公开(公告)号：US10300299B2

公开(公告)日：2019-05-28

申请号：US15786046

申请日：2017-10-17

Applicant: Immunolight, LLC ,  Duke University

Inventor： Frederic A. Bourke, Jr. ,  Tuan Vo-Dinh

IPC: A61K41/00 ,  A61N5/06 ,  A61K31/7056 ,  A61K47/55 ,  A61K31/4427 ,  A61K31/7052

Abstract: The present invention relates to methods for treating cell proliferation disorders comprising: (1) administering to the subject at least one activatable pharmaceutical agent that is capable of activation by a simultaneous two photon absorption event and of effecting a predetermined cellular change when activated; (2) administering at least one plasmonics-active agent to the subject, and (3) applying an initiation energy from an initiation energy source to the subject, wherein the plasmonics-active agent enhances or modifies the applied initiation energy, such that the enhanced or modified initiation energy activates the activatable pharmaceutical agent by the simultaneous two photon absorption event in situ, thus causing the predetermined cellular change to occur, wherein said predetermined cellular change treats the cell proliferation related disorder; and the use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, and the PEPST and EPEP agents and probes; a kit and a computer implemented system for performing the method; a pharmaceutical composition useful in the method; and a method for causing an autovaccine effect in a subject using the method.

公开(公告)号：US10080275B2

公开(公告)日：2018-09-18

申请号：US14688687

申请日：2015-04-16

Applicant: IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

Inventor： Frederic A. Bourke, Jr. ,  Zakaryae Fathi ,  Ian Nicholas Stanton ,  Michael J. Therien ,  Paul Rath Stauffer ,  Paolo Maccarini ,  Katherine Sarah Hansen ,  Diane Renee Fels ,  Cory Robert Wyatt

IPC: H05B41/28 ,  A61L2/10 ,  A61N1/40 ,  A61N1/44 ,  C02F1/32 ,  H01J65/04 ,  A61N2/00 ,  A61N5/10

CPC classification number: H05B41/2806 ,  A61L2/10 ,  A61N1/40 ,  A61N1/44 ,  A61N2/00 ,  A61N5/10 ,  C02F1/32 ,  H01J65/042 ,  Y02B20/22 ,  Y02W10/37

Abstract: Methods and systems for producing a change in a medium. A first method and system (1) place in a vicinity of the medium at least one upconverter including a gas for plasma ignition, with the upconverter being configured, upon exposure to initiation energy, to generate light for emission into the medium, and (2) apply the initiation energy from an energy source including the first wavelength λ1 to the medium, wherein the emitted light directly or indirectly produces the change in the medium. A second method and system (1) place in a vicinity of the medium an agent receptive to microwave radiation or radiofrequency radiation, and (2) apply as an initiation energy the microwave radiation or radiofrequency radiation by which the agent directly or indirectly generates emitted light in the infrared, visible, or ultraviolet range to produce at least one of physical and biological changes in the medium.

公开(公告)号：US09676918B2

公开(公告)日：2017-06-13

申请号：US15183110

申请日：2016-06-15

Applicant: Immunolight, LLC.

Inventor： Zakaryae Fathi ,  John Pacanovsky ,  Frederic A. Bourke, Jr.

IPC: B32B38/10 ,  C08J11/10 ,  B32B7/04 ,  B32B43/00

CPC classification number: C08J11/10 ,  B32B7/04 ,  B32B38/10 ,  B32B43/006 ,  C08J2321/00 ,  Y02W30/702 ,  Y10T156/1153 ,  Y10T156/1917

Abstract: A method is provided for de-bonding objects contained in an article at an interface between the objects, wherein the objects are joined at the interface through an intermediate layer, which involves applying energy from a radiation source, wherein the energy is sufficient to cause destruction of bonds within the intermediate layer; and separating the two objects from one another.

公开(公告)号：US08907109B2

公开(公告)日：2014-12-09

申请号：US13739398

申请日：2013-01-11

Applicant: Immunolight, LLC

Inventor： Eric Toone ,  David Gooden ,  Tuan Vo-Dinh ,  Frederic A. Bourke, Jr.

IPC: C07D493/00 ,  C07D211/92 ,  A61K45/06 ,  A61N5/10 ,  A61K31/453 ,  C07D493/04 ,  A61N5/06 ,  A61K31/4709 ,  A61K41/00 ,  A61K31/4433

CPC classification number: C07D493/04 ,  A61K31/4433 ,  A61K31/453 ,  A61K31/4709 ,  A61K41/0066 ,  A61K45/06 ,  A61N5/062 ,  A61N5/10

Abstract: Psoralen compounds of Formula (I): wherein (N+ Aryl) is a member selected from the group consisting of nitrogen containing aromatic heterocycles of formulae (i)-(iii): wherein Z is a group of formula: wherein R is C1-C30 hydrocarbyl, which may be linear, branched or cyclic and contains from 1 to 15 carbon-carbon double bonds, which may be conjugated or unconjugated with one another or may include an aryl ring, and may contain one or more substituents; R1 is hydrogen, aryl, heteroaryl, alkyl, cycloalkyl, heterocyclyl, alkenyl, alkynyl, alkene-aryl, alkene-heteroaryl, alkene-heterocyclyl, alkene-cycloalkyl, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclyheteroaryl, alkylene-fused cycloalkylaryl, alkylene-fused cycloalkylheteroaryl, alkylene-fused heterocyclylaryl, alkylene-fused heterocyclyheteroaryl; n is an integer from 1 to 8 and X is a pharmaceutically acceptable counter ion; and their use in methods for the treatment of a cell proliferation disorder in a subject, pharmaceutical compositions containing the psoralen derivatives, a kit for performing the method, and a method for causing an autovaccine effect in a subject using the method.

Abstract translation: 式（I）的补骨脂素化合物：其中（N +芳基）是选自式（i） - （iii）的含氮芳族杂环的成员：其中Z是下式的基团：其中R是C1-C30 烃基，其可以是直链，支链或环状的并且含有1至15个碳 - 碳双键，其可以彼此共轭或非共轭或可以包括芳环，并且可以含有一个或多个取代基; R 1是氢，芳基，杂芳基，烷基，环烷基，杂环基，烯基，炔基，烯 - 芳基，烯 - 杂芳基，烯烃 - 杂环基，烯 - 环烷基，稠合环烷基芳基，稠合环烷基杂芳基，稠合杂环基芳基，稠合杂环杂芳基，亚烷基稠合环烷基芳基 亚烷基稠合的环烷基杂芳基，亚烷基稠合的杂环基芳基，亚烷基稠合的杂环杂芳基; n为1〜8的整数，X为药学上可接受的抗衡离子; 及其在治疗受试者的细胞增殖障碍的方法中的用途，含有补骨脂素衍生物的药物组合物，用于进行该方法的试剂盒以及使用该方法在受试者中引起自身疫苗效应的方法。

公开(公告)号：US08658086B2

公开(公告)日：2014-02-25

申请号：US13713974

申请日：2012-12-13

Applicant: Immunolight, LLC

Inventor： Frederic A. Bourke, Jr.

IPC: A61L2/08 ,  C08F2/42 ,  C08J3/28

CPC classification number: A61N5/10 ,  A23L2/50 ,  A23L3/26 ,  A23L3/263 ,  A23L3/28 ,  A23L5/32 ,  A23V2002/00 ,  A61K41/0057 ,  A61K41/0066 ,  A61L2/0011 ,  A61L2/0047 ,  A61L2/0076 ,  A61L2/082 ,  A61L2/088 ,  A61L2/10 ,  A61L2/16 ,  A61L2202/21 ,  A61L2202/22 ,  A61M1/3683 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/1087 ,  A61N2005/1089 ,  A61N2005/1098 ,  B01J19/082 ,  B01J19/085 ,  B01J19/12 ,  B01J19/123 ,  B01J19/125 ,  B01J19/127 ,  B01J19/128 ,  B01J23/50 ,  B01J23/52 ,  B01J31/0275 ,  B01J31/2295 ,  B01J35/0006 ,  B01J35/0013 ,  B01J35/004 ,  B01J37/0072 ,  B01J37/0221 ,  B01J2219/0877 ,  B01J2219/0879 ,  B01J2219/0892 ,  B01J2219/1203 ,  B01J2231/005 ,  B01J2531/005 ,  B01J2531/008 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00 ,  C02F1/30 ,  C02F1/302 ,  C02F1/305 ,  C02F1/307 ,  C02F1/32 ,  C02F1/725 ,  C02F2305/10 ,  C08J3/24 ,  C08J3/28 ,  C08J7/18 ,  C08J2300/00 ,  C09D201/00 ,  C09J5/00 ,  C09J201/00 ,  C09J2205/31 ,  C12H1/06 ,  G02B5/008 ,  G21K5/00 ,  Y02W10/37 ,  Y10S977/774 ,  Y10S977/777 ,  Y10S977/896 ,  Y10S977/915 ,  Y10T156/10

Abstract: A method and a system for producing a change in a medium. The method places in a vicinity of the medium at least one energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

Abstract translation: 一种用于产生介质变化的方法和系统。 该方法在介质附近放置至少一种能量调节剂。 该方法对介质施加引发能量。 引发能与能量调节剂相互作用直接或间接产生介质中的变化。 该系统包括引发能量源，其被配置为向介质施加引发能量以激活能量调节剂。

公开(公告)号：US08618509B2

公开(公告)日：2013-12-31

申请号：US13732882

申请日：2013-01-02

Applicant: Immunolight, LLC

Inventor： Tuan Vo-Dinh ,  Jonathan P. Scaffidi ,  Venkata Gopal Reddy Chada ,  Benoit Lauly ,  Yan Zhang ,  Molly K. Gregas ,  Ian Nicholas Stanton ,  Joshua T. Stecher ,  Michael J. Therien ,  Frederic A. Bourke, Jr. ,  Zak Fathi ,  Jennifer Ann Ayres ,  Zhenyuan Zhang ,  Joseph H. Simmons ,  Stephen John Norton

IPC: G01J1/58

CPC classification number: F21K2/00 ,  A61L2/08 ,  A61L2202/22 ,  A61N5/062 ,  B82Y20/00 ,  B82Y30/00 ,  G01N21/63 ,  G02B5/003 ,  G02F2/02 ,  Y10T428/25 ,  Y10T428/256

Abstract: A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength λ1 of radiation, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1 and 2) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength λ1 or the second wavelength λ2, or with both λ1 and λ2. The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength λ2, generates the photostimulated reaction.

Abstract translation: 一种用于能量上转换和/或下转换的系统和用于在介质中产生光刺激反应的系统。 这些系统包括1）在暴露于辐射的第一波长λ1时配置的纳米颗粒，以产生具有比第一波长λ1更高的能量的辐射的第二波长λ2，以及2）相对于纳米颗粒设置的金属结构。 金属结构的物理特性被设定为金属结构中的表面等离子体共振在以与第一波长λ1或第二波长λ2或与λ1和λ2两者提供光谱重叠的频率谐振的值。 用于在培养基中产生光刺激反应的系统包括设置在接近纳米颗粒的介质中的受体，其在被第二波长λ2激活时产生光刺激反应。

公开(公告)号：US12226483B2

公开(公告)日：2025-02-18

申请号：US17538770

申请日：2021-11-30

Applicant: IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

Inventor： Harold Walder ,  Frederic A. Bourke, Jr. ,  Zakaryae Fathi ,  Wayne F. Beyer ,  Mark Oldham ,  Justus Adamson ,  Michael Nolan

IPC: A61K9/00 ,  A61K31/37 ,  A61K41/00 ,  A61N5/06 ,  A61N5/10 ,  A61K45/06

Abstract: A method for treating a disease in a subject in need thereof is provided involving infusing 8-methoxypsoralen (8-MOP) and a phosphor-containing drug activator into a diseased site in the subject; and delivering a dose of x-rays to the subject for production of the ultraviolet and visible light inside the subject to activate the photoactivatable drug and induce a persistent therapeutic response, the dose including a pulsed sequence of x-rays delivering from 0.5-2 Gy to the tumor, wherein the phosphor-containing drug activator includes an admixture of two or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays; the two or more phosphors including Zn2SiO4:Mn2+ and (3Ca3(PO4)2Ca(F, Cl)2:Sb3+, Mn2+) at a ratio (Zn2SiO4:Mn2+):(3Ca3(PO4)2Ca(F, Cl)2:Sb3+, Mn2+)) of from 1:10 to 10:1; wherein each of the two or more phosphors have at least one coating selected from an ethyl cellulose coating or a diamond-like carbon coating.

公开(公告)号：US11938011B2

公开(公告)日：2024-03-26

申请号：US16915058

申请日：2020-06-29

Applicant: IMMUNOLIGHT, LLC.

Inventor： Frederic A. Bourke, Jr. ,  Harold Walder

IPC: H01L33/50 ,  A61F13/20 ,  A61F13/26 ,  A61F13/551 ,  H10K50/125 ,  H10K59/38

CPC classification number: A61F13/55185 ,  A61F13/2097 ,  A61F13/26 ,  H01L33/504 ,  H10K50/125 ,  H10K59/38 ,  Y10S604/904 ,  Y10T29/4984 ,  Y10T29/49908

Abstract: A light emitting composition including first color emitters and second color emitters. The first color emitters are configured to emit, upon exposure to an energy source, visible light at a target color in response to absorption of energy across a first band of wavelengths. The second color emitters are configured to emit, upon exposure to the energy source, visible light at the target color in response to absorption of energy across a second band of wavelengths. The light intensity observable at the target color is enhanced relative to reflected white light without emission from the first and second color emitters. The light emitting composition can be a part of a paint, an ink, a fabric, a thread, a road sign, a highway marking, an automobile, a boat, a plane, a reflector, a building product, a concrete product, an epoxy product, a jewelry product, colored contact lens, a candle product, a rubber product, a plastic product, or other colored surface.

公开(公告)号：US11678682B2

公开(公告)日：2023-06-20

申请号：US17650997

申请日：2022-02-14

Applicant: IMMUNOLIGHT, LLC

Inventor： Frederic A. Bourke, Jr. ,  Zakaryae Fathi ,  Harold Walder ,  Wayne F. Beyer, Jr.

IPC: A23L3/28 ,  A61L2/08 ,  A23L3/26 ,  A61M1/36 ,  C02F1/32 ,  G03F7/20 ,  A61N5/06 ,  A61L2/00 ,  A61M1/34 ,  C23C16/458 ,  C02F1/30

CPC classification number: A23L3/28 ,  A23L3/263 ,  A61L2/0041 ,  A61L2/0047 ,  A61L2/08 ,  A61L2/082 ,  A61M1/3493 ,  A61M1/3681 ,  A61M1/3683 ,  A61N5/062 ,  A61N5/0624 ,  C02F1/32 ,  C02F1/325 ,  C23C16/458 ,  G03F7/20 ,  A23V2002/00 ,  A61L2202/24 ,  A61N2005/0661 ,  A61N2005/0662 ,  C02F1/307 ,  C02F2201/32 ,  C02F2305/10 ,  Y02W10/37

Abstract: A method and a system for producing a change in a medium. The method places in a vicinity of the medium an energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The energy modulation agent has a normal predominant emission of radiation in a first wavelength range outside of a second wavelength range (WR2) known to produce the change, but under exposure to the applied initiation energy produces the change. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

公开(公告)号：US11452884B2

公开(公告)日：2022-09-27

申请号：US15876401

申请日：2018-01-22

Applicant: IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

Inventor： Eric J. Toone ,  David Gooden ,  Frederic A. Bourke, Jr. ,  Harold Walder

IPC: A61K31/37 ,  A61N5/06 ,  A61N5/10 ,  A61K39/39 ,  C07D493/04

Abstract: Psoralen compounds of compounds having formulae 1A-10A, 1B-10B, 1C-10C, 1D-10D, 1E-10E, 1F-10F, 1G-10G, and 1H-5H as shown in FIG. 1, and pharmaceutically acceptable salts thereof; and their use in methods for the treatment of a cell proliferation disorder in a subject, pharmaceutical compositions containing the psoralen derivatives, a kit for performing the method, and a method for causing an autovaccine effect in a subject using the method.