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1.发明申请Increasing the sensitivity and specificity of nucleic acid chip hybridization tests 审中-公开提高核酸芯片杂交检测的灵敏度和特异性公开(公告)号：US20050164407A1
公开(公告)日：2005-07-28
申请号：US10505898
申请日：2003-02-26
申请人： Cord Stahler , Peer Stahler , Markus Beier
发明人： Cord Stahler , Peer Stahler , Markus Beier
IPC分类号： B01L3/00 , B01L7/00 , C12Q1/68 , G01N33/543
CPC分类号： C12Q1/6837 , B01L3/5027 , B01L7/52 , B01L7/54 , B01L2300/1805 , B01L2300/1844 , B01L2300/1872 , C12Q2565/507
摘要： The invention relates to a method of increasing the sensitivity and specificity of nucleic acid chip hybridization tests and to devices suitable for carrying out the inventive method.
摘要翻译： 本发明涉及增加核酸芯片杂交试验的灵敏度和特异性以及适用于实施本发明方法的装置的方法。
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公开(公告)号：US20110092380A1
公开(公告)日：2011-04-21
申请号：US12521765
申请日：2007-12-31
申请人： Peer Stahler , Markus Beier , Cord Stahler , Daniel Summerer , Mark Matzas , Sonja Vorwerk
发明人： Peer Stahler , Markus Beier , Cord Stahler , Daniel Summerer , Mark Matzas , Sonja Vorwerk
IPC分类号： C40B30/04 , C40B60/14 , C12Q1/68 , C12P19/34 , C40B50/00 , C40B30/00 , C40B50/06 , C40B40/00 , C40B40/06
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00286 , B01J2219/00351 , B01J2219/00439 , B01J2219/00441 , B01J2219/00448 , B01J2219/00527 , B01J2219/00529 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729
摘要： The invention relates to improved molecular-biological processing equipment and an improved method of processing biological samples. The invention combines the provision of biologically functional molecules such as nucleic acids and peptides and of derivatives or analogs of these two classes of molecules in miniaturized flow cells with the sequential addition of reagents or fluids and serves for the processing of biological samples, such as proteins, nucleic acids, biogenic small molecules such as e.g. metabolites, viruses or cells, which for this purpose are introduced into the miniaturized flow cells. The invention further relates to methods and to the use of the molecular-biological processing equipment according to the invention for the detection and/or for the isolation of nucleic acids; for sequencing; for point mutation analysis; for the analysis of genomes and/or chromosomes; for the production of synthetic nucleic acids; for the production of arrays of primers, probes and/or antisense molecules; and other analytical and synthetic methods.
摘要翻译： 本发明涉及改进的分子生物处理设备和改进的生物样品处理方法。 本发明结合了在微型流动池中提供生物功能分子例如核酸和肽以及这两类分子的衍生物或类似物，连续添加试剂或液体，并用于加工生物样品如蛋白质 ，核酸，生物来源的小分子，例如 代谢物，病毒或细胞，为此目的被引入到小型化的流动池中。 本发明还涉及根据本发明的分子生物处理设备的方法和用途，用于检测和/或分离核酸; 用于测序; 用于点突变分析; 用于分析基因组和/或染色体; 用于生产合成核酸; 用于产生引物，探针和/或反义分子的阵列; 和其他分析和合成方法。
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公开(公告)号：US20050164293A1
公开(公告)日：2005-07-28
申请号：US11087627
申请日：2005-03-24
申请人： Peer Stahler , Cord Stahler , Andrea Schlauersbach , Manfred Muller , Michael Baum , Markus Beier
发明人： Peer Stahler , Cord Stahler , Andrea Schlauersbach , Manfred Muller , Michael Baum , Markus Beier
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2523/107
摘要： The invention relates to a method for the determination of analytes using carrier chips comprising arrays of different receptors in immobilized form on the surface of said chips. The method is performed dynamically in several cycles. Information obtained in a previous cycle on the modification or alteration of said receptors is used in the following cycle.
摘要翻译： 本发明涉及使用包含固定形式的不同受体阵列的载体芯片在所述芯片的表面上测定分析物的方法。 该方法在几个周期内动态执行。 在以前的循环中获得的关于所述受体的修饰或改变的信息在以下循环中使用。
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公开(公告)号：US20070196854A1
公开(公告)日：2007-08-23
申请号：US11785505
申请日：2007-04-18
申请人： Peer Stahler , Cord Stahler , Manfred Muller
发明人： Peer Stahler , Cord Stahler , Manfred Muller
CPC分类号： G16B30/00 , B01J19/0046 , B01J19/0093 , B01J2219/00317 , B01J2219/00432 , B01J2219/00436 , B01J2219/00439 , B01J2219/00441 , B01J2219/00448 , B01J2219/00479 , B01J2219/00497 , B01J2219/00511 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00603 , B01J2219/00605 , B01J2219/00608 , B01J2219/00621 , B01J2219/00626 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00702 , B01J2219/00704 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L3/502707 , B01L3/5085 , B01L2300/0654 , B01L2300/069 , B01L2300/0864 , B82Y30/00 , C12N15/10 , C12N15/66 , C12P19/34 , C40B40/06 , C40B40/10 , C40B50/14 , G03F7/70216 , G16B50/00
摘要： The invention relates to a method for producing polymers, in particular synthetic nucleic acid double strands of optional sequence, comprising the steps: (a) provision of a support having a surface area which contains a plurality of individual reaction areas, (b) location-resolved synthesis of nucleic acid fragments having in each case different base sequences in several of the individual reaction areas, and (c) detachment of the nucleic acid fragments from individual reaction areas.
摘要翻译： 本发明涉及用于制备聚合物的方法，特别是任选序列的合成核酸双链，包括以下步骤：（a）提供具有包含多个单独反应区域的表面积的载体，（b） 在几种单独的反应区域中解析各种情况下具有不同碱基序列的核酸片段的合成，和（c）从各个反应区域脱离核酸片段。
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5.发明申请Support for analyte determination methods and method for producing the support 审中-公开支持分析物测定方法和生产支持的方法公开(公告)号：US20070031877A1
公开(公告)日：2007-02-08
申请号：US11510565
申请日：2006-08-28
申请人： Cord Stahler , Peer Stahler , Manfred Muller , Fritz Stahler , Hans Lindner
发明人： Cord Stahler , Peer Stahler , Manfred Muller , Fritz Stahler , Hans Lindner
CPC分类号： G01N21/6454 , B01J19/0046 , B01J19/0093 , B01J2219/00317 , B01J2219/00432 , B01J2219/00436 , B01J2219/00439 , B01J2219/00441 , B01J2219/00448 , B01J2219/00479 , B01J2219/00497 , B01J2219/00511 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00603 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00702 , B01J2219/00704 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L3/502715 , B01L3/5085 , B01L2300/0654 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , B82Y30/00 , C12N15/10 , C12P19/34 , C40B40/06 , C40B40/10 , C40B50/14 , G01N21/253 , G01N33/551 , G03F7/70216 , Y10S435/97 , Y10S435/973
摘要： A method for producing a support for determining analytes. The method comprises the steps of (a) providing a support comprising at least one channel, comprising a conduit having an intake and an outlet for passing fluid from the intake to the outlet, in the support body, (b) passing liquid with building blocks for synthesizing polymeric receptors through the channel or channels of the support body, (c) site- and/or time-specifically immobilizing the receptor building blocks in each case on predetermined positions in the channel or channels by illumination and (d) repeating steps (b) and (c) until the required receptors have been synthesized in each case on the predetermined positions.
摘要翻译： 一种用于制备用于确定分析物的载体的方法。 该方法包括以下步骤：（a）提供包括至少一个通道的支撑件，其包括导管，该导管具有用于将流体从入口传递到出口的入口和出口，在支撑体中，（b） 用于通过支撑体的通道或通道合成聚合物受体，（c）在每种情况下通过照射将通道或通道中的预定位置的受体构建块定位和/或时间特异性地固定，并且（d）重复步骤 b）和（c），直到在每种情况下在预定位置合成所需的受体。
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公开(公告)号：US20050040043A1
公开(公告)日：2005-02-24
申请号：US10492014
申请日：2002-10-10
申请人： Cord Stahler , Peer Stahler , Manfred Muller
发明人： Cord Stahler , Peer Stahler , Manfred Muller
CPC分类号： B82Y30/00 , B01J2219/00286 , B01J2219/00434 , B01J2219/00436 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00704 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00727 , B01J2219/00729 , C12N15/1006 , C12Q1/6806 , G01N30/02 , C12Q2565/629 , C12Q2565/501 , B01D15/3804
摘要： The invention relates to an extraction method for isolating target molecules from a sample using a microfluidic carrier.
摘要翻译： 本发明涉及使用微流体载体从样品中分离靶分子的提取方法。
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公开(公告)号：US20070087349A1
公开(公告)日：2007-04-19
申请号：US10579769
申请日：2004-11-18
申请人： Peer Staehler , Cord Stahler , Markus Beier
发明人： Peer Staehler , Cord Stahler , Markus Beier
CPC分类号： C12Q1/6837 , C12N15/10 , C12P19/34 , C12Q1/6844 , C12Q2537/101 , C12Q2533/101 , C12Q2565/501
摘要： The invention relates to a template-based method for preparing nucleic acid double strands.
摘要翻译： 本发明涉及一种用于制备核酸双链的基于模板的方法。
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公开(公告)号：US20050037407A1
公开(公告)日：2005-02-17
申请号：US10895981
申请日：2004-07-22
申请人： Markus Beier , Cord Stahler
发明人： Markus Beier , Cord Stahler
IPC分类号： G01N33/543 , C12Q1/68 , C12M1/34 , G01N33/53
CPC分类号： G01N33/5438 , G01N33/54373
摘要： The invention relates to a method and an apparatus for determining analytes by electronic detection using a microfluidic support.
摘要翻译： 本发明涉及一种通过使用微流体支持的电子检测来确定分析物的方法和装置。
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