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    Methods for fabricating micro-devices
    53.
    发明授权
    Methods for fabricating micro-devices 有权
    制造微器件的方法

    公开(公告)号：US09487394B2

    公开(公告)日：2016-11-08

    申请号：US14292396

    申请日：2014-05-30

    Applicant: ANPAC BIO-MEDICAL SCIENCE CO., LTD.

    Inventor： Chris Yu

    IPC: B81C1/00 ,  A61M37/00 ,  B01L3/00 ,  B82Y5/00

    CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053 ,  B01L3/502707 ,  B81B7/008 ,  B81B2201/058 ,  B81B2201/06 ,  B81C1/00119 ,  B81C1/00246 ,  B81C1/00341 ,  B82Y5/00 ,  Y10T29/49124

    Abstract: The present invention provides methods utilizing current nano-technological processes for fabricating a range of micro-devices with significantly expanded capabilities, unique functionalities at microscopic levels, enhanced degree of flexibilities, reduced costs and improved performance in the fields of bioscience and medicine. Such fabricated micro-devices have significant improvements in many areas over the existing, conventional methods, which include, but are not limited to reduced overall costs, early disease detection, targeted drug delivery, targeted disease treatment and reduced degree of invasiveness in treatment. Compared with existing, conventional approaches, the said inventive approach disclosed in this patent application is much more microscopic, sensitive, accurate, precise, flexible and effective.

    Abstract translation: 本发明提供了利用当前纳米技术方法制造具有显着扩展的能力的微量器件的范围，在微观水平上的独特功能，增强的柔性程度，降低的成本以及在生物科学和医学领域中改进的性能的方法。 这种制造的微器件在现有的常规方法中在许多领域具有显着的改进，其包括但不限于降低总体成本，早期疾病检测，靶向药物递送，靶向疾病治疗和降低的治疗侵袭程度。 与现有的常规方法相比，本专利申请中公开的所述发明方法更微观，灵敏，准确，精确，灵活和有效。

    Method for functionalising fluid lines contained in a micromechanical device, micromechanical device including functionalised lines, and method for manufacturing same
    54.
    发明授权
    Method for functionalising fluid lines contained in a micromechanical device, micromechanical device including functionalised lines, and method for manufacturing same 有权
    包含在微机械装置中的流体线的功能化方法，包括功能化线的微机械装置及其制造方法

    公开(公告)号：US08968673B2

    公开(公告)日：2015-03-03

    申请号：US13805491

    申请日：2011-06-29

    Applicant: Vincent Agache ,  Antoine Hoang ,  Françoise Vinet

    Inventor： Vincent Agache ,  Antoine Hoang ,  Françoise Vinet

    IPC: G01N33/00 ,  G03F7/24 ,  B81C1/00 ,  F04B19/00

    CPC classification number: G03F7/24 ,  B81B2201/0214 ,  B81B2201/058 ,  B81B2201/06 ,  B81C1/00206 ,  B81C2201/0154 ,  F04B19/006

    Abstract: The present invention relates to a method for functionalizing fluid lines (1b) in a micromechanical device, the walls of which include an opaque layer. For this purpose, the invention provides a method for functionalizing a micromechanical device provided with a fluid line including a peripheral wall (5) having a surface (2) outside the line and an inner surface (3) defining a space (1b) in which a fluid can circulate, the peripheral wall at least partially including a silicon layer (5a). The method includes the following steps: a) providing a device, the peripheral wall (5) of which at least partially includes a silicon layer (5a) having, at least locally, a thickness (e) of more than 100 nm and less than 200 nm, advantageously of 160 to 180 nm; c) silanizing at least the inner surface of the fluid line; d) the localized, selective photo-deprotection on at least the inner surface of the silanized device by exposing the peripheral wall (5) at the point at which said wall has a thickness (e) of more than 100 nm and less than 200 nm, advantageously of 160 to 180 nm.

    Abstract translation: 本发明涉及一种在微机械装置中功能化流体管线（1b）的方法，该方法的壁包括不透明层。 为此，本发明提供了一种功能化微机械装置的方法，该微机械装置具有流体管线，该流体管线包括在管线外部具有表面（2）的周壁（5）和限定空间（1b）的内表面（3） 流体可以循环，周壁至少部分地包括硅层（5a）。 该方法包括以下步骤：a）提供一种器件，其外围壁（5）至少部分地包括硅层（5a），该硅层至少局部地具有大于100nm的厚度（e）并且小于 200nm，有利地为160〜180nm; c）至少使流体管线的内表面硅烷化; d）通过在所述壁的厚度（e）大于100nm且小于200nm的点处暴露外围壁（5），至少在硅烷化装置的内表面上进行局部选择性光 - 去保护 ，有利地为160至180nm。

    Method for the manufacture of articles of thiol-ene polymers
    55.
    发明授权
    Method for the manufacture of articles of thiol-ene polymers 有权
    硫醇聚合物制品的制造方法

    公开(公告)号：US08927664B2

    公开(公告)日：2015-01-06

    申请号：US13876583

    申请日：2011-10-03

    Applicant: Carl Fredrik Carlborg ,  Tommy Haraldsson ,  Kim Öberg ,  Michael Malkoch

    Inventor： Carl Fredrik Carlborg ,  Tommy Haraldsson ,  Kim Öberg ,  Michael Malkoch

    IPC: C08G75/04 ,  C08G77/392 ,  B81C3/00 ,  C09D181/02

    CPC classification number: C08G77/392 ,  B81B2201/058 ,  B81B2201/06 ,  B81C3/001 ,  C08G75/045 ,  C08G75/12 ,  C09D181/02

    Abstract: A method for the manufacture of articles of thiol-ene polymers comprises the steps: a) reacting a compound comprising at least two thiol groups and a compound comprising at least two carbon-carbon double bonds, in off stochiometry ratios to obtain a first intermediate article, wherein said first intermediate article comprises at least one unreacted group selected from an unreacted thiol group and an unreacted carbon-carbon double bond, and b) contacting said first intermediate article with a second article, wherein the surface of said second article at least partially comprises reactive groups and reacting at least a part of said unreacted groups on said first intermediate article with chemical groups on said second article to obtain covalent bonds and forming a final article.

    Abstract translation: 一种用于制备硫醇 - 烯聚合物制品的方法包括以下步骤：a）以脱硫方法比例使包含至少两个硫醇基团的化合物和包含至少两个碳 - 碳双键的化合物反应，以获得第一中间制品 其中所述第一中间制品包含至少一种选自未反应的硫醇基团和未反应的碳 - 碳双键的未反应基团，和b）使所述第一中间制品与第二制品接触，其中所述第二制品的表面至少部分地 包括反应性基团并使所述第一中间体上的所述未反应基团的至少一部分与所述第二制品上的化学基团反应，以获得共价键并形成最终制品。

    METHOD FOR THE MANUFACTURE OF ARTICLES OF THIOL-ENE POLYMERS
    56.
    发明申请
    METHOD FOR THE MANUFACTURE OF ARTICLES OF THIOL-ENE POLYMERS 有权
    制备THIOL-ENE聚合物制品的方法

    公开(公告)号：US20130331528A1

    公开(公告)日：2013-12-12

    申请号：US13876583

    申请日：2011-10-03

    Applicant: Carl Fredrik Carlborg ,  Tommy Haraldsson ,  Kim Öberg ,  Michael Malkoch

    Inventor： Carl Fredrik Carlborg ,  Tommy Haraldsson ,  Kim Öberg ,  Michael Malkoch

    IPC: C08G75/04 ,  C08G77/392

    CPC classification number: C08G77/392 ,  B81B2201/058 ,  B81B2201/06 ,  B81C3/001 ,  C08G75/045 ,  C08G75/12 ,  C09D181/02

    Abstract: A method for the manufacture of articles of thiol-ene polymers comprises the steps: a) reacting a compound comprising at least two thiol groups and a compound comprising at least two carbon-carbon double bonds, in off stochiometry ratios to obtain a first intermediate article, wherein said first intermediate article comprises at least one unreacted group selected from an unreacted thiol group and an unreacted carbon-carbon double bond, and b) contacting said first intermediate article with a second article, wherein the surface of said second article at least partially comprises reactive groups and reacting at least a part of said unreacted groups on said first intermediate article with chemical groups on said second article to obtain covalent bonds and forming a final article.

    Abstract translation: 一种用于制备硫醇 - 烯聚合物制品的方法包括以下步骤：a）以脱硫方法比例使包含至少两个硫醇基团的化合物和包含至少两个碳 - 碳双键的化合物反应，以获得第一中间制品 其中所述第一中间制品包含至少一种选自未反应的硫醇基团和未反应的碳 - 碳双键的未反应基团，和b）使所述第一中间制品与第二制品接触，其中所述第二制品的表面至少部分地 包括反应性基团并使所述第一中间体上的所述未反应基团的至少一部分与所述第二制品上的化学基团反应，以获得共价键并形成最终制品。

    SELF-FOLDING SUB-CENTIMETER STRUCTURES
    58.
    发明申请
    SELF-FOLDING SUB-CENTIMETER STRUCTURES 审中-公开
    自折式分中心结构

    公开(公告)号：US20130045530A1

    公开(公告)日：2013-02-21

    申请号：US13643944

    申请日：2011-04-27

    Applicant: David H. Gracias ,  Anum Azam

    Inventor： David H. Gracias ,  Anum Azam

    IPC: B32B1/02 ,  B32B3/02 ,  F16B4/00 ,  C12M3/00

    CPC classification number: B81C1/00007 ,  B81B2201/06 ,  B81B2203/0315 ,  Y10T403/74 ,  Y10T428/1397 ,  Y10T428/19

    Abstract: A sub-centimeter structure includes a first structural component, a second structural component arranged proximate the first structural component, and a joint connecting the first and second structural components. The joint includes a material that has a first phase that is substantially rigid to hold the first and second structural components in a substantially rigid configuration while the material is in the first phase. The material of the joint has a second phase such that the joint is at least partially fluid to allow the first and second structural components to move relative to each other while the material is in the second phase. The joint interacts with the first and second structural components while the material is in the second phase to cause the first and second structural components to move relative to each other. And, the first and second structural components include a polymer.

    Abstract translation: 亚厘米结构包括第一结构部件，靠近第一结构部件布置的第二结构部件和连接第一和第二结构部件的接头。 接头包括具有第一相的材料，该第一相基本上是刚性的，以在材料处于第一相位时将第一和第二结构部件保持在基本上刚性的构型。 接头的材料具有第二相，使得接头至少部分地是流体的，以允许第一和第二结构部件相对于彼此移动，同时材料处于第二阶段。 接头与第一和第二结构部件相互作用，同时材料处于第二阶段，以使第一和第二结构部件相对于彼此移动。 而且，第一和第二结构组分包括聚合物。

    Method for the production of structured layers of titanium and nickel
    59.
    发明授权
    Method for the production of structured layers of titanium and nickel 失效
    用于生产钛和镍结构层的方法

    公开(公告)号：US08338311B2

    公开(公告)日：2012-12-25

    申请号：US12306646

    申请日：2007-06-27

    Applicant: Eckhard Quandt ,  Clemens Schmutz ,  Christiane Zamponi

    Inventor： Eckhard Quandt ,  Clemens Schmutz ,  Christiane Zamponi

    IPC: H01L21/302

    CPC classification number: C23C14/0005 ,  A61L27/06 ,  A61L31/022 ,  B81B2201/06 ,  B81C99/008 ,  Y10T428/24917

    Abstract: A method for the production of a structured metal layer (7) made from an alloy composed of titanium and nickel includes the following process steps: a sacrificial layer composite (3) is provided, which comprises a second sacrificial layer (2) applied onto a first sacrificial layer (1), the first sacrificial layer (1) is subjected for the purpose of structuring to a wet-chemical etching process in such a manner that undercutting of the sacrificial layer (1) occurs, a metal layer (7) of the alloy is applied indirectly or directly to the structured sacrificial layer composite (3). The first sacrificial layer (1) is at a greater distance from the metal layer (7). The second sacrificial layer (2) facing the metal layer (7) to be deposited is subjected to a dry etching process prior to wet-chemical etching of the first sacrificial layer (1) so that the second sacrificial layer (2) is provided with a structure that corresponds to the desired structure of the metal layer (7). The invention further relates to an object, particularly a stent or an implant, which comprises at least one metal layer (7) that is produced by applying the method for the production of the structured metal layer (7).

    Abstract translation: 制造由钛和镍组成的合金制成的结构金属层（7）的方法包括以下工艺步骤：提供牺牲层复合材料（3），该牺牲层复合材料（3）包括第二牺牲层（2） 第一牺牲层（1），第一牺牲层（1）的目的是以如下方式进行湿法化学蚀刻工艺的构造：使牺牲层（1）发生底切，金属层（7） 该合金间接或直接施加到结构化牺牲层复合材料（3）上。 第一牺牲层（1）距离金属层（7）更大的距离。 在第一牺牲层（1）的湿化学蚀刻之前​​，面对要沉积的金属层（7）的第二牺牲层（2）进行干蚀刻处理，使得第二牺牲层（2）设置有 对应于金属层（7）的所需结构的结构。 本发明还涉及一种物体，特别是支架或植入物，其包括通过施加用于生产结构化金属层（7）的方法而产生的至少一个金属层（7）。

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