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104 条记录 (耗时 0.038 秒)

    Tissue pathogen inactivation/removal process
    51.
    发明授权
    Tissue pathogen inactivation/removal process 有权
    组织病原体灭活/去除过程

    公开(公告)号：US07585461B2

    公开(公告)日：2009-09-08

    申请号：US10766614

    申请日：2004-01-28

    申请人： Lawrence A. Shimp ,  Sheldon Dean ,  Daniel Martins

    发明人： Lawrence A. Shimp ,  Sheldon Dean ,  Daniel Martins

    IPC分类号： A61L2/18

    CPC分类号： A61L2/0088 ,  A61F2/28 ,  A61F2002/2835 ,  A61F2002/302 ,  A61F2002/4646 ,  A61F2002/4649 ,  A61F2230/0065 ,  A61L2/0011

    摘要： Bone such as cortical or cancellous bone or connective tissue are centrifuged as a solution is applied to the tissue in a continuous process. The centrifuge creates forces, which cause the flowing solution to penetrate substantially all of the cavities of the tissue. The solution, which may be alcohol, a detergent, an oxidizer, or a surfactant, with or without water, flushes the cavities of the tissue and removes and inactivates viral and bacterial contaminants. In a second embodiment, bone or connective tissue is centrifuged in a batch process to remove contaminants from cavities in the tissue by first spinning the tissue dry and then submerging the tissue in a viral/bacteria cleansing solution and centrifuging the submerged tissue and solution at a sufficiently high speed and radius from the spin axis to create substantially high G forces on the tissue and solution to force the solution into and through the tissue cavities. The solution with the flushed contaminants is then removed from the vicinity of the tissue. In a further embodiment, an enzyme is centrifuged with the tissue to digest lipids and proteins which are then removed with a flushing solution which may also inactivate viral and bacterial contaminants. In yet a further embodiment, the centrifuge can be used to infuse biologically and/or structurally useful materials into the tissue. Further, the lipids and proteins may be removed by a chemically active agent such as oxo anions.

    摘要翻译： 将骨骼如皮层或松质骨或结缔组织离心，将溶液以连续方式施用于组织。 离心机产生力，这使得流动的溶液基本上穿透组织的所有空腔。 溶液，其可以是醇，洗涤剂，氧化剂或表面活性剂，具有或不具有水，冲洗组织的空腔并去除和灭活病毒和细菌污染物。 在第二个实施方案中，将骨或结缔组织以分批方法离心以通过首先将组织干燥并然后将组织浸没在病毒/细菌清洁溶液中并从而将浸没的组织和溶液离心 从旋转轴线到足够高的速度和半径，以在组织和溶液上产生基本上高的G力，以迫使溶液进入和穿过组织腔。 然后从组织的附近去除具有冲洗的污染物的溶液。 在另一个实施方案中，将酶与组织离心以消化脂质和蛋白质，然后用​​冲洗溶液除去，所述冲洗溶液也可能使病毒和细菌污染物失活。 在又一个实施例中，离心机可用于将生物和/或结构上有用的材料注入组织。 此外，脂质和蛋白质可以通过化学活性剂如氧阴离子去除。

    Method for sterilizing bioactive materials
    53.
    发明授权
    Method for sterilizing bioactive materials 有权
    消毒生物活性物质的方法

    公开(公告)号：US07357895B2

    公开(公告)日：2008-04-15

    申请号：US10250661

    申请日：2002-01-04

    申请人： Lawrence A. Shimp

    发明人： Lawrence A. Shimp

    IPC分类号： A61L2/00

    CPC分类号： A61L2/0035 ,  A61L2/0011 ,  A61L2/0041 ,  A61L2/007

    摘要： A method is provided for sterilizing a bioactive material which comprises contacting the bioactive material with hydrogen gas and while the bioactive material is in contact with hydrogen gas, irradiating the bioactive material with ionizing radiation to sterilize the material.

    摘要翻译： 提供了一种消毒生物活性物质的方法，包括使生物活性材料与氢气接触，同时生物活性材料与氢气接触，用电离辐射照射生物活性材料以消毒该材料。

    Sodium tripolyphosphate manufacture
    54.
    发明授权
    Sodium tripolyphosphate manufacture 失效
    三聚磷酸钠制造

    公开(公告)号：US4590051A

    公开(公告)日：1986-05-20

    申请号：US666932

    申请日：1984-10-31

    申请人： Lawrence A. Shimp

    发明人： Lawrence A. Shimp

    IPC分类号： C01B25/41 ,  C01B25/30

    CPC分类号： C01B25/416

    摘要： In the manufacture of sodium tripolyphosphate, the make up liquor containing the requisite sodium and phosphorus values, is treated with from about 0.01 to 0.1 weight percent of hydrogen peroxide before the liquor is heated to form sodium tripolyphosphate. The hydrogen peroxide treatment prevents dark oily impurities from forming on the surface of aqueous solutions of the sodium tripolyphosphate thus treated.

    摘要翻译： 在三聚磷酸钠的制造中，在加热液体以形成三聚磷酸钠之前，将含有所需钠和磷值的补充液用约0.01至0.1重量％的过氧化氢处理。 过氧化氢处理可以防止在这样处理的三聚磷酸钠水溶液的表面上形成深色油状杂质。

    Method of making bone particles
    58.
    发明授权
    Method of making bone particles 有权
    制造骨颗粒的方法

    公开(公告)号：US08323700B2

    公开(公告)日：2012-12-04

    申请号：US10509585

    申请日：2003-03-31

    申请人： John W. Morris ,  Kenneth C. Petersen ,  Lawrence A. Shimp ,  Mark P. Daugherty

    发明人： John W. Morris ,  Kenneth C. Petersen ,  Lawrence A. Shimp ,  Mark P. Daugherty

    IPC分类号： A61K35/32 ,  A61F2/28

    CPC分类号： A61L27/3683 ,  A01N1/00 ,  A61F2/4644 ,  A61F2002/2835 ,  A61F2002/4645 ,  A61F2002/4649 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/365 ,  A61L2430/02 ,  A61L2430/40

    摘要： The present invention relates to a method for making bone particles from bone of a variety of sizes and a workpiece forming and holding device for use with the method. The workpiece forming device includes a base and a base frame attached to the surface of the base. An apparatus for forming a solidified mass of bone and immobilization medium is also provided which includes the workpiece forming device and a detachable former member enclosing the base frame. Bone is immersed in an immobilization medium within such workpiece forming device, which is solidified to form a solidified mass of bone and immobilization medium and then subdivided to provide particles of bone in association to with immobilization medium. The immobilization medium may be optionally removed to leave bone particles suitable for use in orthopedic applications including implants.

    摘要翻译： 本发明涉及一种用于制造各种尺寸的骨的骨颗粒的方法和用于该方法的工件形成和保持装置。 工件形成装置包括底座和附接到基座表面的底座。 还提供了一种用于形成固化骨和固定介质的装置，其包括工件形成装置和包围基架的可拆卸的成形构件。 将骨浸入这种工件形成装置内的固定介质中，固化介质被固化以形成骨和固定介质的固化块，然后细分以提供与固定介质相关联的骨颗粒。 可以任选地除去固定介质以留下适合用于矫形应用的骨颗粒，包括植入物。

    Methods for Collagen Processing and Products Using Processed Collagen
    60.
    发明申请
    Methods for Collagen Processing and Products Using Processed Collagen 有权
    胶原加工方法和使用加工胶原产品

    公开(公告)号：US20080195202A1

    公开(公告)日：2008-08-14

    申请号：US11673972

    申请日：2007-02-12

    申请人： Nels J. Lauritzen ,  Lawrence A. Shimp

    发明人： Nels J. Lauritzen ,  Lawrence A. Shimp

    IPC分类号： A61F2/02

    CPC分类号： A61L27/54 ,  A61L15/325 ,  A61L27/24 ,  A61L27/34 ,  A61L2300/00

    摘要： Purifying human derived collagen from human tissue includes treating harvested human tissue with an enzyme to form a collagen product, deactivating the enzyme with a non-alkaline enzyme deactivation solution, and collecting the collagen product resulting from the enzyme treatment, where the collected collagen product includes a preserved amount of its natural collagen constituents. Various medical implants can be formed using the isolated, enzymatically-treated human derived collagen having an amount of its natural collagen constituents preserved, and may include implantable sponges, patches, tubes, structural supports and coatings, and which may be used for repair, barrier, support and/or stabilization purposes.

    摘要翻译： 从人体组织中纯化人源胶原蛋白包括用酶处理收获的人体组织以形成胶原产物，用非碱性酶失活溶液使酶失活，以及收集由酶处理产生的胶原产物，其中所收集的胶原产品包括 保留量的天然胶原成分。 可以使用分离的，经酶处理的人源胶原蛋白形成各种医学植入物，其具有保存的天然胶原蛋白成分的量，并且可以包括可植入的海绵，贴剂，管，结构载体和涂层，并且其可用于修复，屏障 ，支持和/或稳定目的。