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公开(公告)号：US08583204B2
公开(公告)日：2013-11-12
申请号：US12718299
申请日：2010-03-05
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/7203 , B33Y70/00 , C12Q1/006 , G01N27/40
摘要： Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.
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公开(公告)号：US20120310281A1
公开(公告)日：2012-12-06
申请号：US13589468
申请日：2012-08-20
申请人： Robert Boock , Nathan Cauldwell
发明人： Robert Boock , Nathan Cauldwell
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B2017/0409 , A61B2017/0414 , A61B2017/044
摘要： A suture anchor is provided including an elongate shank defining a longitudinal axis and having at least one bone-engaging thread formed thereon, and a drive head having a proximal end and a distal end mated to the elongate shank. The drive head has a substantially oval shape and includes at least one suture attachment member formed in a portion of the drive head. The configuration of the drive head is particularly advantages in that it provides a suture anchor having improved physical properties, including a high failure torque and a high stripping strength.
摘要翻译： 提供了缝合锚，其包括限定纵向轴线的细长柄，并且具有形成在其上的至少一个骨接合螺纹，以及具有与所述细长柄配合的近端和远端的驱动头。 驱动头具有大致椭圆形并且包括形成在驱动头的一部分中的至少一个缝合线附接构件。 驱动头的构造是特别的优点，因为它提供了具有改进的物理性能的缝合锚，其包括高故障扭矩和高剥离强度。
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公开(公告)号：US20110077490A1
公开(公告)日：2011-03-31
申请号：US12893850
申请日：2010-09-29
IPC分类号： A61B5/1473
CPC分类号： A61B5/14865 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/6843 , A61B5/6848 , A61B5/6849 , A61B2560/0443 , A61B2562/0209 , A61B2562/04
摘要： A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.
摘要翻译： 提供了经配置以连续测量宿主中的分析物浓度的经皮传感器装置。 在一些实施例中，经皮传感器装置100包括构造成用于插入主体皮肤180下方的体内部分160，以及配置成在传感器插入入口之后保留在主体的皮肤180的表面上方的离体部分170 体内部分。 体内部分可以包括构造成用于刺穿主体的皮肤180的组织刺穿元件110和传感器主体120，传感器主体120包括提供足够的柱强度的材料或支撑构件130，以允许传感器主体能够在主机组织中推动而没有 实质屈曲。 离体部分170可以被配置为包括（或可操作地连接）传感器电子单元，并且可以包括安装单元150.这里还描述了传感器主体和组织刺穿元件的各种构造，其可以用于保护 传感器体的膜。
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公开(公告)号：US20110027458A1
公开(公告)日：2011-02-03
申请号：US12829340
申请日：2010-07-01
申请人： Robert Boock , Jeff Jackson , Huashi Zhang , Jason Mitchell
发明人： Robert Boock , Jeff Jackson , Huashi Zhang , Jason Mitchell
摘要： Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice. For example, a provided elongated conductive body 510 is advanced through a pre-coating treatment station 520, through a coating station 530, through a thickness control station 540, through a drying or curing station 550, through a thickness measurement station 560, and through a post-coating treatment station 570.
摘要翻译： 这里描述了用于连续制造可植入的连续分析物传感器的方法和系统的实施方案。 在一些实施例中，提供了一种用于使细长导电体顺序地前进穿过多个台的方法，每个台被构造成处理细长导电体。 在这些实施例中的一些实施例中，一个或多个工位被配置为使用弯液面涂覆工艺涂覆细长导电体，由此制备由聚合物和溶剂形成的溶液，该溶液被连续循环以在 保持溶液的容器的顶部，并且细长导电体前进通过弯液面。 该方法还可以包括通过使细长导电体通过模头孔从细长导电体去除多余涂层材料的步骤。 例如，提供的细长导电体510通过预涂处理站520，穿过涂覆站530，通过厚度控制站540，穿过干燥或固化站550，穿过厚度测量站560，并通过 后涂层处理站570。
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公开(公告)号：US20110024307A1
公开(公告)日：2011-02-03
申请号：US12829264
申请日：2010-07-01
IPC分类号： G01N27/26 , G01N33/50 , G01N27/416
摘要： Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising a second sensor element 104, and a reference electrode 108 for providing a reference value for measuring the working electrode potential of the sensor elements 102, 104.
摘要翻译： 提供了用于连续测量分析物浓度的装置和方法。 该装置可以包括具有多个传感器元件的传感器，每个传感器元件具有与装置的其它传感器不同的至少一个特性。 在一些实施例中，多个传感器元件各自被调谐以测量分析物浓度的不同范围，从而为器件提供在生理学相关范围内实现基本一致的测量精度水平的能力。 在其他实施例中，该装置包括多个传感器元件，每个传感器元件在插入或植入之后的不同时间期间被调整以测量，从而为传感器提供在宽范围的时间段内连续且精确地测量分析物浓度的能力。 例如，传感器系统180被提供有具有包括第一传感器元件102的第一工作电极150和包括第二传感器元件104的第二工作电极160以及用于提供用于测量工作电极电位的参考值的参考电极108 的传感器元件102,104。
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公开(公告)号：US20090299155A1
公开(公告)日：2009-12-03
申请号：US12362194
申请日：2009-01-29
IPC分类号： A61B5/0205 , A61B5/145
CPC分类号： A61B5/157 , A61B5/0002 , A61B5/14532 , A61B5/14546 , A61B5/15003 , A61B5/150229 , A61B5/150389 , A61B5/150503 , A61B5/150809 , A61B5/150816 , A61B5/150824 , A61B5/15087 , A61B5/153 , A61B5/155 , A61B5/412 , A61B5/7275
摘要： The present invention relates generally to systems and methods for continuous measurement of a cardiac marker in vivo. In some embodiments, the system includes a continuous sensor and a communication device. The continuous sensor is configured to continuously measure a concentration of a cardiac marker in vivo and to provide a signal associated therewith. The communication device includes a processor module configured to process the signal to obtain cardiac information, wherein the communication device is configured to output the cardiac information.
摘要翻译： 本发明一般涉及在体内连续测量心脏标志物的系统和方法。 在一些实施例中，系统包括连续传感器和通信设备。 连续传感器被配置为在体内连续测量心脏标志物的浓度并提供与其相关联的信号。 通信设备包括处理器模块，其被配置为处理该信号以获得心脏信息，其中通信设备被配置为输出心脏信息。
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公开(公告)号：US20090131777A1
公开(公告)日：2009-05-21
申请号：US12267546
申请日：2008-11-07
申请人： Peter C. Simpson , Michael J. Estes , Paul V. Neale , Robert Boock , Jacob S. Leach , Richard C. Yang
发明人： Peter C. Simpson , Michael J. Estes , Paul V. Neale , Robert Boock , Jacob S. Leach , Richard C. Yang
IPC分类号： A61B5/145
CPC分类号： C12Q1/001 , A61B5/0031 , A61B5/145 , A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/412 , A61B5/4839 , A61B5/6848 , A61B5/6849 , A61B5/7275 , A61B5/743 , A61B2560/0223 , A61B2560/04 , A61B2562/085 , A61M5/14 , A61M5/16804 , A61M5/1723 , A61M25/007 , A61M2005/14296 , A61M2230/201 , C12Q1/006 , G06F19/3468 , G16H40/40 , Y02A90/26
摘要： Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.
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公开(公告)号：US20060229512A1
公开(公告)日：2006-10-12
申请号：US11335879
申请日：2006-01-18
申请人： James Petisce , Kum Woo , Victor Ha , Melissa Nicolas , Robert Boock
发明人： James Petisce , Kum Woo , Victor Ha , Melissa Nicolas , Robert Boock
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6833 , A61B5/6848 , A61B5/6849 , G06F19/00 , Y02A90/26
摘要： The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to devices for measurement of glucose in a host that incorporate a cellulosic-based interference domain.
摘要翻译： 本发明一般涉及用于测量宿主中分析物的装置。 更具体地，本发明涉及用于测量掺入基于纤维素基的干扰域的宿主中的葡萄糖的装置。
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公开(公告)号：US20060106461A1
公开(公告)日：2006-05-18
申请号：US10987180
申请日：2004-11-12
申请人： Jill Embry , Robert Boock
发明人： Jill Embry , Robert Boock
IPC分类号： A61F2/44
CPC分类号： A61B17/7097 , A61B17/7095 , A61F2/022 , A61F2/4611 , A61F2002/30092 , A61F2002/30205 , A61F2002/30212 , A61F2002/30253 , A61F2002/30271 , A61F2002/30299 , A61F2002/30565 , A61F2002/30579 , A61F2002/30583 , A61F2002/30588 , A61F2002/30909 , A61F2002/30917 , A61F2210/0014 , A61F2210/0085 , A61F2230/0067 , A61F2230/0076 , A61F2230/0082 , A61F2230/0093
摘要： A vertebral lift device including an expandable member made of a bio-compatible material and having a plurality of interconnected structural members, with the expandable member having a first dimension for insertion thereof into a damaged vertebral body having a damaged dimension, the interconnected structural members of the expandable member being expandable to a second dimension substantially corresponding to dimensions of the vertebral body prior to its damage, wherein the expandable member defines a void area within a periphery defined by the structural members when the expandable member is expanded to the second dimension for receiving a restoration agent; and a covering configured to substantially cover the exterior of the expandable member to inhibit leakage of the restoration agent received within the void area.
摘要翻译： 一种脊椎提升装置，包括由生物相容性材料制成并具有多个相互连接的结构构件的可膨胀构件，所述可扩张构件具有第一尺寸，用于将其插入具有损坏尺寸的受损椎体中，所述互连结构构件 所述可扩张构件可膨胀到基本对应于椎体在其损伤之前的尺寸的第二尺寸，其中当所述可膨胀构件膨胀到所述第二尺寸以便接收时，所述可扩张构件限定由所述结构构件限定的周边内的空隙区域 修复剂; 以及覆盖物，其被配置为基本上覆盖所述可扩张构件的外部，以防止在所述空隙区域内接收的所述恢复剂的泄漏。
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公开(公告)号：US20050059905A1
公开(公告)日：2005-03-17
申请号：US10661460
申请日：2003-09-11
申请人： Robert Boock , Nathan Cauldwell , Keith Orr
发明人： Robert Boock , Nathan Cauldwell , Keith Orr
CPC分类号： A61B10/025 , A61B10/0266 , A61B10/0283 , A61B17/32002
摘要： Devices and methods are provided for extracting and macerating tissue, and optionally for depositing the tissue onto a tissue scaffold. The device generally includes an outer tube having a substantially open distal end that is adapted to be placed on and preferably to form a seal with a tissue surface, and a shaft rotatably disposed within the outer tube and movable between a first, proximal position in which the shaft is fully disposed within the outer tube, and a second, distal position in which a portion of a distal end of the shaft extends through the opening in the distal end of the outer tube. The device also includes a tissue harvesting tip formed on the distal end of the shaft that is effective to excise a tissue sample when the shaft is moved to the distal position, and a cutting member that is coupled to the shaft at a position proximal to the tissue harvesting tip. The cutting member is effective to macerate a tissue sample excised by the tissue harvesting tip.
摘要翻译： 提供了用于提取和浸泡组织以及任选地将组织沉积到组织支架上的装置和方法。 该装置通常包括具有基本上敞开的远端的外管，其适于放置在并且优选地与组织表面形成密封，以及可旋转地设置在外管内并可在第一近端位置之间移动的轴， 所述轴完全设置在所述外管内，以及第二远侧位置，所述轴的远端的一部分延伸穿过所述外管的远端中的所述开口。 所述装置还包括形成在所述轴的所述远端上的组织收获尖端，所述组织收获尖端在所述轴移动到所述远侧位置时有效地切除组织样本;以及切割构件，其在靠近所述远端的位置处联接到所述轴 组织收获尖。 切割构件有效地浸渍由组织收获尖端切除的组织样品。
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