagao filtering to ensure the illuminance constancy of the selected pixels in world coordinates; in the road surface region, extracting the contrast curve which reflects the luminance variation of the road surface, and searching the feature points of the luminance curve to calculate the human eye distinguishable and maximum far pixels in the image with an extinction coefficient; calculating the maximum visibility distance in combination with camera calibration to determine the visibility value. The present invention can take full advantage of existing PTZ camera to video the road condition and acquire the image without the need of providing any artificial marker. Monitoring can be in real time and has a low monitoring cost, and the monitoring requirement of large area road condition can be satisfied. Monitoring is stable and can not be disturbed by environment. It is a visibility detecting method with the advantages of simpleness, easy realization, high precision and excellent use effect.

摘要翻译： 公开了一种基于亮度特性的PTZ视频可见度检测方法，其包括通过利用PTZ摄像机获取道路状况视频图像，提取路面感兴趣区域ROI以获得所选像素的高恒定性; 通过利用基于Nagao过滤的区域增长算法来获取精确的路面区域，以确保世界坐标中所选像素的照度恒定; 在路面区域中，提取反映路面的亮度变化的对比度曲线，并且搜索亮度曲线的特征点以消光系数计算图像中的人眼可辨别和最大远像素; 计算最大可见距离与相机校准相结合以确定可见度值。 本发明可以充分利用现有的PTZ摄像机对道路状况进行视频拍摄，而无需提供任何人造标记。 监控可以实时监控，监控成本低，可以满足大面积道路状况监测要求。 监测稳定，不受环境干扰。 它是一种可视化检测方法，具有简单，易于实现，精度高，使用效果好等优点。

公开(公告)号：US09006801B2

公开(公告)日：2015-04-14

申请号：US13013081

申请日：2011-01-25

申请人： Christian Lavoie ,  Zhengwen Li ,  Ahmet S. Ozcan ,  Filippos Papadatos ,  Chengwen Pei ,  Jian Yu

发明人： Christian Lavoie ,  Zhengwen Li ,  Ahmet S. Ozcan ,  Filippos Papadatos ,  Chengwen Pei ,  Jian Yu

IPC分类号： H01L21/285 ,  H01L21/336 ,  H01L29/78 ,  H01L29/66 ,  H01L21/02 ,  H01L21/311 ,  H01L21/768

CPC分类号： H01L29/7833 ,  H01L21/0217 ,  H01L21/02211 ,  H01L21/02274 ,  H01L21/28518 ,  H01L21/31116 ,  H01L21/32053 ,  H01L21/321 ,  H01L21/32133 ,  H01L21/76802 ,  H01L21/76805 ,  H01L21/76829 ,  H01L23/535 ,  H01L29/1054 ,  H01L29/45 ,  H01L29/456 ,  H01L29/458 ,  H01L29/4975 ,  H01L29/665 ,  H01L29/66545 ,  H01L29/6659 ,  H01L29/7843 ,  H01L29/7845 ,  H01L29/7849

摘要： A method of forming a semiconductor device is provided that includes forming a first metal semiconductor alloy on a semiconductor containing surface, forming a dielectric layer over the first metal semiconductor alloy, forming an opening in the dielectric layer to provide an exposed surface the first metal semiconductor alloy, and forming a second metal semiconductor alloy on the exposed surface of the first metal semiconductor alloy. In another embodiment, the method includes forming a gate structure on a channel region of a semiconductor substrate, forming a dielectric layer over at least a source region and a drain region, forming an opening in the dielectric layer to provide an exposed surface the semiconductor substrate, forming a first metal semiconductor alloy on the exposed surface of the semiconductor substrate, and forming a second metal semiconductor alloy on the first metal semiconductor alloy.

摘要翻译： 提供一种形成半导体器件的方法，包括在半导体容纳表面上形成第一金属半导体合金，在第一金属半导体合金上形成电介质层，在电介质层中形成开口以提供第一金属半导体 合金，并且在第一金属半导体合金的暴露表面上形成第二金属半导体合金。 在另一个实施例中，该方法包括在半导体衬底的沟道区上形成栅极结构，在至少源极区和漏极区上形成电介质层，在电介质层中形成开口以提供暴露表面，半导体衬底 在所述半导体衬底的暴露表面上形成第一金属半导体合金，并在所述第一金属半导体合金上形成第二金属半导体合金。

公开(公告)号：US20140377819A1

公开(公告)日：2014-12-25

申请号：US14358911

申请日：2011-11-17

申请人： Jian Yu

发明人： Jian Yu

IPC分类号： C12P7/62

CPC分类号： C12P7/625

摘要： A process for producing hydroxyalkanoate copolymers, which comprises: (i) pre-treating a sucrose-containing feedstock in an acidic solution; (ii) feeding the pre-treated feedstock into a bioreactor containing polyhydroxyalkanoate producing microbial cells; (iii) cultivating the polyhydroxyalkanoate producing microbial cells to form a cell mass containing the hydroxyalkanoate copolymers; (iv) recoverying the hydroxyalkanoate copolymers from the cell mass. The pre-treating step has the main function of hydrolyzing sucrose into glucose and fructose, which in turn are converted into 4-ketovaleric acid to give a mixture of mono-saccharides and organic precursors for microbial synthesis of hydroxyalkanoate copolymers, and particularly of PHBVV ter-polymers. Complex and expensive purification processes of the substrates obtained from the pre-treating step are not needed. The solutions can be directly used as the feeding solutions for microbial PHA biosynthesis.

摘要翻译： 一种生产羟基链烷酸酯共聚物的方法，其包括：（i）在酸性溶液中预处理含蔗糖的原料; （ii）将预处理的原料进料到含有聚羟基链烷酸酯生产微生物细胞的生物反应器中; （iii）培养产生聚羟基链烷酸酯的微生物细胞以形成含有羟基链烷酸酯共聚物的细胞团; （iv）从细胞团中回收羟基链烷酸酯共聚物。 预处理步骤具有将蔗糖水解成葡萄糖和果糖的主要功能，其又转化为4-酮戊酸，得到单糖和有机前体的混合物，用于微生物合成羟基链烷酸酯共聚物，特别是PHBVV ter 聚合物。 不需要从预处理步骤获得的底物的复杂且昂贵的纯化方法。 该溶液可直接用作微生物PHA生物合成的饲料溶液。

公开(公告)号：US20140113802A1

公开(公告)日：2014-04-24

申请号：US14123643

申请日：2011-09-23

申请人： Jian Yu ,  Feng Guo ,  Juan Yang ,  Yin Wang ,  Li Dong ,  Shiqiu Gao ,  Guangwen Xu

发明人： Jian Yu ,  Feng Guo ,  Juan Yang ,  Yin Wang ,  Li Dong ,  Shiqiu Gao ,  Guangwen Xu

IPC分类号： B01J23/30 ,  B01J21/16

CPC分类号： B01J21/16 ,  B01D53/8628 ,  B01D2255/20707 ,  B01D2255/20723 ,  B01D2255/20776 ,  B01J23/30 ,  B01J35/023 ,  B01J35/04 ,  B01J37/0018 ,  B01J37/0201

摘要： This invention relates to the cleaning of flue gas released from various combustion processes, particularly a surface deposition NH3—SCR honeycomb catalyst and its preparation method. The catalyst is composed of framework material, TiO2, V2O5 and WO3, wherein the framework material is composed of clay, coal ash, mineral waste residue or their mixture. The mass fractions for framework material, TiO2, V2O5, and WO3 are 60 wt. % to 80 wt. %, 13 wt. % to 33 wt. %, 1 wt. % to 5 wt. %, and 0.1 wt. % to 2 wt. %, respectively. The nano V2O5—WO3—TiO2 particles were deposited on the surface of particle pore or honeycomb, and the performance of the catalyst could be greatly improved

摘要翻译： 本发明涉及从各种燃烧过程中释放的烟道气的清洗，特别是表面沉积NH3-SCR蜂窝催化剂及其制备方法。 催化剂由骨架材料TiO2，V2O5和WO3组成，其中骨架材料由粘土，煤灰，矿物废渣或其混合物组成。 骨架材料，TiO 2，V 2 O 5和WO 3的质量分数为60wt。 ％至80wt。 ％，13wt。 ％至33重量％ ％，1重量％ ％至5wt。 ％，和0.1wt。 ％〜2重量％ ％， 分别。 纳米V2O5-WO3-TiO2颗粒沉积在颗粒孔或蜂窝表面，催化剂的性能可大大提高

公开(公告)号：US20120104469A1

公开(公告)日：2012-05-03

申请号：US12912963

申请日：2010-10-27

申请人： Zhengwen Li ,  Dechao Guo ,  Randolph F. Knarr ,  Chengwen Pei ,  Gan Wang ,  Yanfeng Wang ,  Keith Kwong Hon Wong ,  Jian Yu ,  Jun Yuan

发明人： Zhengwen Li ,  Dechao Guo ,  Randolph F. Knarr ,  Chengwen Pei ,  Gan Wang ,  Yanfeng Wang ,  Keith Kwong Hon Wong ,  Jian Yu ,  Jun Yuan

IPC分类号： H01L29/78 ,  H01L21/336

CPC分类号： H01L29/42368 ,  H01L29/42376 ,  H01L29/49 ,  H01L29/66545 ,  H01L29/6659 ,  H01L29/66606 ,  H01L29/78 ,  H01L29/7833

摘要： In a replacement gate scheme, a continuous material layer is deposited on a bottom surface and a sidewall surface in a gate cavity. A vertical portion of the continuous material layer is removed to form a gate component of which a vertical portion does not extend to a top of the gate cavity. The gate component can be employed as a gate dielectric or a work function metal portion to form a gate structure that enhances performance of a replacement gate field effect transistor.

摘要翻译： 在替代栅极方案中，连续材料层沉积在栅极腔中的底表面和侧壁表面上。 去除连续材料层的垂直部分以形成垂直部分不延伸到栅极腔的顶部的栅极部件。 栅组件可以用作栅极电介质或功函数金属部分，以形成增强替代栅极场效应晶体管的性能的栅极结构。

公开(公告)号：US08168383B2

公开(公告)日：2012-05-01

申请号：US12589176

申请日：2009-10-19

申请人： Klarisa Rikova ,  Herbert Haack ,  Laura Sullivan ,  Ailan Guo ,  Anthony Possemato ,  Joan MacNeill ,  Ting-Lei Gu ,  Jian Yu

发明人： Klarisa Rikova ,  Herbert Haack ,  Laura Sullivan ,  Ailan Guo ,  Anthony Possemato ,  Joan MacNeill ,  Ting-Lei Gu ,  Jian Yu

IPC分类号： C12Q1/68 ,  C12Q1/48 ,  C07H21/00 ,  C12N9/12

CPC分类号： G01N33/574 ,  A61K38/00 ,  C07K2319/00 ,  C12N9/1205 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N33/57484 ,  G01N2333/9121 ,  Y10T436/117497

摘要： Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant polypeptides, probes for detecting it, isolated mutant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The invention also provides methods for determining the presence of these mutant polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides.

摘要翻译： 涉及染色体2的新型基因缺失和易位导致融合蛋白的结合，其部分的间变型淋巴瘤激酶（ALK）激酶与部分二级蛋白结合，已经在人类实体瘤中被鉴定。 非小细胞肺癌（NSCLC）。 次级蛋白包括棘皮动物微管相关蛋白样4（EML-4）和TRK-融合基因（TFG）。 确认了保留ALK酪氨酸激酶活性的EML4-ALK融合蛋白，以驱动以这种突变为特征的NSCLC的增殖和存活。 因此，本发明部分地提供分离的多核苷酸和编码所公开的突变多肽的载体，用于检测其的探针，分离的突变多肽和用于检测融合和截短的多肽的试剂。 本发明还提供了用于确定生物样品中这些突变体多肽的存在的方法，用于筛选抑制蛋白质的化合物的方法，以及用于突变多核苷酸或多肽特征的癌症进展抑制方法。

公开(公告)号：US08017483B2

公开(公告)日：2011-09-13

申请号：US12493549

申请日：2009-06-29

申请人： Gregory G. Freeman ,  Shreesh Narasimha ,  Ning Su ,  Hasan M. Nayfeh ,  Nivo Rovedo ,  Werner A. Rausch ,  Jian Yu

发明人： Gregory G. Freeman ,  Shreesh Narasimha ,  Ning Su ,  Hasan M. Nayfeh ,  Nivo Rovedo ,  Werner A. Rausch ,  Jian Yu

IPC分类号： H01L21/336

CPC分类号： H01L21/823425 ,  H01L21/26586 ,  H01L21/823412 ,  H01L29/66492 ,  H01L29/66659

摘要： The present invention provides a method of forming asymmetric field-effect-transistors. The method includes forming at least a first and a second gate-mask stack on top of a semiconductor substrate, wherein the first and second gate-mask stacks include at least, respectively, a first and a second gate conductor of a first and a second transistor and have, respectively, a top surface, a first side, and a second side with the second side being opposite to the first side; performing a first halo implantation from the first side of the first and second gate-mask stacks at a first angle while applying the first gate-mask stack in preventing the first halo implantation from reaching a first source/drain region of the second transistor, wherein the first angle is equal to or larger than a predetermined value; and performing a second halo implantation from the second side of the first and second gate-mask stacks at a second angle, thereby creating halo implant in a second source/drain region of the second transistor, wherein the first and second angles are measured against a normal to the substrate.

摘要翻译： 本发明提供了形成非对称场效应晶体管的方法。 该方法包括在半导体衬底的顶部上形成至少第一和第二栅极掩模叠层，其中第一和第二栅极掩模叠层至少分别包括第一和第二栅极掩模叠层的第一和第二栅极导体 分别具有顶表面，第一侧和第二侧，第二侧与第一侧相对; 以第一角度从第一和第二栅极掩模叠层的第一侧进行第一光晕注入，同时施加第一栅极掩模叠层以防止第一光晕注入到达第二晶体管的第一源极/漏极区域，其中 第一角度等于或大于预定值; 以及以第二角度从所述第一和第二栅极掩模叠层的第二侧执行第二光晕注入，从而在所述第二晶体管的第二源极/漏极区域中产生晕轮注入，其中所述第一和第二角度是针对 与基底垂直。

公开(公告)号：US20100304382A1

公开(公告)日：2010-12-02

申请号：US12714457

申请日：2010-02-27

申请人： Klarisa Rikova ,  Herbert Haack ,  Laura Sullivan ,  Ailan Guo ,  Anthony Possemato ,  Joan MacNeill ,  Ting-Lei Gu ,  Jian Yu

发明人： Klarisa Rikova ,  Herbert Haack ,  Laura Sullivan ,  Ailan Guo ,  Anthony Possemato ,  Joan MacNeill ,  Ting-Lei Gu ,  Jian Yu

IPC分类号： C12Q1/68 ,  C12N15/12 ,  C12N15/85 ,  C12N5/10 ,  C12P21/02 ,  C12N9/96 ,  C12N5/00

CPC分类号： C12Q1/6886 ,  A61K31/713 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  C12N9/12 ,  C12N9/1205 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y207/10001 ,  G01N33/57423 ,  G01N33/57484 ,  G01N33/6893 ,  G01N2333/912 ,  G01N2333/9121

摘要： In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein enables new methods for determining the presence of these mutant ALK kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention.

摘要翻译： 根据本发明，现在已经在人类实体肿瘤中鉴定了涉及染色体2的新基因缺失和易位，导致将部分间变性淋巴瘤激酶（ALK）激酶与部分二级蛋白结合的融合蛋白。 非小细胞肺癌（NSCLC）。 次级蛋白包括棘皮动物微管相关蛋白样4（EML-4）和TRK-融合基因（TFG）。 确认了保留ALK酪氨酸激酶活性的EML4-ALK融合蛋白，以驱动以这种突变为特征的NSCLC的增殖和存活。 因此，本发明部分地提供分离的多核苷酸和编码所公开的突变ALK激酶多肽的载体，用于检测其的探针，分离的突变多肽，重组多肽和用于检测融合和截短的多肽的试剂。 所公开的这种新融合蛋白的鉴定使得能够确定生物样品中这些突变型ALK激酶多肽的存在的新方法，用于筛选抑制蛋白质的化合物的方法，以及用于突变突变型多核苷酸特征的癌症进展抑制方法 或多肽，其也由本发明提供。

公开(公告)号：US07700339B2

公开(公告)日：2010-04-20

申请号：US11787132

申请日：2007-04-13

申请人： Klarisa Rikova ,  Herbert Haack ,  Laura Sullivan ,  Ailan Guo ,  Anthony Possemato ,  Joan MacNeill ,  Ting-Lei Gu ,  Jian Yu

发明人： Klarisa Rikova ,  Herbert Haack ,  Laura Sullivan ,  Ailan Guo ,  Anthony Possemato ,  Joan MacNeill ,  Ting-Lei Gu ,  Jian Yu

IPC分类号： C12N15/63 ,  C12N15/00 ,  C12N1/21 ,  C12N5/10 ,  C12P21/00 ,  C12Q1/68 ,  C07H21/00 ,  C12N9/12 ,  C12Q1/48 ,  C07K14/00

CPC分类号： C12Q1/6886 ,  A61K31/713 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  C12N9/12 ,  C12N9/1205 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y207/10001 ,  G01N33/57423 ,  G01N33/57484 ,  G01N33/6893 ,  G01N2333/912 ,  G01N2333/9121

摘要： In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein enables new methods for determining the presence of these mutant ALK kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention.

公开(公告)号：US20090156475A1

公开(公告)日：2009-06-18

申请号：US11787132

申请日：2007-04-13

申请人： Klarisa Rikova ,  Herbert Haack ,  Laura Sullivan ,  Ailan Guo ,  Anthony Possemato ,  Joan MacNeill ,  Ting-Lei Gu ,  Jian Yu

发明人： Klarisa Rikova ,  Herbert Haack ,  Laura Sullivan ,  Ailan Guo ,  Anthony Possemato ,  Joan MacNeill ,  Ting-Lei Gu ,  Jian Yu

IPC分类号： A61K38/16 ,  C07H21/04 ,  C12N15/74 ,  C07K14/00 ,  C07K16/00 ,  G01N33/53 ,  C12Q1/68 ,  A61P35/00

CPC分类号： C12Q1/6886 ,  A61K31/713 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  C12N9/12 ,  C12N9/1205 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y207/10001 ,  G01N33/57423 ,  G01N33/57484 ,  G01N33/6893 ,  G01N2333/912 ,  G01N2333/9121

摘要： In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein enables new methods for determining the presence of these mutant ALK kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention.

摘要翻译： 根据本发明，现在已经在人类实体肿瘤中鉴定了涉及染色体2的新基因缺失和易位，导致将部分间变性淋巴瘤激酶（ALK）激酶与部分二级蛋白结合的融合蛋白。 非小细胞肺癌（NSCLC）。 次级蛋白包括棘皮动物微管相关蛋白样4（EML-4）和TRK-融合基因（TFG）。 确认了保留ALK酪氨酸激酶活性的EML4-ALK融合蛋白，以驱动以这种突变为特征的NSCLC的增殖和存活。 因此，本发明部分地提供分离的多核苷酸和编码所公开的突变ALK激酶多肽的载体，用于检测其的探针，分离的突变多肽，重组多肽和用于检测融合和截短的多肽的试剂。 所公开的这种新的融合蛋白的鉴定使得能够确定生物样品中这些突变型ALK激酶多肽的存在的新方法，用于筛选抑制蛋白质的化合物的方法，以及用于突变突变型多核苷酸特征的癌症进展抑制方法 或多肽，其也由本发明提供。