Method of making hydroxyalkylcellulose microparticles
    76.
    发明授权
    Method of making hydroxyalkylcellulose microparticles 有权
    制备羟烷基纤维素微粒的方法

    公开(公告)号:US09090714B2

    公开(公告)日:2015-07-28

    申请号:US14021995

    申请日:2013-09-09

    摘要: Provided is a method of producing hydroxyalkylcellulose microparticles, the method including generating a pulse shock wave, and supplying a hydroxyalkylcellulose aqueous solution to the pulse shock wave generation region, thereby crushing and drying the hydroxyalkylcellulose aqueous solution. According to the production method, hydroxyalkylcellulose microparticles having a volume-average particle size of at least 0.1 μm but less than 15 μm are obtained. By mixing the hydroxyalkylcellulose microparticles with a principal agent and subjecting the resulting mixture to a tablet compression, a solid preparation having excellent tensile strength and disintegration properties can be obtained.

    摘要翻译: 提供一种生产羟烷基纤维素微粒的方法,该方法包括产生脉冲冲击波,并将脉冲冲击波产生区域的羟烷基纤维素水溶液供应,从而破碎和干燥羟烷基纤维素水溶液。 根据制造方法,得到体积平均粒径为0.1μm以上且小于15μm的羟烷基纤维素微粒。 通过将羟烷基纤维素微粒与主剂混合并将所得混合物进行片剂压片,可以获得具有优异拉伸强度和崩解性能的固体制剂。