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    Alkylenediamine derivative anti-ulcer drug and antibacterial drug
    3.
    发明授权
    Alkylenediamine derivative anti-ulcer drug and antibacterial drug 失效
    烷二胺衍生物抗溃疡药和抗菌药

    公开(公告)号：US5814634A

    公开(公告)日：1998-09-29

    申请号：US842891

    申请日：1997-04-17

    申请人： Chikao Nishino ,  Fumitaka Sato ,  Tomohiro Uetake ,  Hirotada Fukunishi ,  Nao Kojima

    发明人： Chikao Nishino ,  Fumitaka Sato ,  Tomohiro Uetake ,  Hirotada Fukunishi ,  Nao Kojima

    IPC分类号： C07D295/12 ,  A61K31/445 ,  A61K31/495 ,  A61K31/505 ,  A61K31/535 ,  A61K31/5375 ,  A61P1/04 ,  A61P31/04 ,  C07D211/14 ,  C07D239/42 ,  C07D277/20 ,  C07D277/38 ,  C07D277/82 ,  C07D295/13 ,  C07D317/58 ,  C07D211/32 ,  C07D265/30

    CPC分类号： C07D295/13

    摘要： The invention provides a compound which has anti-ulcer effect and antibacterial activity against Helicobacter pyroli. This compound is an alkylenediamine derivative or salt which has a general formula of (1): ##STR1## wherein each of R.sub.4, R.sub.5, and R.sub.6 is hydrogen or lower alkyl; n represents an integer of 1 to 6; Y is --CH.sub.2 --, --O--, or --N(R.sub.7)--, wherein R.sub.7 is lower alkyl, aryl, carbamoyl lower alkyl, aralkyl, or a heterocyclic group having 5 to 9 carbon numbers; and, W is a group expressed by formulas 2 or 3: ##STR2## wherein (1) in formula 2: each of R.sub.1 and R.sub.2 is hydrogen, lower alkoxy, alkenyloxy, or a halogen atom; each of R.sub.3 and R.sub.3 is methyl, prenyl, or geranyl; when one of R.sub.3 and R.sub.3 is prenyl or geranyl, the other must be a methyl group; and X is oxygen or sulfur; and (2) in formula 3, R.sub.10 is a lower alkyl, and R.sub.11 is a halogen atom.

    摘要翻译： 本发明提供了一种对幽门螺杆菌具有抗溃疡作用和抗菌活性的化合物。 该化合物是具有通式（1）：式1的亚烷基二胺衍生物或盐，其中R 4，R 5和R 6各自为氢或低级烷基; n表示1〜6的整数， Y是-CH 2 - ， - O-或-N（R 7） - ，其中R 7是低级烷基，芳基，氨基甲酰基低级烷基，芳烷基或具有5至9个碳数的杂环基; 式3中，式（1）中，R 1和R 2各自为氢，低级烷氧基，链烯氧基或卤素原子，式中，（1）表示2或3表示的基团。 R 3和R 3各自为甲基，异戊烯基或香叶基; 当R3和R3之一是异戊烯基或香叶基时，另一个必须是甲基; X为氧或硫; 和（2）在式3中，R 10是低级烷基，R 11是卤素原子。

    N-acylpiperazine derivative, antibacterial drug and anti-ulcer drug
    4.
    发明授权
    N-acylpiperazine derivative, antibacterial drug and anti-ulcer drug 失效
    N-酰基哌嗪衍生物，抗菌药物和抗溃疡药

    公开(公告)号：US5756505A

    公开(公告)日：1998-05-26

    申请号：US625992

    申请日：1996-04-01

    申请人： Chikao Nishino ,  Fumitaka Sato ,  Tomohiro Uetake ,  Hirotada Fukunishi ,  Nao Kojima ,  Koji Kobayashi

    发明人： Chikao Nishino ,  Fumitaka Sato ,  Tomohiro Uetake ,  Hirotada Fukunishi ,  Nao Kojima ,  Koji Kobayashi

    IPC分类号： C07D295/18 ,  A61K31/495 ,  A61P1/04 ,  A61P31/04 ,  C07D295/185 ,  C07D295/192 ,  C07D295/205 ,  C07D405/12

    CPC分类号： C07D295/185 ,  C07D295/192

    摘要： An N-acylpiperazine derivative or a salt thereof in accordance with the present invention is represented by the following formula 1: ##STR1## wherein R.sub.1 represents a lower alkyl, hydroxy lower alkyl, lower acyl, or arylcarbonyloxy lower alkyl group; R.sub.2 represents hydrogen atom or a lower alkyl, lower alkoxy, lower alkenyl, amino, or nitro group; R.sub.3 and R.sub.4, which are identical to or different from each other, represent hydrogen atoms, halogen atoms, or cyano, nitro, lower alkyl, or lower alkoxy groups; and n represents 0 or 1. The N-acylpiperazine derivative has anti-ulcer effect or an antibacterial activity against Helicobacter pyroli to be available for prevention or cure of ulsers.

    摘要翻译： 根据本发明的N-酰基哌嗪衍生物或其盐由下式1表示：其中R 1表示低级烷基，羟基低级烷基，低级酰基或芳基羰基氧基低级烷基; R2代表氢原子或低级烷基，低级烷氧基，低级烯基，氨基或硝基; R 3和R 4彼此相同或不同，表示氢原子，卤原子或氰基，硝基，低级烷基或低级烷氧基; 并且n表示0或1. N-酰基哌嗪衍生物具有抗溃疡作用或对幽门螺杆菌具有抗菌活性，可用于预防或治愈酏剂。

    Thiadiazoleamide derivative and anti-ulcer drug
    7.
    发明授权
    Thiadiazoleamide derivative and anti-ulcer drug 有权
    噻二唑衍生物和抗溃疡药

    公开(公告)号：US5912258A

    公开(公告)日：1999-06-15

    申请号：US157376

    申请日：1998-09-21

    申请人： Chikao Nishino ,  Fumitaka Sato ,  Tomohiro Uetake ,  Hirotada Fukunishi ,  Nao Kojima

    发明人： Chikao Nishino ,  Fumitaka Sato ,  Tomohiro Uetake ,  Hirotada Fukunishi ,  Nao Kojima

    IPC分类号： C07D285/12 ,  C07D285/135 ,  C07D417/12 ,  C07D289/135 ,  A61K31/41

    CPC分类号： C07D285/135 ,  C07D417/12

    摘要： A thiadiazoleamide derivative or a salt thereof expressed by the following Formula 1: ##STR1## wherein each of R.sub.1 and R.sub.2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylamino group or an alkenyloxy group; wherein when either R.sub.1 or R.sub.2 is a hydrogen atom, the other is not a hydrogen atom; R.sub.3 represents a lower alkyl group, an aryl group, a pyridyl group or --N(R.sub.4)R.sub.5, wherein R.sub.4 and R.sub.5 represent lower alkyl groups or together represent a saturated heterocyclic ring having 4-8 members; wherein when R.sub.1 or R.sub.2 is a lower alkoxy group, R.sub.3 is --N(R.sub.4)R.sub.5 or a pyridyl group; and n represents an integer of 1-3. The derivatives have anti-ulcer effect to be available for preventing or curing ulcers in mammals.

    摘要翻译： 由下式1表示的噻二唑衍生物或其盐：其中R 1和R 2各自表示氢原子，低级烷基，低级烷氧基，低级烷基氨基或烯氧基; 其中当R 1或R 2是氢原子时，另一个不是氢原子; R3表示低级烷基，芳基，吡啶基或-N（R4）R5，其中R4和R5代表低级烷基或一起代表具有4-8个成员的饱和杂环; 其中当R1或R2为低级烷氧基时，R3为-N（R4）R5或吡啶基; n表示1-3的整数。 该衍生物具有抗溃疡作用，可用于预防或治疗哺乳动物的溃疡。

    Oily solid cosmetic
    8.
    发明授权
    Oily solid cosmetic 有权
    油性固体化妆品

    公开(公告)号：US09078817B2

    公开(公告)日：2015-07-14

    申请号：US13127003

    申请日：2009-10-28

    申请人： Kiriko Chiba ,  Fumitaka Sato

    发明人： Kiriko Chiba ,  Fumitaka Sato

    IPC分类号： A61K8/02 ,  A61K8/25 ,  A61K8/29 ,  A61K8/31 ,  A61Q1/06 ,  A61Q1/02 ,  A61Q1/10

    CPC分类号： A61K8/022 ,  A61K8/025 ,  A61K8/0254 ,  A61K8/25 ,  A61K8/29 ,  A61K8/31 ,  A61K2800/412 ,  A61K2800/436 ,  A61K2800/592 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q1/10

    摘要： An oily solid cosmetic is capable of effectively diminishing morphological problems, such as vertical wrinkles, in particular on the lip, over a long period of time. The present invention provides an oily solid cosmetic which contains: (A) a plate-like composite powder presenting interference colors, (B) a spherical composite powder wherein the surface of a spherical powder having a refractive index of 1.40 to 1.60 is coated with a coating component having a refractive index of 2.00 to 2.90, and (C) 1 to 40% by mass of a semi-solid oil component. Preferably, the cosmetic of the present invention further contains (D) heavy isoparaffin. The cosmetic of the present invention is capable of diminishing vertical wrinkles, in particular on the lip, over a long period of time, and of maintaining a glossy lip.

    摘要翻译： 油性固体化妆品能够长时间有效地减少形态学问题，例如垂直皱纹，特别是在唇部上。 本发明提供一种油性固体化妆品，其含有：（A）具有干涉色的板状复合粉末，（B）球状复合粉末，其中折射率为1.40〜1.60的球形粉末的表面涂布有 涂料成分的折射率为2.00〜2.90，（C）为1〜40质量％的半固体成分。 优选本发明的化妆品还含有（D）重质异链烷烃。 本发明的化妆品能够长时间地减少垂直皱纹，特别是在唇部上，并且保持光泽的唇部。

    METHOD FOR GROWING GROUP III NITRIDE CRYSTAL
    10.
    发明申请
    METHOD FOR GROWING GROUP III NITRIDE CRYSTAL 审中-公开
    生长III类氮化物晶体的方法

    公开(公告)号：US20100275836A1

    公开(公告)日：2010-11-04

    申请号：US12812338

    申请日：2009-01-08

    申请人： Fumitaka Sato ,  Seiji Nakahata

    发明人： Fumitaka Sato ,  Seiji Nakahata

    IPC分类号： C30B23/04

    CPC分类号： C30B29/406 ,  C30B25/18 ,  C30B25/186 ,  H01L21/02389 ,  H01L21/0243 ,  H01L21/02433 ,  H01L21/02458 ,  H01L21/0254 ,  H01L21/02609 ,  H01L21/0262 ,  H01L21/02658

    摘要： The present method for growing group III nitride crystal includes the steps of: preparing a substrate including group III nitride seed crystal constituting one main surface thereof; forming a plurality of facets on the main surface of the substrate through vapor phase etching; and growing group III nitride crystal on the main surface on which the facets are formed. In this way, group III nitride crystal having a low dislocation density can be obtained readily and efficiently.

    摘要翻译： 用于生长III族氮化物晶体的本发明方法包括以下步骤：制备包含构成其一个主表面的III族氮化物晶种的衬底; 通过气相蚀刻在基板的主表面上形成多个面; 并且在其上形成有小平面的主表面上生长III族氮化物晶体。 以这种方式，可以容易且有效地获得具有低位错密度的III族氮化物晶体。