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    Agar gel bead composition and method
    72.
    发明授权
    Agar gel bead composition and method 失效
    琼脂凝胶珠组成及方法

    公开(公告)号：US06319507B1

    公开(公告)日：2001-11-20

    申请号：US09431742

    申请日：1999-11-01

    Applicant: Pascal E. Delrieu ,  Li Ding

    Inventor： Pascal E. Delrieu ,  Li Ding

    IPC: A61K914

    CPC classification number: A61K8/042 ,  A61K8/025 ,  A61K8/11 ,  A61K8/365 ,  A61K8/645 ,  A61K8/676 ,  A61K8/73 ,  A61K8/731 ,  A61K8/735 ,  A61K2800/56 ,  A61Q19/00 ,  Y10S514/937 ,  Y10S514/944

    Abstract: Crushable gel beads 10 formed of an agar complex provide novel cosmetic, pharmaceutical, etc. delivery vehicles for topical delivery of biologically or cosmetically active agents. Preferred agar beads 10 are complexes of a continuous phase of agar gel 12 in a self-supporting solid or semi-solid form with a restraining polymer 14. Entrapped in and dispersed randomly throughout each agar bead 10 is a water-soluble, preferably polar, restraining polymer 14, preferably a quaternized cationic polymer, such as polyquaternium 24 or steardimonium hydroxyethylcellulose. Various active agents 16 may be bound to restraining polymer 14, for example ascorbic acid, lactic acid or papain. Methods of manufacture are also described.

    Abstract translation: 由琼脂复合物形成的可破碎的凝胶珠10提供用于局部递送生物或化妆活性剂的新型化妆品，药​​物等输送载体。 优选的琼脂珠10是具有抑制性聚合物14的自支撑固体或半固体形式的琼脂凝胶12的连续相的复合物。包埋并随机分散在每个琼脂珠10中是水溶性的，优选极性的， 约束聚合物14，优选季铵化阳离子聚合物，例如聚季铵盐24或羟乙基纤维素。 各种活性剂16可以与约束聚合物14结合，例如抗坏血酸，乳酸或木瓜蛋白酶。 还描述了制造方法。

    Human diacylglycerol kinase iota
    73.
    发明授权
    Human diacylglycerol kinase iota 有权
    人二酰甘油激酶

    公开(公告)号：US06255095B1

    公开(公告)日：2001-07-03

    申请号：US09412545

    申请日：1999-10-05

    Applicant: Stephen M. Prescott ,  Li Ding ,  Elie Traer

    Inventor： Stephen M. Prescott ,  Li Ding ,  Elie Traer

    IPC: C12N912

    CPC classification number: C12N9/1205

    Abstract: Diacylglycerol (DAG) plays a central role in both the synthesis of complex lipids and in intracellular signaling; diacylglycerol kinase (DGK) catalyzes the phosphorylation of DAG, which yields phosphatidic acid. A family of DGKs has been identified in multicellular organisms over the past few years, but the physiological function(s) of this diversity is not clear. One clue has come from the Drosophila DGK2, rdgA, since mutations in this gene cause retinal degeneration. The present invention relates to a novel DGK, designated DGK&igr;, which was isolated from human retina and brain libraries. DGK&igr; contains two cysteine-rich repeats, a region similar to the phosphorylation site domain of MARCKS, a conserved catalytic domain, and four ankyrin repeats at its C-terminus. By primary structure, DGK&igr; is most similar to human DGK&zgr; and Drosophila rdgA. A>12 kb mRNA for DGK&igr; was detected only in brain and retina among the tissues examined. In cells transfected with the DGK&igr; cDNA, an approximately 130 kDa protein was detected by immunoassay, and activity assays demonstrated that it encodes a functional DAG kinase. The protein was found to be in both the cytoplasm and nucleus, with this localization controlled by PKC isoforms &agr; and &ggr;. The gene encoding DGK&igr; was localized to human chromosome 7q32.3-33, which is known to be a locus for an inherited form of retinitis pigmentosa. These results have defined a novel isoform of DAG kinase, which may have important cellular functions in the retina and brain.

    Abstract translation: 二酰基甘油（DAG）在复合脂质的合成和细胞内信号传导中起重要作用; 二酰基甘油激酶（DGK）催化DAG的磷酸化，其产生磷脂酸。 过去几年，DGKs家族已被鉴定为多细胞生物，但这种多样性的生理功能尚不清楚。 一个线索来自果蝇DGK2，rdgA，因为该基因的突变导致视网膜变性。 本发明涉及一种从人视网膜和脑文库中分离得到的一种称为DGK和igr的新型DGK。 DGK＆igr 含有两个富含半胱氨酸的重复序列，一个与MARCKS的磷酸化位点结构域相似的区域，一个保守的催化结构域，在其C-末端有四个锚蛋白重复序列​​。 通过主要结构，DGK＆igr; 最类似于人类DGK＆zgr; 和果蝇rdgA。 A> 12 kb的mRNA用于DGK和igr; 在所检查的组织中仅在脑和视网膜中检测到。 在用DGK和igr转染的细胞中 cDNA通过免疫测定检测到约130kDa的蛋白质，活性测定证明它编码功能性DAG激酶。 发现蛋白质在细胞质和细胞核两者中，其定位受PKC同种型α和γ的控制。 编码DGK和igr的基因 被定位于人染色体7q32.3-33，其被认为是色素性视网膜炎的遗传形式的基因座。 这些结果定义了DAG激酶的新型同工型，其可能在视网膜和脑中具有重要的细胞功能。

    PROCESS AND APPARATUS FOR GENERATING A THREE-DIMENSIONAL SWEPT ENVELOPE OF A VEHICLE
    76.
    发明申请
    PROCESS AND APPARATUS FOR GENERATING A THREE-DIMENSIONAL SWEPT ENVELOPE OF A VEHICLE 有权
    用于产生车辆三维开关的过程和装置

    公开(公告)号：US20140032184A1

    公开(公告)日：2014-01-30

    申请号：US14110703

    申请日：2012-04-05

    Applicant: Milton Santano Elias Carrasco ,  Daniel Akwera Shihundu ,  Billy Siu Fai Chan ,  Steven Kin-Shing Cheng ,  Christian Grant Milne ,  Guanggui Pei ,  Darren Earl Brown ,  Li Ding

    Inventor： Milton Santano Elias Carrasco ,  Daniel Akwera Shihundu ,  Billy Siu Fai Chan ,  Steven Kin-Shing Cheng ,  Christian Grant Milne ,  Guanggui Pei ,  Darren Earl Brown ,  Li Ding

    IPC: G06F17/50

    CPC classification number: G06F17/5009 ,  G06F17/5095

    Abstract: A method, apparatus, media and signals for generating a computer representation of a three-dimensional swept envelope of a vehicle having a wheeled chassis operable to support a vehicle body for movement along a terrain is disclosed. The method involves receiving terrain data representing a 3D terrain, receiving data defining parameters of the vehicle, and receiving data defining a path for movement of the vehicle from an initial position on the terrain to a displaced position on the terrain. The method also involves disposing a computer representation of the vehicle on the 3D representation of the terrain at successive locations along the path using the parameters. Disposing involves determining points of engagement between wheels of the wheeled chassis and the 3D representation of the terrain to dispose the chassis with respect to the terrain, and determining a corresponding 3D location of the vehicle body with respect to the terrain. The method further involves generating a plurality of spatial extents of the vehicle at the successive locations, the spatial extents defining the 3D swept envelope of the vehicle when moving between the initial position and the displaced position. In another aspect a method for generating a computer representation of a three-dimensional swept envelope of an object moving along a guideway disposed with respect to a 3D representation of a terrain is disclosed.

    Abstract translation: 公开了一种用于产生具有可操作以支撑车身沿着地形运动的轮式底盘的车辆的三维扫掠包络的计算机表示的方法，装置，介质和信号。 该方法包括接收表示3D地形的地形数据，接收定义车辆参数的数据，以及接收定义用于使车辆从地形上的初始位置移动到地形上的位移位置的路径的数据。 该方法还涉及使用参数在路径的连续位置处将车辆的计算机表示设置在地形的3D表示上。 处置涉及确定轮式底盘的车轮与地形的3D表示之间的接合点，以相对于地形布置底盘，以及相对于地形确定车体的对应3D位置。 该方法还包括在连续位置处产生车辆的多个空间范围，当在初始位置和位移位置之间移动时，空间范围限定车辆的3D扫描包络线。 在另一方面，公开了一种用于生成沿着相对于地形的3D表示布置的导轨移动的物体的三维扫描包络的计算机表示的方法。

    Modeling circuit cells for waveform propagation
    77.
    发明授权
    Modeling circuit cells for waveform propagation 有权
    建模用于波形传播的电路单元

    公开(公告)号：US08478573B2

    公开(公告)日：2013-07-02

    申请号：US11166659

    申请日：2005-06-23

    Applicant: Li Ding ,  Peivand Fallah-Tehrani ,  Alireza Kasnavi

    Inventor： Li Ding ,  Peivand Fallah-Tehrani ,  Alireza Kasnavi

    IPC: G06F17/50

    CPC classification number: G06F17/5031

    Abstract: A model for a circuit cell used in timing and signal integrity analysis in an integrated circuit design is automatically generated. A behavioral model, such as a gate current model is used in which the current in the circuit cell is determined as a function of the input voltage and the output voltage of the circuit cell as well as the history of at least one of the current, voltage, and charge values of the circuit cell. For example, the current in the circuit cell may be a function of the history of the current, which may be calculated incrementally using recursive convolution at each time step when using the model.

    Abstract translation: 自动生成用于集成电路设计中的时序和信号完整性分析的电路单元的模型。 使用诸如栅极电流模型的行为模型，其中电路单元中的电流被确定为电路单元的输入电压和输出电压的函数以及电流单元中的至少一个的历史， 电压和电荷值。 例如，电路单元中的电流可以是电流的历史的函数，其可以在使用该模型时在每个时间步长处使用递归卷积来逐渐计算。

    Device for separating, enriching and detecting ions
    78.
    发明授权
    Device for separating, enriching and detecting ions 有权
    用于分离，富集和检测离子的装置

    公开(公告)号：US08384025B2

    公开(公告)日：2013-02-26

    申请号：US13130254

    申请日：2009-11-26

    Applicant: Wenjian Sun ,  Li Ding

    Inventor： Wenjian Sun ,  Li Ding

    IPC: H01J49/26 ,  H01J49/42 ,  H01J49/10

    CPC classification number: G01N27/622 ,  G01N15/0266

    Abstract: A device for separating, enriching and detecting ions comprises: a gas tube, in which a carrier gas flows at a uniform rate; an ion source; multiple electrodes provided in the gas tube and applied with electric voltages respectively, so that at least an electric field is produced along the axis of the gas tube; an ion detector; and an ion extraction channel, by which specific enriched ions will be guided across the side wall of the gas tube toward the ion detector and be analyzed. The device enriches ions utilizing the following characteristic: compound ions with specific ion mobility maintain a dynamic balance for a period of time in a flow field under the combination of a carrier gas and a suitable electrical field against the direction of the carrier gas. Simultaneously, multiple compound particles with different ion motilities can be separated and enriched at positions with different electrical field intensities in a flow field in the same manner. The device also comprises synchronously export latitudinally enriched ions at different positions in a flow field, and performs later mass analysis using a mass spectrometer.

    Abstract translation: 用于分离，富集和检测离子的装置包括：气体管，其中载气以均匀的速率流动; 离子源; 设置在气体管中并分别施加电压的多个电极，使得沿着气体管的轴线产生至少一个电场; 离子检测器 和离子提取通道，通过该离子提取通道将特定的富集离子引导穿过气体管的侧壁朝离子检测器进行分析。 该装置利用以下特征丰富离子：具有特定离子迁移率的复合离子在载气和合适的电场相对于载气方向的组合下在流场中保持动态平衡一段时间。 同时，具有不同离子运动的多种化合物颗粒可以以相同的方式在流场中分离富集在具有不同电场强度的位置。 该装置还包括在流场中同步输出纬向富集的离子，并使用质谱仪进行质量分析。

    Crosstalk time-delay analysis using random variables
    79.
    发明授权
    Crosstalk time-delay analysis using random variables 有权
    使用随机变量的串扰延时分析

    公开(公告)号：US08341574B2

    公开(公告)日：2012-12-25

    申请号：US12399704

    申请日：2009-03-06

    Applicant: Ravikishore Gandikota ,  Li Ding ,  Peivand Tehrani ,  Nahmsuk Oh ,  Alireza Kasnavi

    Inventor： Ravikishore Gandikota ,  Li Ding ,  Peivand Tehrani ,  Nahmsuk Oh ,  Alireza Kasnavi

    IPC: G06F17/50

    CPC classification number: G06F17/5031 ,  G06F2217/84

    Abstract: Embodiments of a computer system, a method, an integrated circuit and a computer-program product (i.e., software) for use with the computer system are described. These devices and techniques may be used to calculate the total time delay in a signal path due to crosstalk from a group of crosstalk aggressors that are associated with a group of signal paths. In order to properly account for statistical behaviors in the switching times and directions of the switching patterns in the group of signal paths, the time-delay contribution from each of these crosstalk aggressors may be modeled as a corresponding statistical random variable. Because the number of crosstalk aggressors are usually much larger than the number of stages in the signal path, the calculated total path delay may be less pessimistic. Furthermore, in order to detect potential timing violations, the time-delay contributions from additional dominant crosstalk aggressors can be modeled using non-statistical worst-case deterministic values.

    Abstract translation: 描述了与计算机系统一起使用的计算机系统，方法，集成电路和计算机程序产品（即，软件）的实施例。 这些装置和技术可用于计算由于与一组信号路径相关联的一组串扰侵扰者的串扰引起的信号路径中的总时间延迟。 为了适当地考虑信号路径组中的切换模式的切换时间和方向的统计行为，来自每个这些串扰侵略者的时间延迟贡献可以被建模为相应的统计随机变量。 因为串扰攻击者的数量通常远大于信号路径中的级数，所以计算的总路径延迟可能不那么悲观。 此外，为了检测潜在的定时违规，可以使用非统计最坏情况确定性值来对附加的主要串扰侵扰者的时间延迟贡献进行建模。

    Mass spectrometric analyzer
    80.
    发明授权
    Mass spectrometric analyzer 有权
    质谱仪

    公开(公告)号：US08294085B2

    公开(公告)日：2012-10-23

    申请号：US13140346

    申请日：2009-12-22

    Applicant: Li Ding

    Inventor： Li Ding

    IPC: H01J49/40 ,  H01J49/26 ,  B01D59/44

    CPC classification number: H01J49/027 ,  H01J49/0036 ,  H01J49/4245

    Abstract: A mass spectrometric analyzer and an analysis method based on the detection of ion image current are provided. The method in one embodiment includes using electrostatic reflectors or electrostatic deflectors to enable pulsed ions to move periodically for multiple times in the analyzer, forming time focusing in a portion of the ion flight region thereof, and forming an confined ion beam in space; enabling the ion beam to pass through multiple tubular image current detectors arranged in series along an axial direction of the ion beam periodically, using a low-noise electronic amplification device to detect image currents picked up by the multiple tubular detectors differentially, and using a data conversion method, such as a least square regression, to acquire a mass spectrum.

    Abstract translation: 提供了基于离子图像电流检测的质谱分析仪和分析方法。 在一个实施例中的方法包括使用静电反射器或静电偏转器使得脉冲离子能够在分析器中周期性移动多次，形成时间聚焦在其离子飞行区域的一部分中，并在空间中形成约束离子束; 使得离子束能够通过使用低噪声电子放大装置周期性地沿着离子束的轴向方向串联布置的多个管状图像电流检测器，以差分地检测由多个管状检测器拾取的图像电流，并使用数据 转换方法，如最小二乘回归，以获得质谱。

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