公开(公告)号：US20170181677A1

公开(公告)日：2017-06-29

申请号：US14980260

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Yunfeng Lu ,  Jay Mung

IPC: A61B5/145 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/053 ,  A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7278

Abstract: A single, optimal, fused sensor glucose value may be calculated based on respective sensor glucose values of a plurality of redundant working electrodes (WEs) of a glucose sensor. Respective electrochemical impedance spectroscopy (EIS) procedures may be performed for each of the WEs to obtain values of membrane resistance (Rmem) for each WE. A noise value and a calibration factor (CF) value may be calculated for each WE, and respective fusion weights may be calculated for Rmem, noise, and CF for each WE. An overall fusion weight may then be calculated based on the WE's Rmem fusion weight, noise fusion weight, and CF fusion weight, such that a single, optimal, fused sensor glucose value may be calculated based on the respective overall fusion weight and sensor glucose value of each of the plurality of redundant working electrodes.

公开(公告)号：US09649058B2

公开(公告)日：2017-05-16

申请号：US14261011

申请日：2014-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1455 ,  A61B5/1495 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20170049963A1

公开(公告)日：2017-02-23

申请号：US15240726

申请日：2016-08-18

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Yunfeng Lu ,  Keith Nogueira ,  Jeffrey Nishida

IPC: A61M5/172 ,  G06F19/00

CPC classification number: A61M5/1723 ,  A61B5/0022 ,  A61B5/02438 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/7239 ,  A61B5/7242 ,  A61B2560/0242 ,  A61B2562/0219 ,  A61M5/14244 ,  A61M2205/3569 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/70 ,  A61M2230/005 ,  A61M2230/06 ,  A61M2230/201 ,  G06F19/3468 ,  G16H10/60 ,  G16H15/00 ,  G16H40/40 ,  G16H40/63 ,  G16H50/20 ,  G16H50/50

Abstract: Medical devices and related patient management systems and parameter modeling methods are provided. An exemplary method of operating a sensing device associated with a patient involves obtaining current operational context information associated with the sensing device, obtaining a parameter model associated with the patient, calculating a current parameter value based on the parameter model and the current operational context information, obtaining one or more signals from a sensing element configured to measure a condition in a body of the patient, and providing an output that is influenced by the calculated current parameter value and the one or more signals.

Abstract translation: 提供了医疗设备和相关的患者管理系统和参数建模方法。 操作与患者相关联的感测装置的示例性方法涉及获得与感测装置相关联的当前操作上下文信息，获得与患者相关联的参数模型，基于参数模型和当前操作上下文信息计算当前参数值， 从被配置为测量患者体内的状况的感测元件获得一个或多个信号，以及提供受所计算的当前参数值和所述一个或多个信号影响的输出。

公开(公告)号：US20240423495A1

公开(公告)日：2024-12-26

申请号：US18829615

申请日：2024-09-10

Applicant: Medtronic MiniMed, Inc.

Inventor： Andrea Varsavsky ,  Fei Yu ,  Ning Yang

IPC: A61B5/0537 ,  A61B5/00 ,  A61B5/0538 ,  A61B5/145 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61M5/142 ,  A61M5/158 ,  A61M5/172 ,  G01N27/02

Abstract: Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

公开(公告)号：US20240345011A1

公开(公告)日：2024-10-17

申请号：US18735347

申请日：2024-06-06

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai ,  Andrea Varsavsky ,  Fei Yu

IPC: G01N27/02 ,  G01N33/487 ,  G01N33/49

CPC classification number: G01N27/026 ,  G01N33/48707 ,  G01N33/49

Abstract: A method of optimizing operation of a glucose sensor includes performing an electrochemical impedance spectroscopy (EIS) procedure to obtain imaginary impedance values for an electrode of a glucose sensor, calculating a change value as a difference between a threshold reference for the imaginary impedance values and a most-recent imaginary impedance value, and obtaining measurements of the calibration factor for the glucose sensor. The method also includes comparing the change value to a first threshold and the calibration factor to a second threshold and determining, based on the comparison, whether sensor data from the glucose sensor is valid.

公开(公告)号：US11793930B2

公开(公告)日：2023-10-24

申请号：US16893141

申请日：2020-06-04

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Chia-Hung Chiu ,  Rebecca K. Gottlieb ,  Ellis Garai ,  Akhil Srinivasan ,  Andrea Varsavsky ,  Adam S. Trock ,  Ashwin K. Rao ,  Hsifu Wang ,  Daniel E. Pesantez ,  Isabella Ella Miya ,  Xinrui Zhang ,  Guruguhan Meenakshisundaram

IPC: A61M5/142 ,  A61M39/10 ,  A61M5/172 ,  A61M5/162 ,  A61M5/168 ,  A61M37/00

CPC classification number: A61M5/14248 ,  A61M5/162 ,  A61M5/16831 ,  A61M5/1723 ,  A61M37/0015 ,  A61M39/10 ,  A61M2005/14252 ,  A61M2037/0023 ,  A61M2205/50 ,  A61M2205/8206 ,  A61M2205/8243 ,  A61M2230/201

Abstract: A fluid infusion system includes a housing configured to be adhesively coupled to an anatomy of a user, and a tube configured to extend from the housing for insertion into the anatomy of the user. The tube includes a plurality of conduits defined within the tube. The plurality of conduits include a fluid delivery conduit configured to facilitate a fluidic connection between a fluid source and the anatomy of the user, and one or more conduits configured to accommodate a plurality of electrodes for determining a physiological characteristic of the user.

公开(公告)号：US11670425B2

公开(公告)日：2023-06-06

申请号：US16848687

申请日：2020-04-14

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Elaine Gee ,  Peter Ajemba ,  Bahman Engheta ,  Jeffrey Nishida ,  Andrea Varsavsky ,  Keith Nogueira

IPC: G16H40/40 ,  G16H50/30 ,  G16H50/50 ,  G16H50/20 ,  G16H40/67 ,  G16H10/60 ,  G16H20/17 ,  G16H70/60 ,  G06N3/088 ,  A61B5/00 ,  A61B5/145 ,  G06N3/045 ,  A61M5/172

CPC classification number: G16H40/40 ,  A61B5/0022 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/7253 ,  A61B5/7267 ,  A61B5/7275 ,  G06N3/045 ,  G06N3/088 ,  G16H10/60 ,  G16H20/17 ,  G16H40/67 ,  G16H50/20 ,  G16H50/30 ,  G16H50/50 ,  G16H70/60 ,  A61B2560/0223 ,  A61B2560/0228 ,  A61M5/1723 ,  A61M2205/3303 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2205/70 ,  A61M2230/201

Abstract: Medical devices and related systems and methods are provided. A method of estimating a physiological condition involves determining a translation model based at least in part on relationships between first measurement data corresponding to instances of a first sensing arrangement and second measurement data corresponding to instances of a second sensing arrangement, obtaining third measurement data associated with the second sensing arrangement, determining simulated measurement data for the first sensing arrangement by applying the translation model to the third measurement data, and determining an estimation model for a physiological condition using the simulated measurement data, wherein the estimation model is applied to subsequent measurement output provided by an instance of the first sensing arrangement to obtain an estimated value for the physiological condition.

公开(公告)号：US20230157566A1

公开(公告)日：2023-05-25

申请号：US18100610

申请日：2023-01-24

Applicant: Medtronic MiniMed, Inc.

Inventor： Andrea Varsavsky ,  Fei Yu ,  Ning Yang

IPC: A61B5/0537 ,  A61B5/145 ,  A61B5/1468 ,  A61B5/00 ,  A61M5/158 ,  A61B5/0538 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/1486 ,  G01N27/02

CPC classification number: A61B5/0537 ,  A61B5/14532 ,  A61B5/1468 ,  A61B5/7246 ,  A61B5/7221 ,  A61M5/1582 ,  A61B5/0538 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/14865 ,  G01N27/026 ,  A61M2005/1726

Abstract: Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration. gross (sensor) failure analysis, and intelligent sensor diagnostics and faith detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

公开(公告)号：US20230069375A1

公开(公告)日：2023-03-02

申请号：US18045034

申请日：2022-10-07

Applicant: Medtronic MiniMed, Inc.

Inventor： Andrea Varsavsky ,  Yunfeng Lu ,  Keith Nogueira ,  Jeffrey Nishida

IPC: A61M5/172 ,  G16H40/63 ,  G16H40/40 ,  G16H50/20 ,  G16H10/60 ,  G16H50/50 ,  G16H20/17 ,  A61B5/145 ,  A61B5/00

Abstract: A processor-implemented method comprises obtaining current operational context information associated with a sensing device; obtaining an expected calibration factor parameter model associated with a patient; calculating an expected calibration factor value based on the expected calibration factor parameter model and the current operational context information; obtaining one or more electrical signals from the sensing device, the one or more electrical signals having a signal characteristic indicative of a physiological condition; converting the one or more electrical signals into a calibrated measurement value for the physiological condition using the expected calibration factor value; and outputting the calibrated measurement value for the physiological condition.

公开(公告)号：US20220354394A1

公开(公告)日：2022-11-10

申请号：US17859427

申请日：2022-07-07

Applicant: Medtronic MiniMed, Inc.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/145 ,  A61B5/1495 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1455 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N21/84 ,  G01N27/27 ,  C12Q1/00 ,  G01N21/59 ,  G01N27/327

Abstract: The disclosed techniques include obtaining a first signal generated by an electrochemical glucose sensor and a second signal generated by an optical glucose sensor, and obtaining a glucose value indicative of a user's blood glucose level, where the glucose value and the second signal are obtained at different times. The disclosed techniques further cause calculating a mapped value for the second signal based on the first signal, and calibrating the mapped value of the second signal based on the glucose value.