利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

97 条记录 (耗时 0.045 秒)

    Systems for monitoring and controlling fluid flow rates in microfluidic systems
    51.
    发明授权
    Systems for monitoring and controlling fluid flow rates in microfluidic systems 有权
    用于监测和控制微流体系统中流体流速的系统

    公开(公告)号：US06616823B2

    公开(公告)日：2003-09-09

    申请号：US09784647

    申请日：2001-02-15

    申请人： Anne R. Kopf-Sill

    发明人： Anne R. Kopf-Sill

    IPC分类号： G01N27453

    CPC分类号： G01N27/44752 ,  B01L3/502746 ,  B01L2200/143 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0418 ,  B01L2400/0487 ,  B01L2400/082

    摘要： The present invention generally provides methods and systems for monitoring and controlling electroosmotic flow rates in microfluidic systems. Generally, such methods and systems monitor flow rates in electroosmotically driven microfluidic systems by flowing signaling elements within these channels and measuring the flow rate of these signals. The methods of monitoring flow rates are also applied to methods and systems for continuously monitoring and controlling these flow rates in electroosmotically driven microfluidic systems.

    摘要翻译： 本发明通常提供用于监测和控制微流体系统中电渗流速的方法和系统。 通常，这些方法和系统通过在这些通道内流动信号元件并测量这些信号的流速来监测电动驱动微流体系统中的流速。 监测流速的方法也适用于在电动驱动的微流体系统中连续监测和控制这些流速的方法和系统。

    Error checking in blood analyzer
    58.
    发明授权
    Error checking in blood analyzer 失效
    血液分析仪检查错误

    公开(公告)号：US5590052A

    公开(公告)日：1996-12-31

    申请号：US227554

    申请日：1994-04-14

    申请人： Anne R. Kopf-Sill ,  Steven N. Buhl ,  Glenda L. Choate ,  Lloyd A. Schick ,  Robert E. Nagle ,  Jenq C. Chang ,  Daniel Bernstein ,  Wayne A. Britt

    发明人： Anne R. Kopf-Sill ,  Steven N. Buhl ,  Glenda L. Choate ,  Lloyd A. Schick ,  Robert E. Nagle ,  Jenq C. Chang ,  Daniel Bernstein ,  Wayne A. Britt

    IPC分类号： G01N21/25 ,  G01N35/00 ,  G01N35/02 ,  G01N21/17

    CPC分类号： G01N35/00594 ,  G01N21/253 ,  G01N35/025 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165

    摘要： The present invention provides various methods for detecting errors in a blood analysis system. The system includes a blood analyzer and a molded plastic rotor with a series of chambers and capillary channels through which blood is processed and distributed to cuvettes which contain lyophilized reagents. The rotor is placed in the analyzer which spins the rotor, and an optical system reads the cuvettes as light is flashed through the cuvettes. The invention provides checks for: confirming the presence of a reagent in the cuvettes before a sample is applied to the cuvettes; determining whether a fluid sample has been properly distributed to the cuvettes of the rotor; determining whether an adequate amount of fluid sample was applied to the analytical rotor; determining whether a fluid sample has been properly distributed to a cuvette of an analytical rotor; determining whether a reaction chemistry in a cuvette has reached an end point; checking the noise level and non-linearity of a reaction rate in a cuvette; determining whether an adequate amount of diluent was delivered to the cuvettes of an analytical rotor; determining dilution systematic failure when measuring different reaction chemistries in the cuvettes of the rotor; determining whether a blood sample in a cuvette is hemolyzed, lipemic, or icteric; determining the degradation of a reagent in a cuvette; determining proper light source and light detector operation; and determining proper motor function and cuvette mark detection.

    摘要翻译： 本发明提供了用于检测血液分析系统中的错误的各种方法。 该系统包括血液分析仪和具有一系列腔室和毛细通道的模制塑料转子，通过血液分析器和毛细管通道将血液加工并分配到含有冻干试剂的比色皿。 将转子放置在旋转转子的分析仪中，当光通过反应杯闪烁时，光学系统读取比色皿。 本发明提供了以下检查：在将样品施加到比色杯之前，确认试剂在试管中的存在; 确定流体样品是否已经被适当地分配到转子的比色杯中; 确定足够量的流体样品是否被施加到分析转子; 确定流体样品是否已经被适当地分配到分析转子的比色杯中; 确定比色皿中的反应化学物质是否达到终点; 检查反应杯中的反应速率的噪声水平和非线性; 确定足够量的稀释剂是否被输送到分析转子的比色杯中; 测量转子的比色杯中的不同反应化学物质时的稀释系统失效; 确定比色皿中的血液样品是否溶血，脂肪或黄疸; 确定试剂在试管中的降解; 确定适当的光源和光检测器的操作; 并确定适当的运动功能和比色皿标记检测。

    DEVICES AND METHODS FOR DIAGNOSING, PROGNOSING, OR THERANOSING A CONDITION BY ENRICHING RARE CELLS
    59.
    发明申请
    DEVICES AND METHODS FOR DIAGNOSING, PROGNOSING, OR THERANOSING A CONDITION BY ENRICHING RARE CELLS 审中-公开
    用于通过增加稀有细胞来诊断，预处理或治疗条件的装置和方法

    公开(公告)号：US20140017776A1

    公开(公告)日：2014-01-16

    申请号：US13906206

    申请日：2013-05-30

    申请人： Anne R. Kopf-Sill

    发明人： Anne R. Kopf-Sill

    IPC分类号： G01N1/31

    CPC分类号： G01N33/57488 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/156 ,  G01N1/31 ,  G01N33/5091 ,  G01N33/57484 ,  G01N33/57492 ,  G01N2333/705 ,  G01N2333/71 ,  G01N2333/912 ,  G01N2333/96433

    摘要： The invention encompasses methods and devices for diagnosing, theranosing, or prognosing a condition in a patient by enriching a sample in rare cells. The devices can be a microfluidic device comprising an array of obstacles and one or more binding moieties. The devices and methods can allow for enrichment of cells based on size and affinity, recovery of cells in locations on the microfluidic device, release of cells from the microfluidic device, flow of sample through the microfluidic device, and retention of rare cells from a sample obtained from a patient having a condition.

    摘要翻译： 本发明包括通过在罕见细胞中富集样品来诊断，鉴别或预测病人状况的方法和装置。 装置可以是包含障碍物阵列和一个或多个结合部分的微流体装置。 装置和方法可以允许基于大小和亲和力富集细胞，在微流体装置上的位置回收细胞，从微流体装置释放细胞，通过微流体装置的样品流，以及从样品中保留稀有细胞 从具有病症的患者获得。