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351 条记录 (耗时 0.053 秒)

    Controlled local delivery of chemotherapeutic agents for treating solid tumors
    62.
    发明授权
    Controlled local delivery of chemotherapeutic agents for treating solid tumors 失效
    用于治疗实体瘤的化疗药物的局部控制

    公开(公告)号：US5626862A

    公开(公告)日：1997-05-06

    申请号：US284341

    申请日：1994-08-02

    申请人： Henry Brem ,  Robert S. Langer ,  Abraham J. Domb

    发明人： Henry Brem ,  Robert S. Langer ,  Abraham J. Domb

    IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/22 ,  A61K31/282 ,  A61K31/337 ,  A61K31/47 ,  A61K31/4745 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K47/34 ,  A61K31/335

    CPC分类号： A61K9/0085 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/555 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/204

    摘要： A method and devices for localized delivery of a chemotherapeutic agent to solid tumors, wherein the agent does not cross the blood-brain barrier and is characterized by poor bioavailability and/or short half-lives in vivo, are described. The devices consist of reservoirs which release drug over an extended time period while at the same time preserving the bioactivity and bioavailability of the agent. In the most preferred embodiment, the device consists of biodegradable polymeric matrixes, although reservoirs can also be formulated from non-biodegradable polymers or reservoirs connected to implanted infusion pumps. The devices are implanted within or immediately adjacent the tumors to be treated or the site where they have been surgically removed. The examples demonstrate the efficacy of paclitaxel and camptothecin delivered in polymeric implants prepared by compression molding of biodegradable and non-biodegradable polymers, respectively. The results are highly statistically significant.

    摘要翻译： 描述了用于将化学治疗剂局部递送至实体瘤的方法和装置，其中所述药物不穿过血脑屏障并且其特征在于体内生物利用度差和/或半衰期短。 这些装置包括在延长的时间段内释放药物的储存器，同时保持药剂的生物活性和生物利用度。 在最优选的实施方案中，该装置由可生物降解的聚合物基质组成，尽管储存器也可以由与植入的输注泵连接的不可生物降解的聚合物或储存器配制。 这些装置被植入到待治疗的肿瘤内或紧邻其中，或被手术切除的部位。 这些实施例证明分别通过压缩成型可生物降解和不可生物降解的聚合物制备的聚合物植入物中递送的紫杉醇和喜树碱的功效。 结果具有很高的统计学意义。

    Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
    66.
    发明授权
    Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers 失效
    用超声波和化学增强剂增强透皮监护应用

    公开(公告)号：US5458140A

    公开(公告)日：1995-10-17

    申请号：US152442

    申请日：1993-11-15

    申请人： Jonathan A. Eppstein ,  Deborah A. Eppstein ,  Joseph Kost ,  Robert S. Langer

    发明人： Jonathan A. Eppstein ,  Deborah A. Eppstein ,  Joseph Kost ,  Robert S. Langer

    IPC分类号： A61B5/00 ,  A61B17/00 ,  A61B18/20 ,  A61K41/00 ,  A61K49/22 ,  A61M37/00

    CPC分类号： A61B5/1486 ,  A61B5/14514 ,  A61B5/681 ,  A61K41/0047 ,  A61K49/22 ,  A61B18/203 ,  A61B2017/00172 ,  A61B2017/00765 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61B2562/0295 ,  A61M2037/0007 ,  A61M37/0092

    摘要： A method of enhancing the permeability of the skin or mucosa to an analyte for diagnostic purposed is described utilizing ultrasound or ultrasound plus a chemical enhancer. If desired the ultrasound may be modulated by means of frequency modulation, amplitude modulation, phase modulation and/or combinations thereof. A frequency modulation from low to high develops a local pressure gradient directed out of the body, thus permitting analytes in the body to traverse the skin and be collected and measured outside the body. The concentration of an analyte in the body is preferably determined by enhancing the permeability of the skin or other biological membrane optionally with a chemical enhancer, applying ultrasound optionally at a modulated frequency, amplitude, phase, or combinations thereof that further induces a local pressure gradient out of the body, collecting the analyte, and utilizing the analyte collection data calculating the concentration of the analyte in the body.

    摘要翻译： 使用超声波或超声波加上化学增强剂来描述增强皮肤或粘膜对于诊断用途分析物的渗透性的方法。 如果需要，可以通过频率调制，幅度调制，相位调制和/或其组合来调制超声波。 从低到高的频率调制产生了引导出身体的局部压力梯度，从而允许身体中的分析物穿过皮肤并在体外被收集和测量。 体内分析物的浓度优选通过任选地用化学增强剂增强皮肤或其他生物膜的渗透性，任选地以调制的频率，幅度，相位或其组合施加超声来进一步诱导局部压力梯度来确定 收集分析物，并利用分析物收集数据计算体内分析物的浓度。

    Polyanhydride bioerodible controlled release implants for administration of stabilized growth hormone
    67.
    发明授权
    Polyanhydride bioerodible controlled release implants for administration of stabilized growth hormone 失效
    用于施用稳定生长激素的聚酐生物可蚀性控释植入物

    公开(公告)号：US5122367A

    公开(公告)日：1992-06-16

    申请号：US332554

    申请日：1989-03-31

    申请人： Eyal Ron ,  Mark Chasin ,  Tom Turek ,  Robert S. Langer

    发明人： Eyal Ron ,  Mark Chasin ,  Tom Turek ,  Robert S. Langer

    IPC分类号： A61K9/20 ,  A61K38/27 ,  A61K47/26

    CPC分类号： A61K38/27 ,  A61K47/26 ,  A61K9/2018 ,  A61K9/2031

    摘要： A controlled release device for the administration of biologically active growth hormone proteins or peptide fragments, and method of preparation thereof, wherein biologically active growth hormone is stabilized and release rate modulated by incorporation of a stabilizing compound. The controlled release devices are prepared by mixing a stabilizer, such as sucrose, with a biologically active growth hormone, such as bovine somatotropic hormone, in solution, lyophilizing, then incorporating the dried powder into a surface erodible, biocompatible polymeric matrix, such as a poly(anhydride) or poly(orthoester) matrix.

    摘要翻译： 用于施用生物活性生长激素蛋白质或肽片段的控制释放装置及其制备方法，其中生物活性生长激素被稳定并通过引入稳定化合物释放速率。 控制释放装置通过将稳定剂如蔗糖与生物活性生长激素如牛生长激素在溶液中混合来制备，冻干，然后将干燥的粉末掺入表面可侵蚀的生物相容性聚合物基质中，例如 聚（酸酐）或聚（原酸酯）基质。

    System for controlled release of biologically active compounds
    68.
    发明授权
    System for controlled release of biologically active compounds 失效
    用于控制释放生物活性化合物的系统

    公开(公告)号：US4933185A

    公开(公告)日：1990-06-12

    申请号：US223887

    申请日：1988-07-11

    申请人： Margaret A. Wheatley ,  Robert S. Langer ,  Herman N. Eisen

    发明人： Margaret A. Wheatley ,  Robert S. Langer ,  Herman N. Eisen

    IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K9/62

    CPC分类号： A61K9/1664 ,  A61K9/1652 ,  A61K9/5031 ,  Y10S514/885 ,  Y10S514/963 ,  Y10T428/2984 ,  Y10T428/2985

    摘要： A controlled release system for delivery of a biologically-active substance. In one embodiment, there is a delayed release of a biologically-active substance. In a second embodiment, the delayed release is preceded by an initial release of biologically active substance. In other variations of the system, there are mulitple discrete releases over time or a continuous slow release combined with discrete releases. The delayed exposure is achieved through the design and construction of the system, specifically, formation of ionically-coated microcapsules around the biologically-active substance in conjunction with a microcapsule core-degrading enzyme. Release of active substance takes place in a burst at such a time as the core degrading enzyme has reduced the core to a molecular weight too low to support enough interaction with the cationic skin to maintain its integrity as a skin. In one example, microcapsules are formed of an ionically cross-linked polysaccharide, calcium alginate, which is further ionically coated with a poly-cationic skin of poly-L-lysine. The capsule coating serves a dual purpose: to control diffusion of the biologically-active substance and the core-degrading enzyme and as a substrate for the mechanism by which the biologically-active substance is released after a time delay.

    摘要翻译： 用于递送生物活性物质的控制释放系统。 在一个实施方案中，存在生物活性物质的延迟释放。 在第二个实施方案中，延迟释放之前是生物活性物质的初始释放。 在系统的其他变体中，随着时间的推移有多种离散的释放，或者连续的缓慢释放与离散的释放相结合。 延迟曝光是通过系统的设计和构建来实现的，具体地说，在微生物活性物质周围与微胶囊核心降解酶结合形成离子涂覆的微胶囊。 活性物质的释放在核心降解酶已经将核心降低到分子量太低以至于不能支持与阳离子皮肤的足够相互作用以维持其作为皮肤的完整性的时候发生。 在一个实例中，微胶囊由离子交联的多糖，藻酸钙形成，其进一步离子地涂覆有聚-L-赖氨酸的多阳离子皮肤。 胶囊涂层具有双重目的：控制生物活性物质和核心降解酶的扩散，并且作为延迟后释放生物活性物质的机制的底物。

    Bioerodible articles useful as implants and prostheses having predictable degradation rates
    69.
    发明授权
    Bioerodible articles useful as implants and prostheses having predictable degradation rates 失效
    用作具有可预测降解速率的植入物和假体的生物蚀刻制品

    公开(公告)号：US4886870A

    公开(公告)日：1989-12-12

    申请号：US702168

    申请日：1985-02-15

    申请人： Patricia D'Amore ,  Kam W. Leong ,  Robert S. Langer

    发明人： Patricia D'Amore ,  Kam W. Leong ,  Robert S. Langer

    IPC分类号： A61L17/10 ,  A61L27/18 ,  A61L27/58 ,  C08G67/04

    CPC分类号： C08G67/04 ,  A61L17/10 ,  A61L27/18 ,  A61L27/58

    摘要： A novel series of articles useful as implants and prostheses and methods for their preparation and use are provided which utilize polyanhydride polymeric matrices as a general class of materials. These articles are biocompatible, non-inflammatory and degrade predictably into non-toxic residues after introduction in-vivo. The articles may be formed in any desired dimensions and configuration and may take specific shape as vascular or skin grafts, as biodegradable sutures or as orthopedic appliances such as bone plates and the like.

    摘要翻译： 提供了可用作植入物和假体的新型系列文章及其制备和使用方法，其利用聚酐聚合物基质作为一般材料类。 这些制品在生物相容性，非炎症性和体内引入后可预测地降解成无毒性残留。 制品可以以任何期望的尺寸和构型形成，并且可以具有特定形状作为血管或皮肤移植物，例如可生物降解的缝线或矫形器具如骨板等。