MOLECULE ATTACHMENT TO NANOPARTICLES
    63.
    发明申请
    MOLECULE ATTACHMENT TO NANOPARTICLES 审中-公开
    分子与纳米颗粒的连接

    公开(公告)号:US20100167290A1

    公开(公告)日:2010-07-01

    申请号:US12527623

    申请日:2008-02-27

    CPC分类号: C12Q1/6876 G01N33/5432

    摘要: Disclosed herein are molecule-modified nanoparticles and methods of making and using the same. More specifically, disclosed herein are molecule-modified nanoparticles wherein the molecule is attached to the surface of the nanoparticle via an oligonucleotide. Also disclosed are methods of preparing nanoparticles having oligonucleotides and molecules (e.g., biomolecules, such as proteins, peptides, antibodies, lipids, and/or carbohydrates) attached to the nanoparticle surface, wherein the oligonucleotide and molecule are covalently attached. Further disclosed are methods of detecting an analyte of interest using these disclosed molecule-modified nanoparticles.

    摘要翻译: 本文公开了分子修饰的纳米颗粒及其制备和使用方法。 更具体地,本文公开了分子修饰的纳米颗粒,其中分子经由寡核苷酸连接到纳米颗粒的表面。 还公开了制备与寡核苷酸和分子(例如生物分子,如蛋白质,肽,抗体,脂质和/或碳水化合物)连接在纳米颗粒表面上的纳米颗粒的方法,其中寡核苷酸和分子是共价连接的。 进一步公开的是使用这些公开的分子修饰的纳米颗粒检测感兴趣分析物的方法。

    Independently-addressable, self-correcting inking for cantilever arrays
    67.
    发明申请
    Independently-addressable, self-correcting inking for cantilever arrays 失效
    用于悬臂阵列的独立寻址,自校正上墨

    公开(公告)号:US20090133169A1

    公开(公告)日:2009-05-21

    申请号:US12222464

    申请日:2008-08-08

    IPC分类号: G12B21/08 G12B21/02

    摘要: An improved method of loading tips and other surfaces with patterning compositions or inks for use in deposition. A method of patterning is described, the method comprising: (i) providing at least one array of tips; (ii) providing a plurality of patterning compositions; (iii) ink jet printing at least some of the patterning compositions onto some of the tips; and (iv) depositing at least some of the patterning compositions onto a substrate surface; wherein the ink jet printing is adapted to prevent substantial cross-contamination of the patterning composition on the tips. Good printing reproducibility and control of printing rate can be achieved. The surfaces subjected to ink jet printing can be treated to encourage localization of the ink at the tip. The method is particularly important for high density arrays.

    摘要翻译: 用于沉积的图案化组合物或油墨加载尖端和其它表面的改进方法。 描述了一种图案化方法,该方法包括:(i)提供至少一个尖端阵列; (ii)提供多个图案化组合物; (iii)将至少一些图案化组合物喷墨印刷到一些尖端上; 和(iv)将至少一些所述图案化组合物沉积到基底表面上; 其中喷墨印刷适于防止图案化组合物在尖端上的显着交叉污染。 可以实现良好的打印再现性和打印速度的控制。 可以处理进行喷墨印刷的表面以促进墨水在尖端处的定位。 该方法对于高密度阵列特别重要。