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    METABOLIC DOWNREGULATION FOR CELL SURVIVAL
    61.
    发明申请
    METABOLIC DOWNREGULATION FOR CELL SURVIVAL 审中-公开
    细胞生存的代谢下调

    公开(公告)号：US20150025031A1

    公开(公告)日：2015-01-22

    申请号：US14382921

    申请日：2013-03-05

    Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

    Inventor： James Yoo ,  Sang Jin Lee ,  Jachyun Kim ,  Anthony Atala

    IPC: A61K31/7076

    CPC classification number: A61K31/7076 ,  C12N5/0018 ,  C12N2500/40 ,  C12N2501/73

    Abstract: The present invention provides a system and method of maintaining and/or increasing cell viability by downregulating cellular metabolic rate under hypoxic conditions, wherein the availability of adenosine or derivatives thereof in the cell is increased and/or prolonged. The present invention also relates to a system and method of prolonging the survival of implanted cells that are under hypoxic condition until host neovascularization is achieved, wherein the availability of adenosine or derivatives thereof in the cell is increased and/or prolonged. The present invention also provides a system and method of maintaining and/or increasing cell viability by downregulating cellular metabolic rate under hypoxic conditions, wherein at least one purine metabolism enzyme inhibitor is applied to the cell.

    Abstract translation: 本发明提供通过在低氧条件下下调细胞代谢速率来维持和/或增加细胞活力的系统和方法，其中细胞中腺苷或其衍生物的可用性增加和/或延长。 本发明还涉及延长在缺氧条件下进行宿主新生血管形成的植入细胞的存活的系统和方法，其中细胞中腺苷或其衍生物的可用性增加和/或延长。 本发明还提供了通过在缺氧条件下下调细胞代谢速率来维持和/或增加细胞活力的系统和方法，其中至少一种嘌呤代谢酶抑制剂被施用于细胞。

    Amniotic Membrane Hydrogel and Methods of Making
    63.
    发明申请
    Amniotic Membrane Hydrogel and Methods of Making 有权
    羊膜水凝胶及其制备方法

    公开(公告)号：US20140348940A1

    公开(公告)日：2014-11-27

    申请号：US14449867

    申请日：2014-08-01

    Applicant: Wake Forest University Health Sciences

    Inventor： Sean V. Murphy ,  Aleksander Skardal ,  Anthony Atala

    IPC: A61K35/50 ,  A61K47/42 ,  A61K47/36

    CPC classification number: A61K35/50 ,  A61K47/36 ,  A61K47/42 ,  A61L15/40 ,  A61L26/0057 ,  A61L26/0076 ,  A61L27/34 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/48 ,  A61L27/52 ,  A61L2430/40 ,  C12N5/0068 ,  C12N2533/92 ,  C08L89/00

    Abstract: The present invention provides compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane of the placenta. In certain embodiments, the composition comprises amniotic membrane powder or solubilized amniotic membrane (SAM). In some aspects, the composition is cell-free and rich in cytokines, extracellular matrix proteins, and other components that improve tissue regeneration. In one aspect, the composition is a hydrogel scaffold that comprises amniotic membrane. The present invention reduces contraction and improves blood vessel development in regenerating tissue.

    Abstract translation: 本发明提供了用于伤口愈合和组织再生的组合物和方法。 本发明的组合物包含胎盘的羊膜。 在某些实施方案中，组合物包含羊膜膜或溶解羊膜（SAM）。 在一些方面，组合物是无细胞的并且富含细胞因子，细胞外基质蛋白质和改善组织再生的其它成分。 一方面，组合物是包含羊膜的水凝胶支架。 本发明减少收缩并改善再生组织中的血管发育。

    Amniotic Membrane Powder and Methods of Making
    64.
    发明申请
    Amniotic Membrane Powder and Methods of Making 审中-公开
    羊膜粉及其制作方法

    公开(公告)号：US20140342015A1

    公开(公告)日：2014-11-20

    申请号：US14449705

    申请日：2014-08-01

    Applicant: Wake Forest University Health Sciences

    Inventor： Sean V. Murphy ,  Aleksander Skardal ,  Anthony Atala

    IPC: A61K35/50

    Abstract: The present invention provides compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane of the placenta. In certain embodiments, the composition comprises amniotic membrane powder or solubilized amniotic membrane (SAM). In some aspects, the composition is cell-free and rich in cytokines, extracellular matrix proteins, and other components that improve tissue regeneration. In one aspect, the composition is a hydrogel scaffold that comprises amniotic membrane. The present invention reduces contraction and improves blood vessel development in regenerating tissue.

    Abstract translation: 本发明提供了用于伤口愈合和组织再生的组合物和方法。 本发明的组合物包含胎盘的羊膜。 在某些实施方案中，组合物包含羊膜膜或溶解羊膜（SAM）。 在一些方面，组合物是无细胞的并且富含细胞因子，细胞外基质蛋白质和改善组织再生的其它成分。 一方面，组合物是包含羊膜的水凝胶支架。 本发明减少收缩并改善再生组织中的血管发育。

    MEDICAL DEVICES INCORPORATING COLLAGEN INHIBITORS
    66.
    发明申请
    MEDICAL DEVICES INCORPORATING COLLAGEN INHIBITORS 审中-公开
    包含胶原抑制剂的医疗器械

    公开(公告)号：US20140128416A1

    公开(公告)日：2014-05-08

    申请号：US14153609

    申请日：2014-01-13

    Applicant: Wake Forest University Health Sciences

    Inventor： Christopher A. Sullivan ,  Steve J. Hodges ,  Anthony Atala ,  James J. Yoo

    IPC: A61K9/70 ,  A61K9/14 ,  A61K31/517

    CPC classification number: A61K9/7007 ,  A61B17/04 ,  A61F2/02 ,  A61F2/042 ,  A61F2/82 ,  A61K9/0034 ,  A61K9/146 ,  A61K31/517 ,  A61L15/44 ,  A61L17/00 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/432 ,  Y10S606/907

    Abstract: Provided herein are implantable or insertable biomedical devices comprising a substrate and a collagen inhibitor on or in said substrate, and methods of treatment using the same. In some embodiments, the device is a urethral, ureteral, or nephroureteral catheter or stent. In some embodiments, the device is an absorbable esophageal or tracheal stent. Wound closure devices are also provided herein, including a substrate and a collagen inhibitor on or in the substrate. Also provided are surgical packings, including a substrate and a collagen inhibitor on or in the substrate. A barrier material for preventing adhesions in a subject is further provided, including a preformed or in situ formable barrier substrate and a collagen inhibitor on or in the substrate. Kits comprising the coated substrates are also provided.

    Abstract translation: 本文提供的是可植入或可插入的生物医学装置，其包含基材和胶原抑制剂在所述底物上或所述底物中，以及使用其的处理方法。 在一些实施例中，该装置是尿道，输尿管或肾输尿管导管或支架。 在一些实施例中，该装置是可吸收的食管或气管支架。 本文还提供了伤口闭合装置，其包括衬底上的衬底和胶原抑制剂。 还提供了外科包装，包括底物上的基质和胶原抑制剂。 还提供了用于防止受试者粘连的阻挡材料，其包括预先形成的或原位可形成的屏障底物和在基底上或基底中的胶原抑制剂。 还提供了包含涂覆的基底的试剂盒。

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