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公开(公告)号:US20200294781A1
公开(公告)日:2020-09-17
申请号:US16809171
申请日:2020-03-04
Applicant: Purdue Research Foundation
Inventor: Robert Graham Cooks , Ahmed Mohamed Hamid , Alan Keith Jarmusch , Zheng Ouyang
Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
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公开(公告)号:US20200121229A1
公开(公告)日:2020-04-23
申请号:US16720991
申请日:2019-12-19
Applicant: Purdue Research Foundation
Inventor: Robert Graham Cooks , Zheng Ouyang , Chien-hsun Chen , Ziqing Lin , Livia Schiavinato Eberlin
IPC: A61B5/1477 , G01N33/483 , H01J49/34 , H01J49/16 , H01J49/04 , H01J49/00 , A61M25/00 , A61M11/00 , A61B10/00
Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
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公开(公告)号:US10555694B2
公开(公告)日:2020-02-11
申请号:US16539562
申请日:2019-08-13
Applicant: Purdue Research Foundation
Inventor: Robert Graham Cooks , Zheng Ouyang , Chien-hsun Chen , Ziqing Lin , Livia Schiavinato Eberlin
IPC: H01J49/00 , A61B5/1477 , H01J49/34 , H01J49/16 , H01J49/04 , A61M25/00 , A61M11/00 , A61B10/00 , G01N33/483 , A61B5/145 , A61B5/15 , G01N1/02 , A61B5/157
Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
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54.
公开(公告)号:US20190277735A1
公开(公告)日:2019-09-12
申请号:US16302379
申请日:2017-06-02
Applicant: Purdue Research Foundation
Inventor: Zheng Ouyang , Wenpeng Zhang
Abstract: Systems and methods for analyzing an analyte extracted from a sample using an adsorbent material.
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公开(公告)号:US20180286651A1
公开(公告)日:2018-10-04
申请号:US15988698
申请日:2018-05-24
Applicant: Purdue Research Foundation
Inventor: Zheng Ouyang , Robert Graham Cooks , Sandilya Venkata Garimella , Jason David Harper , Nicholas Alan Charipar
CPC classification number: H01J49/0404 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0409 , H01J49/0422 , H01J49/0459 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/4215
Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
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公开(公告)号:US09960028B2
公开(公告)日:2018-05-01
申请号:US15318846
申请日:2015-06-16
Applicant: Purdue Research Foundation
Inventor: Zheng Ouyang , Xiao Wang , Xiaoyu Zhou
CPC classification number: H01J49/04 , H01J49/0013 , H01J49/0468 , H01J49/24
Abstract: The invention generally relates to systems and methods for analyzing a sample from a surface. In certain aspects, the invention provides systems that include a sample introduction member that has an inlet, an outlet, and an opening along a wall of the sample introduction member. The sample introduction member may be configured such that the opening couples with a surface that includes a sample in a manner in which molecules of the sample enter the sample introduction member via the opening and exit the sample introduction member via the outlet. A mass spectrometer is configured to receive the molecules of the sample.
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公开(公告)号:US20170140912A1
公开(公告)日:2017-05-18
申请号:US15318846
申请日:2015-06-16
Applicant: Purdue Research Foundation
Inventor: Zheng Ouyang , Xiao Wang , Xiaoyu Zhou
CPC classification number: H01J49/04 , H01J49/0013 , H01J49/0468 , H01J49/24
Abstract: The invention generally relates to systems and methods for analyzing a sample from a surface. In certain aspects, the invention provides systems that include a sample introduction member that has an inlet, an outlet, and an opening along a wall of the sample introduction member. The sample introduction member may be configured such that the opening couples with a surface that includes a sample in a manner in which molecules of the sample enter the sample introduction member via the opening and exit the sample introduction member via the outlet. A mass spectrometer is configured to receive the molecules of the sample.
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58.
公开(公告)号:US20160181077A1
公开(公告)日:2016-06-23
申请号:US14909269
申请日:2014-08-06
Applicant: Purdue Research Foundation
Inventor: Zheng Ouyang , Linfan Li , Xiaoyu Zhou
CPC classification number: H01J49/0031 , H01J49/0013 , H01J49/004 , H01J49/0422
Abstract: The invention generally relates to sample analysis with a miniature mass spectrometer. In certain embodiments, the invention provides methods that involve generating ions of a first analyte and ions of a second analyte. Those ions are transferred through a discontinuous sample introduction interface into a first ion trap of a mass spectrometer in a manner in which the discontinuous sample introduction interface remains open during the transferring. The discontinuous sample introduction interface is closed and the ions are sequentially transferred to a second ion trap of the mass spectrometer where they are sequentially analyzed.
Abstract translation: 本发明一般涉及使用微型质谱仪的样品分析。 在某些实施方案中,本发明提供涉及产生第一分析物的离子和第二分析物的离子的方法。 这些离子以不连续的样品引入界面在转移期间保持打开的方式通过不连续的样品引入界面转移到质谱仪的第一离子阱中。 关闭不连续的样品引入界面,并将离子顺序地转移到质谱仪的第二离子阱上,在其中依次分析它们。
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公开(公告)号:US09165752B2
公开(公告)日:2015-10-20
申请号:US14566838
申请日:2014-12-11
Applicant: Purdue Research Foundation
Inventor: Robert Graham Cooks , Guangtao Li , Xin Li , Zheng Ouyang
CPC classification number: H01J49/0459 , G01N33/28 , H01J49/0031 , H01J49/0431 , H01J49/06 , H01J49/42 , Y10T436/214 , Y10T436/24 , Y10T436/25875
Abstract: The invention generally relates to systems and methods for sample analysis. In certain embodiments, the invention provides a system for analyzing a sample that includes a probe including a material connected to a high voltage source, a device for generating a heated gas, and a mass analyzer.
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公开(公告)号:US09129786B2
公开(公告)日:2015-09-08
申请号:US14305489
申请日:2014-06-16
Applicant: Purdue Research Foundation
Inventor: Zheng Ouyang , Tsung-Chi Chen
CPC classification number: H01J49/0422 , H01J49/0013 , H01J49/0495 , H01J49/10 , H01J49/168 , H01J49/24 , H01J49/26
Abstract: The invention generally relates to systems and methods for sample analysis. In certain embodiments, the invention provides systems for analyzing a sample that include an electric source, a vacuum chamber including a conducting member, in which the conducting member is coupled to the electric source, a sample introduction member coupled to the vacuum chamber, and a mass analyzer. The system is configured such that a distal end of the sample introduction member resides within the vacuum chamber and proximate the conducting member, such that an electrical discharge may be produced between the sample introduction member and the conducting member. A neutral gas that has been introduced into the vacuum chamber interacts with the generated discharge, producing ions within the vacuum chamber that are subsequently transferred into the mass analyzer in the vacuum chamber.
Abstract translation: 本发明一般涉及用于样品分析的系统和方法。 在某些实施例中,本发明提供了用于分析包括电源的样品,包括导电构件的真空室的系统,其中导电构件耦合到电源,耦合到真空室的样品引入构件和 质量分析仪 该系统构造成使得样品引入构件的远端位于真空室内并且靠近导电构件,使得可以在样品引入构件和导电构件之间产生放电。 已经引入真空室的中性气体与产生的排放物相互作用,在真空室内产生离子,随后将其转移到真空室中的质量分析器中。
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