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公开(公告)号：US20110092380A1
公开(公告)日：2011-04-21
申请号：US12521765
申请日：2007-12-31
申请人： Peer Stahler , Markus Beier , Cord Stahler , Daniel Summerer , Mark Matzas , Sonja Vorwerk
发明人： Peer Stahler , Markus Beier , Cord Stahler , Daniel Summerer , Mark Matzas , Sonja Vorwerk
IPC分类号： C40B30/04 , C40B60/14 , C12Q1/68 , C12P19/34 , C40B50/00 , C40B30/00 , C40B50/06 , C40B40/00 , C40B40/06
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00286 , B01J2219/00351 , B01J2219/00439 , B01J2219/00441 , B01J2219/00448 , B01J2219/00527 , B01J2219/00529 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729
摘要： The invention relates to improved molecular-biological processing equipment and an improved method of processing biological samples. The invention combines the provision of biologically functional molecules such as nucleic acids and peptides and of derivatives or analogs of these two classes of molecules in miniaturized flow cells with the sequential addition of reagents or fluids and serves for the processing of biological samples, such as proteins, nucleic acids, biogenic small molecules such as e.g. metabolites, viruses or cells, which for this purpose are introduced into the miniaturized flow cells. The invention further relates to methods and to the use of the molecular-biological processing equipment according to the invention for the detection and/or for the isolation of nucleic acids; for sequencing; for point mutation analysis; for the analysis of genomes and/or chromosomes; for the production of synthetic nucleic acids; for the production of arrays of primers, probes and/or antisense molecules; and other analytical and synthetic methods.
摘要翻译： 本发明涉及改进的分子生物处理设备和改进的生物样品处理方法。 本发明结合了在微型流动池中提供生物功能分子例如核酸和肽以及这两类分子的衍生物或类似物，连续添加试剂或液体，并用于加工生物样品如蛋白质 ，核酸，生物来源的小分子，例如 代谢物，病毒或细胞，为此目的被引入到小型化的流动池中。 本发明还涉及根据本发明的分子生物处理设备的方法和用途，用于检测和/或分离核酸; 用于测序; 用于点突变分析; 用于分析基因组和/或染色体; 用于生产合成核酸; 用于产生引物，探针和/或反义分子的阵列; 和其他分析和合成方法。
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2.发明申请FLEXIBLE EXTRACTION METHOD FOR THE PRODUCTION OF SEQUENCE-SPECIFIC MOLECULE LIBRARIES 审中-公开用于生产序列特异性分子库的灵活提取方法公开(公告)号：US20100256012A1
公开(公告)日：2010-10-07
申请号：US12744390
申请日：2008-11-24
申请人： Markus Beier , Stephan Bau , Daniel Summerer , Mark Matzas , Peer F. Staehler
发明人： Markus Beier , Stephan Bau , Daniel Summerer , Mark Matzas , Peer F. Staehler
IPC分类号： C40B30/04
CPC分类号： C12Q1/6837 , C12Q2565/507 , C12Q2523/107 , C12Q2563/143 , C12Q2533/101
摘要： The invention relates to an extraction method for isolating target molecules from a sample with the help of a molecule library.
摘要翻译： 本发明涉及借助于分子文库从样品中分离靶分子的提取方法。
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公开(公告)号：US20120045771A1
公开(公告)日：2012-02-23
申请号：US13139320
申请日：2009-12-11
申请人： Markus Beier , Peer F. Staehler , Cord F. Staehler , Daniel Summerer , Jack T. Leonard , Stephan Bau , Anthony Caruso , Nadine Schracke , Andreas Keller , Helmut Hanenberg , Olaf Eckermann
发明人： Markus Beier , Peer F. Staehler , Cord F. Staehler , Daniel Summerer , Jack T. Leonard , Stephan Bau , Anthony Caruso , Nadine Schracke , Andreas Keller , Helmut Hanenberg , Olaf Eckermann
CPC分类号： C12Q1/6834 , C12N15/1006 , C12Q1/6806 , C12Q2565/518 , C12Q2525/191
摘要： The invention relates to a method for isolation of target molecules from a nucleic acid population.
摘要翻译： 本发明涉及从核酸群体分离靶分子的方法。
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公开(公告)号：US08759061B1
公开(公告)日：2014-06-24
申请号：US10588570
申请日：2005-02-04
CPC分类号： C12N9/1252 , C12Q1/6858 , C12Q2521/101
摘要： The present invention relates to DNA polymerases with a special mutation which have an enhanced mismatch discrimination, the preparation and use thereof. The thermostable DNA polymerases with this mutation are particularly suitable for diagnostic and molecular-biological methods, e.g., allele-specific PCR.
摘要翻译： 本发明涉及具有特异突变的DNA聚合酶，其具有增强的错配鉴别，其制备和用途。 具有该突变的耐热性DNA聚合酶特别适用于诊断和分子生物学方法，例如等位基因特异性PCR。
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5.发明申请Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids 审中-公开用于体内并入非天然氨基酸的正交翻译组分公开(公告)号：US20130244245A1
公开(公告)日：2013-09-19
申请号：US13492296
申请日：2012-06-08
申请人： Peter G. Schultz , Lital Alfonta , Johnathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng , Mohammad Seyedsayamdost , James Turner
发明人： Peter G. Schultz , Lital Alfonta , Johnathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng , Mohammad Seyedsayamdost , James Turner
CPC分类号： C12N9/93 , C12N15/1058 , C12P21/00 , C12P21/02
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate unnatural amino acid into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将非天然氨基酸掺入在诸如大肠杆菌或真核宿主如酵母细胞中的细胞宿主细胞中产生的蛋白质中。 本发明提供了例如但不限于新的正交合成酶，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸的蛋白质的方法和翻译系统。
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6.发明授权Orthogonal translation components for the in vivo incorporation of unnatural amino acids 有权用于体内引入非天然氨基酸的正交翻译组分公开(公告)号：US09102932B2
公开(公告)日：2015-08-11
申请号：US13492296
申请日：2012-06-08
申请人： Peter G. Schultz , Lital Alfonta , Johnathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng , Mohammad Seyedsayamdost , James Turner
发明人： Peter G. Schultz , Lital Alfonta , Johnathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng , Mohammad Seyedsayamdost , James Turner
CPC分类号： C12N9/93 , C12N15/1058 , C12P21/00 , C12P21/02
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate unnatural amino acid into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将非天然氨基酸掺入在诸如大肠杆菌或真核宿主如酵母细胞中的细胞宿主细胞中产生的蛋白质中。 本发明提供了例如但不限于新的正交合成酶，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸的蛋白质的方法和翻译系统。
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7.发明申请Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids 有权用于体内并入非天然氨基酸的正交翻译组分公开(公告)号：US20080233611A1
公开(公告)日：2008-09-25
申请号：US11665083
申请日：2005-10-27
申请人： Peter G. Schultz , Lital Alfonta , Jonathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng
发明人： Peter G. Schultz , Lital Alfonta , Jonathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng
CPC分类号： C12N9/93 , C12N15/1058 , C12P21/00 , C12P21/02
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将非天然氨基酸掺入到在细菌宿主细胞如大肠杆菌或真核宿主如酵母细胞中产生的蛋白质中。 本发明提供了例如但不限于新的正交合成酶，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸的蛋白质的方法和翻译系统。
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