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    Method and apparatus for ion analysis and detection using reverse mode suppression
    53.
    发明授权
    Method and apparatus for ion analysis and detection using reverse mode suppression 失效
    使用反向模式抑制的离子分析和检测方法和装置

    公开(公告)号：US4455233A

    公开(公告)日：1984-06-19

    申请号：US522829

    申请日：1983-08-12

    Applicant: Christopher A. Pohl ,  Rosanne W. Slingsby ,  Edward L. Johnson ,  Leilani Angers

    Inventor： Christopher A. Pohl ,  Rosanne W. Slingsby ,  Edward L. Johnson ,  Leilani Angers

    IPC: G01N30/88 ,  B01D15/08 ,  G01N30/02 ,  G01N30/60 ,  G01N30/96

    CPC classification number: B01D15/367 ,  B01D15/1871 ,  B01D15/361 ,  G01N30/96 ,  G01N2030/965

    Abstract: a method of ion analysis and detection of weakly dissociated anions or cations in an eluent by first separating such ions on a chromatographic separation medium by ion exclusion chromatography or mobile phase ion exclusion chromatography. The eluent include an acid or base with a co-ion of the same charge as the ions to be separated, such co-ions being in the hydronium or hydroxide form. In one embodiment the effluent from the separation medium is contacted with one side of an ion-exchange membrane having exchangeable ions of opposite charge to the ionic species. The opposite side of the membrane includes a regenerant with salt-forming suppression ions capable of forming a weakly conducting salt with the co-ions. Then the separated ionic species are detected preferably by a conductivity detector. In another embodiment, the membrane is replaced by a resin bed with ion-exchanging sites of opposite charge to the co-ions. There, co-ions form a suppressed salt with the exchangeable ions.

    Abstract translation: 通过离子排斥色谱法或流动相离子排除色谱法首先在色谱分离介质上分离这些离子，进行离子分析和检测洗脱液中弱解离的阴离子或阳离子的方法。 洗脱液包括具有与待分离的离子相同电荷的共离子的酸或碱，这些共离子是水合氢或氢氧化物形式。 在一个实施方案中，来自分离介质的流出物与离子物质具有相反电荷的可交换离子的离子交换膜的一侧接触。 膜的相反侧包括具有能够与共离子形成弱导电盐的成盐抑制离子的再生剂。 然后分离的离子物质优选由电导检测器检测。 在另一个实施方案中，膜被树脂床代替，其具有与共离子相反电荷的离子交换位点。 在那里，共离子与可交换离子形成抑制盐。

    Chromatographic separation and quantitative analysis of ionic species
    54.
    发明授权
    Chromatographic separation and quantitative analysis of ionic species 失效
    离子物质的色谱分离和定量分析

    公开(公告)号：US4265634A

    公开(公告)日：1981-05-05

    申请号：US128836

    申请日：1980-03-10

    Applicant: Christopher A. Pohl

    Inventor： Christopher A. Pohl

    IPC: B01J39/26 ,  G01N30/46 ,  G01N30/60 ,  G01N30/96 ,  G01N31/04 ,  G01N31/06 ,  G01N31/08

    CPC classification number: G01N30/461 ,  B01J39/26 ,  G01N30/96 ,  G01N2030/965

    Abstract: Method and apparatus for chromatographic separation and quantitative analysis of ions of like charges in a sample, e.g., cations or anions. For the analysis of inorganic anions, the sample and an eluent are directed to a hydrophobic chromatographic separation bed without permanently attached ion exchange sites. The eluent (a polar mobile liquid) includes an organic cation which reversibly adsorbs to the bed to create ion exchange sites which differentially retard the anions for chromatographic resolution. The eluent also includes a developing reagent of the same charge as the ion to be analyzed. The eluent including the resolved anions is then passed through an ion exchange resin which precludes passage of the counter ion and its co-ion in ionized form and then through a conductivity cell for quantitative detection. Inorganic cations may be detected in an analogous manner. The system may also be employed to analyze highly organic cations or anions (e.g., surfactants). In this instance, the organic ion of interest is already strongly attracted to the hydrophobic separation bed, and so the counter ion may be inorganic.

    Abstract translation: 用于色谱分离和定量分析样品中类似电荷的离子的方法和装置，例如阳离子或阴离子。 对于无机阴离子的分析，样品和洗脱液被引导到疏水性色谱分离床，而没有永久附着的离子交换位点。 洗脱液（极性流动液体）包括可逆地吸附到床上以产生差异延迟阴离子以进行色谱分离的离子交换位点的有机阳离子。 洗脱液还包括与待分析离子相同电荷的显影试剂。 然后将含有分辨阴离子的洗脱液通过离子交换树脂，其排除了离子形式的抗衡离子及其离子的通过，然后通过用于定量检测的电导池。 可以以类似的方式检测无机阳离子。 该系统也可用于分析高度有机阳离子或阴离子（例如表面活性剂）。 在这种情况下，感兴趣的有机离子已经被强力吸引到疏水分离床，因此反离子可以是无机的。

    High capacity ion chromatography stationary phases and method of forming
    56.
    发明授权
    High capacity ion chromatography stationary phases and method of forming 有权
    高容量离子色谱固定相和成型方法

    公开(公告)号：US09132364B2

    公开(公告)日：2015-09-15

    申请号：US12714253

    申请日：2010-02-26

    Applicant: Kannan Srinivasan ,  Christopher A. Pohl ,  Sheetal Bhardwaj ,  Rong Lin

    Inventor： Kannan Srinivasan ,  Christopher A. Pohl ,  Sheetal Bhardwaj ,  Rong Lin

    IPC: B01D15/36 ,  B01J39/26 ,  B01J41/04 ,  B01J41/20 ,  B01J47/00

    CPC classification number: B01D15/36 ,  B01D15/361 ,  B01J39/17 ,  B01J39/19 ,  B01J39/26 ,  B01J41/04 ,  B01J41/13 ,  B01J41/20 ,  B01J47/00

    Abstract: The present invention provides a new design for high capacity stationary phases for chromatography, for example, ion chromatography. The stationary phases include a first polymer layer in contact with and at least partially coating the substrate of the stationary phase. The first polymer layer serves as a foundation for the attachment, and in various embodiments, the growth and attachment, of a highly hyperbranched polymer structure, typically based on one or more products of condensation polymerization. Multiple components are of use in forming the first polymer layer and the hyperbranched polymer structure, thereby providing a stationary phase that can be engineered to have a desired property such as ion capacity, ion selectivity, and the like. Exemplary condensation polymers are formed by the reaction of at least one polyfunctional compound with at least one compound of complimentary reactivity, e.g., a nucleophilic polyfunctional compound reacting with an electrophilic compound.

    Abstract translation: 本发明提供了用于色谱法的高容量固定相的新设计，例如离子色谱法。 固定相包括与固定相的基底接触并且至少部分地涂覆固定相的基底的第一聚合物层。 第一聚合物层用作连接的基础，并且在各种实施方案中，通常基于一个或多个缩聚产物的高度超支化的聚合物结构的生长和附着。 多个组分可用于形成第一聚合物层和超支化聚合物结构，从而提供可被工程化以具有所需性质如离子容量，离子选择性等的固定相。 示例性缩合聚合物通过至少一种多官能化合物与至少一种互补反应性化合物的反应形成，例如与亲电子化合物反应的亲核多官能化合物。

    High pressure degas assembly for chromatography system and method
    60.
    发明授权
    High pressure degas assembly for chromatography system and method 有权
    高压脱气装置用于色谱系统和方法

    公开(公告)号：US08414684B2

    公开(公告)日：2013-04-09

    申请号：US12791732

    申请日：2010-06-01

    Applicant: Yan Liu ,  Christopher A. Pohl ,  Michael McAdams ,  Hamish Small ,  Zhongqing Lu ,  Milton Liu ,  Khosro Moshfegh

    Inventor： Yan Liu ,  Christopher A. Pohl ,  Michael McAdams ,  Hamish Small ,  Zhongqing Lu ,  Milton Liu ,  Khosro Moshfegh

    IPC: B01D53/22 ,  B01D19/00

    CPC classification number: B01D19/0073 ,  B01D19/0031 ,  B01D19/0036 ,  G01N30/32 ,  G01N30/96 ,  G01N2030/146

    Abstract: A degas assembly including a low pressure fluid channel for carrying a wash fluid at a first pressure, a pressurized channel for carrying eluent including a gas at a second pressure higher than the first pressure, and a degas separator defining a fluid barrier between the low pressure fluid channel and pressurized fluid channel, the separator configured to retain liquid in the pressurized fluid channel and allow gas to flow through the separator to the low pressure fluid channel. The pressurized fluid channel may extend along an outer periphery of the low pressure fluid channel. The eluent may be received from an eluent generator at a pressure of at least about 3300 psi, and in various embodiments up to about 5000 psi. A liquid chromatography system and method are also disclosed.

    Abstract translation: 一种脱气组件，包括用于在第一压力下承载洗涤流体的低压流体通道，用于承载包含在高于第一压力的第二压力的气体的洗脱液的加压通道，以及限定低压下的流体阻挡层的脱气分离器 流体通道和加压流体通道，分离器构造成将液体保持在加压流体通道中并允许气体通过分离器流动到低压流体通道。 加压流体通道可以沿着低压流体通道的外周延伸。 洗脱液可以在至少约3300psi的压力下从洗脱液发生器接收，并且在各种实施方案中可高达约5000psi。 还公开了液相色谱系统和方法。

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