公开(公告)号：US08366857B2

公开(公告)日：2013-02-05

申请号：US12695297

申请日：2010-01-28

Applicant: Kenneth Hayworth ,  Amy Au Hayworth

Inventor： Kenneth Hayworth ,  Amy Au Hayworth

IPC: B32B37/22 ,  B32B38/10 ,  B32B38/04 ,  B65C9/04 ,  B65C9/06 ,  G01N1/06 ,  B65H75/00 ,  B32B37/02 ,  B65H75/04 ,  B65H81/02

CPC classification number: G01N1/06 ,  G01N1/286 ,  G01N1/312 ,  G01N2001/066 ,  G01N2001/362 ,  H01J2237/201 ,  H01J2237/202 ,  H01J2237/26 ,  Y10T156/1052 ,  Y10T156/1056 ,  Y10T156/1057 ,  Y10T156/1059 ,  Y10T156/1062 ,  Y10T156/12 ,  Y10T156/1322 ,  Y10T156/1712

Abstract: Methods, apparatus and systems for collecting thin tissue samples for imaging. Thin tissue sections may be cut from tissue samples using a microtome-quality knife. In one example, tissue samples are mounted to a substrate that is rotated such that thin tissue sections are acquired via lathing. Collection of thin tissue sections may be facilitated by a conveyor belt. Thin tissue sections may be mounted to a thin substrate (e.g., by adhering thin tissue sections to a thin substrate via a roller mechanism) that may be imaged, for example, by an electron beam (e.g., in an electron microscope). This tissue sections may be strengthened before cutting via a blockface thinfilm deposition technique and/or a blockface taping technique. An automated reel-to-reel imaging technique may be employed for collected/mounted tissue sections to facilitate random-access imaging of tissue sections and maintaining a comprehensive library including a large volume of samples.

Abstract translation: 用于收集用于成像的薄组织样本的方法，装置和系统。 可以使用切片机质量刀从组织样品切割薄组织切片。 在一个实例中，将组织样品安装到旋转的基底上，使得通过车床获得薄的组织切片。 通过传送带可以促进薄组织切片的收集。 薄组织切片可以例如通过电子束（例如，在电子显微镜中）被安装到薄基底（例如，通过将薄组织切片通过辊机构粘附到薄基底上）。 在经由块状薄膜沉积技术和/或块状胶带技术切割之前，可以加强该组织切片。 可以采用自动卷线对卷成像技术来收集/安装的组织切片，以促进组织切片的随机取景成像并维持包括大量样品的综合库。

公开(公告)号：US20130019725A1

公开(公告)日：2013-01-24

申请号：US13187416

申请日：2011-07-20

Applicant: Sanjay Shivayogi Magavi ,  Jack Barger ,  Michael Paul Emery ,  James Edward Sinclair ,  Jorge Arturo Ayala

Inventor： Sanjay Shivayogi Magavi ,  Jack Barger ,  Michael Paul Emery ,  James Edward Sinclair ,  Jorge Arturo Ayala

IPC: G01N1/06 ,  B26D7/06

CPC classification number: G01N1/312 ,  G01N1/06 ,  Y10T83/0453 ,  Y10T83/2066 ,  Y10T83/2179 ,  Y10T83/2216 ,  Y10T83/222

Abstract: Disclosed herein are apparatuses and methods handling a portion of a tissue sample when sectioned by a microtome. The apparatuses include a container, a tissue sample holder in the container, and one or more outlets configured to allow flow of a fluid from the container. the flow through the outlet causes a portion of the tissue sample sectioned by a microtome to move into the outlet. The methods include sectioning one or more portions of a tissue sample, and flowing a fluid past the tissue sample to cause the one or more portions of the tissue sample to move away from the tissue sample and toward at least one fluid outlet.

公开(公告)号：US08356525B2

公开(公告)日：2013-01-22

申请号：US12399515

申请日：2009-03-06

Applicant: Yuichi Hamada ,  Kunio Ueno

Inventor： Yuichi Hamada ,  Kunio Ueno

IPC: B01L3/02

CPC classification number: G01N1/00 ,  G01N1/06 ,  G01N35/026

Abstract: An analyzer comprising: a first measurement unit for measuring samples; a second measurement unit; and a transportation device operable to transport a plurality of sample containers accommodated in a first rack and containing samples and a plurality of sample containers accommodated in a second rack and containing samples, to the first measurement unit and the second measurement unit, wherein the transportation device comprises a first transportation section operable to transport the plurality of sample containers on the first rack to the first measurement unit and the second measurement unit by transporting the first rack on a transport path, and a second transportation section operable to transport the plurality of sample containers on the second rack to the first measurement unit and the second measurement unit by transporting the second rack on the transport path independently from movement of the first rack, is disclosed. A transportation device is also disclosed.

Abstract translation: 一种分析器，包括：用于测量样品的第一测量单元; 第二测量单元; 以及运送装置，其可操作地将容纳在第一机架中的多个样本容器和容纳在第二机架中并容纳样品的多个样本容器运送到第一测量单元和第二测量单元，其中运输设备 包括第一输送部，其可操作以通过在输送路径上输送所述第一齿条而将所述第一齿条上的所述多个样本容器输送到所述第一测量单元和所述第二测量单元;以及第二输送部，其可操作以运送所述多个样本容器 公开了在第二机架上通过与第一机架的移动独立地运送传送路径上的第二机架的第一测量单元和第二测量单元。 还公开了一种运输装置。

公开(公告)号：US08309038B2

公开(公告)日：2012-11-13

申请号：US12738822

申请日：2008-11-14

Applicant: Roland Walter ,  Andreas Laudat ,  Christoph Schmitt

Inventor： Roland Walter ,  Andreas Laudat ,  Christoph Schmitt

IPC: A61B10/00

CPC classification number: G01N1/06

Abstract: A device for applying a histological section to a slide is described. The histological section is generated by a cutting action performed by a blade of a microtome. The device comprises a positioning device having a component that is rotatably mounted to a bearing and has a receptacle for receiving and holding the slide, wherein the positioning device is designed such that the slide received in the receptacle can be rotated about an axis of rotation of the rotatably mounted component.

Abstract translation: 描述了将组织学部分应用于载玻片的装置。 组织切片由切片机的刀片进行的切割动作产生。 该装置包括定位装置，其具有可旋转地安装在轴承上的部件，并具有用于容纳和保持滑块的插座，其中定位装置被设计成使得容纳在容器中的滑块能够围绕 可旋转安装的部件。

公开(公告)号：US20120240737A1

公开(公告)日：2012-09-27

申请号：US13071185

申请日：2011-03-24

Applicant: Hwai-Jyh Michael Yang ,  Xuan S. Bui

Inventor： Hwai-Jyh Michael Yang ,  Xuan S. Bui

IPC: G01N1/06 ,  B26D7/01

CPC classification number: G01N1/06 ,  Y10S83/9155 ,  Y10T83/04 ,  Y10T83/141 ,  Y10T83/525 ,  Y10T83/536 ,  Y10T83/538 ,  Y10T83/6572

Abstract: A sample sectioning device includes a cutting mechanism, a sample holder, a drive system, and a surface orientation sensor. The sample holder is operable to hold a sample. The cutting mechanism is operable to cut sections from the sample. The drive system is coupled with the sample holder. The drive system is operable to drive movement between the sample held by the sample holder and the cutting mechanism. The surface orientation sensor is operable to sense an orientation of a surface of the sample held by the sample holder.

Abstract translation: 样品切片装置包括切割机构，样品保持器，驱动系统和表面取向传感器。 样品架可操作以容纳样品。 切割机构可操作以从样品切割切片。 驱动系统与样品架连接。 驱动系统可操作地驱动由样品架保持的样品与切割机构之间的运动。 表面取向传感器可操作以感测由样品保持器保持的样品的表面的取向。

公开(公告)号：US08274063B2

公开(公告)日：2012-09-25

申请号：US12733091

申请日：2008-08-06

Applicant: Takashi Kaito ,  Yoshitomo Nakagawa ,  Junichi Tashiro ,  Yasuhiko Sugiyama ,  Toshiaki Fujii ,  Kazuo Aita ,  Takashi Ogawa

Inventor： Takashi Kaito ,  Yoshitomo Nakagawa ,  Junichi Tashiro ,  Yasuhiko Sugiyama ,  Toshiaki Fujii ,  Kazuo Aita ,  Takashi Ogawa

IPC: H01J49/00

CPC classification number: H01J37/08 ,  G01N1/04 ,  G01N1/06 ,  H01J37/3005 ,  H01J37/3056 ,  H01J2237/0807 ,  H01J2237/0817 ,  H01J2237/31745

Abstract: A composite focused ion beam device has a first ion beam irradiation system that irradiates a first ion beam for processing a sample and a second ion beam irradiation system that irradiates a second ion beam for processing or observing the sample. The first ion beam irradiation system has a plasma type gas ion source that generates first ions for forming the first ion beam, each of the first ions having a first mass. The second ion beam irradiation system has a gas field ion source that generates second ions for forming the second ion beam. Each of the second ions has a second mass smaller than that of the first mass.

Abstract translation: 复合聚焦离子束装置具有照射用于处理样品的第一离子束的第一离子束照射系统和照射第二离子束用于处理或观察样品的第二离子束照射系统。 第一离子束照射系统具有产生用于形成第一离子束的第一离子的等离子体型气体离子源，每个第一离子具有第一质量。 第二离子束照射系统具有产生用于形成第二离子束的第二离子的气体场离子源。 每个第二离子具有比第一质量小的第二质量。

公开(公告)号：US20120223228A1

公开(公告)日：2012-09-06

申请号：US13408054

申请日：2012-02-29

Applicant: Simon Galloway

Inventor： Simon Galloway

IPC: H01J37/02 ,  B26D5/00 ,  G01N1/06

CPC classification number: H01J37/20 ,  G01N1/06 ,  H01J2237/206 ,  H01J2237/226 ,  H01J2237/24495 ,  H01J2237/24578 ,  Y10T83/8748 ,  Y10T83/8749

Abstract: A microtome for in situ residence within a chamber of a scanning electron microscope (SEM) and a SEM including the microtome is disclosed. The microtome includes a specimen holder for holding a specimen thereon at high voltage to produce a retardation field thereat and a movable knife. The SEM includes a backscatter electron detector disposed adjacent to specimen holder. The knife arranged is to be carried into engagement with the specimen on the specimen holder to slice a portion of the specimen away to expose a new face of the specimen without interfering with the high voltage on the specimen, and is mounted so that after having engaged the specimen to expose a new face of the specimen it is withdrawn to a retracted position whereupon it does not interfere with the retardation field.

Abstract translation: 公开了一种用于在扫描电子显微镜（SEM）的室内原位居住的切片机和包括切片机的SEM。 切片机包括用于在高压下保持样品以在其上产生延迟场的样本保持器和可动刀。 扫描电子显微镜（SEM）包括邻近样品架设置的反向散射电子检测器。 布置的刀将与试样夹持器上的试样接合，以将样品的一部分切开以露出样品的新面，而不干扰样品上的高电压，并且安装成使得在已经接合之后 试样露出样品的新面，它被抽出到缩回位置，因此它不会妨碍延迟场。

公开(公告)号：US08191453B2

公开(公告)日：2012-06-05

申请号：US12472275

申请日：2009-05-26

Applicant: Shu Ichihara

Inventor： Shu Ichihara

IPC: G01N1/28

CPC classification number: G01N1/06 ,  G01N2001/2873 ,  Y10T83/05 ,  Y10T83/0524 ,  Y10T83/6955 ,  Y10T83/7587 ,  Y10T83/858 ,  Y10T83/8878 ,  Y10T83/8886 ,  Y10T83/8889

Abstract: A specimen slicing guide for use in slicing a biopsy specimen taken from a human patient or an animal patient includes a base extending in a longitudinal direction. A plurality of needles extends substantially perpendicularly to the base and the needles are spaced along the longitudinal direction of the base. Two specimen slicing guides are coupled via at least one link, which is adapted to allow an adjustable spacing of the two specimen slicing guides in a parallel relationship. A method of cutting a biopsy specimen includes fixing the biopsy specimen relative to a support surface using the needles of two, parallel-arranged specimen slicing guides, inserting a cutting tool between corresponding needle gap pairs and then downwardly moving the cutting tool under guidance of adjacent needles.

Abstract translation: 用于切片从人类患者或动物患者取出的活检标本用的切片引导件包括沿纵向延伸的基部。 多根针基本上垂直于基部延伸，并且针沿着基部的纵向方向间隔开。 两个样本切片引导件通过至少一个连接件联接，该连杆适于以两个平行的关系允许两个样本切片引导件的可调间距。 切割活检标本的方法包括使用两个平行布置的样本切片引导件的针将活检样本相对于支撑表面固定，在相应的针间对之间插入切割工具，然后在相邻的针间隙的引导下向下移动切割工具 针。

公开(公告)号：US08187536B2

公开(公告)日：2012-05-29

申请号：US12959755

申请日：2010-12-03

Applicant: Dag Graupner ,  Rolf Metzner

Inventor： Dag Graupner ,  Rolf Metzner

IPC: G01N21/00

CPC classification number: B01L3/545 ,  B01L2300/021 ,  B01L2300/0822 ,  G01N1/06 ,  G01N1/31 ,  G01N35/00732 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/2575

Abstract: A system (100) and a method for the unequivocal allocation of histological cassettes (30) and specimen slides (60) is described. The system encompasses a microtome (1) and at least one reading unit (80). The data (33) of the histological cassette (30) and the data (33) of the at least one specimen slide (60) are read by means of the reading unit (80). The reading unit (80) is provided with at least one indicating element (83) that outputs a signal in accordance with the degree of correspondence between the data (33) of the histological cassette (30) and the data (33) on the specimen slide (60).

Abstract translation: 描述了系统（100）和用于明确分配组织学盒（30）和标本片（60）的方法。 系统包括切片机（1）和至少一个读取单元（80）。 通过读取单元（80）读取组织学盒（30）的数据（33）和至少一个样本滑块（60）的数据（33）。 读取单元（80）设置有至少一个指示元件（83），其根据组织学盒（30）的数据（33）与样本上的数据（33）之间的对应度输出信号 幻灯片（60）。

公开(公告)号：US08172927B2

公开(公告)日：2012-05-08

申请号：US13221697

申请日：2011-08-30

Applicant: Christoph Schmitt ,  Roland Walter

Inventor： Christoph Schmitt ,  Roland Walter

IPC: B01D50/00

CPC classification number: B01D46/24 ,  B01D46/0043 ,  B01D46/4272 ,  G01N1/06 ,  Y10T83/207 ,  Y10T83/242

Abstract: An apparatus and a method for filtering sectioning wastes of a microtome that are present in an air stream are described. The apparatus has an aspiration device with which sectioning waste can be aspirated from a blade region of the microtome with an air stream. A main filter and a prefilter are provided. A valve is provided for opening and closing an opening so that the air stream so that if desired an air stream can be directed through a filter insert in the prefilter for emptying the prefilter into the main filter. According to the method, an air stream that is used for aspirating sectioning waste from a blade region of the microtome is shut off immediately before emptying the prefilter.

Abstract translation: 描述了存在于空气流中的用于过滤切片机的切片废料的装置和方法。 该装置具有抽吸装置，利用空气流可以从切片机的叶片区域吸入切片废料。 提供主过滤器和预过滤器。 提供一个阀门，用于打开和关闭一个开口，使空气流使得如果需要的话，气流可以被引导通过预过滤器中的过滤器插件，以便将预过滤器排空到主过滤器中。 根据该方法，在排空预过滤器之前立即关闭用于从切片机的叶片区域吸取切片废料的气流。