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1.发明申请SYSTEMS AND METHODS FOR PREPARING NANOCRYSTALLINE COMPOSITIONS USING FOCUSED ACOUSTICS 审中-公开使用聚焦声学制备纳米晶体组合物的系统和方法公开(公告)号：US20130026669A1
公开(公告)日：2013-01-31
申请号：US13548384
申请日：2012-07-13
IPC分类号： B29B9/12
CPC分类号： C30B7/00 , B01F11/0241 , B01F11/0283 , B01F2215/0454 , C30B29/60
摘要： Methods and systems for preparing nanocrystalline compositions using focused acoustic processing to cause and/or enhance crystal growth. A flow through system may be employed to expose sample material having a volume of greater or less than 30 mL to focused acoustic energy while flowing through a process chamber at a rate of at least 0.1 mL/min. Sample material may be processed by a suitable focused acoustic field in a cyclic fashion and/or with adjustment of processing parameters based on monitored characteristics of the sample, such as level of crystallinity. Nanocrystalline particles within the sample may have a tight particle size distribution with an average particle size between 10 nm and 1 micron. Stable nanocrystalline compositions may be reproducibly prepared using focused acoustics to have controllable morphologies and dimensions.
摘要翻译： 使用聚焦声学处理制备纳米晶体组合物以引起和/或增强晶体生长的方法和系统。 可以采用流通系统将具有大于或小于30mL的体积的样品材料暴露于聚焦的声能，同时以至少0.1mL / min的速率流过处理室。 样品材料可以通过合适的聚焦声场以循环方式和/或通过基于监测的样品特性（诸如结晶度的水平）调整加工参数进行处理。 样品内的纳米晶体颗粒可以具有紧密的粒度分布，平均粒度在10nm和1微米之间。 稳定的纳米晶体组合物可以使用聚焦声学重复地制备以具有可控的形态和尺寸。
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公开(公告)号：US20120234625A1
公开(公告)日：2012-09-20
申请号：US13422086
申请日：2012-03-16
IPC分类号： G10K11/00
CPC分类号： A61B8/00 , B01F11/0258 , G10K11/28
摘要： Methods and systems for acoustically treating material using a continuous process in which material may be caused to flow in a continuous or intermittent fashion into/out of an acoustic treatment chamber where the material is exposed to focused acoustic energy. The methods and systems may be arranged to permit continuous processing for extended periods while an acoustic energy source operates at a relatively high power output. Treatment chambers may include features such as an acoustic window and/or a chamber wall which may comprise an acoustically reflective material or a gas/wall interface that serves to reflect acoustic energy to form one or more secondary focal zones. Treatment system configurations relating to arrangements of a treatment chamber relative to an acoustic source and coupling medium, material flow paths, and others are provided.
摘要翻译： 使用连续方法来声学处理材料的方法和系统，其中可以使材料以连续或间歇的方式流入/离开材料暴露于聚焦声能的声学处理室。 方法和系统可以被布置成允许在较长时间内连续处理，同时声能源以相对高的功率输出操作。 处理室可以包括诸如声窗和/或室壁的特征，其可以包括声反射材料或气体/壁界面，其用于反射声能以形成一个或多个次焦点区域。 提供了与处理室相对于声源和耦合介质，材料流动路径等的布置相关的处理系统配置。
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公开(公告)号：US20120103098A1
公开(公告)日：2012-05-03
申请号：US12914370
申请日：2010-10-28
IPC分类号： G01N29/28
CPC分类号： B01J19/10 , A61L2/025 , B01F3/08 , B01F3/12 , B01F11/02 , B01F11/0283 , B01F2215/0037 , B01J19/006 , B01J19/008 , B01J19/245 , B01J2219/00094 , C12N13/00
摘要： Methods and systems for acoustically treating material using a continuous process in which material may be caused to flow in a continuous or intermittent fashion into/out of an acoustic treatment chamber where the material is exposed to focused acoustic energy. The methods and systems may be arranged to permit continuous processing for extended periods while an acoustic energy source operates at a relatively high power output. Treatment chambers may include features such as an acoustic window, a heat exchanger, inlet/outlet flow arrangements, an inspection window, insert elements that define a treatment volume size or shape, etc. Treatment system configurations relating to arrangements of a treatment chamber relative to an acoustic source and coupling medium, material flow paths, and others are provided.
摘要翻译： 使用连续方法来声学处理材料的方法和系统，其中可以使材料以连续或间歇的方式流入/离开材料暴露于聚焦声能的声学处理室。 方法和系统可以被布置成允许在较长时间内连续处理，同时声能源以相对高的功率输出操作。 治疗室可以包括诸如声窗，热交换器，入口/出口流布置，检查窗，限定治疗体积大小或形状的插入元件等特征。与治疗室相对于治疗室的布置有关的治疗系统构型 提供声源和耦合介质，材料流动路径等。
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4.发明申请公开(公告)号：US20120015419A1
公开(公告)日：2012-01-19
申请号：US13186858
申请日：2011-07-20
CPC分类号： C12N13/00 , B01F11/0283 , B01J2219/00308 , B01J2219/00344 , B01J2219/00486 , B01J2219/00722 , B01J2219/0074 , G01N1/286 , G01N2035/00554
摘要： Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by positioning a suitable element so as to reduce and/or eliminate a headspace size at a sample/gas interface. An interaction between the acoustic energy and the sample may be controlled, e.g., by using a headspace control element positioned at least partially in the sample that helps to reduce splashing or other sample ejection that would otherwise occur.
摘要翻译： 用于控制包括液体的样品的声学处理的方法和装置。 可以例如通过定位合适的元件来控制样品进行声学处理的处理体积，以减少和/或消除样品/气体界面处的顶空尺寸。 可以例如通过使用至少部分定位在样品中的顶空控制元件来控制声能和样品之间的相互作用，所述顶空控制元件有助于减少否则会发生的飞溅或其它样品喷射。
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公开(公告)号：US20100197894A1
公开(公告)日：2010-08-05
申请号：US12698599
申请日：2010-02-02
CPC分类号： C07K1/22 , B01D15/1807 , B01D15/3866 , C12N15/1006
摘要： A method and apparatus for exposing a sample, including a liquid and another material, to sonic energy to produce a desired result such as, suspending a material support in the liquid. The material support may be a bead or other particle with at least one surface feature to which the material may bind. Material in the liquid may attach to the material support, such as by specific or non-specific binding, entrapment or other, so as to facilitate separation of the material from the liquid. Separation of the material supports from the liquid and other unbound material may be done by allowing the material supports to settle out, e.g., under the force of gravity and/or as assisted by centrifugation, by applying a magnetic field in case the supports or material bound to the supports are movable by way of a magnetic field, or other techniques.
摘要翻译： 一种用于将包括液体和另一种材料的样品暴露于声能以产生期望结果的方法和装置，例如将材料支撑物悬浮在液体中。 材料载体可以是具有材料可以结合的至少一个表面特征的珠粒或其它颗粒。 液体中的材料可以附着到材料载体上，例如通过特异性或非特异性结合，捕获或其它物质，以促进材料与液体的分离。 材料支撑物与液体和其它未结合材料的分离可以通过允许材料载体例如在重力作用下和/或通过离心辅助下沉积，通过在支撑物或材料的情况下施加磁场来进行 通过磁场或其他技术可以移动支撑件。
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公开(公告)号：US20100011845A1
公开(公告)日：2010-01-21
申请号：US12486050
申请日：2009-06-17
IPC分类号： G01N29/02
CPC分类号： B01F13/0059 , B01F11/02 , B01F11/0283 , B01F13/0222 , B01F13/0277 , B01F15/00175 , B01F15/00285 , B01F2215/0427 , B01F2215/0431 , B01F2215/045 , B01F2215/0454 , B01F2215/0468 , B01F2215/0477 , B01J19/0046 , B01J19/008 , B01J19/0093 , B01J19/10 , B01J2219/00308 , B01J2219/00315 , B01J2219/00317 , B01J2219/00486 , B01J2219/00495 , B01J2219/00659 , B01J2219/00722 , B01J2219/00783 , B01J2219/00889 , B01L3/50273 , B01L3/5085 , B01L2400/0436 , C40B60/14 , G01N2035/00554 , G01N2291/02836 , G01N2291/02872 , G01N2291/02881
摘要： The present invention provides systems, methods, and devices for using acoustic energy. In some embodiments, a fluid bath may be provided in the system where the fluid bath quality may be monitored using acoustic energy. An assessment of fluid bath quality can be determined through a comparison that is made of an initial power signal of the acoustic energy with a reflected power signal of the acoustic energy.
摘要翻译： 本发明提供了使用声能的系统，方法和装置。 在一些实施例中，可以在系统中提供流体浴，其中可以使用声能监测流体浴质量。 可以通过将声能的初始功率信号与声能的反射功率信号进行比较来确定流体浴质量的评估。
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公开(公告)号：US20120077283A1
公开(公告)日：2012-03-29
申请号：US13242665
申请日：2011-09-23
CPC分类号： B01L3/50215 , B01L3/5021 , B01L3/50255 , B01L2200/0631 , B01L2200/0663 , B01L2200/141 , B01L2300/042 , B01L2300/0681 , B01L2300/0838 , B01L2300/0841 , B01L2300/0854 , B01L2400/0409 , B01L2400/0463 , B01L2400/086 , C12N15/10 , C12Q1/6806 , G01N1/28 , Y10T436/25
摘要： Systems and methods include processing devices used to fragment nucleic acids to average nucleic acid sizes ranging from between about 5 kbp and about 20 kbp. A processing device may include an inlet portion and a channel upstream from a shearing region arranged so that a relatively constant pressure is established and maintained (e.g., a pressure that changes by less than about 40%) at an entrance of the shearing region during a majority of sample flow through the shearing region. In some embodiments, after forcing the sample through the shearing region once, the processing device may be taken out of the centrifuge, inverted and placed back into the centrifuge so that the sample is forced through the shearing region again.
摘要翻译： 系统和方法包括用于分解核酸以平均约5kbp至约20kbp的核酸大小的加工装置。 处理装置可以包括入口部分和从剪切区域上游的通道，其布置成使得在剪切区域的入口处建立和维持相对恒定的压力（例如，变化小于约40％的压力） 大部分样品流过剪切区域。 在一些实施方案中，在将样品强制通过剪切区域一次之后，处理装置可以从离心机中取出，倒置并放回到离心机中，使得样品再次被迫穿过剪切区域。
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公开(公告)号：US20120167786A1
公开(公告)日：2012-07-05
申请号：US12984919
申请日：2011-01-05
CPC分类号： G01N1/286 , G01N2001/2866
摘要： Method and apparatus for holding and/or treating a sample material. A sample material may be positioned in a vessel between top and bottom flexible films where the flexible films are connected together by a substantially rigid support structure that surrounds the sample material. A crushing force may be applied to the sample material via the top and bottom flexible films, e.g., to pulverize the sample at cryogenic temperatures. A sample holder may have two vessels, one arranged for applying a crushing force to a first sample and another for holding a sample for other processing, such as a histology analysis.
摘要翻译： 用于保持和/或处理样品材料的方法和设备。 样品材料可以位于顶部和底部柔性膜之间的容器中，其中柔性膜通过围绕样品材料的基本刚性的支撑结构连接在一起。 可以通过顶部和底部柔性膜将样品材料施加破碎力，例如在低温下粉碎样品。 样品架可以具有两个容器，一个被布置用于对第一个样品施加破碎力，另一个容纳用于其他处理的样品，例如组织学分析。
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9.发明申请Methods and apparatus for treating samples with acoustic energy to form particles and particulates 有权用声能处理样品以形成颗粒和颗粒的方法和装置公开(公告)号：US20120144905A1
公开(公告)日：2012-06-14
申请号：US11986274
申请日：2007-11-20
申请人： James A. Laugharn, JR. , Edwin Rudd
发明人： James A. Laugharn, JR. , Edwin Rudd
IPC分类号： G01N15/06
CPC分类号： B01J2/18
摘要： The invention relates to a method of forming solid particles from a sample, which includes the step of exposing the sample to a focused acoustic field having an acoustic wave variable, until the solid particles achieve a desired state of particularization. The acoustic wave variable may be selected based, at least in part, on the desired state of particularization. The sample may be exposed to the focused acoustic field through a medium.
摘要翻译： 本发明涉及从样品形成固体颗粒的方法，其包括将样品暴露于具有声波可变的聚焦声场的步骤，直到固体颗粒达到期望的特定化状态。 声波变量可以至少部分地基于期望的特定化状态来选择。 样品可以通过介质暴露于聚焦声场。
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10.发明申请METHODS AND APPARATUS FOR ACOUSTIC TREATMENT OF SAMPLES FOR HEATING AND COOLING 审中-公开用于加热和冷却样品的声处理方法和装置公开(公告)号：US20120024867A1
公开(公告)日：2012-02-02
申请号：US13193004
申请日：2011-07-28
摘要： Methods and systems relate to enhancing heat transfer between a vessel wall and a sample or coupling medium during focused acoustic processing. The vessel containing the sample may include a heat exchanger on an inner surface and/or an outer surface of the vessel that can have any suitable shape or dimension that increases the surface area of the vessel wall. In some embodiments, heat exchanger features may disrupt a boundary layer of a liquid sample at the vessel wall during focused acoustic processing. Accordingly, the temperature of the liquid sample can be appropriately controlled. In some cases, heating and/or cooling of the liquid sample may be performed efficiently. In an embodiment, a liquid sample may be heated at a rate of at least about 25 degrees C. per ml per minute.
摘要翻译： 方法和系统涉及在聚焦声学处理期间增强血管壁和样品或耦合介质之间的热传递。 容纳样品的容器可以包括在容器的内表面和/或外表面上的热交换器，其可以具有增加容器壁的表面积的任何合适的形状或尺寸。 在一些实施例中，在聚焦声学处理期间，热交换器特征可能破坏液体样品在血管壁处的边界层。 因此，可以适当地控制液体试样的温度。 在一些情况下，可以有效地进行液体样品的加热和/或冷却。 在一个实施方案中，可以以每分钟至少约25摄氏度的速率加热液体样品。
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