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公开(公告)号：US09067954B2
公开(公告)日：2015-06-30
申请号：US14081263
申请日：2013-11-15
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Nini H. Kjus , Geir Fonnum , Bruce Branchaud , Lai-Qiang Ying , Steven M. Menchen , Dmitriy Gremyachinskiy , Hee Chol Kang
IPC: C07F7/10 , C08L9/00 , C08F230/08 , C07F7/18 , C08F222/38 , C08F220/58 , C08F236/20 , C08K3/20
CPC classification number: C08F230/08 , C07F7/10 , C07F7/1804 , C08F220/58 , C08F222/385 , C08F236/20 , C08K3/20
Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.
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公开(公告)号：US20150175698A1
公开(公告)日：2015-06-25
申请号：US14402463
申请日：2013-03-06
Applicant: LIFE TECHNOLOGIES AS
Inventor： Karoline Schjetne , Tanja Aarvak , Lars Norderhaug
IPC: C07K16/28 , C12N5/0783
CPC classification number: C07K16/2803 , C07K16/00 , C07K16/2809 , C07K16/2896 , C07K2317/53 , C07K2317/55 , C12N5/0636
Abstract: Provided are methods and composition useful in isolating or otherwise preparing a population of target cells. In part, it relates to recombinant antibodies comprising an exogenous proteolytic cleavage site and nucleic acid molecules encoding the antibodies.
Abstract translation: 提供了可用于分离或以其它方式制备靶细胞群体的方法和组合物。 其部分涉及包含外源蛋白水解切割位点和编码抗体的核酸分子的重组抗体。
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公开(公告)号：US09062080B2
公开(公告)日：2015-06-23
申请号：US14081224
申请日：2013-11-15
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Nini H. Kjus , Geir Fonnum , Bruce Branchaud , Lai-Qiang Ying , Steven M. Menchen , Dmitriy Gremyachinskiy , Hee Chol Kang
IPC: C07F7/10 , C08F236/08 , C07F7/18 , C08F222/38 , C08F220/58 , C08F236/20 , C08K3/20
CPC classification number: C08F230/08 , C07F7/10 , C07F7/1804 , C08F220/58 , C08F222/385 , C08F236/20 , C08K3/20
Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.
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公开(公告)号：US20140142254A1
公开(公告)日：2014-05-22
申请号：US14082368
申请日：2013-11-18
Applicant: LIFE TECHNOLOGIES AS , LIFE TECHNOLOGIES CORPORATION
Inventor： Geir FONNUM , Grete I. MODAHL , Nini H. KJUS , Astrid E. MOLTEBERG , Diem TRAN , Jo AASERUD , Talha M. GOKMEN , Steven M. MENCHEN , Carl FULLER , Luisa ANDRUZZI , Wolfgang HINZ
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US20140073715A1
公开(公告)日：2014-03-13
申请号：US14082419
申请日：2013-11-18
Applicant: LIFE TECHNOLOGIES AS , LIFE TECHNOLOGIES CORPORATION
Inventor： Geir FONNUM , Grete I. MODAHL , Nini H. KJUS , Astrid E. MOLTEBERG , Diem TRAN , Jo AASERUD , Talha M. GOKMEN , Steven M. MENCHEN , Carl FULLER , Luisa ANDRUZZI , Wolfgang HINZ
IPC: C08F222/38
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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Patent Agency Ranking
公开(公告)号：US20130164312A1
公开(公告)日：2013-06-27
申请号：US13689530
申请日：2012-11-29
Applicant: Life Technologies AS
Inventor： Tanja AARVAK , Anne-Marie RASMUSSEN , Gunnar KVALHEIM , Walter Gabriell Borelli PIEDRAS , Anne BRUNSVIG
IPC: C12N5/0783
CPC classification number: C12N5/0637 , A61K31/12 , A61K35/17 , A61K2035/122 , C12N5/0636 , C12N2501/04 , C12N2501/2302 , C12N2501/2304 , C12N2501/998 , C12N2501/999
Abstract: Methods are disclosed for the generation of immunosuppressive regulatory T cells. The methods can include contacting a population of CD4+CD25− T cells with a T cell receptor (TCR)/CD3 activator, a TCR co-stimulator activator, and rapamycin. Kits for the generation of immunosuppressive regulatory T cells, methods of use, and cell populations are also disclosed.
Abstract translation: 公开了用于产生免疫抑制性调节性T细胞的方法。 所述方法可以包括使CD4 + CD25-T细胞群与T细胞受体（TCR）/ CD3激活剂，TCR共刺激因子激活剂和雷帕霉素接触。 还公开了用于产生免疫抑制性调节性T细胞，使用方法和细胞群的试剂盒。
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公开(公告)号：US11851514B2
公开(公告)日：2023-12-26
申请号：US17460058
申请日：2021-08-27
Applicant: LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Nils Pontus Lundberg , Muhammed Talha Gokmen , Synne Larsen , Wilhelm Glomm , Heidi Johnsen , Ruth Schmid , Lars Kilaas
IPC: C08F265/10 , C08F120/54 , C08F265/06
CPC classification number: C08F265/10 , C08F120/54 , C08F265/06 , C08F265/10 , C08F220/56
Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.
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公开(公告)号：US20230407288A1
公开(公告)日：2023-12-21
申请号：US18252283
申请日：2021-11-10
Applicant: LIFE TECHNOLOGIES AS
Inventor： Laure JOBERT , Marie BOSNES , Hannah Kim LINDSTROM
CPC classification number: C12N15/1013 , C12P19/34
Abstract: A method of separating RNA from a sample, comprising providing: a sample comprising RNA, a binding solution comprising an oligoethylene glycol and a salt, and a solid support having a hydrophilic surface. The method further comprises contacting the sample with the binding solution and solid support, under conditions that allow binding of the RNA in the sample to the surface of the solid support, thereby providing a solid support with bound RNA in contact with residual solution; and separating the solid support with bound RNA from the residual solution. During the binding of the RNA to the surface of the solid support, oligoethylene glycol is present at a concentration of at least about 35% v/v and the salt is present at a concentration of between about 1 M and about 2 M. Methods for producing purified RNA are also provided, comprising in vitro transcription to produce an RNA molecule with a first magnetic bead and purification with a second magnetic bead. Also provided are kits and uses.
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公开(公告)号：US11680113B2
公开(公告)日：2023-06-20
申请号：US16478452
申请日：2018-01-19
Applicant: Life Technologies AS
Inventor： Per Nils Pontus Lundberg , Geir Fonnum , Kristian Andersson
IPC: C08L33/26 , C08F2/38 , C08F228/02 , C08F230/02 , C08K5/5333 , C08K3/22 , C08K5/42
CPC classification number: C08F2/38 , C08F228/02 , C08F230/02 , C08K5/5333 , C08L33/26 , C08K3/22 , C08K5/42 , C08K2003/2275 , C08K2201/01 , C08L2312/00
Abstract: This invention relates to monodisperse magnetic hydrogel polymer particles comprising a magnetic material and a polymer formed from (a) a hydrophilic vinylic monomer having a log Poct/wat (log P) of less than about 0.5; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse coated hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer having a log Poct/wat (log P) of less than about 0.5; and (b) a crosslinker comprising at least two vinyl groups; and a coating. Also provided are methods of forming the monodisperse magnetic hydrogel polymer particles and monodisperse coated polymer particles.
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公开(公告)号：US20220056184A1
公开(公告)日：2022-02-24
申请号：US17460058
申请日：2021-08-27
Applicant: Life Technologies AS
Inventor： Geir Fonnum , Nils Pontus Lundberg , Muhammed Talha Gokmen , Synne Larsen , Wilhelm Glomm , Heidi Johnsen , Ruth Schmid , Lars Kilaas
IPC: C08F265/10 , C08F120/54 , C08F265/06
Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.
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