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    Method and device for the determination of an analyte using super paramagnetic reactive particles
    61.
    发明授权
    Method and device for the determination of an analyte using super paramagnetic reactive particles 失效
    使用超顺磁反应性颗粒测定分析物的方法和装置

    公开(公告)号：US5925573A

    公开(公告)日：1999-07-20

    申请号：US732447

    申请日：1996-12-13

    申请人： Bruno Colin ,  Alain Theretz

    发明人： Bruno Colin ,  Alain Theretz

    IPC分类号： G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  B03C1/00 ,  C12M1/34 ,  G01N33/546

    CPC分类号： G01N33/54333 ,  G01N2446/20 ,  G01N2446/30 ,  G01N35/00029 ,  G01N35/0098 ,  Y10S436/806

    摘要： A process for the qualitative and/or quantitative determination of an analyte in a sample. The process includes providing a sample containing an analyte of interest in a liquid phase, providing at least one reagent having super-paramagnetic reactive metal particles linked to a substance that binds to the analyte, contacting the sample and the reagent to allow binding of the analyte in the sample and the reagent, applying a magnetic field to the mixture of sample and reagent, and detecting the presence of the analyte in the sample. The device includes a support for the sample and reagent, means for contacting the sample and reagent, magnetic means for confining and separating the analyte from the other components of the sample, and detection means for qualitative and/or quantitative measurement of the analyte.

    摘要翻译： PCT No.PCT / IB96 / 00245 Sec。 371日期1996年12月13日第 102（e）日期1996年12月13日PCT 1996年3月20日PCT公布。 WO96 / 29601 PCT出版物 日期1996年9月26日一种用于定性和/或定量测定样品中分析物的方法。 该方法包括在液相中提供含有感兴趣分析物的样品，提供至少一种具有与结合分析物的物质连接的超顺磁反应性金属颗粒的试剂，使样品和试剂接触以允许分析物结合 在样品和试剂中，向样品和试剂的混合物施加磁场，并检测样品中分析物的存在。 该装置包括用于样品和试剂的载体，用于接触样品和试剂的装置，用于限制和分离分析物与样品其他组分的磁性装置，以及用于定性和/或定量测量分析物的检测装置。

    Process for metering, in particular microvolumes of a liquid; application to obtaining controlled dilutions, especially nanomolar dilutions
    64.
    发明授权
    Process for metering, in particular microvolumes of a liquid; application to obtaining controlled dilutions, especially nanomolar dilutions 失效
    用于计量的方法，特别是液体的微量体积; 用于获得受控稀释度，特别是纳摩尔稀释度

    公开(公告)号：US5594183A

    公开(公告)日：1997-01-14

    申请号：US272398

    申请日：1994-07-26

    申请人： Bruno Colin

    发明人： Bruno Colin

    IPC分类号： B01L99/00 ,  C12M1/26 ,  G01F11/00 ,  G01N1/38 ,  G01N1/14

    CPC分类号： B01L3/0293 ,  C12M33/07 ,  G01F11/00 ,  G01N1/38

    摘要： A capillary cavity is provided in communication with a liquid bath container. The cavity is metered with a predetermined quantity of a liquid by a process that includes: (a) providing at least one capillary cavity, which outwardly emerges via an introduction orifice and is dimensioned such that the liquid cannot enter or leave the cavity spontaneously; (b) providing a bath of the liquid; (c) evacuating the cavity, initially free of any liquid, in order to bring its internal pressure to a value that is less than a pressure prevailing above the liquid bath; (d) connecting the interior of the capillary cavity, which is at least partially evacuated, to the liquid bath via the introduction orifice, thereby filling the cavity; (e) separating the filled capillary cavity from a remainder of the liquid bath; (f) emptying the capillary cavity which is filled and separated from the liquid bath via the introduction orifice. The method and device have applications including, for example, diluting a precise amount of liquid with a diluent.

    摘要翻译： 提供与液浴容器连通的毛细管腔。 通过包括以下步骤的方法对空腔计量预定量的液体：（a）提供至少一个毛细管腔，其经由引入孔向外出现，并且尺寸使得液体不能自发地进入或离开空腔; （b）提供液体浴; （c）抽空空腔，最初没有任何液体，以使其内部压力达到小于液槽上方压力的值; （d）通过引入孔将至少部分抽真空的毛细管腔的内部连接到液槽，从而填充空腔; （e）将填充的毛细管腔与液体浴的其余部分分离; （f）通过引入孔排空从液槽中填充和分离的毛细管腔。 该方法和装置具有应用，例如，用稀释剂稀释精确量的液体。

    METHODS FOR INOCULATING CULTURE MEDIA ON PETRI DISHES BY MEANS OF VIBRATION FREQUENCIES
    66.
    发明申请
    METHODS FOR INOCULATING CULTURE MEDIA ON PETRI DISHES BY MEANS OF VIBRATION FREQUENCIES 有权
    通过振动频率对培养基培养培养基的方法

    公开(公告)号：US20140220616A1

    公开(公告)日：2014-08-07

    申请号：US14238673

    申请日：2012-08-30

    申请人： Bruno Colin ,  Marie-Pierre Montet

    发明人： Bruno Colin ,  Marie-Pierre Montet

    IPC分类号： C12Q1/24 ,  C12M1/22

    CPC分类号： C12Q1/24 ,  C12M23/10 ,  C12M23/38 ,  C12M33/08

    摘要： The present invention relates to a method for inoculating at least one agar culture medium, contained in a Petri dish, with at least one sample likely to contain microorganisms. The method includes the steps of: providing at least one agar culture medium contained in a Petri dish; providing the sample likely to contain microorganisms in liquid form; performing at least one deposition of the liquid sample onto the lid of the Petri dish such that the liquid sample can be transferred from the lid to the agar culture medium; and spraying the liquid sample, initially deposited onto the cover, onto the agar culture medium by vibrating the Petri dish.

    摘要翻译： 本发明涉及用至少一种可能含有微生物的样品接种培养皿中含有的至少一种琼脂培养基的方法。 该方法包括以下步骤：提供培养皿中所含的至少一种琼脂培养基; 提供样品可能含有液体形式的微生物; 将液体样品的至少一次沉积物执行到培养皿的盖上，使得液体样品可以从盖子转移到琼脂培养基中; 并通过振动培养皿将初始沉积到盖上的液体样品喷洒到琼脂培养基上。

    METHOD FOR ISOLATING A SAMPLE WELL OF A TEST CARD FOR ANALYSIS, AND RESULTING TEST CARD
    67.
    发明申请
    METHOD FOR ISOLATING A SAMPLE WELL OF A TEST CARD FOR ANALYSIS, AND RESULTING TEST CARD 有权
    用于分析测试卡的样品的分析方法和分析测试卡

    公开(公告)号：US20130273592A1

    公开(公告)日：2013-10-17

    申请号：US13879887

    申请日：2011-10-19

    申请人： Bruno Colin ,  Cecile Paris

    发明人： Bruno Colin ,  Cecile Paris

    IPC分类号： C12Q1/24

    CPC分类号： B01L3/50853 ,  B01L3/502738 ,  B01L2200/0689 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2400/0481 ,  B01L2400/0638 ,  B01L2400/0655 ,  C12Q1/24

    摘要： The invention relates to a method for isolating at least one fluid sample well laid out in a test card for analyses, said test card including a plate (3) having at least one first main face from which is laid out at least one channel communicating with at least said well, this first face being coated with a membrane (17) provided with an adhesive (18) and which will cover said channel with a covering area (171), the method for isolation including a phase for introducing a fluid sample into at least said well and a phase for isolating said well consisting of exerting a force on at least one portion of the covering area (171) of the adhesive membrane (17) for ensuring displacement of the adhesive into an obturation area for the sample well.

    摘要翻译： 本发明涉及一种用于分离在测试卡中布置的至少一个流体样本的方法，用于分析，所述测试卡包括具有至少一个第一主面的板（3），所述板（3）布置在与 至少所述井，该第一面涂覆有具有粘合剂（18）的膜（17），并且其将覆盖所述通道并具有覆盖区域（171），所述隔离方法包括用于将流体样品引入的相 至少所述井以及用于隔离所述井的相，其包括在所述粘合膜（17）的覆盖区域（171）的至少一部分上施加力，以确保所述粘合剂移动到所述样品井的封闭区域。

    Device for implementing an analysis pack, analysis pack and method using same
    69.
    发明授权
    Device for implementing an analysis pack, analysis pack and method using same 失效
    用于实现分析包，分析包和使用其的方法的设备

    公开(公告)号：US07491497B2

    公开(公告)日：2009-02-17

    申请号：US11251758

    申请日：2005-10-18

    申请人： Bruno Colin ,  Jacques Dachaud ,  Marie Privat ,  Cécile Paris

    发明人： Bruno Colin ,  Jacques Dachaud ,  Marie Privat ,  Cécile Paris

    IPC分类号： C12Q1/68 ,  G01N21/00

    CPC分类号： G01N35/1097 ,  B01L3/5025

    摘要： A device for implementing a test card inside which sequential reactions and fluid transfer operations are performed under the effect of a control integrated into the card; the card includes at least two sequential reaction systems arranged in parallel, each reaction system having at least two fluid transfer systems arranged in series. A test card and the method for implementing the device and the card are also disclosed. The device contains at least one actuator per reaction line, and all the actuators are at a regular distance from one another, with the actuators preferably being equidistant. The invention is particularly applicable for the micromanipulation of fluids in biological applications.

    摘要翻译： 一种用于实现测试卡的装置，其中在集成到卡中的控制的作用下执行顺序反应和流体转移操作; 卡片包括平行布置的至少两个顺序反应系统，每个反应系统具有串联布置的至少两个流体转移系统。 还公开了一种测试卡和用于实现设备和卡的方法。 该装置每个反应管线包含至少一个致动器，并且所有致动器彼此间隔一定距离，致动器优选等距。 本发明特别适用于生物应用中流体的显微操作。