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公开(公告)号：US09410891B2
公开(公告)日：2016-08-09
申请号：US13031146
申请日：2011-02-18
IPC分类号： G01N21/64 , G01N21/77 , B01L3/00 , G01N21/75 , B82Y20/00 , G01N33/543 , G02B6/122 , G01N21/03 , G01N21/05 , C12Q1/68 , H01L27/144
CPC分类号： C12Q1/6874 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , B01L2300/0663 , B01L2300/0816 , B01L2300/168 , B82Y20/00 , C12Q1/6825 , C12Q1/6869 , G01N21/03 , G01N21/0303 , G01N21/05 , G01N21/64 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/6454 , G01N21/6456 , G01N21/648 , G01N21/75 , G01N21/77 , G01N33/54373 , G01N2021/0346 , G01N2021/6434 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/757 , G01N2021/7786 , G01N2201/067 , G01N2201/068 , G01N2201/08 , G02B6/1226 , Y10T436/143333
摘要： Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.
摘要翻译： 提供光学收集和检测系统，用于随着时间的推移从光源阵列测量光信号。 还描述了使用光学器件收集和检测系统的方法。
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公开(公告)号：US08709725B2
公开(公告)日：2014-04-29
申请号：US11925650
申请日：2007-10-26
申请人： Stephen Turner , Jonas Korlach
发明人： Stephen Turner , Jonas Korlach
CPC分类号： G01N21/77 , C12Q1/6806 , C12Q1/6869 , G01N21/00 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N2021/6439 , G01N2021/6463 , G01N2021/7786 , G01N2201/06113
摘要： The present invention relates to optical confinements, methods of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis.
摘要翻译： 本发明涉及光学限制，其制备方法和使用它们分析分子和/或监测化学反应的方法。 本发明中体现的装置和方法对于高通量和低成本的单分子分析特别有用。
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公开(公告)号：US08501405B2
公开(公告)日：2013-08-06
申请号：US12767673
申请日：2010-04-26
申请人： Jonas Korlach , Stephen Turner , Eric Schadt
发明人： Jonas Korlach , Stephen Turner , Eric Schadt
CPC分类号： C12Q1/6869 , C12Q1/702 , C12Q2565/518 , C12Q2547/101
摘要： The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of a variety of different biological reactions. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to either enhance or inhibit such reactions. In certain preferred embodiments, RNA templates are used in single-molecule real-time sequencing reactions.
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公开(公告)号：US20130130363A1
公开(公告)日：2013-05-23
申请号：US13477865
申请日：2012-05-22
申请人： Paul Lundquist , Stephen Turner
发明人： Paul Lundquist , Stephen Turner
IPC分类号： G01N21/64
CPC分类号： C12Q1/6874 , B01L2300/0636 , C12Q1/6869 , G01N21/64 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N21/7703 , G01N21/7743 , G01N2021/6439 , G01N2021/7786 , G01N2201/08 , G02B6/10 , G02B6/43
摘要： Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical operations, including, inter alia, nucleic acid analysis, including hybridization and sequencing analyses, cellular analyses and other molecular analyses.
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公开(公告)号：US20130039096A1
公开(公告)日：2013-02-14
申请号：US13558633
申请日：2012-07-26
IPC分类号： H02M7/44
CPC分类号： H02J3/383 , H02S50/00 , Y02E10/563
摘要： An electrical power generating system based on a photovoltaic cell array comprises means for monitoring the output of the array in order to determine whether the output is sufficient to sustain supply to a connected power network. The output of the array is monitored by sensing the voltage across a resistor connected across the array output. The array is connected to the network when a predetermined threshold is reached.
摘要翻译： 基于光伏电池阵列的发电系统包括用于监视阵列的输出以便确定输出是否足以维持对连接的电力网络的供应的装置。 通过感测跨阵列输出连接的电阻上的电压来监视阵列的输出。 当达到预定阈值时，阵列连接到网络。
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公开(公告)号：US08318094B1
公开(公告)日：2012-11-27
申请号：US13162433
申请日：2011-06-16
申请人： Hovig Bayandorian , Yujuan Cheng , John Dixon , Kevin Hester , Yanqiao Huang , Paul Lundquist , Joy Roy , Stephen Turner , Peiqian Zhao , Cheng Frank Zhong
发明人： Hovig Bayandorian , Yujuan Cheng , John Dixon , Kevin Hester , Yanqiao Huang , Paul Lundquist , Joy Roy , Stephen Turner , Peiqian Zhao , Cheng Frank Zhong
IPC分类号： G01N31/00
CPC分类号： G01N21/645 , G01N35/0099 , G01N2021/6417 , G01N2035/00039 , Y10T436/11
摘要： This invention provides systems for analyzing substrates. Also provided by the invention are improved optical systems for enhanced multiplex illumination, optical systems with compact multi-wavelength illumination architectures, optical systems for enhanced detection of optical signals, and optical systems for reduced autofluorescence background noise.
摘要翻译： 本发明提供了用于分析衬底的系统。 本发明还提供了用于增强多重照明的改进的光学系统，具有紧凑的多波长照明结构的光学系统，用于增强光信号的检测的光学系统以及用于减少自发荧光背景噪声的光学系统。
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57.发明授权Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources 有权用于同时实时监测来自多个来源的光信号的方法和系统公开(公告)号：US08264687B2
公开(公告)日：2012-09-11
申请号：US13102551
申请日：2011-05-06
申请人： Paul Lundquist , Denis Zaccarin , Yves Lacroix , Mark Maxham , Mathieu Foquet , Stephen Turner
发明人： Paul Lundquist , Denis Zaccarin , Yves Lacroix , Mark Maxham , Mathieu Foquet , Stephen Turner
IPC分类号： G01N21/25
CPC分类号： G01N21/6452 , G01J3/02 , G01J3/0224 , G01J3/10 , G01J3/14 , G01J3/2803 , G01N21/6445 , G01N21/6456 , G01N21/648 , G01N2021/6417 , G01N2201/126
摘要： Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.
摘要翻译： 用于实时监测来自信号源阵列的光信号的方法和系统，特别是具有频谱不同信号分量的光信号源。 系统包括与光学列车光学通信的信号源阵列，其将激发辐射引导到来自这种阵列的信号和从这些阵列发出的信号，并将信号映射到检测器阵列上，从而可以对这些信号进行额外的处理。
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公开(公告)号：US20120164631A1
公开(公告)日：2012-06-28
申请号：US13169991
申请日：2011-06-27
申请人： Stephen Turner , Jonas Korlach
发明人： Stephen Turner , Jonas Korlach
CPC分类号： G01N21/77 , C12Q1/6806 , C12Q1/6869 , G01N21/00 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N2021/6439 , G01N2021/6463 , G01N2021/7786 , G01N2201/06113
摘要： The present invention relates to optical confinements, methods of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis.
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59.发明授权Articles having localized molecules disposed thereon and methods of producing same 有权具有位于其上的局部分子的制品及其制备方法公开(公告)号：US08193123B2
公开(公告)日：2012-06-05
申请号：US11978171
申请日：2007-10-26
申请人： David R. Rank , Jeffery Wegener , Jonas Korlach , Daniel Roitman , Yue Xu , John Lyle , Stephen Turner , Paul Peluso , Geoff Otto , Ron Cicero
发明人： David R. Rank , Jeffery Wegener , Jonas Korlach , Daniel Roitman , Yue Xu , John Lyle , Stephen Turner , Paul Peluso , Geoff Otto , Ron Cicero
IPC分类号： C40B99/00
CPC分类号： C12Q1/6874 , B01J19/0046 , B01J2219/00427 , B01J2219/0045 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y20/00 , B82Y30/00 , C12Q1/6837 , Y10T29/49002 , C12Q2565/629 , C12Q2527/127
摘要： Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
摘要翻译： 通过使用底物的元素来辅助活性化学基团在基底的所需区域中的定位来制备具有选定的活性化学区域的基底的方法。 所述方法可以包括用于沉积，去除，激活和/或去活衬底的选定区域中的化学基团的光学，化学和/或机械方法，以提供衬底的选择性活性区域。
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公开(公告)号：US20120077190A1
公开(公告)日：2012-03-29
申请号：US13245578
申请日：2011-09-26
申请人： Paul Lundquist , Stephen Turner
发明人： Paul Lundquist , Stephen Turner
CPC分类号： C12Q1/6874 , B01L2300/0636 , C12Q1/6869 , G01N21/64 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N21/7703 , G01N21/7743 , G01N2021/6439 , G01N2021/7786 , G01N2201/08 , G02B6/10 , G02B6/43
摘要： Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical operations, including, inter alia, nucleic acid analysis, including hybridization and sequencing analyses, cellular analyses and other molecular analyses.
摘要翻译： 用于分析材料的衬底，系统和方法，其包括设置在衬底上或衬底内的波导阵列，使得从波导发出的消逝场照射设置在衬底表面上或其附近的材料，从而允许分析这些材料。 底物，系统和方法用于各种分析操作，包括核酸分析，包括杂交和测序分析，细胞分析和其他分子分析。
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