公开(公告)号：US20200239920A1

公开(公告)日：2020-07-30

申请号：US16774075

申请日：2020-01-28

申请人： AJINOMOTO CO., INC.

发明人： Hiromi Noguchi ,  Yo Nishiyama ,  Yoshihiro Ito

IPC分类号： C12P13/14 ,  C12N15/74 ,  C07K14/265

摘要： A method for producing an L-amino acid such as L-glutamic acid is provided. An L-amino acid is produced by culturing in a medium a bacterium having an L-amino acid-producing ability, which has been modified so that the activity of a c1795 protein is reduced or the activity of a protein of which the expression is repressed by a c1795 protein is increased, and collecting the L-amino acid from the medium or cells of the bacterium.

公开(公告)号：US10711088B2

公开(公告)日：2020-07-14

申请号：US16295077

申请日：2019-03-07

申请人： AJINOMOTO CO., INC.

发明人： Kota Torii

IPC分类号： C08F18/00 ,  C08F20/00 ,  C08F2/00 ,  C08G61/04 ,  C08G59/24 ,  C08K3/013 ,  C08L63/00 ,  C08L61/06 ,  C08L79/04 ,  C08L79/02 ,  C08G65/18 ,  C08L71/02 ,  C08G59/30 ,  H05K1/03 ,  C08L67/02 ,  C08G59/62 ,  C08G59/42 ,  C08G59/68

摘要： Provided is a resin composition that can provide a cured product of low dielectric tangent, high mechanical strength, and high adhesiveness. The resin composition contains (A) a resin having a thermosetting functional group FA, (B) a resin having a radical polymerizable functional group FB, and (C) a resin having a functional group FA′ reacting with the thermosetting functional group FA and a functional group FB′ reacting with the radical polymerizable functional group FB. A number na of the functional group FA′ of the component (C) when the number of the thermosetting functional group FA of the component (A) is defined as 1 and a number nb of the functional group FB′ of the component (C) when the number of the radical polymerizable functional group FB of the component (B) is defined as 1 satisfy 0.01≤na≤200 and 0.01≤nb≤400, respectively.

公开(公告)号：US10695276B2

公开(公告)日：2020-06-30

申请号：US14538113

申请日：2014-11-11

申请人： AJINOMOTO CO., INC.

发明人： Rina Yumioka

IPC分类号： A61K8/44 ,  A61K8/34 ,  A61Q19/00 ,  A61Q19/10

摘要： The present invention aims to provide a production method of a composition containing (A) glycerol and (B) glycine, which includes using glycerol substantially free of dihydroxyacetone or having a dihydroxyacetone content of not more than 150 ppm. According to the present invention, a composition, particularly a cosmetic composition, having a moist feeling but free of stickiness and showing suppressed coloration can be provided.

公开(公告)号：US20200181588A1

公开(公告)日：2020-06-11

申请号：US16795991

申请日：2020-02-20

申请人： AJINOMOTO CO., INC.

发明人： Chihiro Tsuji ,  Tomoko Shimizu ,  Uno Tagami ,  Yasuhiro Mihara ,  Masayuki Sugiki ,  Shogo Nakano ,  Tomoharu Motoyama ,  Sohei Ito

IPC分类号： C12N9/10 ,  C12P19/26 ,  C08B37/00

摘要： The present invention provides a 2-OST mutant exhibiting a high activity. Specifically, the present invention provides a 2-O-sulfation enzyme mutant, having a substitution of a leucine residue at position 321 with a basic amino acid residue in any one amino acid sequence of: (a) the amino acid sequence of SEQ ID NO: 2; (b) an amino acid sequence comprising one or several amino acid substitutions, deletions, insertions, or additions in the amino acid sequence of SEQ ID NO: 2; (c) an amino acid sequence having 90% or more identity to the amino acid sequence of SEQ ID NO: 2; (d) the amino acid sequence consisting of amino acid residues at positions 69 to 356 in the amino acid sequence of SEQ ID NO: 2; (e) an amino acid sequence comprising one or several amino acid substitutions, deletions, insertions, or additions in the amino acid sequence consisting of amino acid residues at positions 69 to 356 in the amino acid sequence of SEQ ID NO: 2; (f) an amino acid sequence having 90% or more identity to the amino acid sequence consisting of amino acid residues at positions 69 to 356 in the amino acid sequence of SEQ ID NO: 2; and having a 2-O-sulfate transfer activity.

公开(公告)号：US10662411B2

公开(公告)日：2020-05-26

申请号：US16242463

申请日：2019-01-08

申请人： AJINOMOTO CO., INC.

发明人： Sho Senda ,  Tomomi Yoshida ,  Satoru Okamoto ,  Yoko Kuriyama ,  Manabu Kitazawa ,  Ikue Harata ,  Nao Sugimoto

IPC分类号： C12N5/00 ,  C12N5/02 ,  C12N5/074 ,  C12N5/0735

摘要： Cultivating a pluripotent stem cell in a medium comprising at least one member selected from the group consisting of ethanolamine, an ethanolamine analog, and a pharmaceutically acceptable salt thereof, and which is substantially free of β-mercaptoethanol or contains β-mercaptoethanol at a concentration of not more than 9 μM, and the like, is effective for the proliferation of a pluripotent stem cell while maintaining an undifferentiated state.

公开(公告)号：US10538798B2

公开(公告)日：2020-01-21

申请号：US15790495

申请日：2017-10-23

申请人： AJINOMOTO CO., INC.

发明人： Yoshihiko Matsuda ,  Yumi Ito ,  Yukari Kashima ,  Naoko Yamada ,  Noriko Tsurui ,  Hiroshi Itaya

IPC分类号： C12P21/00 ,  C07K14/34 ,  C12N9/12

摘要： A novel technique for improving secretory production of a heterologous protein by coryneform bacteria is described, as well as a method for secretory production of a heterologous protein. A coryneform bacterium is described that has been modified to have a specific mutation so as to harbor a phoS gene, and when cultured, is able to to produce a heterologous protein by secretory production.

公开(公告)号：US10537128B2

公开(公告)日：2020-01-21

申请号：US15352928

申请日：2016-11-16

申请人： AJINOMOTO CO., INC.

发明人： Hiroaki Nishiuchi ,  Misato Morita ,  Wataru Hoshino ,  Junko Yamazaki ,  Takayuki Ito ,  Kazuo Yamagishi

IPC分类号： C12P13/14 ,  A23L31/15 ,  A23L27/22 ,  A23L27/24 ,  C12P13/04 ,  A23L33/145 ,  A23L5/00

摘要： A yeast extract containing 0.2% or more of γ-Glu-Abu based on dry weight of the yeast extract is produced by culturing a yeast, such as Saccharomyces cervisiae or Candida utilis, in a medium containing a compound selected from Abu (L-2-aminobutyric acid) and γ-Glu-Abu (L-γ-glutamyl-L-2-aminobutyric acid), and preparing a yeast extract from the obtained cells.

公开(公告)号：US20200009167A1

公开(公告)日：2020-01-09

申请号：US16579191

申请日：2019-09-23

申请人： AJINOMOTO CO., INC.

发明人： Keishi Kameyama ,  Momoka Tsuneyoshi

IPC分类号： A61K31/702 ,  A61K31/4172 ,  A61K31/401 ,  A61K31/198 ,  A61K31/195 ,  A61K9/00 ,  A61K9/48 ,  A23K20/142 ,  A23K20/163 ,  A23K50/30 ,  A23K50/60

摘要： A feed composition for improving intestinal environment by promoting proliferation of intestinal bifidobacteria is described herein. The feed composition for improving intestinal environment can contain a combination of (1) an enteric composition containing an amino acid or a salt thereof, and (2) an indigestible polysaccharide or a composition containing an indigestible polysaccharide.

公开(公告)号：US20200002697A1

公开(公告)日：2020-01-02

申请号：US16566236

申请日：2019-09-10

申请人： AJINOMOTO CO., INC.

发明人： Hiroki Yamaguchi ,  Masayuki Sugiki ,  Kunio Nakata

IPC分类号： C12N9/88 ,  C12N15/70 ,  C12Q1/527

摘要： The present invention provides a mutated histidine decarboxylase suitable for a practical use. Specifically, the present invention provides a mutated histidine decarboxylase having at least one amino acid residue mutated as compared to a wild-type histidine decarboxylase, and having higher histidine decarboxylase activity and/or stability than the wild-type histidine decarboxylase, and also a use thereof. The mutated histidine decarboxylase has Motifs (1) to (6), and an amino acid residue in at least one motif thereof can be mutated. The mutated histidine decarboxylase can also have a mutation of at least one amino acid residue in an amino acid sequence designated by SEQ ID NO: 3 and in a homologous sequence thereto.

公开(公告)号：US10450407B2

公开(公告)日：2019-10-22

申请号：US15349491

申请日：2016-11-11

申请人： AJINOMOTO CO., INC.

发明人： Takayuki Tanaka ,  Eriko Satou ,  Yuji Koshima ,  Junji Ohashi

IPC分类号： C08G59/50 ,  C09J163/00 ,  C08K5/14 ,  H01B1/22 ,  C09K5/14

摘要： An object of the present invention is to provide curing agent composite particles for epoxy resin, which are less likely to aggregate, and are excellent in storage stability and solvent resistance. Coated particles of the present invention comprise (A) curing agent particles for epoxy resin, and (B) an alkoxy oligomer, wherein the surfaces of the curing agents for epoxy resin particle are coated with the alkoxy oligomer.