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322 条记录 (耗时 0.058 秒)

    Method of extensive culture of antigen-specific cytotoxic T cells
    62.
    发明申请
    Method of extensive culture of antigen-specific cytotoxic T cells 审中-公开
    广泛培养抗原特异性细胞毒性T细胞的方法

    公开(公告)号：US20080166325A1

    公开(公告)日：2008-07-10

    申请号：US11790025

    申请日：2007-04-23

    申请人： Hiroaki Sagawa ,  Mitsuko Ideno ,  Ikunoshin Kato

    发明人： Hiroaki Sagawa ,  Mitsuko Ideno ,  Ikunoshin Kato

    IPC分类号： A01N63/00 ,  C12Q1/20 ,  C12N5/00

    CPC分类号： C12N5/0636 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5158 ,  A61K2039/55583 ,  C12N2501/515 ,  C12N2501/90 ,  C12N2760/16134

    摘要： The present invention provides methods for inducing, maintaining and expanding CTL (cytotoxic T cell) having an antigen-specific cytotoxic activity at a high level, which is useful in the adoptive immunotherapy, by using as an effective ingredient at least one compound selected from the group consisting of acidic polysaccharides, acidic oligosaccharides, acidic monosaccharides, and salts thereof. The above-mentioned compounds include fucoidans, heparins, alginic acid, chondroitin sulfate A, chondroitin sulfate B, pectic acid, hyaluronic acid, degradation products of fucoidans, sulfated glucose, sulfated fucose and salts thereof.

    摘要翻译： 本发明提供用于诱导，维持和扩增具有高水平的抗原特异性细胞毒性活性的CTL（细胞毒性T细胞）的方法，其可用于过继性免疫治疗，通过使用至少一种选自以下的化合物作为有效成分： 由酸性多糖，酸性寡糖，酸性单糖及其盐组成的组。 上述化合物包括岩藻多糖，肝素，海藻酸，硫酸软骨素A，硫酸软骨素B，果胶酸，透明质酸，岩藻多糖的降解产物，硫酸化葡萄糖，硫酸岩藻糖及其盐。

    Polypeptide Having Rnase III Activity
    63.
    发明申请
    Polypeptide Having Rnase III Activity 审中-公开
    具有Rnase III活性的多肽

    公开(公告)号：US20070218524A1

    公开(公告)日：2007-09-20

    申请号：US10573381

    申请日：2004-09-29

    申请人： Jun Tomono ,  Harumi Ueno ,  Hiroaki Sagawa ,  Ikunoshin Kato

    发明人： Jun Tomono ,  Harumi Ueno ,  Hiroaki Sagawa ,  Ikunoshin Kato

    IPC分类号： C12P21/00 ,  C07H21/02 ,  C07K2/00

    CPC分类号： C12N15/111 ,  C12N9/22 ,  C12N2310/14 ,  C12N2330/30 ,  C12Y301/26003

    摘要： A polypeptide having an RNase III activity with which the length of a dsRNA degradation product can be easily controlled depending on reaction conditions and, in preparing a dsRNA having a length allowing it to serve as an siRNA in RNA interference, a low-molecular weight product having little RNA interferring effect is scarcely formed; a method of degrading a dsRNA with the use of the above polypeptide; and a composition and a kit for the above method.

    摘要翻译： 可以根据反应条件容易地控制dsRNA降解产物的长度的具有RNase III活性的多肽，并且在制备具有允许其在RNA干扰中作为siRNA的长度的dsRNA时，低分子量产物 几乎没有形成RNA干扰效果; 使用上述多肽降解dsRNA的方法; 以及用于上述方法的组合物和试剂盒。

    Methods of degrading dsrna and synthesizing rna
    64.
    发明申请
    Methods of degrading dsrna and synthesizing rna 审中-公开
    降解dsrna并合成rna的方法

    公开(公告)号：US20070105113A1

    公开(公告)日：2007-05-10

    申请号：US10567731

    申请日：2004-08-10

    申请人： Hiroaki Sagawa ,  Jun Tomono ,  Harumi Ueno ,  Ikunoshin Kato

    发明人： Hiroaki Sagawa ,  Jun Tomono ,  Harumi Ueno ,  Ikunoshin Kato

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12N9/22

    CPC分类号： C12N9/22 ,  C12P19/34

    摘要： A protein having an activity of degrading a dsRNA, namely, being capable of acting on a long-chain dsRNA to form a dsRNA of a definite length; a method of efficiently preparing a dsRNA of a definite length which comprises treating a dsRNA with the protein having an activity of degrading a dsRNA in the coexistence of a protein having an activity of binding to a nucleic acid such as a protein having an RNA-binding activity; and a method of using the protein having an activity of binding to a nucleic acid to elevate the efficiency in an RNA synthesis reaction typified by dsRNA synthesis.

    摘要翻译： 具有降解dsRNA活性的蛋白质，即能够作用于长链dsRNA以形成一定长度的dsRNA; 一种有效制备一定长度的dsRNA的方法，该方法包括在具有与核酸如具有RNA结合性的蛋白质结合的蛋白质共存的蛋白质共同存在下具有降解dsRNA活性的蛋白质对dsRNA进行处理 活动; 以及使用具有与核酸结合的活性的蛋白质以提高以dsRNA合成为代表的RNA合成反应中的效率的方法。

    Remedies
    69.
    发明申请
    Remedies 审中-公开
    补救措施

    公开(公告)号：US20060199774A1

    公开(公告)日：2006-09-07

    申请号：US11408946

    申请日：2006-04-24

    申请人： Hiromu Ohnogi ,  Masahiro Shiraga ,  Hiroaki Sagawa ,  Ikunoshin Kato

    发明人： Hiromu Ohnogi ,  Masahiro Shiraga ,  Hiroaki Sagawa ,  Ikunoshin Kato

    IPC分类号： A61K31/366 ,  A61K31/7048

    CPC分类号： A61K31/7048 ,  A23K20/116 ,  A23K20/163 ,  A23L33/105 ,  A61K31/366 ,  A61K31/37 ,  C07H17/04 ,  C07H17/075

    摘要： The present invention relates to a medicament, a food, a beverage or a feed, each comprising as an effective ingredient a compound having an enhancing action for NGF production, which is effective for a treatment, an amelioration of symptom, prevention or the like of a disease requiring enhancement of NGF production, wherein the compound has a coumarin and/or chroman backbone. Since no toxicity is especially found in the effective ingredient of the present invention, and there is no risk of incidence of adverse actions, the treatment or the like of the above disease can be safely and appropriately carried out.

    摘要翻译： 本发明涉及一种药物，食品，饮料或饲料，其各自包含作为有效成分的具有NGF生产增强作用的化合物，其有效治疗，改善症状，预防等 需要增强NGF生产的疾病，其中所述化合物具有香豆素和/或色胺骨架。 由于在本发明的有效成分中没有特别的毒性，并且不存在不良反应的发生风险，所以可以安全，适当地进行上述疾病的治疗等。