公开(公告)号：US09909984B2

公开(公告)日：2018-03-06

申请号：US15019974

申请日：2016-02-10

Applicant: Tian Yang

Inventor： Tian Yang ,  Xiaolong He

IPC: G01N21/49 ,  G02B6/28 ,  G01N33/487 ,  G02B6/26 ,  G01N33/497

CPC classification number: G01N21/49 ,  G01N21/554 ,  G01N21/7703 ,  G01N33/487 ,  G01N33/497 ,  G01N2021/7773 ,  G01N2201/06113 ,  G01N2201/0621 ,  G01N2201/0683 ,  G01N2201/0846 ,  G02B6/262 ,  G02B6/2808 ,  G02B6/354 ,  G02B6/3624

Abstract: The present invention provides a multichannel label-free biosensing fiber-optic system, which comprises one or more light sources coupled into optical fibers, one or more optical fiber circuits for performing coupling or/and directional transmission of optical-fiber guided lightwaves, one or more optical-fiber-input and optical-fiber-output optical switches, a plurality of optical fibers provided with label-free optical sensing elements working in the reflection manner on the optical fiber ends, and the light detection parts, wherein the optical-fiber-input and optical-fiber-output optical switch is provided with a plurality of outputs and/or a plurality of inputs, and with the plurality of outputs and/or plurality of inputs, by the switching function, the reflected light from the label-free optical sensing elements working in the reflection manner on the designated optical fiber ends is received by the light detection part, so that multichannel sensing is realized.

公开(公告)号：US09903861B2

公开(公告)日：2018-02-27

申请号：US14894452

申请日：2014-05-30

Applicant: OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION

Inventor： Takuya Iida ,  Shiho Tokonami

IPC: G01N21/21 ,  G01N33/543 ,  G01N21/552 ,  G01N21/65 ,  G01N33/53 ,  G01N33/553 ,  C12Q1/68

CPC classification number: G01N33/54346 ,  C12Q1/6834 ,  C12Q2563/155 ,  C12Q2565/628 ,  G01N21/21 ,  G01N21/554 ,  G01N21/658 ,  G01N33/5308 ,  G01N33/553 ,  G01N2201/061 ,  G01N2201/0683

Abstract: A detection device detects an analyte that may be contained in a specimen. The detection device includes a plurality of gold nanoparticles, an optical trapping light source, an illumination light source, an objective lens, an image pick-up device, and a computation unit. The plurality of gold nanoparticles are each modified with a probe DNA allowing the analyte to specifically adhere thereto. The optical trapping light source emits polarized light for assembling the plurality of gold nanoparticles together. The objective lens focuses and introduces the polarized light into a liquid containing a specimen and the plurality of gold nanoparticles. The image pick-up device receives light from the liquid. The computation unit detects an analyte based on a signal received from the image pick-up device.

公开(公告)号：US09897543B2

公开(公告)日：2018-02-20

申请号：US14364574

申请日：2012-08-06

Applicant: Anjan Kr. Dasgupta ,  Sarita Roy

Inventor： Anjan Kr. Dasgupta ,  Sarita Roy

IPC: G01N21/21 ,  G01N21/64 ,  G01N33/15 ,  G01N33/58 ,  B01D59/00 ,  G01N15/14 ,  G01N15/00

CPC classification number: G01N21/64 ,  B01D59/00 ,  G01N15/1459 ,  G01N21/21 ,  G01N21/6445 ,  G01N21/6486 ,  G01N33/15 ,  G01N33/582 ,  G01N2015/0038 ,  G01N2015/149 ,  G01N2201/0683

Abstract: A technique for determining whether or not a fluorescent material exhibits a directionally dependent property, such as anisotropy or chirality, involves illuminating the particle at its excitation wavelength to stimulate fluorescent emission at both a full-frequency (fundamental) wavelength and a half-frequency wavelength. The ratio of the full-frequency signal strength to the half-frequency signal strength provides an indication of the sample's directionally dependent property. This half-frequency spectral analysis can be used to sort anisotropic particles suspended in fluid flowing through a flow cytometer. For instance, the present technique may be used to separate racemic mixtures of chiral enantiomers of cells, pharmaceutical compounds, and other samples.

公开(公告)号：US09810633B2

公开(公告)日：2017-11-07

申请号：US15047563

申请日：2016-02-18

Applicant: Seagate Technology LLC

Inventor： Joachim Walter Ahner ,  David M. Tung ,  Samuel Kah Hean Wong ,  Henry Luis Lott ,  Stephen Keith McLaurin ,  Maissarath Nassirou ,  Florin Zavaliche

IPC: G01N21/64 ,  G01N21/88 ,  G01N21/95 ,  G01N21/63 ,  G01N21/47 ,  G01N21/94

CPC classification number: G01N21/6456 ,  G01N21/47 ,  G01N21/63 ,  G01N21/64 ,  G01N21/8851 ,  G01N21/94 ,  G01N21/95 ,  G01N21/9501 ,  G01N21/9506 ,  G01N2021/8864 ,  G01N2201/06153 ,  G01N2201/0683

Abstract: Provided herein is an apparatus, including a photon emitter configured to emit photons onto a surface of an article, a photon detector array configured to receive photons from surface features of the article; and a processing means configured for processing photon-detector-array signals corresponding to photons scattered from the surface features and photons fluoresced from the surface features, wherein the processing means is further configured for classifying the surface features of the article.

公开(公告)号：US09778245B2

公开(公告)日：2017-10-03

申请号：US15425729

申请日：2017-02-06

Applicant: Case Western Reserve University

Inventor： Brian T. Grimberg ,  Robert Deissler ,  William Condit ,  Robert Brown ,  Jason Jones ,  Richard Bihary

IPC: G01N33/48 ,  G01N33/49

CPC classification number: G01N33/48 ,  G01N1/28 ,  G01N21/21 ,  G01N21/59 ,  G01N33/49 ,  G01N2201/06113 ,  G01N2201/0683

Abstract: A diagnostic device is provided that comprises a light source for transmitting a light beam through a blood sample to a light detector, and a permanent magnet, wherein one of the permanent magnet and blood sample is automatically movable relative to the other between a “HIGH” magnetic state position and a “LOW” magnetic state position, such that a substantially high magnetic field is applied to the blood sample causing any hemozoin in the blood sample to tend toward perpendicular orientation to the substantially magnetic field and the suppression, or enhancement of light based on its polarization, and a zero-to-near-zero magnetic field is applied to the blood sample causing the randomization of any hemozoin in the blood sample and a baseline amount of light to pass through the blood sample in the “LOW” magnetic state position.

公开(公告)号：US20170276613A1

公开(公告)日：2017-09-28

申请号：US15468608

申请日：2017-03-24

Applicant: KLA-Tencor Corporation

Inventor： Sheng Liu ,  Guoheng Zhao

IPC: G01N21/88 ,  G01N21/95 ,  G01N21/21

CPC classification number: G01N21/8806 ,  G01N21/21 ,  G01N21/9501 ,  G01N2021/8848 ,  G01N2201/0683

Abstract: Disclosed are methods and apparatus for inspecting a semiconductor sample. This system comprises an illumination optics subsystem for generating and directing an incident beam towards a defect on a surface of a wafer. The illumination optics subsystem includes a light source for generating the incident beam and one or more polarization components for adjusting a ratio and/or a phase difference for the incident beam's electric field components. The system further includes a collection optics subsystem for collecting scattered light from the defect and/or surface in response to the incident beam, and the collection optics subsystem comprises an adjustable aperture at the pupil plane, followed by a rotatable waveplate for adjusting a phase difference of electric field components of the collected scattered light, followed by a rotatable analyzer. The system also includes a controller that is configured for (i) selecting a polarization of the incident beam, (ii) obtaining a defect scattering map, (iii) obtaining a surface scattering map, and (iv) determining a configuration of the one or more polarization components, aperture mask, and rotatable ¼ waveplate, and analyzer based on analysis of the defect and surface scattering map so as to maximize a defect signal to noise ratio,

公开(公告)号：US09696254B2

公开(公告)日：2017-07-04

申请号：US15093749

申请日：2016-04-08

Applicant: Taiwan Biophotonic Corporation

Inventor： Yu-Tang Li ,  Chang-Sheng Chu ,  Pei-Cheng Ho ,  Kuan-Jui Ho ,  Shuang-Chao Chung ,  Chih-Hsun Fan ,  Jyh-Chern Chen

IPC: G01B11/00 ,  G01N21/21 ,  A61B5/1455 ,  G01B11/27 ,  G01N33/483 ,  A61B3/10 ,  A61B3/15

CPC classification number: G01N21/21 ,  A61B3/10 ,  A61B3/152 ,  A61B5/1455 ,  G01B11/272 ,  G01N33/483 ,  G01N2201/0633 ,  G01N2201/0683 ,  G01N2201/126

Abstract: The present disclosure generally relates to a device and a method for alignment. The alignment device provides optical architecture to align the alignment device to an analyte and measure the optical properties of an analyte. The method for alignment provides steps for aligning an optical measurement device to an analyte.

公开(公告)号：US20170176324A1

公开(公告)日：2017-06-22

申请号：US15129553

申请日：2015-04-15

Applicant: Halliburton Energy Services, Inc.

Inventor： David L. Perkins ,  James M. Price

IPC: G01N21/25 ,  G01N21/31

CPC classification number: G01N21/251 ,  G01N21/25 ,  G01N21/31 ,  G01N33/2823 ,  G01N2201/0683

Abstract: An optical computing device includes a light source that emits electromagnetic radiation into an optical train extending from the light source to a detector. A substance optically interacts with the electromagnetic radiation. A processor array is positioned in the optical train and includes a plurality of integrated computational element (ICE) cores that optically interact with the electromagnetic radiation, wherein the detector receives modified electromagnetic radiation generated through optical interaction of the electromagnetic radiation with the substance and the processor array. A weighting array is positioned in the optical train and includes a plurality of weighting devices that optically apply corresponding weighting factors to the modified electromagnetic radiation. A broadband angle selective filter (BASF) array is positioned in the optical train to selectively pass electromagnetic radiation at a predetermined angle of incidence. The detector generates an output signal indicative of a characteristic of the substance.

公开(公告)号：US09683930B2

公开(公告)日：2017-06-20

申请号：US14893157

申请日：2014-05-20

Applicant: Hinds Instruments, Inc.

Inventor： John Freudenthal ,  Andy Leadbetter ,  Baoliang Wang

IPC: G01J4/00 ,  G01N21/23 ,  G01N21/21

CPC classification number: G01N21/23 ,  G01J4/00 ,  G01N21/21 ,  G01N2201/0621 ,  G01N2201/0683

Abstract: This disclosure is generally directed to systems for imaging polarization properties of optical-material samples. As one example, there is provided a system for precise, simultaneous imaging of both the in-plane and out-of-plane birefringence properties of sample material over a wide range of incidence angles. An example spatially resolved imaging approach described herein is amenable to determination of a wide range of polarimetric properties, in addition to the in-plane and out-of-plane birefringence measure discussed as a preferred embodiment.

公开(公告)号：US09683929B2

公开(公告)日：2017-06-20

申请号：US14668880

申请日：2015-03-25

Applicant: Anton Paar GmbH

Inventor： Martin Ostermeyer

IPC: G01J4/00 ,  G01N21/21 ,  G01N21/01 ,  G01N21/03 ,  G01N21/05

CPC classification number: G01N21/21 ,  G01N21/01 ,  G01N21/0332 ,  G01N21/05 ,  G01N2021/0106 ,  G01N2021/0367 ,  G01N2201/061 ,  G01N2201/0683

Abstract: An optical measuring system measures polarization optical properties of a sample. The system includes (a) a light source that emits measuring light along an optical axis of an analysis beam path, (b) a polarization state generator, arranged downstream with respect to the light source in the analysis beam path which provides light with a defined polarization state, (c) a sample holder, arranged downstream with respect to the polarization state generator in the analysis beam path which accommodates the sample, (d) a polarization state analyzer, arranged downstream with respect to the sample holder in the analysis beam path which measures the polarization state of the measuring light after passing through the sample, and (e) a mechanical support structure, at which at least the polarization state generator, the sample holder and the polarization state analyzer are directly attached. Also described is a method for producing such an optical measuring system.