公开(公告)号：US11872049B2

公开(公告)日：2024-01-16

申请号：US17867527

申请日：2022-07-18

Applicant: Shane Harrah ,  Christina J. Harrah

Inventor： Shane Harrah ,  Christina J. Harrah

IPC: A61B5/00 ,  A61B5/16 ,  A61B5/01 ,  A61B5/08

CPC classification number: A61B5/4011 ,  A61B5/4088 ,  A61B5/41

Abstract: A system and method for collecting symptomatic data to screen for a targeted disease. Testing hardware incorporates a plurality of testing units with corresponding indicators that can be altered to indicate whether a symptom is present or not. The resulting data from the testing use can then be analyzed to determine the likelihood of presence of a disease.

公开(公告)号：US20180031547A1

公开(公告)日：2018-02-01

申请号：US15631152

申请日：2017-06-23

Applicant: Maria D. F. S. Barbosa

Inventor： Maria D. F. S. Barbosa

IPC: G01N33/543 ,  G01N33/531 ,  G01N33/53 ,  A61B5/145

CPC classification number: G01N33/54366 ,  A61B5/00 ,  A61B5/145 ,  A61B5/14546 ,  A61B5/41 ,  A61B5/4833 ,  A61B5/7275 ,  G01N33/5302 ,  G01N33/531 ,  G01N33/54386 ,  G01N33/558 ,  G01N33/6854 ,  G01N2800/24 ,  G01N2800/50 ,  G06F19/00

Abstract: Portable devices for anti-drug antibody (ADA) testing, to estimate safety and/or efficacy of therapeutic agents are provided. These devices can be used to perform point of care risk assessment for various applications, including but not restricted to one or more of the following: selection of therapeutic drug for patient treatment; evaluation of the need to change therapeutic drug or to apply tolerance regimens; patient immune status prior and after vaccination; selection of patients for clinical trials; comparison of therapeutic drugs marketed for a given disease and also gene therapy; testing pre-existing antibodies as a risk factor; postmarketing surveillance of therapeutic drugs.

公开(公告)号：US20170360356A1

公开(公告)日：2017-12-21

申请号：US15533365

申请日：2015-12-03

Applicant: Lifecycle Technologies PTY LTD

Inventor： Luke Ashdown ,  Daniel Trenton

IPC: A61B5/00 ,  G09B5/06 ,  A61B5/0205 ,  A61B10/00 ,  A63B71/06 ,  G06F19/00 ,  G09B19/00 ,  A63B24/00 ,  A61B5/145 ,  A61B5/021 ,  A61B5/024

CPC classification number: A61B5/41 ,  A61B5/0022 ,  A61B5/02055 ,  A61B5/021 ,  A61B5/02405 ,  A61B5/145 ,  A61B5/4857 ,  A61B5/486 ,  A61B5/7275 ,  A61B10/0051 ,  A63B24/0075 ,  A63B71/0622 ,  A63B2071/0625 ,  G01N33/48 ,  G01N33/50 ,  G01N2800/24 ,  G01N2800/56 ,  G06F7/06 ,  G06F19/324 ,  G06F19/3418 ,  G06F19/3475 ,  G06F19/3481 ,  G06Q50/22 ,  G09B5/06 ,  G09B19/0092 ,  G16H10/60 ,  G16H50/20

Abstract: A system and method for determining the immune status or immune cycle in a subject is provided. A sampling component for obtaining physiological data from the subject is provided together with a data storage component for storing the physiological data obtained from the subject. A processing component is provided to analyse the physiological data and thereby determine the immune status or periodicity of the immune cycle and the immune cycle of the subject. An output component for outputting the immune status or periodicity of the immune cycle, and the immune cycle of the subject and/or the future status or immune cycle of the subject is provided.

公开(公告)号：US20170354812A1

公开(公告)日：2017-12-14

申请号：US15627422

申请日：2017-06-19

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Matthew J. Callaghan ,  Joelle A. Faulkner ,  Kevin Zi Jun Chao ,  John Avi Roop ,  Stephen Arie Leeflang ,  Christian Scott Eversull

IPC: A61M39/02 ,  A61M25/01 ,  A61B5/03 ,  A61B5/145 ,  A61B5/0215 ,  A61B5/00 ,  A61F2/82 ,  A61F2/06 ,  A61M25/00 ,  A61M27/00

CPC classification number: A61M39/0247 ,  A61B5/0215 ,  A61B5/036 ,  A61B5/14539 ,  A61B5/41 ,  A61B5/413 ,  A61B5/418 ,  A61F2/064 ,  A61F2/82 ,  A61F2002/061 ,  A61M25/01 ,  A61M27/002 ,  A61M2025/0057 ,  A61M2025/0197 ,  A61M2039/0258 ,  A61M2039/0276 ,  A61M2039/0291 ,  A61M2039/0297 ,  A61M2202/0405 ,  A61M2230/208

Abstract: Devices and methods for draining excess lymph fluid are disclosed. The device can be fixed to the blood vessel adjacent to the thoracic duct. The device can have a port for withdrawing lymph fluid exiting the thoracic duct. The device can have a cannula and/or subcutaneous port to draw the lymph fluid away from the thoracic duct and reduce hemostatic pressure in the lymphatic system.

公开(公告)号：US20170296118A1

公开(公告)日：2017-10-19

申请号：US14953394

申请日：2016-01-26

Applicant: DEF Medical Technologies, Inc.

Inventor： ELSA SWANSON ,  FORREST MILLER ,  Emily Cen ,  David Xing

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1495 ,  A61F2/38 ,  A61B5/07 ,  A61F2/30

CPC classification number: A61B5/4851 ,  A61B5/076 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/1495 ,  A61B5/41 ,  A61B5/686 ,  A61B5/7282 ,  A61B5/7435 ,  A61B5/746 ,  A61B5/748 ,  A61B2560/0219 ,  A61B2562/0238 ,  A61B2562/164 ,  A61B2562/166 ,  A61F2/38 ,  A61F2/4657 ,  A61F2002/3067 ,  A61F2002/30698 ,  A61F2002/4697 ,  A61F2002/48

Abstract: This invention relates to diagnostic medical instruments and procedures, and more particularly to implantable devices and methods for monitoring physiological parameters. A device for providing in vivo diagnostics of infections in orthopedic implants having at least one signal processing device operatively coupled with sensors. The signal processing device is operable to receive the output signal from the sensors and transmit a signal corresponding with the output signal. The invention also relates to a method using the device of the invention for detecting infection associated with implants in a human or animal subject.

公开(公告)号：US20160086500A1

公开(公告)日：2016-03-24

申请号：US14945600

申请日：2015-11-19

Applicant: KC Holdings I

Inventor： Robert Louis Kaleal, III

IPC: G09B5/02 ,  A61B5/20 ,  A61B5/08 ,  A61B5/00 ,  A61B5/02

CPC classification number: G09B5/06 ,  A61B5/0205 ,  A61B5/02055 ,  A61B5/08 ,  A61B5/11 ,  A61B5/165 ,  A61B5/20 ,  A61B5/40 ,  A61B5/41 ,  A61B5/42 ,  A61B5/43 ,  A61B5/44 ,  A61B5/45 ,  A61B5/486 ,  A61B5/7246 ,  A61B5/7264 ,  A61B5/744 ,  A61B5/7445 ,  G06F1/1626 ,  G06F19/00 ,  G06F19/3481 ,  G06Q50/01 ,  G06T13/40 ,  G06T19/00 ,  G06T2219/2012 ,  G09B5/02 ,  G09B19/00 ,  G09B19/0092 ,  G16H20/40 ,  G16H40/63

Abstract: Systems and methods are disclosed that facilitate providing guidance to a user during performance of a program or routine using a personalized avatar. In an aspect, a system includes a reception component configured to receive biochemical information about a physiological state or condition of a user, including information identifying a presence or a status of one or more biomarkers. The system further includes an analysis component configured to determine or infer one or more characteristics of the physiological state or condition of the user based on the information identifying the presence or the status of the one or more biomarkers, and a visualization component configured to adapt an appearance of an avatar presented to the user based on the one or more characteristics to reflect the one or more characteristics.

Abstract translation: 公开了系统和方法，其便于在使用个性化头像执行程序或例程期间向用户提供指导。 在一方面，一种系统包括被配置为接收关于用户的生理状况或状态的生化信息的接收组件，包括识别一种或多种生物标志物的存在或状态的信息。 该系统还包括分析组件，其被配置为基于识别一个或多个生物标志物的存在或状态的信息来确定或推断用户的生理状态或状况的一个或多个特征，以及可视化组件， 基于一个或多个特征呈现给用户的化身的外观以反映一个或多个特征。

公开(公告)号：US20160029948A1

公开(公告)日：2016-02-04

申请号：US14818571

申请日：2015-08-05

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Eva M. SEVICK-MURACA ,  Caroline E. FIFE ,  Milton V. MARSHALL ,  Erik A. MAUS ,  John C. RASMUSSEN ,  I-Chih TAN

IPC: A61B5/00

CPC classification number: A61B5/414 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/41 ,  A61B5/415 ,  A61B5/418 ,  A61K49/0034

Abstract: Methods and imaging agents are used to functionally image lymph structures and to identify, diagnose, assess, monitor and direct therapies for lymphatic disorders. Embodiments of the methods utilize highly sensitive optical imaging and fluorescent spectroscopy techniques capable of rapid temporal resolution to non-invasively track or monitor packets of imaging agents flowing in one or more lymphatic structures in human patients to provide quantitative information regarding lymph propulsion and functionality of the lymphatic structures. An imaging agent comprises a fluorophore labeled peptide capable of binding integrin α9β1 on a lymphatic structure.

Abstract translation: 方法和成像剂用于功能性影像淋巴结构，并识别，诊断，评估，监测和直接治疗淋巴系统疾病。 该方法的实施例利用高灵敏度的光学成像和荧光光谱技术，其能够快速的时间分辨率非侵入性地跟踪或监测在人类患者的一个或多个淋巴结构中流动的成像剂的分组，以提供关于淋巴推进和功能的定量信息 淋巴结构。 成像剂包括能够在淋巴结构上结合整联蛋白α9和bgr1的荧光团标记的肽。

公开(公告)号：US09239904B2

公开(公告)日：2016-01-19

申请号：US13848128

申请日：2013-03-21

Applicant: BIOTEMPUS LIMITED

Inventor： Martin Leonard Ashdown ,  Andrew Robinson

IPC: G01N33/48 ,  G06F19/00 ,  G01N33/564 ,  G01N33/574 ,  A61B5/00 ,  G06F19/24 ,  G06F19/12

CPC classification number: G06F19/12 ,  A61B5/41 ,  A61B5/413 ,  A61B5/4836 ,  A61B5/7267 ,  A61K31/495 ,  G01N33/564 ,  G01N33/57407 ,  G01N33/68 ,  G01N2333/4737 ,  G01N2800/042 ,  G01N2800/102 ,  G01N2800/104 ,  G01N2800/24 ,  G01N2800/28 ,  G01N2800/2821 ,  G01N2800/2828 ,  G01N2800/52 ,  G01N2800/60 ,  G06F19/00 ,  G06F19/24 ,  G06F19/34 ,  G16H50/50

Abstract: The present invention relates to computer-implemented methods and system for analyzing a biomarker which cycles in a subject. In some other aspects, the present invention relates to analyzing a biomarker which at least initially increases or decreases in amount in a subject following a treatment for a disease. In further aspects, the present invention relates to computer-implemented methods and systems for determining a preferred time to administer a therapy to treat a disease in a subject. The present invention also relates to computer program product to implement the methods. Further, the present invention relates to methods of determining the timing of treating a disease in a subject in which the immune system is cycling.

公开(公告)号：US09122778B2

公开(公告)日：2015-09-01

申请号：US13322357

申请日：2010-05-27

Applicant: Martin Leonard Ashdown ,  Andrew Robinson

Inventor： Martin Leonard Ashdown ,  Andrew Robinson

IPC: G01N33/48 ,  G06F19/00 ,  G01N33/564 ,  G01N33/574 ,  A61B5/00 ,  G06F19/24 ,  G06F19/12

CPC classification number: G06F19/12 ,  A61B5/41 ,  A61B5/413 ,  A61B5/4836 ,  A61B5/7267 ,  A61K31/495 ,  G01N33/564 ,  G01N33/57407 ,  G01N33/68 ,  G01N2333/4737 ,  G01N2800/042 ,  G01N2800/102 ,  G01N2800/104 ,  G01N2800/24 ,  G01N2800/28 ,  G01N2800/2821 ,  G01N2800/2828 ,  G01N2800/52 ,  G01N2800/60 ,  G06F19/00 ,  G06F19/24 ,  G06F19/34 ,  G16H50/50

Abstract: The present invention relates to computer-implemented methods and system for analyzing a biomarker which cycles in a subject. In some other aspects, the present invention relates to analyzing a biomarker which at least initially increases or decreases in amount in a subject following a treatment for a disease. In further aspects, the present invention relates to computer-implemented methods and systems for determining a preferred time to administer a therapy to treat a disease in a subject. The present invention also relates to computer program product to implement the methods. Further, the present invention relates to methods of determining the timing of treating a disease in a subject in which the immune system is cycling.

Abstract translation: 本发明涉及用于分析在受试者中循环的生物标志物的计算机实现的方法和系统。 在一些其它方面，本发明涉及分析生物标志物，其在治疗疾病之后至少最初增加或减少受试者的量。 在其它方面，本发明涉及用于确定施用治疗以治疗受试者的疾病的优选时间的计算机实现的方法和系统。 本发明还涉及实现该方法的计算机程序产品。 此外，本发明涉及确定在免疫系统循环的受试者中治疗疾病的时机的方法。

公开(公告)号：US08989847B2

公开(公告)日：2015-03-24

申请号：US14072581

申请日：2013-11-05

Applicant: Board of Regents, The University of Texas System

Inventor： Kristen Adams ,  Ruchi Sharma ,  John C. Rasmussen ,  Eva M. Sevick-Muraca

IPC: A61M25/00 ,  A61B5/00 ,  A61K47/48 ,  A61K49/00 ,  A61M5/00

CPC classification number: A61B5/0071 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/41 ,  A61B5/415 ,  A61B5/418 ,  A61K47/61 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0041 ,  A61K49/0054 ,  A61M5/007

Abstract: Novel methods and imaging agents for functional imaging of lymph structures are disclosed herein. Embodiments of the methods utilize highly sensitive optical imaging and fluorescent spectroscopy techniques to track or monitor packets of organic dye flowing in one or more lymphatic structures. The packets of organic dye may be tracked to provide quantitative information regarding lymph propulsion and function. In particular, lymph flow velocity and pulse frequency may be determined using the disclosed methods.

Abstract translation: 本文公开了用于淋巴结构的功能成像的新方法和成像剂。 该方法的实施例利用高灵敏度的光学成像和荧光光谱技术来跟踪或监测在一个或多个淋巴结构中流动的有机染料的包。 可以跟踪有机染料的包装以提供关于淋巴推进和功能的定量信息。 特别地，可以使用公开的方法确定淋巴流速度和脉搏频率。