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公开(公告)号：US09187570B2
公开(公告)日：2015-11-17
申请号：US13923974
申请日：2013-06-21
Applicant: AJINOMOTO CO., INC.
Inventor： Ippei Inoue , Ichiro Yamashita , Bin Zheng , Hisashi Yasueda , Yukiharu Uraoka , Yasuaki Ishikawa
IPC: C07K19/00 , C07K14/195 , C07K7/06 , C07K7/08 , C12N15/62
CPC classification number: C07K19/00 , C07K7/06 , C07K7/08 , C07K14/195 , C07K2319/00 , C12N15/62
Abstract: The present invention provides means useful for making devices, materials and the like that are excellent in photocatalytic activity, electric property or the like. Specifically, the present invention provides a fusion protein comprising a polypeptide portion capable of forming a multimer having an internal cavity, and a first peptide portion capable of binding to a first target substance and a second peptide portion capable of binding to a second target substance; a multimer of the fusion protein; a complex comprising the multimer of the fusion protein; and the like.
Abstract translation: 本发明提供了用于制备光催化活性，电性等优异的器件，材料等的方法。 具体而言，本发明提供一种融合蛋白，其包含能够形成具有内腔的多聚体的多肽部分和能够结合第一靶物质的第一肽部分和能够结合第二目标物质的第二肽部分的融合蛋白质; 融合蛋白的多聚体; 包含融合蛋白的多聚体的复合物; 等等。
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公开(公告)号：US20140150855A1
公开(公告)日：2014-06-05
申请号：US14176543
申请日：2014-02-10
Applicant: AJINOMOTO CO., INC.
Inventor： Ippei INOUE , Ichiro Yamashita , Bin Zheng , Hisashi Yasueda , Yukiharu Uraoka , Yasuaki Ishikawa
CPC classification number: H01L31/1884 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C01B32/16 , C01B32/174 , C01G9/02 , C01G23/047 , C07K14/195 , C07K2319/00 , C07K2319/20 , C07K2319/70 , H01G9/2031 , H01G9/204 , H01G9/2045 , H01L51/0049 , H01L51/0093 , H01L51/444 , H01M4/8605 , Y02E10/542 , Y02E10/549 , Y02P70/521
Abstract: A functional material having excellent photocatalytic activity, electric characteristics and the like is provided. A porous structure body 10 comprises a first target material 20 and an aggregate body 30 formed by aggregation of the first material. The aggregate body 30 adheres to the first target material and is located so as to surround the first target material. The aggregate body has a plurality of first pores 32 unevenly distributed near the first target material in the aggregate body and a plurality of second pores 34 scattered over the aggregate body.
Abstract translation: 提供了具有优异的光催化活性，电特性等的功能材料。 多孔结构体10包括第一靶材料20和通过第一材料的聚集形成的骨料体30。 聚集体30粘附到第一目标材料并且被定位成围绕第一靶材料。 骨料主体具有多个不均匀分布在聚集体中的第一目标材料附近的第一孔32和散布在聚集体上的多个第二孔34。
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公开(公告)号：US20210269840A1
公开(公告)日：2021-09-02
申请号：US17326677
申请日：2021-05-21
Applicant: AJINOMOTO CO., INC.
Inventor： Shuhei Hashiro , Hisashi Yasueda , Mayu Mitsuhashi , Sergei Vladimirovich Mashko , Aleksandr Aleksandrovich Krylov , Yuliya Sergeevna Lobanova
Abstract: A method for producing RNA is provided. Objective RNA is produced by culturing a coryneform bacterium having an expression unit for the objective RNA, which has been modified so that the activity of ribonuclease III is reduced, in a medium, to express the objective RNA and accumulate the objective RNA in cells of the bacterium, and collecting the objective RNA from the cells.
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公开(公告)号：US20210024931A1
公开(公告)日：2021-01-28
申请号：US16993692
申请日：2020-08-14
Applicant: AJINOMOTO CO., INC
Inventor： Shuhei Hashiro , Hisashi Yasueda , Mayu Nakano , Teruyuki Niimi , Haruka Kawaguchi
IPC: C12N15/113 , C12N9/22 , C12N15/70 , C12N15/77 , A01N63/10
Abstract: A method for efficiently inducing RNA silencing in a target organism is provided. RNA silencing is induced in a target organism by allowing the target organism to ingest cells of a microorganism, wherein the microorganism is able to produce RNA that induces RNA silencing after treating the cells with an organic solvent.
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公开(公告)号：US20200024629A1
公开(公告)日：2020-01-23
申请号：US16582385
申请日：2019-09-25
Applicant: AJINOMOTO CO., INC.
Inventor： Shuhei Hashiro , Hisashi Yasueda , Mayu Mitsuhashi , Sergei Vladimirovich Mashko , Aleksandr Aleksandrovich Krylov , Yuliya Sergeevna Lobanova
Abstract: A method for producing RNA is provided. Objective RNA is produced by culturing a coryneform bacterium having an expression unit for the objective RNA, which has been modified so that the activity of ribonuclease III is reduced, in a medium, to express the objective RNA and accumulate the objective RNA in cells of the bacterium, and collecting the objective RNA from the cells.
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Patent Agency Ranking
公开(公告)号：US11046986B2
公开(公告)日：2021-06-29
申请号：US16582385
申请日：2019-09-25
Applicant: AJINOMOTO CO., INC.
Inventor： Shuhei Hashiro , Hisashi Yasueda , Mayu Mitsuhashi , Sergei Vladimirovich Mashko , Aleksandr Aleksandrovich Krylov , Yuliya Sergeevna Lobanova
Abstract: A method for producing RNA is provided. Objective RNA is produced by culturing a coryneform bacterium having an expression unit for the objective RNA, which has been modified so that the activity of ribonuclease III is reduced, in a medium, to express the objective RNA and accumulate the objective RNA in cells of the bacterium, and collecting the objective RNA from the cells.
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公开(公告)号：US08753849B2
公开(公告)日：2014-06-17
申请号：US13774153
申请日：2013-02-22
Applicant: Ajinomoto Co., Inc.
Inventor： Yury Ivanovich Kozlov , Akito Chinen , Hiroshi Izui , Yoshihiko Hara , Hisashi Yasueda , Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Joanna Yosifovna Katashkina
IPC: C12P13/14
CPC classification number: C12P13/24 , C12N9/88 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/62 , C12P13/06 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12Y401/02009 , C12Y401/02022
Abstract: The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium.
Abstract translation: 本发明提供一种具有生产乙酰辅酶A的有用代谢物的能力，例如L-谷氨酸，L-谷氨酰胺，L-脯氨酸，L-精氨酸，L-亮氨酸，L-半胱氨酸，琥珀酸酯 和聚羟基丁酸酯，其中所述细菌被修饰，使得D-木酮糖-5-磷酸磷酸酮糖苷酶和/或果糖-6-磷酸磷酸酮醇酶的活性增强。 本发明还提供了使用该细菌生产有用代谢物的方法。
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公开(公告)号：US08969048B2
公开(公告)日：2015-03-03
申请号：US14268110
申请日：2014-05-02
Applicant: Ajinomoto Co., Inc.
Inventor： Yury Ivanovich Kozlov , Akito Chinen , Hiroshi Izui , Yoshihiko Hara , Hisashi Yasueda , Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Joanna Yosifovna Katashkina
IPC: C12P13/24 , C12N9/88 , C12P7/46 , C12P7/62 , C12P13/06 , C12P13/10 , C12P13/14 , C12P7/44 , C12P13/12 , C12P13/20 , C12P7/42
CPC classification number: C12P13/24 , C12N9/88 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/62 , C12P13/06 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12Y401/02009 , C12Y401/02022
Abstract: The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium.
Abstract translation: 本发明提供一种具有生产乙酰辅酶A的有用代谢物的能力，例如L-谷氨酸，L-谷氨酰胺，L-脯氨酸，L-精氨酸，L-亮氨酸，L-半胱氨酸，琥珀酸酯 和聚羟基丁酸酯，其中所述细菌被修饰，使得D-木酮糖-5-磷酸磷酸酮糖苷酶和/或果糖-6-磷酸磷酸酮醇酶的活性增强。 本发明还提供了使用该细菌生产有用代谢物的方法。
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公开(公告)号：US20140242643A1
公开(公告)日：2014-08-28
申请号：US14268110
申请日：2014-05-02
Applicant: AJINOMOTO CO., INC.
Inventor： Yury Ivanovich Kozlov , Akito Chinen , Hiroshi Izui , Yoshihiko Hara , Hisashi Yasueda , Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Joanna Yosifovna Katashkina
CPC classification number: C12P13/24 , C12N9/88 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/62 , C12P13/06 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12Y401/02009 , C12Y401/02022
Abstract: The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium.
Abstract translation: 本发明提供一种具有生产乙酰辅酶A的有用代谢物的能力，例如L-谷氨酸，L-谷氨酰胺，L-脯氨酸，L-精氨酸，L-亮氨酸，L-半胱氨酸，琥珀酸酯 和聚羟基丁酸酯，其中所述细菌被修饰，使得D-木酮糖-5-磷酸磷酸酮糖苷酶和/或果糖-6-磷酸磷酸酮醇酶的活性增强。 本发明还提供了使用该细菌生产有用代谢物的方法。
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10.发明申请公开(公告)号：US20130171700A1
公开(公告)日：2013-07-04
申请号：US13772959
申请日：2013-02-21
Applicant: Ajinomoto Co., Inc.
Inventor： Yoshiya Gunji , Hisashi Yasueda , Shinichi Sugimoto , Nobuharu Tsujimoto , Megumi Shimaoka , Yuri Miyata , Manami Oba
IPC: C12P13/08
CPC classification number: C12P13/08 , C12N9/1217 , C12N9/88 , C12P13/04 , C12R1/01
Abstract: An L-amino acid is produced by culturing a Methylophilus bacterium which can grow by using methanol as the main carbon source and has L-amino acid-producing ability, for example, a Methylophilus bacterium in which dihydrodipicolinate synthase activity and aspartokinase activity are enhanced by transformation of cells with a DNA coding for dihydrodipicolinate synthase that is desensitized to feedback inhibition by L-lysine and a DNA coding for aspartokinase that is desensitized to feedback inhibition by L-lysine, or a Methylophilus bacterium which is casamino acid auxotrophic, in a medium containing methanol as a main carbon source, to produce and accumulate an L-amino acid in culture, and collecting the L-amino acid from the culture.
Abstract translation: 通过培养可以通过使用甲醇作为主要碳源生长并且具有L-氨基酸生产能力的甲型幽门螺杆菌细菌产生L-氨基酸，例如其中二氢吡啶二酸合成酶活性和天冬氨酸激酶活性被增强的甲基幽门螺杆菌 将编码二脱氧叶酸二磷酸合酶的DNA转化为L-赖氨酸的反馈抑制的脱氧赖氨酸的编码天冬氨酸激酶的DNA或L-赖氨酸反馈抑制的天冬氨酸的DNA或作为酪蛋白氨基酸营养缺陷型的细鳞状芽孢杆菌属细菌的DNA在培养基 含有甲醇作为主要碳源，在培养中产生和积累L-氨基酸，并从培养物中收集L-氨基酸。
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