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    Affinity adsorbents for fibrinogen
    1.
    发明授权
    Affinity adsorbents for fibrinogen 有权
    纤维蛋白原亲和吸附剂

    公开(公告)号：US09221768B2

    公开(公告)日：2015-12-29

    申请号：US13954237

    申请日：2013-07-30

    申请人： PROMETIC BIOSCIENCES LTD

    发明人： Jason Richard Betley ,  James Christopher Pearson ,  Ben Martin Beacom ,  Tadeusz Antoni Podgorski ,  Robert William Pannell

    IPC分类号： C07D251/00 ,  A61K31/5375 ,  C07K1/22 ,  G01N30/02 ,  C07D251/48 ,  B01J20/286 ,  B01J20/289 ,  C07K14/75 ,  G01N33/86 ,  B01J20/32

    CPC分类号： C07D251/48 ,  B01J20/286 ,  B01J20/289 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3255 ,  B01J2220/54 ,  B01J2220/58 ,  C07K14/75 ,  G01N33/86

    摘要： For the separation, removal, isolation, purification, characterisation, identification or quantification of fibrinogen or a protein that is a fibrinogen analogue, an affinity adsorbent is used that is a compound of formula II wherein one X is N and the other is N, C—CI or C—CN; Y is O, S or NR2; Z is O, S or NR3; R2 and R3 are each H, alkyl, hydroxyalkyl, benzyl or β-phenylethyl; n is 0 to 6; A is a support matrix, optionally linked to the triazine ring by a spacer; R7 is a group bearing a positive charge at neutral pH; W is an optional linker; V is an aromatic group; and R8 and R9 are each H, OH, alkyl, alkoxy, amino, NH2, acyloxy, acylamino, CO2H, sulphonic acid, carbamoyl, sulphamoyl, alkylsulphonyl or halogen or a cyclic structure such as a morpholino group, or R8 and R9 are linked to form such a cyclic structure.

    摘要翻译： 为了纤维蛋白原或纤维蛋白原类似物的蛋白质的分离，去除，分离，纯化，表征，鉴定或定量，使用亲和吸附剂，其为一种式II化合物，其中一个X为N，另一个为N，C -CI或C-CN; Y是O，S或NR2; Z是O，S或NR 3; R 2和R 3各自为H，烷基，羟基烷基，苄基或苯乙基; n为0〜6; A是支持基质，任选地通过间隔基与三嗪环连接; R7是在中性pH下带正电荷的基团; W是可选的接头; V是芳族基团; 并且R 8和R 9各自为H，OH，烷基，烷氧基，氨基，NH 2，酰氧基，酰基氨基，CO 2 H，磺酸，氨基甲酰基，氨磺酰基，烷基磺酰基或卤素或环状结构如吗啉代基或R8和R9 形成这样的循环结构。

    Medium-Chain Length Fatty Acids and Glycerides as Nephroprotection Agents
    3.
    发明申请
    Medium-Chain Length Fatty Acids and Glycerides as Nephroprotection Agents 有权
    中链长度脂肪酸和甘油酯作为肾保护剂

    公开(公告)号：US20100286269A1

    公开(公告)日：2010-11-11

    申请号：US12740700

    申请日：2008-11-03

    申请人： Vincent Pichette ,  Francois Leblond ,  Mouna Lagraoui ,  Lyne Gagnon

    发明人： Vincent Pichette ,  Francois Leblond ,  Mouna Lagraoui ,  Lyne Gagnon

    IPC分类号： A61K31/23 ,  A61K31/20 ,  A61P35/00 ,  A61P13/12 ,  A61P3/10 ,  A61P37/00 ,  A61P9/00 ,  A61P29/00

    CPC分类号： A61K31/20 ,  A61K31/23 ,  A61K45/06 ,  A61K2300/00

    摘要： Use of medium-chain length fatty acids such as capric acid, caprylic acid or lauric acid and their salts or mono- or di- or triglycerides as nephroprotection agents to protect against renal failure progression in chronic kidney diseases This includes the treatment of kidney diseases associated with nephrectomy, renal fibrosis, glomerular scelrosis and end-stage renal disease Also includes the protection of the kidney against cytotoxic agent used in chemotherapy or autoimmune diseases or transplantation Further includes the treatment of renal failure progression associated with hypertension, infarct, tumour, diabetes mellitus, autoimmunity or inflammation.

    摘要翻译： 使用中链长度脂肪酸如癸酸，辛酸或月桂酸及其盐或单 - 或二 - 或甘油三酸酯作为肾保护剂，以防止慢性肾脏疾病中的肾衰竭进展这包括治疗肾脏疾病相关 肾切除术，肾纤维化，肾小球结肠炎和终末期肾脏疾病还包括对化疗或自身免疫性疾病或移植中使用的细胞毒性剂的肾脏保护进一步包括治疗与高血压，梗塞，肿瘤，糖尿病相关的肾衰竭进展 ，自身免疫或炎症。

    Medium-chain length fatty alcohols as stimulators of hematopoiesis
    4.
    发明授权
    Medium-chain length fatty alcohols as stimulators of hematopoiesis 有权
    中链长脂肪醇作为造血刺激物

    公开(公告)号：US08071580B2

    公开(公告)日：2011-12-06

    申请号：US11663888

    申请日：2005-09-29

    申请人： Christopher Penney ,  Lyne Gagnon ,  Jean Barabé

    发明人： Christopher Penney ,  Lyne Gagnon ,  Jean Barabé

    IPC分类号： A61K31/33 ,  A61K31/045

    CPC分类号： A61K31/045

    摘要： Medium-chain length fatty alcohols such as octanol, decanol, dodecanol, or analogues thereof can be used as a stimulator of hematopoiesis, hematopoietic stem cell proliferation, and/or proliferation of one or more of the progenitors of red or white blood cells (e.g., erythrocyte, leukocyte, neutrophil, granulocyte, megakaryocyte, or any combination thereof). It also relates to the treatment of myelosuppression; in particular, this includes the treatment of anemia and/or neutropenia associated with chemotherapy and/or radiotherapy. Moreover, anemia arising from chronic renal failure or treatment of HIV-infected patients with AZT (zidovudine), or other inhibitors of reverse transcriptase, can be treated. Furthermore, neutropenia arising from infections, hematologic diseases, or nutritional deficiencies can be treated. It also relates to reducing drug toxicity and enhancing drug efficiency.

    摘要翻译： 中链长度脂肪醇如辛醇，癸醇，十二烷醇或其类似物可用作红细胞或白细胞的一种或多种祖细胞造血干细胞增殖和/或增殖的刺激物（例如， ，红细胞，白细胞，嗜中性粒细胞，粒细胞，巨核细胞或其任何组合）。 它还涉及骨髓抑制的治疗; 特别地，这包括治疗与化学疗法和/或放射疗法相关的贫血和/或中性白细胞减少症。 此外，可以治疗由慢性肾衰竭引起的贫血或治疗感染AZT（齐多夫定）的HIV感染患者或其他逆转录酶抑制剂的贫血。 此外，可以治疗由感染，血液病或营养缺乏引起的中性粒细胞减少症。 它还涉及降低药物毒性和提高药物效率。