公开(公告)号：US09875884B2

公开(公告)日：2018-01-23

申请号：US14634745

申请日：2015-02-28

申请人： Agilent Technologies, Inc.

发明人： Viorica Lopez-Avila ,  Mark Denning ,  Mehrnoosh Vahidpour

IPC分类号： H01J49/10 ,  H01J49/04 ,  H01J49/00 ,  H01J49/16 ,  H05H1/46 ,  G01N21/71 ,  G01N30/95 ,  H01J27/16

CPC分类号： H01J49/102 ,  G01N21/714 ,  G01N30/95 ,  H01J27/16 ,  H01J49/0031 ,  H01J49/0409 ,  H01J49/049 ,  H01J49/105 ,  H01J49/161 ,  H05H1/46

摘要： An ion source includes a plasma generator for supplying plasma at an ionization region proximate to a sample surface. The plasma generator applies energy that may be utilized for desorbing analytes from the sample surface as well as for generating plasma by which analytes are excited or ionized. Desorption and ionization/excitation may be controlled as individual modes. The ion source may be interfaced with an ion-based or optical-based spectrometer. A sample support may be provided, which may be capable of performing analytical separation.

公开(公告)号：US09863921B2

公开(公告)日：2018-01-09

申请号：US13974549

申请日：2013-08-23

申请人： AGILENT TECHNOLOGIES, INC.

发明人： Holger Rapp

IPC分类号： G01N30/38 ,  G01N30/62 ,  G01L1/12 ,  B01L3/00 ,  G01N30/60

CPC分类号： G01N30/38 ,  B01L3/502715 ,  B01L3/502746 ,  B01L2300/0864 ,  B01L2400/0487 ,  G01L1/125 ,  G01N30/6017 ,  G01N30/62 ,  G01N2030/6013 ,  Y10T137/0318 ,  Y10T137/85938

摘要： A fluid transfer device transfers a fluid from a first fluid channel with a first cross-sectional area into a second fluid channel with a second cross-sectional area, larger than the first cross-sectional area. The fluid transfer device includes a fluid inlet interface at which the fluid is transferable from the first fluid channel into the fluid transfer device; an inlet branch configured to split the fluid from the first fluid channel into multiple inlet branch channels; multiple outlet branches, each of which is configured to split the fluid from the inlet branch channels into respective outlet branch channels; and a fluid outlet interface configured to transfer the fluid in the outlet branch channels into the second fluid channel. The inlet and output branches and branch channels are disposed such that the fluid exits from the fluid outlet interface, distributed in a two-dimensional manner across the second cross-sectional area.

公开(公告)号：USD805164S1

公开(公告)日：2017-12-12

申请号：US29531557

申请日：2015-06-26

申请人： Agilent Technologies, Inc.

设计人： Wesley M. Norman ,  Wei J. Song

公开(公告)号：US09833754B2

公开(公告)日：2017-12-05

申请号：US14443126

申请日：2012-11-15

申请人： AGILENT TECHNOLOGIES, INC.

发明人： Herbert Anderer

IPC分类号： B01F3/08 ,  B01F15/02 ,  B01F15/00 ,  G01N35/10 ,  G01N30/06 ,  G01N1/38

CPC分类号： B01F3/0865 ,  B01F3/088 ,  B01F15/00188 ,  B01F15/00253 ,  B01F15/00422 ,  B01F15/026 ,  B01F2003/0896 ,  B01F2215/0037 ,  G01N1/38 ,  G01N30/06 ,  G01N35/1097 ,  G01N2001/383

摘要： A dilution apparatus (100) for diluting a fluidic sample in accordance with a specifiable dilution ratio, wherein the dilution apparatus (100) comprises a dilution fluid supply device (102) configured for supplying a dilution fluid at a first quantity per time, a transport fluid supply device (104) configured for supplying a transport fluid at a second quantity per time, a first fluid accommodation unit (106) configured for accommodating a first fluid volume, a second fluid accommodation unit (108) configured for accommodating a second fluid volume, and a control device (110, 112) configured for controlling the flow of the dilution fluid, the transport fluid and the fluidic sample so that in a first operation mode, the fluidic sample, being accommodated in the first fluid accommodation unit (106), is forced to flow to the second fluid accommodation unit (108) while being diluted by being mixed with dilution fluid, and in a second operation mode, the mixture of dilution fluid and fluidic sample, being accommodated in the second fluid accommodation unit (108), is forced to flow from the second fluid accommodation unit (108) to the first fluid accommodation unit (106) while being further diluted by being mixed with further dilution fluid.

公开(公告)号：US09823226B2

公开(公告)日：2017-11-21

申请号：US14898392

申请日：2013-06-14

申请人： Agilent Technologies, Inc.

发明人： Klaus Witt ,  Konstantin Shoykhet ,  Manfred Berndt

IPC分类号： G01N1/00 ,  G01N30/00 ,  G01N30/20 ,  G01N30/46 ,  G01N30/02

CPC分类号： G01N30/20 ,  G01N30/465 ,  G01N2030/027 ,  G01N2030/202 ,  G01N2030/208

摘要： Disclosed is a sample dispatcher configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a separation system configured for separating compounds of the sample fluids. The separation system comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher comprises a plurality of sample reservoirs, each configured for receiving and temporarily storing a respective sample fluid portion or at least a part thereof. The sample dispatcher is configured for selectively coupling one of the plurality of sample reservoirs between the mobile phase drive and the separation unit, and further for coupling at least two of the plurality of sample reservoirs in parallel between the mobile phase drive and the separation unit.

公开(公告)号：US09803782B2

公开(公告)日：2017-10-31

申请号：US13695878

申请日：2010-05-03

申请人： Bernhard Dehmer

发明人： Bernhard Dehmer

IPC分类号： F16L17/10 ,  F16L19/04 ,  F16L19/06 ,  G01N30/60 ,  B01D15/14 ,  F16L19/07

CPC分类号： F16L17/10 ,  B01D15/14 ,  F16L19/041 ,  F16L19/046 ,  F16L19/06 ,  F16L19/07 ,  G01N30/6039

摘要： A fitting element, in particular for an HPLC application, is configured for providing a fluidic coupling of a tubing to a fluidic device. The fitting element comprises a gripping piece to exert—upon coupling of the tubing to the fluidic device—a grip force (G) between the fitting element and the tubing. The gripping piece comprises a hydraulic element configured to transform an axial force (S) into a hydraulic pressure (P) within the hydraulic element. The hydraulic pressure (P) in the hydraulic element causes the grip force (G).

公开(公告)号：US09802975B2

公开(公告)日：2017-10-31

申请号：US14724613

申请日：2015-05-28

申请人： Agilent Technologies, Inc.

发明人： Benjamin D. Lunstad ,  Douglas J. Dellinger

IPC分类号： C07H5/06 ,  C07H7/06 ,  C07H23/00 ,  C07H21/00 ,  C07D211/00

CPC分类号： C07H23/00 ,  C07D211/00 ,  C07H7/06 ,  C07H21/00 ,  Y02P20/55

摘要： The present disclosure provides nucleoside compounds and oligonucleotides including an unnatural 6-amino-2-pyridone heterocyclic base where the 6-amino and 2-positions are protected. The 2-position of the heterocyclic base can be protected with an acyl-oxy-methyl protecting group. In some embodiments, the protected heterocyclic base has the following structure where AcOM is an acetyl-oxy-methyl group and R is a ribose or deoxyribose sugar: Methods for synthesizing an oligonucleotide are provided in which the subject compounds find use. The method can include protecting an unnatural (e.g., Z) nucleotide with an acetyl-oxy-methyl group; incorporating the protected unnatural nucleotide into a nucleotide sequence on a solid support; and removing the acetyl-oxy-methyl group from the unnatural nucleotide incorporated into the nucleotide sequence. The compounds and methods find use in the synthesis of long oligonucleotides including Z nucleotides.

公开(公告)号：US09792416B2

公开(公告)日：2017-10-17

申请号：US13252731

申请日：2011-10-04

申请人： Gerd Heinje ,  Rainer Jaeger

发明人： Gerd Heinje ,  Rainer Jaeger

IPC分类号： G06F19/00 ,  G06T11/20

CPC分类号： G06F19/707 ,  G06F19/708 ,  G06T11/206

摘要： A device for analyzing measurement data having a plurality of data sets, each data set being assigned to a respective one of a plurality of measurements, each data set having multiple features being indicative of different fractions of a fluidic sample, the device comprising a cluster determining unit configured for determining feature clusters by clustering features from different data sets presumably relating to the same fraction, a spread determining unit configured for determining for at least a part of the feature clusters a spread of the features within a respective feature cluster, and a display unit configured for displaying at least the part of the feature clusters together with a graphical indication of the corresponding spread.

公开(公告)号：US09782692B2

公开(公告)日：2017-10-10

申请号：US14396938

申请日：2012-04-25

申请人： Klaus Witt ,  Konstantin Shoykhet

发明人： Klaus Witt ,  Konstantin Shoykhet

IPC分类号： B01D15/12 ,  B01L3/00 ,  G01N30/34 ,  G01N30/16

CPC分类号： B01D15/12 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2400/0487 ,  B01L2400/0644 ,  G01N30/16 ,  G01N30/34

摘要： A fluid supply system configured for supplying fluids includes a fluid packet supply unit configured for controlling supply of a sequence of fluid packets. The fluid packets include a packet of first fluid and a packet of second fluid, wherein the first fluid and the second fluid are media being prone to a phase separation upon direct interaction between the packet of first fluid and the packet of second fluid. The fluid supply system further includes a phase separation inhibiting unit configured for inhibiting phase separation by inserting an intermediate fluid packet between the packet of first fluid and the packet of second fluid.

公开(公告)号：US09752978B2

公开(公告)日：2017-09-05

申请号：US14376430

申请日：2012-02-03

申请人： Karsten Kraiczek ,  John Mannion ,  Kevin P. Killeen

发明人： Karsten Kraiczek ,  John Mannion ,  Kevin P. Killeen

IPC分类号： G01N21/05 ,  B01L3/00 ,  G01N30/74 ,  G01N33/543 ,  B32B37/18 ,  B32B38/10 ,  G01N21/03 ,  G01N30/02

CPC分类号： G01N21/05 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0838 ,  B32B37/18 ,  B32B38/10 ,  B32B2551/00 ,  G01N30/74 ,  G01N33/54373 ,  G01N2021/0346 ,  G01N2021/052 ,  G01N2021/056 ,  G01N2030/027 ,  G01N2030/746 ,  G01N2201/08 ,  Y10T156/10

摘要： A micromachined flow cell includes a substrate and a freestanding tube, delimiting a fluidic conduit therein and being integrally formed from material of the substrate.